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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38037

FusionGeneSummary for THRB_PVRL3

check button Fusion gene summary
Fusion gene informationFusion gene name: THRB_PVRL3
Fusion gene ID: 38037
HgeneTgene
Gene symbol

THRB

PVRL3

Gene ID

7068

25945

Gene namethyroid hormone receptor betanectin cell adhesion molecule 3
SynonymsC-ERBA-2|C-ERBA-BETA|ERBA2|GRTH|NR1A2|PRTH|THR1|THRB1|THRB2CD113|CDW113|NECTIN-3|PPR3|PRR3|PVRL3|PVRR3
Cytomap

3p24.2

3q13.13

Type of geneprotein-codingprotein-coding
Descriptionthyroid hormone receptor betanuclear receptor subfamily 1 group A member 2oncogene ERBA2thyroid hormone nuclear receptor beta variant 1thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)nectin-3nectin 3poliovirus receptor-related 3poliovirus receptor-related protein 3
Modification date2018052320180523
UniProtAcc

P10828

Ensembl transtripts involved in fusion geneENST00000396671, ENST00000356447, 
ENST00000416420, ENST00000280696, 
ENST00000493615, ENST00000485303, 
ENST00000319792, ENST00000488016, 
Fusion gene scores* DoF score3 X 3 X 3=271 X 1 X 1=1
# samples 31
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: THRB [Title/Abstract] AND PVRL3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-HT-7477-01BTHRBchr3

24338717

-PVRL3chr3

110830877

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000396671ENST00000493615THRBchr3

24338717

-PVRL3chr3

110830877

+
5UTR-3CDSENST00000396671ENST00000485303THRBchr3

24338717

-PVRL3chr3

110830877

+
5UTR-3CDSENST00000396671ENST00000319792THRBchr3

24338717

-PVRL3chr3

110830877

+
5UTR-3UTRENST00000396671ENST00000488016THRBchr3

24338717

-PVRL3chr3

110830877

+
intron-3CDSENST00000356447ENST00000493615THRBchr3

24338717

-PVRL3chr3

110830877

+
intron-3CDSENST00000356447ENST00000485303THRBchr3

24338717

-PVRL3chr3

110830877

+
intron-3CDSENST00000356447ENST00000319792THRBchr3

24338717

-PVRL3chr3

110830877

+
intron-3UTRENST00000356447ENST00000488016THRBchr3

24338717

-PVRL3chr3

110830877

+
5UTR-3CDSENST00000416420ENST00000493615THRBchr3

24338717

-PVRL3chr3

110830877

+
5UTR-3CDSENST00000416420ENST00000485303THRBchr3

24338717

-PVRL3chr3

110830877

+
5UTR-3CDSENST00000416420ENST00000319792THRBchr3

24338717

-PVRL3chr3

110830877

+
5UTR-3UTRENST00000416420ENST00000488016THRBchr3

24338717

-PVRL3chr3

110830877

+
intron-3CDSENST00000280696ENST00000493615THRBchr3

24338717

-PVRL3chr3

110830877

+
intron-3CDSENST00000280696ENST00000485303THRBchr3

24338717

-PVRL3chr3

110830877

+
intron-3CDSENST00000280696ENST00000319792THRBchr3

24338717

-PVRL3chr3

110830877

+
intron-3UTRENST00000280696ENST00000488016THRBchr3

24338717

-PVRL3chr3

110830877

+

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FusionProtFeatures for THRB_PVRL3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
THRB

P10828

PVRL3

Nuclear hormone receptor that can act as a repressor oractivator of transcription. High affinity receptor for thyroidhormones, including triiodothyronine and thyroxine.{ECO:0000269|PubMed:12699376, ECO:0000269|PubMed:14673100,ECO:0000269|PubMed:16781732, ECO:0000269|PubMed:17418816,ECO:0000269|PubMed:18237438, ECO:0000269|PubMed:18798561,ECO:0000269|PubMed:19926848}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for THRB_PVRL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for THRB_PVRL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
THRBPSMC5, BRD8, NCOA2, NRBF2, NCOA6, RXRA, CCND1, TBL1X, TRIP4, PRMT1, TSG101, TP53, PPARGC1B, PPARGC1A, COPS2, THRB, NCOR2, NCOA1, NR2F6, NCOR1, SRC, LRIF1, PRKDC, SMC1A, PARP1, LIG3, XRCC5, XRCC6, HSPA4, TBL1XR1, HDAC3, GPS2, CAMK2B, NRIP1, HMGN3, NCOA3, RXRG, RXRB, MED21, ROBO4, ANP32A, ATF2, C1D, MMS19, ADAT3, RANBP9, NSD1, UBE2I, ACTA2, ACTBL2, ACTB, PDLIM7, DNM3, NRASPVRL3PVR, PARD3, PVRL3, MLLT4, PVRL1, PVRL2, TIGIT, BAG3, RGS20, KRTAP4-2, KRTAP10-7, KRTAP10-9, KRTAP10-8, KRTAP10-3, NOTCH2NL, LGALS8, NPTX1, SDF2, ASPH, FBXO2, COL14A1, MAK, ERO1LB, INPP5K, PDK1, FBXO7, SMEK1, NLRP3, CHMP4B, FBXW7, SDF2L1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for THRB_PVRL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneTHRBP10828DB00451LevothyroxineThyroid hormone receptor betasmall moleculeapproved
HgeneTHRBP10828DB00509DextrothyroxineThyroid hormone receptor betasmall moleculeapproved|investigational
HgeneTHRBP10828DB01118AmiodaroneThyroid hormone receptor betasmall moleculeapproved|investigational
HgeneTHRBP10828DB00279LiothyronineThyroid hormone receptor betasmall moleculeapproved|vet_approved

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RelatedDiseases for THRB_PVRL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTHRBC2937288THYROID HORMONE RESISTANCE, GENERALIZED, AUTOSOMAL DOMINANT19CTD_human;UNIPROT
HgeneTHRBC1840364THYROID HORMONE RESISTANCE, SELECTIVE PITUITARY3CTD_human;ORPHANET;UNIPROT
HgeneTHRBC2940786Thyroid Hormone Resistance Syndrome2CTD_human;HPO;ORPHANET
HgeneTHRBC0019284Diaphragmatic Hernia1CTD_human
HgeneTHRBC0206682Follicular thyroid carcinoma1CTD_human
HgeneTHRBC0376634Craniofacial Abnormalities1CTD_human