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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38040

FusionGeneSummary for THSD1_LARS

check button Fusion gene summary
Fusion gene informationFusion gene name: THSD1_LARS
Fusion gene ID: 38040
HgeneTgene
Gene symbol

THSD1

LARS

Gene ID

55901

51520

Gene namethrombospondin type 1 domain containing 1leucyl-tRNA synthetase
SynonymsTMTSP|UNQ3010HSPC192|ILFS1|LARS1|LEURS|LEUS|LFIS|LRS|PIG44|RNTLS|hr025Cl
Cytomap

13q14.3

5q32

Type of geneprotein-codingprotein-coding
Descriptionthrombospondin type-1 domain-containing protein 14833423O18Rikthrombospondin, type I, domain containing 1transmembrane molecule with thrombospondin moduleleucine--tRNA ligase, cytoplasmiccytoplasmic leucyl-tRNA synthetasecytosolic leucyl-tRNA synthetaseleucine tRNA ligase 1, cytoplasmicleucine translaseproliferation-inducing gene 44
Modification date2018032920180523
UniProtAcc

Q9NS62

Q9P2J5

Ensembl transtripts involved in fusion geneENST00000544466, ENST00000349258, 
ENST00000258613, 
ENST00000394434, 
ENST00000545646, ENST00000274562, 
ENST00000510191, ENST00000511505, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 3=27
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: THSD1 [Title/Abstract] AND LARS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLARS

GO:0006425

glutaminyl-tRNA aminoacylation

26869582


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE087245THSD1chr13

52971647

-LARSchr5

145537358

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000544466ENST00000394434THSD1chr13

52971647

-LARSchr5

145537358

-
intron-3CDSENST00000544466ENST00000545646THSD1chr13

52971647

-LARSchr5

145537358

-
intron-3CDSENST00000544466ENST00000274562THSD1chr13

52971647

-LARSchr5

145537358

-
intron-3CDSENST00000544466ENST00000510191THSD1chr13

52971647

-LARSchr5

145537358

-
intron-5UTRENST00000544466ENST00000511505THSD1chr13

52971647

-LARSchr5

145537358

-
intron-3CDSENST00000349258ENST00000394434THSD1chr13

52971647

-LARSchr5

145537358

-
intron-3CDSENST00000349258ENST00000545646THSD1chr13

52971647

-LARSchr5

145537358

-
intron-3CDSENST00000349258ENST00000274562THSD1chr13

52971647

-LARSchr5

145537358

-
intron-3CDSENST00000349258ENST00000510191THSD1chr13

52971647

-LARSchr5

145537358

-
intron-5UTRENST00000349258ENST00000511505THSD1chr13

52971647

-LARSchr5

145537358

-
intron-3CDSENST00000258613ENST00000394434THSD1chr13

52971647

-LARSchr5

145537358

-
intron-3CDSENST00000258613ENST00000545646THSD1chr13

52971647

-LARSchr5

145537358

-
intron-3CDSENST00000258613ENST00000274562THSD1chr13

52971647

-LARSchr5

145537358

-
intron-3CDSENST00000258613ENST00000510191THSD1chr13

52971647

-LARSchr5

145537358

-
intron-5UTRENST00000258613ENST00000511505THSD1chr13

52971647

-LARSchr5

145537358

-

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FusionProtFeatures for THSD1_LARS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
THSD1

Q9NS62

LARS

Q9P2J5

Catalyzes the specific attachment of an amino acid toits cognate tRNA in a two step reaction: the amino acid (AA) isfirst activated by ATP to form AA-AMP and then transferred to theacceptor end of the tRNA. Exhibits a post-transfer editingactivity to hydrolyze mischarged tRNAs.{ECO:0000269|PubMed:19426743}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for THSD1_LARS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for THSD1_LARS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for THSD1_LARS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for THSD1_LARS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLARSC3809522INFANTILE LIVER FAILURE SYNDROME 11ORPHANET;UNIPROT