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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 38041

FusionGeneSummary for THSD4_ADAM10

check button Fusion gene summary
Fusion gene informationFusion gene name: THSD4_ADAM10
Fusion gene ID: 38041
HgeneTgene
Gene symbol

THSD4

ADAM10

Gene ID

79875

102

Gene namethrombospondin type 1 domain containing 4ADAM metallopeptidase domain 10
SynonymsADAMTSL-6|ADAMTSL6|FVSY9334|PRO34005AD10|AD18|CD156c|CDw156|HsT18717|MADM|RAK|kuz
Cytomap

15q23

15q21.3

Type of geneprotein-codingprotein-coding
Descriptionthrombospondin type-1 domain-containing protein 4A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6ADAMTS-like protein 6thrombospondin, type I, domain containing 4disintegrin and metalloproteinase domain-containing protein 10a disintegrin and metalloprotease domain 10kuzbanian protein homologmammalian disintegrin-metalloprotease
Modification date2018051920180519
UniProtAcc

Q6ZMP0

O14672

Ensembl transtripts involved in fusion geneENST00000355327, ENST00000261862, 
ENST00000357769, ENST00000567838, 
ENST00000260408, ENST00000402627, 
ENST00000561288, ENST00000396140, 
ENST00000558733, 
Fusion gene scores* DoF score9 X 8 X 7=5044 X 4 X 4=64
# samples 154
** MAII scorelog2(15/504*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: THSD4 [Title/Abstract] AND ADAM10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneADAM10

GO:0006509

membrane protein ectodomain proteolysis

12714508|17557115|18355449|18419754|18676862|19114711

TgeneADAM10

GO:0007162

negative regulation of cell adhesion

12714508

TgeneADAM10

GO:0034612

response to tumor necrosis factor

11831872

TgeneADAM10

GO:0051089

constitutive protein ectodomain proteolysis

12714508


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-CG-4444-01ATHSD4chr15

71549054

+ADAM10chr15

58957396

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000355327ENST00000260408THSD4chr15

71549054

+ADAM10chr15

58957396

-
5CDS-intronENST00000355327ENST00000402627THSD4chr15

71549054

+ADAM10chr15

58957396

-
5CDS-intronENST00000355327ENST00000561288THSD4chr15

71549054

+ADAM10chr15

58957396

-
5CDS-intronENST00000355327ENST00000396140THSD4chr15

71549054

+ADAM10chr15

58957396

-
5CDS-5UTRENST00000355327ENST00000558733THSD4chr15

71549054

+ADAM10chr15

58957396

-
In-frameENST00000261862ENST00000260408THSD4chr15

71549054

+ADAM10chr15

58957396

-
5CDS-intronENST00000261862ENST00000402627THSD4chr15

71549054

+ADAM10chr15

58957396

-
5CDS-intronENST00000261862ENST00000561288THSD4chr15

71549054

+ADAM10chr15

58957396

-
5CDS-intronENST00000261862ENST00000396140THSD4chr15

71549054

+ADAM10chr15

58957396

-
5CDS-5UTRENST00000261862ENST00000558733THSD4chr15

71549054

+ADAM10chr15

58957396

-
intron-3CDSENST00000357769ENST00000260408THSD4chr15

71549054

+ADAM10chr15

58957396

-
intron-intronENST00000357769ENST00000402627THSD4chr15

71549054

+ADAM10chr15

58957396

-
intron-intronENST00000357769ENST00000561288THSD4chr15

71549054

+ADAM10chr15

58957396

-
intron-intronENST00000357769ENST00000396140THSD4chr15

71549054

+ADAM10chr15

58957396

-
intron-5UTRENST00000357769ENST00000558733THSD4chr15

71549054

+ADAM10chr15

58957396

-
intron-3CDSENST00000567838ENST00000260408THSD4chr15

71549054

+ADAM10chr15

58957396

-
intron-intronENST00000567838ENST00000402627THSD4chr15

71549054

+ADAM10chr15

58957396

-
intron-intronENST00000567838ENST00000561288THSD4chr15

71549054

+ADAM10chr15

58957396

-
intron-intronENST00000567838ENST00000396140THSD4chr15

71549054

+ADAM10chr15

58957396

-
intron-5UTRENST00000567838ENST00000558733THSD4chr15

71549054

+ADAM10chr15

58957396

-

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FusionProtFeatures for THSD4_ADAM10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
THSD4

Q6ZMP0

ADAM10

O14672

Promotes FBN1 matrix assembly. Attenuates TGFBsignaling, possibly by accelerating the sequestration of largelatent complexes of TGFB or active TGFB by FBN1 microfibrilassembly, thereby negatively regulating the expression of TGFBregulatory targets, such as POSTN (By similarity). {ECO:0000250}. Cleaves the membrane-bound precursor of TNF-alpha at'76-Ala-|-Val-77' to its mature soluble form. Responsible for theproteolytical release of soluble JAM3 from endothelial cellssurface (PubMed:20592283). Responsible for the proteolytic releaseof several other cell-surface proteins, including heparin-bindingepidermal growth-like factor, ephrin-A2, CD44, CDH2 and forconstitutive and regulated alpha-secretase cleavage of amyloidprecursor protein (APP) (PubMed:26686862, PubMed:11786905,PubMed:29224781). Contributes to the normal cleavage of thecellular prion protein (PubMed:11477090). Involved in the cleavageof the adhesion molecule L1 at the cell surface and in releasedmembrane vesicles, suggesting a vesicle-based protease activity(PubMed:12475894). Controls also the proteolytic processing ofNotch and mediates lateral inhibition during neurogenesis (Bysimilarity). Responsible for the FasL ectodomain shedding and forthe generation of the remnant ADAM10-processed FasL (FasL APL)transmembrane form (PubMed:17557115). Also cleaves the ectodomainof the integral membrane proteins CORIN and ITM2B(PubMed:19114711, PubMed:21288900). May regulate the EFNA5-EPHA3signaling (PubMed:16239146). {ECO:0000250|UniProtKB:O35598,ECO:0000269|PubMed:11477090, ECO:0000269|PubMed:11786905,ECO:0000269|PubMed:12475894, ECO:0000269|PubMed:16239146,ECO:0000269|PubMed:17557115, ECO:0000269|PubMed:19114711,ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:21288900,ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:29224781}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTHSD4chr15:71549054chr15:58957396ENST00000261862+51753_3073381019DomainTSP type-1 1
HgeneTHSD4chr15:71549054chr15:58957396ENST00000355327+61853_3073381019DomainTSP type-1 1
TgeneADAM10chr15:71549054chr15:58957396ENST00000260408-316555_673161749Compositional biasCys-rich
TgeneADAM10chr15:71549054chr15:58957396ENST00000260408-316220_456161749DomainPeptidase M12B
TgeneADAM10chr15:71549054chr15:58957396ENST00000260408-316457_551161749DomainDisintegrin
TgeneADAM10chr15:71549054chr15:58957396ENST00000260408-316171_178161749MotifCysteine switch
TgeneADAM10chr15:71549054chr15:58957396ENST00000260408-316708_715161749MotifSH3-binding
TgeneADAM10chr15:71549054chr15:58957396ENST00000260408-316722_728161749MotifSH3-binding
TgeneADAM10chr15:71549054chr15:58957396ENST00000260408-316694_748161749Topological domainCytoplasmic
TgeneADAM10chr15:71549054chr15:58957396ENST00000260408-316673_693161749TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTHSD4chr15:71549054chr15:58957396ENST00000261862+517676_7373381019DomainTSP type-1 2
HgeneTHSD4chr15:71549054chr15:58957396ENST00000261862+517739_7923381019DomainTSP type-1 3
HgeneTHSD4chr15:71549054chr15:58957396ENST00000261862+517793_8513381019DomainTSP type-1 4
HgeneTHSD4chr15:71549054chr15:58957396ENST00000261862+517852_9113381019DomainTSP type-1 5
HgeneTHSD4chr15:71549054chr15:58957396ENST00000261862+517912_9683381019DomainTSP type-1 6
HgeneTHSD4chr15:71549054chr15:58957396ENST00000261862+517971_10083381019DomainPLAC
HgeneTHSD4chr15:71549054chr15:58957396ENST00000355327+618676_7373381019DomainTSP type-1 2
HgeneTHSD4chr15:71549054chr15:58957396ENST00000355327+618739_7923381019DomainTSP type-1 3
HgeneTHSD4chr15:71549054chr15:58957396ENST00000355327+618793_8513381019DomainTSP type-1 4
HgeneTHSD4chr15:71549054chr15:58957396ENST00000355327+618852_9113381019DomainTSP type-1 5
HgeneTHSD4chr15:71549054chr15:58957396ENST00000355327+618912_9683381019DomainTSP type-1 6
HgeneTHSD4chr15:71549054chr15:58957396ENST00000355327+618971_10083381019DomainPLAC
TgeneADAM10chr15:71549054chr15:58957396ENST00000260408-31620_672161749Topological domainExtracellular


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FusionGeneSequence for THSD4_ADAM10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_THSD4_ENST00000355327_chr15_71549054_+_ADAM10_ENST00000260408_chr15_58957396_-_926aa
MVSHFMGSLSVLCFLLLLGFQFVCPQPSTQHRKVPQRMAAEGAPEDDGGGGAPGVWGAWGPWSACSRSCSGGVMEQTRPCLPRSYRLRGG
QRPGAPARAFADHVVSAVRTSVPLHRSRDETPALAGTDASRQGPTVLRGSRHPQPQGLEVTGDRRSRTRGTIGPGKYGYGKAPYILPLQT
DTAHTPQRLRRQKLSSRHSRSQGASSARHGYSSPAHQVPQHGPLYQSDSGPRSGLQAAEAPIYQLPLTHDQGYPAASSLFHSPETSNNHG
VGTHGATQSFSQPARSTAISCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGRFYEWEPFAEDYPHKYGPQGGCADHSVFERMR
KYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVK
RIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGII
TVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFV
ESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALC
PASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCN
DFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRR

>In-frame_THSD4_ENST00000261862_chr15_71549054_+_ADAM10_ENST00000260408_chr15_58957396_-_926aa
MVSHFMGSLSVLCFLLLLGFQFVCPQPSTQHRKVPQRMAAEGAPEDDGGGGAPGVWGAWGPWSACSRSCSGGVMEQTRPCLPRSYRLRGG
QRPGAPARAFADHVVSAVRTSVPLHRSRDETPALAGTDASRQGPTVLRGSRHPQPQGLEVTGDRRSRTRGTIGPGKYGYGKAPYILPLQT
DTAHTPQRLRRQKLSSRHSRSQGASSARHGYSSPAHQVPQHGPLYQSDSGPRSGLQAAEAPIYQLPLTHDQGYPAASSLFHSPETSNNHG
VGTHGATQSFSQPARSTAISCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGRFYEWEPFAEDYPHKYGPQGGCADHSVFERMR
KYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVK
RIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGII
TVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFV
ESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALC
PASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCN
DFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRR


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_THSD4_ENST00000355327_chr15_71549054_+_ADAM10_ENST00000260408_chr15_58957396_-_2778nt
ATGGTTTCCCATTTCATGGGGTCTCTCAGTGTCCTGTGTTTCCTTCTGCTGCTTGGATTCCAGTTCGTCTGCCCACAGCCCTCCACTCAA
CACAGGAAGGTCCCGCAGCGGATGGCGGCGGAGGGCGCCCCCGAGGACGACGGCGGCGGCGGCGCCCCGGGAGTGTGGGGCGCCTGGGGC
CCCTGGTCGGCCTGCTCGCGTAGCTGCAGCGGCGGCGTGATGGAGCAGACGCGGCCCTGCCTGCCCCGCTCCTACCGCCTGCGCGGCGGC
CAGCGGCCTGGCGCCCCTGCGCGCGCCTTCGCGGACCACGTGGTGTCGGCGGTGCGCACGTCGGTGCCACTGCACCGGAGCCGCGACGAG
ACGCCAGCGCTGGCCGGTACGGACGCCAGCCGCCAGGGCCCCACGGTGCTGCGAGGCAGCCGGCACCCACAGCCCCAGGGCCTCGAAGTC
ACTGGGGACAGAAGGAGCAGGACCCGTGGTACCATTGGCCCTGGCAAGTATGGCTATGGTAAGGCCCCATATATCTTACCACTGCAGACA
GACACTGCACACACGCCACAGAGGCTCCGGAGACAGAAGCTCTCATCCCGCCATTCCAGGTCCCAGGGAGCATCTTCTGCTAGGCATGGC
TACAGTTCACCAGCCCACCAGGTCCCCCAACATGGGCCTTTGTACCAAAGTGACAGTGGCCCTCGCTCTGGACTGCAGGCTGCGGAGGCC
CCCATCTACCAGCTACCTTTGACCCATGATCAAGGCTACCCTGCAGCTTCAAGTCTCTTTCACAGCCCAGAAACAAGCAACAACCACGGT
GTGGGGACCCATGGGGCAACTCAGAGCTTCTCTCAGCCTGCCCGATCTACAGCAATCTCATGCATCGGGGCCTATCGGCAGTACAAGCTG
TGCAACACCAACGTATGTCCAGAAAGCAGTAGAAGTATCCGGGAGGTACAGTGTGCATCCTACAACAACAAGCCATTCATGGGCCGGTTT
TATGAGTGGGAACCATTTGCAGAAGACTATCCCCATAAATACGGTCCTCAGGGGGGCTGTGCAGATCATTCAGTATTTGAAAGAATGAGG
AAATACCAGATGACTGGTGTAGAGGAAGTAACACAGATACCTCAAGAAGAACATGCTGCTAATGGTCCAGAACTTCTGAGGAAAAAACGT
ACAACTTCAGCTGAAAAAAATACTTGTCAGCTTTATATTCAGACTGATCATTTGTTCTTTAAATATTACGGAACACGAGAAGCTGTGATT
GCCCAGATATCCAGTCATGTTAAAGCGATTGATACAATTTACCAGACCACAGACTTCTCCGGAATCCGTAACATCAGTTTCATGGTGAAA
CGCATAAGAATCAATACAACTGCTGATGAGAAGGACCCTACAAATCCTTTCCGTTTCCCAAATATTGGTGTGGAGAAGTTTCTGGAATTG
AATTCTGAGCAGAATCATGATGACTACTGTTTGGCCTATGTCTTCACAGACCGAGATTTTGATGATGGCGTACTTGGTCTGGCTTGGGTT
GGAGCACCTTCAGGAAGCTCTGGAGGAATATGTGAAAAAAGTAAACTCTATTCAGATGGTAAGAAGAAGTCCTTAAACACTGGAATTATT
ACTGTTCAGAACTATGGGTCTCATGTACCTCCCAAAGTCTCTCACATTACTTTTGCTCACGAAGTTGGACATAACTTTGGATCCCCACAT
GATTCTGGAACAGAGTGCACACCAGGAGAATCTAAGAATTTGGGTCAAAAAGAAAATGGCAATTACATCATGTATGCAAGAGCAACATCT
GGGGACAAACTTAACAACAATAAATTCTCACTCTGTAGTATTAGAAATATAAGCCAAGTTCTTGAGAAGAAGAGAAACAACTGTTTTGTT
GAATCTGGCCAACCTATTTGTGGAAATGGAATGGTAGAACAAGGTGAAGAATGTGATTGTGGCTATAGTGACCAGTGTAAAGATGAATGC
TGCTTCGATGCAAATCAACCAGAGGGAAGAAAATGCAAACTGAAACCTGGGAAACAGTGCAGTCCAAGTCAAGGTCCTTGTTGTACAGCA
CAGTGTGCATTCAAGTCAAAGTCTGAGAAGTGTCGGGATGATTCAGACTGTGCAAGGGAAGGAATATGTAATGGCTTCACAGCTCTCTGC
CCAGCATCTGACCCTAAACCAAACTTCACAGACTGTAATAGGCATACACAAGTGTGCATTAATGGGCAATGTGCAGGTTCTATCTGTGAG
AAATATGGCTTAGAGGAGTGTACGTGTGCCAGTTCTGATGGCAAAGATGATAAAGAATTATGCCATGTATGCTGTATGAAGAAAATGGAC
CCATCAACTTGTGCCAGTACAGGGTCTGTGCAGTGGAGTAGGCACTTCAGTGGTCGAACCATCACCCTGCAACCTGGATCCCCTTGCAAC
GATTTTAGAGGTTACTGTGATGTTTTCATGCGGTGCAGATTAGTAGATGCTGATGGTCCTCTAGCTAGGCTTAAAAAAGCAATTTTTAGT
CCAGAGCTCTATGAAAACATTGCTGAATGGATTGTGGCTCATTGGTGGGCAGTATTACTTATGGGAATTGCTCTGATCATGCTAATGGCT
GGATTTATTAAGATATGCAGTGTTCATACTCCAAGTAGTAATCCAAAGTTGCCTCCTCCTAAACCACTTCCAGGCACTTTAAAGAGGAGG

>In-frame_THSD4_ENST00000261862_chr15_71549054_+_ADAM10_ENST00000260408_chr15_58957396_-_2778nt
ATGGTTTCCCATTTCATGGGGTCTCTCAGTGTCCTGTGTTTCCTTCTGCTGCTTGGATTCCAGTTCGTCTGCCCACAGCCCTCCACTCAA
CACAGGAAGGTCCCGCAGCGGATGGCGGCGGAGGGCGCCCCCGAGGACGACGGCGGCGGCGGCGCCCCGGGAGTGTGGGGCGCCTGGGGC
CCCTGGTCGGCCTGCTCGCGTAGCTGCAGCGGCGGCGTGATGGAGCAGACGCGGCCCTGCCTGCCCCGCTCCTACCGCCTGCGCGGCGGC
CAGCGGCCTGGCGCCCCTGCGCGCGCCTTCGCGGACCACGTGGTGTCGGCGGTGCGCACGTCGGTGCCACTGCACCGGAGCCGCGACGAG
ACGCCAGCGCTGGCCGGTACGGACGCCAGCCGCCAGGGCCCCACGGTGCTGCGAGGCAGCCGGCACCCACAGCCCCAGGGCCTCGAAGTC
ACTGGGGACAGAAGGAGCAGGACCCGTGGTACCATTGGCCCTGGCAAGTATGGCTATGGTAAGGCCCCATATATCTTACCACTGCAGACA
GACACTGCACACACGCCACAGAGGCTCCGGAGACAGAAGCTCTCATCCCGCCATTCCAGGTCCCAGGGAGCATCTTCTGCTAGGCATGGC
TACAGTTCACCAGCCCACCAGGTCCCCCAACATGGGCCTTTGTACCAAAGTGACAGTGGCCCTCGCTCTGGACTGCAGGCTGCGGAGGCC
CCCATCTACCAGCTACCTTTGACCCATGATCAAGGCTACCCTGCAGCTTCAAGTCTCTTTCACAGCCCAGAAACAAGCAACAACCACGGT
GTGGGGACCCATGGGGCAACTCAGAGCTTCTCTCAGCCTGCCCGATCTACAGCAATCTCATGCATCGGGGCCTATCGGCAGTACAAGCTG
TGCAACACCAACGTATGTCCAGAAAGCAGTAGAAGTATCCGGGAGGTACAGTGTGCATCCTACAACAACAAGCCATTCATGGGCCGGTTT
TATGAGTGGGAACCATTTGCAGAAGACTATCCCCATAAATACGGTCCTCAGGGGGGCTGTGCAGATCATTCAGTATTTGAAAGAATGAGG
AAATACCAGATGACTGGTGTAGAGGAAGTAACACAGATACCTCAAGAAGAACATGCTGCTAATGGTCCAGAACTTCTGAGGAAAAAACGT
ACAACTTCAGCTGAAAAAAATACTTGTCAGCTTTATATTCAGACTGATCATTTGTTCTTTAAATATTACGGAACACGAGAAGCTGTGATT
GCCCAGATATCCAGTCATGTTAAAGCGATTGATACAATTTACCAGACCACAGACTTCTCCGGAATCCGTAACATCAGTTTCATGGTGAAA
CGCATAAGAATCAATACAACTGCTGATGAGAAGGACCCTACAAATCCTTTCCGTTTCCCAAATATTGGTGTGGAGAAGTTTCTGGAATTG
AATTCTGAGCAGAATCATGATGACTACTGTTTGGCCTATGTCTTCACAGACCGAGATTTTGATGATGGCGTACTTGGTCTGGCTTGGGTT
GGAGCACCTTCAGGAAGCTCTGGAGGAATATGTGAAAAAAGTAAACTCTATTCAGATGGTAAGAAGAAGTCCTTAAACACTGGAATTATT
ACTGTTCAGAACTATGGGTCTCATGTACCTCCCAAAGTCTCTCACATTACTTTTGCTCACGAAGTTGGACATAACTTTGGATCCCCACAT
GATTCTGGAACAGAGTGCACACCAGGAGAATCTAAGAATTTGGGTCAAAAAGAAAATGGCAATTACATCATGTATGCAAGAGCAACATCT
GGGGACAAACTTAACAACAATAAATTCTCACTCTGTAGTATTAGAAATATAAGCCAAGTTCTTGAGAAGAAGAGAAACAACTGTTTTGTT
GAATCTGGCCAACCTATTTGTGGAAATGGAATGGTAGAACAAGGTGAAGAATGTGATTGTGGCTATAGTGACCAGTGTAAAGATGAATGC
TGCTTCGATGCAAATCAACCAGAGGGAAGAAAATGCAAACTGAAACCTGGGAAACAGTGCAGTCCAAGTCAAGGTCCTTGTTGTACAGCA
CAGTGTGCATTCAAGTCAAAGTCTGAGAAGTGTCGGGATGATTCAGACTGTGCAAGGGAAGGAATATGTAATGGCTTCACAGCTCTCTGC
CCAGCATCTGACCCTAAACCAAACTTCACAGACTGTAATAGGCATACACAAGTGTGCATTAATGGGCAATGTGCAGGTTCTATCTGTGAG
AAATATGGCTTAGAGGAGTGTACGTGTGCCAGTTCTGATGGCAAAGATGATAAAGAATTATGCCATGTATGCTGTATGAAGAAAATGGAC
CCATCAACTTGTGCCAGTACAGGGTCTGTGCAGTGGAGTAGGCACTTCAGTGGTCGAACCATCACCCTGCAACCTGGATCCCCTTGCAAC
GATTTTAGAGGTTACTGTGATGTTTTCATGCGGTGCAGATTAGTAGATGCTGATGGTCCTCTAGCTAGGCTTAAAAAAGCAATTTTTAGT
CCAGAGCTCTATGAAAACATTGCTGAATGGATTGTGGCTCATTGGTGGGCAGTATTACTTATGGGAATTGCTCTGATCATGCTAATGGCT
GGATTTATTAAGATATGCAGTGTTCATACTCCAAGTAGTAATCCAAAGTTGCCTCCTCCTAAACCACTTCCAGGCACTTTAAAGAGGAGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_THSD4_ENST00000355327_chr15_71549054_+_ADAM10_ENST00000260408_chr15_58957396_-_5255nt
ATCAGACCAACGTGAATTGAATCACAGCAGTTCAGAAAGAGGAAACTGGATTCAGGACTTGAACGCAACTCCCAATTGCAGAAAATTGGC
AACGTCTCTGAAGAGCCCTTGCTTTTGCCTGGACCCCCAGCATCATGGTTTCCCATTTCATGGGGTCTCTCAGTGTCCTGTGTTTCCTTC
TGCTGCTTGGATTCCAGTTCGTCTGCCCACAGCCCTCCACTCAACACAGGAAGGTCCCGCAGCGGATGGCGGCGGAGGGCGCCCCCGAGG
ACGACGGCGGCGGCGGCGCCCCGGGAGTGTGGGGCGCCTGGGGCCCCTGGTCGGCCTGCTCGCGTAGCTGCAGCGGCGGCGTGATGGAGC
AGACGCGGCCCTGCCTGCCCCGCTCCTACCGCCTGCGCGGCGGCCAGCGGCCTGGCGCCCCTGCGCGCGCCTTCGCGGACCACGTGGTGT
CGGCGGTGCGCACGTCGGTGCCACTGCACCGGAGCCGCGACGAGACGCCAGCGCTGGCCGGTACGGACGCCAGCCGCCAGGGCCCCACGG
TGCTGCGAGGCAGCCGGCACCCACAGCCCCAGGGCCTCGAAGTCACTGGGGACAGAAGGAGCAGGACCCGTGGTACCATTGGCCCTGGCA
AGTATGGCTATGGTAAGGCCCCATATATCTTACCACTGCAGACAGACACTGCACACACGCCACAGAGGCTCCGGAGACAGAAGCTCTCAT
CCCGCCATTCCAGGTCCCAGGGAGCATCTTCTGCTAGGCATGGCTACAGTTCACCAGCCCACCAGGTCCCCCAACATGGGCCTTTGTACC
AAAGTGACAGTGGCCCTCGCTCTGGACTGCAGGCTGCGGAGGCCCCCATCTACCAGCTACCTTTGACCCATGATCAAGGCTACCCTGCAG
CTTCAAGTCTCTTTCACAGCCCAGAAACAAGCAACAACCACGGTGTGGGGACCCATGGGGCAACTCAGAGCTTCTCTCAGCCTGCCCGAT
CTACAGCAATCTCATGCATCGGGGCCTATCGGCAGTACAAGCTGTGCAACACCAACGTATGTCCAGAAAGCAGTAGAAGTATCCGGGAGG
TACAGTGTGCATCCTACAACAACAAGCCATTCATGGGCCGGTTTTATGAGTGGGAACCATTTGCAGAAGACTATCCCCATAAATACGGTC
CTCAGGGGGGCTGTGCAGATCATTCAGTATTTGAAAGAATGAGGAAATACCAGATGACTGGTGTAGAGGAAGTAACACAGATACCTCAAG
AAGAACATGCTGCTAATGGTCCAGAACTTCTGAGGAAAAAACGTACAACTTCAGCTGAAAAAAATACTTGTCAGCTTTATATTCAGACTG
ATCATTTGTTCTTTAAATATTACGGAACACGAGAAGCTGTGATTGCCCAGATATCCAGTCATGTTAAAGCGATTGATACAATTTACCAGA
CCACAGACTTCTCCGGAATCCGTAACATCAGTTTCATGGTGAAACGCATAAGAATCAATACAACTGCTGATGAGAAGGACCCTACAAATC
CTTTCCGTTTCCCAAATATTGGTGTGGAGAAGTTTCTGGAATTGAATTCTGAGCAGAATCATGATGACTACTGTTTGGCCTATGTCTTCA
CAGACCGAGATTTTGATGATGGCGTACTTGGTCTGGCTTGGGTTGGAGCACCTTCAGGAAGCTCTGGAGGAATATGTGAAAAAAGTAAAC
TCTATTCAGATGGTAAGAAGAAGTCCTTAAACACTGGAATTATTACTGTTCAGAACTATGGGTCTCATGTACCTCCCAAAGTCTCTCACA
TTACTTTTGCTCACGAAGTTGGACATAACTTTGGATCCCCACATGATTCTGGAACAGAGTGCACACCAGGAGAATCTAAGAATTTGGGTC
AAAAAGAAAATGGCAATTACATCATGTATGCAAGAGCAACATCTGGGGACAAACTTAACAACAATAAATTCTCACTCTGTAGTATTAGAA
ATATAAGCCAAGTTCTTGAGAAGAAGAGAAACAACTGTTTTGTTGAATCTGGCCAACCTATTTGTGGAAATGGAATGGTAGAACAAGGTG
AAGAATGTGATTGTGGCTATAGTGACCAGTGTAAAGATGAATGCTGCTTCGATGCAAATCAACCAGAGGGAAGAAAATGCAAACTGAAAC
CTGGGAAACAGTGCAGTCCAAGTCAAGGTCCTTGTTGTACAGCACAGTGTGCATTCAAGTCAAAGTCTGAGAAGTGTCGGGATGATTCAG
ACTGTGCAAGGGAAGGAATATGTAATGGCTTCACAGCTCTCTGCCCAGCATCTGACCCTAAACCAAACTTCACAGACTGTAATAGGCATA
CACAAGTGTGCATTAATGGGCAATGTGCAGGTTCTATCTGTGAGAAATATGGCTTAGAGGAGTGTACGTGTGCCAGTTCTGATGGCAAAG
ATGATAAAGAATTATGCCATGTATGCTGTATGAAGAAAATGGACCCATCAACTTGTGCCAGTACAGGGTCTGTGCAGTGGAGTAGGCACT
TCAGTGGTCGAACCATCACCCTGCAACCTGGATCCCCTTGCAACGATTTTAGAGGTTACTGTGATGTTTTCATGCGGTGCAGATTAGTAG
ATGCTGATGGTCCTCTAGCTAGGCTTAAAAAAGCAATTTTTAGTCCAGAGCTCTATGAAAACATTGCTGAATGGATTGTGGCTCATTGGT
GGGCAGTATTACTTATGGGAATTGCTCTGATCATGCTAATGGCTGGATTTATTAAGATATGCAGTGTTCATACTCCAAGTAGTAATCCAA
AGTTGCCTCCTCCTAAACCACTTCCAGGCACTTTAAAGAGGAGGAGACCTCCACAGCCCATTCAGCAACCCCAGCGTCAGCGGCCCCGAG
AGAGTTATCAAATGGGACACATGAGACGCTAACTGCAGCTTTTGCCTTGGTTCTTCCTAGTGCCTACAATGGGAAAACTTCACTCCAAAG
AGAAACCTATTAAGTCATCATCTCCAAACTAAACCCTCACAAGTAACAGTTGAAGAAAAAATGGCAAGAGATCATATCCTCAGACCAGGT
GGAATTACTTAAATTTTAAAGCCTGAAAATTCCAATTTGGGGGTGGGAGGTGGAAAAGGAACCCAATTTTCTTATGAACAGATATTTTTA
ACTTAATGGCACAAAGTCTTAGAATATTATTATGTGCCCCGTGTTCCCTGTTCTTCGTTGCTGCATTTTCTTCACTTGCAGGCAAACTTG
GCTCTCAATAAACTTTTACCACAAATTGAAATAAATATATTTTTTTCAACTGCCAATCAAGGCTAGGAGGCTCGACCACCTCAACATTGG
AGACATCACTTGCCAATGTACATACCTTGTTATATGCAGACATGTATTTCTTACGTACACTGTACTTCTGTGTGCAATTGTAAACAGAAA
TTGCAATATGGATGTTTCTTTGTATTATAAAATTTTTCCGCTCTTAATTAAAAATTACTGTTTAATTGACATACTCAGGATAACAGAGAA
TGGTGGTATTCAGTGGTCCAGGATTCTGTAATGCTTTACACAGGCAGTTTTGAAATGAAAATCAATTTACCTTTCTGTTACGATGGAGTT
GGTTTTGATACTCATTTTTTCTTTATCACATGGCTGCTACGGGCACAAGTGACTATACTGAAGAACACAGTTAAGTGTTGTGCAAACTGG
ACATAGCAGCACATACTACTTCAGAGTTCATGATGTAGATGTCTGGTTTCTGCTTACGTCTTTTAAACTTTCTAATTCAATTCCATTTTT
CAATTAATAGGTGAAATTTTATTCATGCTTTGATAGAAATTATGTCAATGAAATGATTCTTTTTATTTGTAGCCTACTTATTTGTGTTTT
TCATATATCTGAAATATGCTAATTATGTTTTCTGTCTGATATGGAAAAGAAAAGCTGTGTCTTTATCAAAATATTTAAACGGTTTTTTCA
GCATATCATCACTGATCATTGGTAACCACTAAAGATGAGTAATTTGCTTAAGTAGTAGTTAAAATTGTAGATAGGCCTTCTGACATTTTT
TTTCCTAAAATTTTTAACAGCATTGAAGGTGAAACAGCACAATGTCCCATTCCAAATTTATTTTTGAAACAGATGTAAATAATTGGCATT
TTAAAGAGAAAGCAAAAACATTTAATGTATTAACAGGCTTATTGCTATGCAGGAAATAGAAGGGGCATTACAAAAATTGAAGCTTGTGAC
ATATTTATTGCTTCTGTTTTCCAACTACATCACTTCAACTAGAAGTAAAGCTATGATTTTCCTGACTTCACATAGGAGGCAAATTTAGAG
AAAGTTGTAAAGATTTCTATGTTTTGGGTTTTTTTTTTTCCTTTTTTTTTTTAAGAGTATAAGGTTTACACAATCATTCTCATAATGTGA
CGCAAGCCAGCAAGGCCAAAAATGCTAGAGAAAATAACGGGATCTCTTCCTTGTAAACTTGTACAGTATGTGGTGACTTTTTCAAAATAC
AGCTTTTTGTACATGATTTAGAGACAAATTTTGTACATGAAACCCCAGATAGACTATAAATAATTCTAAACAAACAAGTAGGTAGATATG
TATGTAATTGCTTTTAAATCATTTAAATGCCTTTGTTTTTGGACTGTGCAAAGGTTGGAAGTGGGTTTGCATTTCTAAAATGGTGACTTT
TATTCTGCAAGAGTTCTTAGTAACTTCTTGAGTGTGGTAGACTTTGGAACATGTAAATTTTTTGCTTGTAATGTTATCCTGTGGTAGGAT
TTTGGCAGGTACACACACTGCCCTATTTTATTTTGAGTCTAAGTTAAATGTTTTCTGAAAAGAGATACATGCACTGAACTCTTTCCACTG
CGAATCAAGATGTGGTAATATAAAAGGATCAAGACAAATGAGATCTAATACTACTGTCAGTTTTAATGTCCACTGTGTTTTATACAGTAT
CTTTTTTTGTTCACTTTGGAAATTTTTACTAAAAATTGCAAAAAATAAAGTATTGTGCAAAGATGTAAGGTTTTTTGAAACTTGAAATGC
ATTAATAAATAGACGATTAAATCAACTTGAAGGTTCTATACTCTTTGAACTCTGAGAACTATCACAAGAAGCTTCCCACAAGGCAGTGTT
TTCTTACAGTTGTCTCTTCCTACAAAAGTATAGATTATCTTTATTCTTAATACTTTGGAATCCATGTAGAAAATTTCCAGTTAGATACTC

>In-frame_THSD4_ENST00000261862_chr15_71549054_+_ADAM10_ENST00000260408_chr15_58957396_-_5200nt
GACTTGAACGCAACTCCCAATTGCAGAAAATTGGCAACGTCTCTGAAGAGCCCTTGCTTTTGCCTGGACCCCCAGCATCATGGTTTCCCA
TTTCATGGGGTCTCTCAGTGTCCTGTGTTTCCTTCTGCTGCTTGGATTCCAGTTCGTCTGCCCACAGCCCTCCACTCAACACAGGAAGGT
CCCGCAGCGGATGGCGGCGGAGGGCGCCCCCGAGGACGACGGCGGCGGCGGCGCCCCGGGAGTGTGGGGCGCCTGGGGCCCCTGGTCGGC
CTGCTCGCGTAGCTGCAGCGGCGGCGTGATGGAGCAGACGCGGCCCTGCCTGCCCCGCTCCTACCGCCTGCGCGGCGGCCAGCGGCCTGG
CGCCCCTGCGCGCGCCTTCGCGGACCACGTGGTGTCGGCGGTGCGCACGTCGGTGCCACTGCACCGGAGCCGCGACGAGACGCCAGCGCT
GGCCGGTACGGACGCCAGCCGCCAGGGCCCCACGGTGCTGCGAGGCAGCCGGCACCCACAGCCCCAGGGCCTCGAAGTCACTGGGGACAG
AAGGAGCAGGACCCGTGGTACCATTGGCCCTGGCAAGTATGGCTATGGTAAGGCCCCATATATCTTACCACTGCAGACAGACACTGCACA
CACGCCACAGAGGCTCCGGAGACAGAAGCTCTCATCCCGCCATTCCAGGTCCCAGGGAGCATCTTCTGCTAGGCATGGCTACAGTTCACC
AGCCCACCAGGTCCCCCAACATGGGCCTTTGTACCAAAGTGACAGTGGCCCTCGCTCTGGACTGCAGGCTGCGGAGGCCCCCATCTACCA
GCTACCTTTGACCCATGATCAAGGCTACCCTGCAGCTTCAAGTCTCTTTCACAGCCCAGAAACAAGCAACAACCACGGTGTGGGGACCCA
TGGGGCAACTCAGAGCTTCTCTCAGCCTGCCCGATCTACAGCAATCTCATGCATCGGGGCCTATCGGCAGTACAAGCTGTGCAACACCAA
CGTATGTCCAGAAAGCAGTAGAAGTATCCGGGAGGTACAGTGTGCATCCTACAACAACAAGCCATTCATGGGCCGGTTTTATGAGTGGGA
ACCATTTGCAGAAGACTATCCCCATAAATACGGTCCTCAGGGGGGCTGTGCAGATCATTCAGTATTTGAAAGAATGAGGAAATACCAGAT
GACTGGTGTAGAGGAAGTAACACAGATACCTCAAGAAGAACATGCTGCTAATGGTCCAGAACTTCTGAGGAAAAAACGTACAACTTCAGC
TGAAAAAAATACTTGTCAGCTTTATATTCAGACTGATCATTTGTTCTTTAAATATTACGGAACACGAGAAGCTGTGATTGCCCAGATATC
CAGTCATGTTAAAGCGATTGATACAATTTACCAGACCACAGACTTCTCCGGAATCCGTAACATCAGTTTCATGGTGAAACGCATAAGAAT
CAATACAACTGCTGATGAGAAGGACCCTACAAATCCTTTCCGTTTCCCAAATATTGGTGTGGAGAAGTTTCTGGAATTGAATTCTGAGCA
GAATCATGATGACTACTGTTTGGCCTATGTCTTCACAGACCGAGATTTTGATGATGGCGTACTTGGTCTGGCTTGGGTTGGAGCACCTTC
AGGAAGCTCTGGAGGAATATGTGAAAAAAGTAAACTCTATTCAGATGGTAAGAAGAAGTCCTTAAACACTGGAATTATTACTGTTCAGAA
CTATGGGTCTCATGTACCTCCCAAAGTCTCTCACATTACTTTTGCTCACGAAGTTGGACATAACTTTGGATCCCCACATGATTCTGGAAC
AGAGTGCACACCAGGAGAATCTAAGAATTTGGGTCAAAAAGAAAATGGCAATTACATCATGTATGCAAGAGCAACATCTGGGGACAAACT
TAACAACAATAAATTCTCACTCTGTAGTATTAGAAATATAAGCCAAGTTCTTGAGAAGAAGAGAAACAACTGTTTTGTTGAATCTGGCCA
ACCTATTTGTGGAAATGGAATGGTAGAACAAGGTGAAGAATGTGATTGTGGCTATAGTGACCAGTGTAAAGATGAATGCTGCTTCGATGC
AAATCAACCAGAGGGAAGAAAATGCAAACTGAAACCTGGGAAACAGTGCAGTCCAAGTCAAGGTCCTTGTTGTACAGCACAGTGTGCATT
CAAGTCAAAGTCTGAGAAGTGTCGGGATGATTCAGACTGTGCAAGGGAAGGAATATGTAATGGCTTCACAGCTCTCTGCCCAGCATCTGA
CCCTAAACCAAACTTCACAGACTGTAATAGGCATACACAAGTGTGCATTAATGGGCAATGTGCAGGTTCTATCTGTGAGAAATATGGCTT
AGAGGAGTGTACGTGTGCCAGTTCTGATGGCAAAGATGATAAAGAATTATGCCATGTATGCTGTATGAAGAAAATGGACCCATCAACTTG
TGCCAGTACAGGGTCTGTGCAGTGGAGTAGGCACTTCAGTGGTCGAACCATCACCCTGCAACCTGGATCCCCTTGCAACGATTTTAGAGG
TTACTGTGATGTTTTCATGCGGTGCAGATTAGTAGATGCTGATGGTCCTCTAGCTAGGCTTAAAAAAGCAATTTTTAGTCCAGAGCTCTA
TGAAAACATTGCTGAATGGATTGTGGCTCATTGGTGGGCAGTATTACTTATGGGAATTGCTCTGATCATGCTAATGGCTGGATTTATTAA
GATATGCAGTGTTCATACTCCAAGTAGTAATCCAAAGTTGCCTCCTCCTAAACCACTTCCAGGCACTTTAAAGAGGAGGAGACCTCCACA
GCCCATTCAGCAACCCCAGCGTCAGCGGCCCCGAGAGAGTTATCAAATGGGACACATGAGACGCTAACTGCAGCTTTTGCCTTGGTTCTT
CCTAGTGCCTACAATGGGAAAACTTCACTCCAAAGAGAAACCTATTAAGTCATCATCTCCAAACTAAACCCTCACAAGTAACAGTTGAAG
AAAAAATGGCAAGAGATCATATCCTCAGACCAGGTGGAATTACTTAAATTTTAAAGCCTGAAAATTCCAATTTGGGGGTGGGAGGTGGAA
AAGGAACCCAATTTTCTTATGAACAGATATTTTTAACTTAATGGCACAAAGTCTTAGAATATTATTATGTGCCCCGTGTTCCCTGTTCTT
CGTTGCTGCATTTTCTTCACTTGCAGGCAAACTTGGCTCTCAATAAACTTTTACCACAAATTGAAATAAATATATTTTTTTCAACTGCCA
ATCAAGGCTAGGAGGCTCGACCACCTCAACATTGGAGACATCACTTGCCAATGTACATACCTTGTTATATGCAGACATGTATTTCTTACG
TACACTGTACTTCTGTGTGCAATTGTAAACAGAAATTGCAATATGGATGTTTCTTTGTATTATAAAATTTTTCCGCTCTTAATTAAAAAT
TACTGTTTAATTGACATACTCAGGATAACAGAGAATGGTGGTATTCAGTGGTCCAGGATTCTGTAATGCTTTACACAGGCAGTTTTGAAA
TGAAAATCAATTTACCTTTCTGTTACGATGGAGTTGGTTTTGATACTCATTTTTTCTTTATCACATGGCTGCTACGGGCACAAGTGACTA
TACTGAAGAACACAGTTAAGTGTTGTGCAAACTGGACATAGCAGCACATACTACTTCAGAGTTCATGATGTAGATGTCTGGTTTCTGCTT
ACGTCTTTTAAACTTTCTAATTCAATTCCATTTTTCAATTAATAGGTGAAATTTTATTCATGCTTTGATAGAAATTATGTCAATGAAATG
ATTCTTTTTATTTGTAGCCTACTTATTTGTGTTTTTCATATATCTGAAATATGCTAATTATGTTTTCTGTCTGATATGGAAAAGAAAAGC
TGTGTCTTTATCAAAATATTTAAACGGTTTTTTCAGCATATCATCACTGATCATTGGTAACCACTAAAGATGAGTAATTTGCTTAAGTAG
TAGTTAAAATTGTAGATAGGCCTTCTGACATTTTTTTTCCTAAAATTTTTAACAGCATTGAAGGTGAAACAGCACAATGTCCCATTCCAA
ATTTATTTTTGAAACAGATGTAAATAATTGGCATTTTAAAGAGAAAGCAAAAACATTTAATGTATTAACAGGCTTATTGCTATGCAGGAA
ATAGAAGGGGCATTACAAAAATTGAAGCTTGTGACATATTTATTGCTTCTGTTTTCCAACTACATCACTTCAACTAGAAGTAAAGCTATG
ATTTTCCTGACTTCACATAGGAGGCAAATTTAGAGAAAGTTGTAAAGATTTCTATGTTTTGGGTTTTTTTTTTTCCTTTTTTTTTTTAAG
AGTATAAGGTTTACACAATCATTCTCATAATGTGACGCAAGCCAGCAAGGCCAAAAATGCTAGAGAAAATAACGGGATCTCTTCCTTGTA
AACTTGTACAGTATGTGGTGACTTTTTCAAAATACAGCTTTTTGTACATGATTTAGAGACAAATTTTGTACATGAAACCCCAGATAGACT
ATAAATAATTCTAAACAAACAAGTAGGTAGATATGTATGTAATTGCTTTTAAATCATTTAAATGCCTTTGTTTTTGGACTGTGCAAAGGT
TGGAAGTGGGTTTGCATTTCTAAAATGGTGACTTTTATTCTGCAAGAGTTCTTAGTAACTTCTTGAGTGTGGTAGACTTTGGAACATGTA
AATTTTTTGCTTGTAATGTTATCCTGTGGTAGGATTTTGGCAGGTACACACACTGCCCTATTTTATTTTGAGTCTAAGTTAAATGTTTTC
TGAAAAGAGATACATGCACTGAACTCTTTCCACTGCGAATCAAGATGTGGTAATATAAAAGGATCAAGACAAATGAGATCTAATACTACT
GTCAGTTTTAATGTCCACTGTGTTTTATACAGTATCTTTTTTTGTTCACTTTGGAAATTTTTACTAAAAATTGCAAAAAATAAAGTATTG
TGCAAAGATGTAAGGTTTTTTGAAACTTGAAATGCATTAATAAATAGACGATTAAATCAACTTGAAGGTTCTATACTCTTTGAACTCTGA
GAACTATCACAAGAAGCTTCCCACAAGGCAGTGTTTTCTTACAGTTGTCTCTTCCTACAAAAGTATAGATTATCTTTATTCTTAATACTT


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FusionGenePPI for THSD4_ADAM10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
THSD4ZNF195, ALMS1, KRBA1, CEP164, GLI3, ZNF609, FOXG1, APPBP2, HSPA8, USP54, OFD1, RIPK1, ARID5B, MLF1, NUFIP2, HELZ, KANK2, VSIG8, HSPA2ADAM10EFNA2, MAD2L1, GRB2, LCK, OR4S2, MSRB2, PDIA3, FBXO6, PXN, DLG1, TSPAN5, TSPAN14, TSPAN15, TSPAN17, TSPAN33, TSPAN10, TAZ, B3GNT2, KRAS, MPPE1, TRIM25, NOTCH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for THSD4_ADAM10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for THSD4_ADAM10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTHSD4C0236969Substance-Related Disorders1CTD_human
TgeneADAM10C3810041ALZHEIMER DISEASE 182UNIPROT
TgeneADAM10C0406811Reticulate acropigmentation of Kitamura1ORPHANET;UNIPROT
TgeneADAM10C1458155Mammary Neoplasms1CTD_human