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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38039

FusionGeneSummary for THRSP_KCTD14

check button Fusion gene summary
Fusion gene informationFusion gene name: THRSP_KCTD14
Fusion gene ID: 38039
HgeneTgene
Gene symbol

THRSP

KCTD14

Gene ID

7069

65987

Gene namethyroid hormone responsivepotassium channel tetramerization domain containing 14
SynonymsLPGP1|Lpgp|S14|SPOT14|THRP-
Cytomap

11q14.1

11q14.1

Type of geneprotein-codingprotein-coding
Descriptionthyroid hormone-inducible hepatic proteinSPOT14 homologlipogenic protein 1spot 14 proteinthyroid hormone responsive (SPOT14 homolog, rat)thyroid hormone responsive SPOT14BTB/POZ domain-containing protein KCTD14potassium channel tetramerisation domain containing 14
Modification date2018052220180519
UniProtAcc

Q92748

Q9BQ13

Ensembl transtripts involved in fusion geneENST00000281030, ENST00000353172, 
ENST00000533144, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 3 X 3=45
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: THRSP [Title/Abstract] AND KCTD14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AN-A0FV-01ATHRSPchr11

77775387

+KCTD14chr11

77728316

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000281030ENST00000353172THRSPchr11

77775387

+KCTD14chr11

77728316

-
3UTR-3CDSENST00000281030ENST00000533144THRSPchr11

77775387

+KCTD14chr11

77728316

-

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FusionProtFeatures for THRSP_KCTD14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
THRSP

Q92748

KCTD14

Q9BQ13

Plays a role in the regulation of lipogenesis,especially in lactating mammary gland. Important for thebiosynthesis of triglycerides with medium-length fatty acidchains. May modulate lipogenesis by interacting with MID1IP1 andpreventing its interaction with ACACA (By similarity). Mayfunction as transcriptional coactivator. May modulate thetranscription factor activity of THRB. {ECO:0000250,ECO:0000269|PubMed:17418816, ECO:0000269|PubMed:18299245}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for THRSP_KCTD14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for THRSP_KCTD14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
THRSPTHRSP, AKT1, AURKA, BAG4, BCAR3, BRMS1, FZR1, ERBB2, FGFR4, HMMR, IGF1R, KRAS, LSP1, PALB2, PARP1, PIK3CA, PTPN1, RB1CC1, SMAD4, STK11, TGFB1, TSG101, WT1KCTD14TCF4, STK16, KCTD14, ACSF3, TUBGCP6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for THRSP_KCTD14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for THRSP_KCTD14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTHRSPC0024667Animal Mammary Neoplasms1CTD_human
HgeneTHRSPC0024668Mammary Neoplasms, Experimental1CTD_human