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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38024

FusionGeneSummary for THRAP3_USP6

check button Fusion gene summary
Fusion gene informationFusion gene name: THRAP3_USP6
Fusion gene ID: 38024
HgeneTgene
Gene symbol

THRAP3

USP6

Gene ID

9967

9098

Gene namethyroid hormone receptor associated protein 3ubiquitin specific peptidase 6
SynonymsBCLAF2|TRAP150HRP1|TRE17|TRE2|TRESMCR|Tre-2|USP6-short
Cytomap

1p34.3

17p13.2

Type of geneprotein-codingprotein-coding
Descriptionthyroid hormone receptor-associated protein 3BCLAF1 and THRAP3 family member 2TR-associated protein, 150-kDathyroid hormone receptor-associated protein complex 150 kDa componentthyroid hormone receptor-associated protein, 150 kDa subunitubiquitin carboxyl-terminal hydrolase 6TBC1D3 and USP32 fusiondeubiquitinating enzyme 6hyperpolymorphic gene 1proto-oncogene TRE-2ubiquitin specific peptidase 6 (Tre-2 oncogene)ubiquitin specific protease 6 (Tre-2 oncogene)ubiquitin thioesterase 6
Modification date2018052220180523
UniProtAcc

Q9Y2W1

P35125

Ensembl transtripts involved in fusion geneENST00000354618, ENST00000469141, 
ENST00000466743, 
ENST00000332776, 
ENST00000574788, ENST00000304328, 
ENST00000250066, ENST00000572429, 
Fusion gene scores* DoF score16 X 7 X 11=12326 X 5 X 1=30
# samples 1912
** MAII scorelog2(19/1232*10)=-2.69693093236395
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/30*10)=2
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: THRAP3 [Title/Abstract] AND USP6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTHRAP3

GO:0000956

nuclear-transcribed mRNA catabolic process

20123736

HgeneTHRAP3

GO:0006367

transcription initiation from RNA polymerase II promoter

12218053

HgeneTHRAP3

GO:0030518

intracellular steroid hormone receptor signaling pathway

11867769

HgeneTHRAP3

GO:0030521

androgen receptor signaling pathway

12218053

HgeneTHRAP3

GO:0045893

positive regulation of transcription, DNA-templated

10198638

HgeneTHRAP3

GO:0045944

positive regulation of transcription by RNA polymerase II

12037571

TgeneUSP6

GO:0016579

protein deubiquitination

16127172

TgeneUSP6

GO:0060627

regulation of vesicle-mediated transport

15509780


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AY624559THRAP3chr1

36690107

+USP6chr17

5033229

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000354618ENST00000332776THRAP3chr1

36690107

+USP6chr17

5033229

+
5UTR-5UTRENST00000354618ENST00000574788THRAP3chr1

36690107

+USP6chr17

5033229

+
5UTR-5UTRENST00000354618ENST00000304328THRAP3chr1

36690107

+USP6chr17

5033229

+
5UTR-5UTRENST00000354618ENST00000250066THRAP3chr1

36690107

+USP6chr17

5033229

+
5UTR-intronENST00000354618ENST00000572429THRAP3chr1

36690107

+USP6chr17

5033229

+
5UTR-5UTRENST00000469141ENST00000332776THRAP3chr1

36690107

+USP6chr17

5033229

+
5UTR-5UTRENST00000469141ENST00000574788THRAP3chr1

36690107

+USP6chr17

5033229

+
5UTR-5UTRENST00000469141ENST00000304328THRAP3chr1

36690107

+USP6chr17

5033229

+
5UTR-5UTRENST00000469141ENST00000250066THRAP3chr1

36690107

+USP6chr17

5033229

+
5UTR-intronENST00000469141ENST00000572429THRAP3chr1

36690107

+USP6chr17

5033229

+
intron-5UTRENST00000466743ENST00000332776THRAP3chr1

36690107

+USP6chr17

5033229

+
intron-5UTRENST00000466743ENST00000574788THRAP3chr1

36690107

+USP6chr17

5033229

+
intron-5UTRENST00000466743ENST00000304328THRAP3chr1

36690107

+USP6chr17

5033229

+
intron-5UTRENST00000466743ENST00000250066THRAP3chr1

36690107

+USP6chr17

5033229

+
intron-intronENST00000466743ENST00000572429THRAP3chr1

36690107

+USP6chr17

5033229

+

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FusionProtFeatures for THRAP3_USP6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
THRAP3

Q9Y2W1

USP6

P35125

Involved in pre-mRNA splicing. Remains associated withspliced mRNA after splicing which probably involves interactionswith the exon junction complex (EJC). Can trigger mRNA decay whichseems to be independent of nonsense-mediated decay involvingpremature stop codons (PTC) recognition. May be involved innuclear mRNA decay. Involved in regulation of signal-inducedalternative splicing. During splicing of PTPRC/CD45 is proposed tosequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in restingT-cells. Involved in cyclin-D1/CCND1 mRNA stability probably byacting as component of the SNARP complex which associates withboth the 3'end of the CCND1 gene and its mRNA. Involved inresponse to DNA damage. Is excluced from DNA damage sites in amanner that parallels transcription inhibition; the function mayinvolve the SNARP complex. Initially thought to play a role intranscriptional coactivation through its association with the TRAPcomplex; however, it is not regarded as a stable Mediator complexsubunit. Cooperatively with HELZ2, enhances the transcriptionalactivation mediated by PPARG, maybe through the stabilization ofthe PPARG binding to DNA in presence of ligand. May play a role inthe terminal stage of adipocyte differentiation. Plays a role inthe positive regulation of the circadian clock. Acts as acoactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes itstranscriptional activator activity and binding to circadian targetgenes (PubMed:24043798). {ECO:0000269|PubMed:20123736,ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773,ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. Deubiquitinase with an ATP-independent isopeptidaseactivity, cleaving at the C-terminus of the ubiquitin moiety.Catalyzes its own deubiquitination. In vitro, isoform 2, but notisoform 3, shows deubiquitinating activity. Promotes plasmamembrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiatetumorigenesis by inducing the production of matrixmetalloproteinases following NF-kappa-B activation.{ECO:0000269|PubMed:15509780, ECO:0000269|PubMed:16127172,ECO:0000269|PubMed:20418905}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for THRAP3_USP6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for THRAP3_USP6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
THRAP3RNPS1, TRIP6, CLEC3B, RUNX1T1, LXN, CDK8, VDR, MED1, PARP1, H3F3A, TERF2, POT1, SMN1, TRA, YWHAG, SREK1, ARRB1, ARRB2, CAND1, RBM14, HNRNPU, DDX21, PRPF6, S100A9, PRPF3, NCSTN, SF3B2, SAP18, SFPQ, PHGDH, DHX9, IK, SF3A1, SNRPA1, DEK, SRSF11, SF3B6, HNRNPM, ACIN1, EEF1A1, SF3B3, PSIP1, DDX5, SART1, PSAP, ESR1, BARD1, MDC1, PAXIP1, MAGOH, EIF4A3, SMURF1, ALB, CSNK2A1, PAN2, LMNA, HDAC11, CLK3, SRPK2, SRPK1, CLK2, SRPK3, APBB1, NEDD4, PIN1, WWOX, ASB3, ASB18, LGR4, CSNK2A2, DROSHA, IVNS1ABP, SART3, TP53, CBX1, CUL7, OBSL1, EZH2, SUZ12, RNF2, BMI1, LUZP4, SPIN1, TRA2A, PRMT8, LUC7L, LUC7L2, SNIP1, WHSC1, FBXW11, NTRK1, PUF60, RPS19, SSRP1, BCLAF1, MED4, CLK1, XPO1, HIST1H3E, AHSA1, THOC1, PLK2, GAN, FOXK2, FOXL2, ALKBH3, MCM5, U2AF2, PNN, SNRNP70, TNFRSF13B, C11orf57, CHCHD10, APOBEC3D, CAMKV, LLGL2, CYLD, COQ2, COX15, DLD, DLST, PARK7, PDHA1, VDAC1, TRIM25, UBE2A, TESUSP6USP32, CALM2, RAC1, CDC42, RAB33B, ARF6, MYL2, ANKRD44, ATXN7L3, APP, MDFI, EXOSC8, KRAS, JUN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for THRAP3_USP6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for THRAP3_USP6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource