	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 38017

FusionGeneSummary for THRAP3_MAP7D1

Fusion gene summary

Fusion gene information	Fusion gene name: THRAP3_MAP7D1
	Fusion gene ID: 38017
		Hgene	Tgene
	Gene symbol	THRAP3	MAP7D1
	Gene ID	9967	55700
	Gene name	thyroid hormone receptor associated protein 3	MAP7 domain containing 1
	Synonyms	BCLAF2\|TRAP150	PARCC1\|RPRC1
	Cytomap	1p34.3	1p34.3
	Type of gene	protein-coding	protein-coding
	Description	thyroid hormone receptor-associated protein 3BCLAF1 and THRAP3 family member 2TR-associated protein, 150-kDathyroid hormone receptor-associated protein complex 150 kDa componentthyroid hormone receptor-associated protein, 150 kDa subunit	MAP7 domain-containing protein 1arginine/proline rich coiled-coil 1arginine/proline-rich coiled-coil domain-containing protein 1proline arginine rich coiled coil 1proline/arginine-rich coiled-coil domain-containing protein 1
	Modification date	20180522	20180523
	UniProtAcc	Q9Y2W1	Q3KQU3
	Ensembl transtripts involved in fusion gene	ENST00000354618, ENST00000469141, ENST00000466743,	ENST00000316156, ENST00000373150, ENST00000373151, ENST00000474796, ENST00000373148,
Fusion gene scores	* DoF score	16 X 7 X 11=1232	5 X 5 X 5=125
	# samples	19	8
	** MAII score	log2(19/1232*10)=-2.69693093236395 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/125*10)=-0.643856189774725 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: THRAP3 [Title/Abstract] AND MAP7D1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	THRAP3	GO:0000956	nuclear-transcribed mRNA catabolic process	20123736
Hgene	THRAP3	GO:0006367	transcription initiation from RNA polymerase II promoter	12218053
Hgene	THRAP3	GO:0030518	intracellular steroid hormone receptor signaling pathway	11867769
Hgene	THRAP3	GO:0030521	androgen receptor signaling pathway	12218053
Hgene	THRAP3	GO:0045893	positive regulation of transcription, DNA-templated	10198638
Hgene	THRAP3	GO:0045944	positive regulation of transcription by RNA polymerase II	12037571

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	ACC	TCGA-OR-A5JZ-01A	THRAP3	chr1	36690106	+	MAP7D1	chr1	36645267	+
TCGA	RV	BRCA	TCGA-LL-A6FQ-01A	THRAP3	chr1	36690106	+	MAP7D1	chr1	36636572	+
TCGA	RV	LIHC	TCGA-RC-A6M6-01A	THRAP3	chr1	36748301	+	MAP7D1	chr1	36636572	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000354618	ENST00000316156	THRAP3	chr1	36690106	+	MAP7D1	chr1	36645267	+
5UTR-3CDS	ENST00000354618	ENST00000373150	THRAP3	chr1	36690106	+	MAP7D1	chr1	36645267	+
5UTR-3CDS	ENST00000354618	ENST00000373151	THRAP3	chr1	36690106	+	MAP7D1	chr1	36645267	+
5UTR-intron	ENST00000354618	ENST00000474796	THRAP3	chr1	36690106	+	MAP7D1	chr1	36645267	+
5UTR-intron	ENST00000354618	ENST00000373148	THRAP3	chr1	36690106	+	MAP7D1	chr1	36645267	+
5UTR-3CDS	ENST00000469141	ENST00000316156	THRAP3	chr1	36690106	+	MAP7D1	chr1	36645267	+
5UTR-3CDS	ENST00000469141	ENST00000373150	THRAP3	chr1	36690106	+	MAP7D1	chr1	36645267	+
5UTR-3CDS	ENST00000469141	ENST00000373151	THRAP3	chr1	36690106	+	MAP7D1	chr1	36645267	+
5UTR-intron	ENST00000469141	ENST00000474796	THRAP3	chr1	36690106	+	MAP7D1	chr1	36645267	+
5UTR-intron	ENST00000469141	ENST00000373148	THRAP3	chr1	36690106	+	MAP7D1	chr1	36645267	+
intron-3CDS	ENST00000466743	ENST00000316156	THRAP3	chr1	36690106	+	MAP7D1	chr1	36645267	+
intron-3CDS	ENST00000466743	ENST00000373150	THRAP3	chr1	36690106	+	MAP7D1	chr1	36645267	+
intron-3CDS	ENST00000466743	ENST00000373151	THRAP3	chr1	36690106	+	MAP7D1	chr1	36645267	+
intron-intron	ENST00000466743	ENST00000474796	THRAP3	chr1	36690106	+	MAP7D1	chr1	36645267	+
intron-intron	ENST00000466743	ENST00000373148	THRAP3	chr1	36690106	+	MAP7D1	chr1	36645267	+
5UTR-3CDS	ENST00000354618	ENST00000316156	THRAP3	chr1	36690106	+	MAP7D1	chr1	36636572	+
5UTR-3CDS	ENST00000354618	ENST00000373150	THRAP3	chr1	36690106	+	MAP7D1	chr1	36636572	+
5UTR-3CDS	ENST00000354618	ENST00000373151	THRAP3	chr1	36690106	+	MAP7D1	chr1	36636572	+
5UTR-intron	ENST00000354618	ENST00000474796	THRAP3	chr1	36690106	+	MAP7D1	chr1	36636572	+
5UTR-intron	ENST00000354618	ENST00000373148	THRAP3	chr1	36690106	+	MAP7D1	chr1	36636572	+
5UTR-3CDS	ENST00000469141	ENST00000316156	THRAP3	chr1	36690106	+	MAP7D1	chr1	36636572	+
5UTR-3CDS	ENST00000469141	ENST00000373150	THRAP3	chr1	36690106	+	MAP7D1	chr1	36636572	+
5UTR-3CDS	ENST00000469141	ENST00000373151	THRAP3	chr1	36690106	+	MAP7D1	chr1	36636572	+
5UTR-intron	ENST00000469141	ENST00000474796	THRAP3	chr1	36690106	+	MAP7D1	chr1	36636572	+
5UTR-intron	ENST00000469141	ENST00000373148	THRAP3	chr1	36690106	+	MAP7D1	chr1	36636572	+
intron-3CDS	ENST00000466743	ENST00000316156	THRAP3	chr1	36690106	+	MAP7D1	chr1	36636572	+
intron-3CDS	ENST00000466743	ENST00000373150	THRAP3	chr1	36690106	+	MAP7D1	chr1	36636572	+
intron-3CDS	ENST00000466743	ENST00000373151	THRAP3	chr1	36690106	+	MAP7D1	chr1	36636572	+
intron-intron	ENST00000466743	ENST00000474796	THRAP3	chr1	36690106	+	MAP7D1	chr1	36636572	+
intron-intron	ENST00000466743	ENST00000373148	THRAP3	chr1	36690106	+	MAP7D1	chr1	36636572	+
Frame-shift	ENST00000354618	ENST00000316156	THRAP3	chr1	36748301	+	MAP7D1	chr1	36636572	+
Frame-shift	ENST00000354618	ENST00000373150	THRAP3	chr1	36748301	+	MAP7D1	chr1	36636572	+
Frame-shift	ENST00000354618	ENST00000373151	THRAP3	chr1	36748301	+	MAP7D1	chr1	36636572	+
5CDS-intron	ENST00000354618	ENST00000474796	THRAP3	chr1	36748301	+	MAP7D1	chr1	36636572	+
5CDS-intron	ENST00000354618	ENST00000373148	THRAP3	chr1	36748301	+	MAP7D1	chr1	36636572	+
Frame-shift	ENST00000469141	ENST00000316156	THRAP3	chr1	36748301	+	MAP7D1	chr1	36636572	+
Frame-shift	ENST00000469141	ENST00000373150	THRAP3	chr1	36748301	+	MAP7D1	chr1	36636572	+
Frame-shift	ENST00000469141	ENST00000373151	THRAP3	chr1	36748301	+	MAP7D1	chr1	36636572	+
5CDS-intron	ENST00000469141	ENST00000474796	THRAP3	chr1	36748301	+	MAP7D1	chr1	36636572	+
5CDS-intron	ENST00000469141	ENST00000373148	THRAP3	chr1	36748301	+	MAP7D1	chr1	36636572	+
intron-3CDS	ENST00000466743	ENST00000316156	THRAP3	chr1	36748301	+	MAP7D1	chr1	36636572	+
intron-3CDS	ENST00000466743	ENST00000373150	THRAP3	chr1	36748301	+	MAP7D1	chr1	36636572	+
intron-3CDS	ENST00000466743	ENST00000373151	THRAP3	chr1	36748301	+	MAP7D1	chr1	36636572	+
intron-intron	ENST00000466743	ENST00000474796	THRAP3	chr1	36748301	+	MAP7D1	chr1	36636572	+
intron-intron	ENST00000466743	ENST00000373148	THRAP3	chr1	36748301	+	MAP7D1	chr1	36636572	+

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FusionProtFeatures for THRAP3_MAP7D1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
THRAP3 Q9Y2W1	MAP7D1 Q3KQU3
Involved in pre-mRNA splicing. Remains associated withspliced mRNA after splicing which probably involves interactionswith the exon junction complex (EJC). Can trigger mRNA decay whichseems to be independent of nonsense-mediated decay involvingpremature stop codons (PTC) recognition. May be involved innuclear mRNA decay. Involved in regulation of signal-inducedalternative splicing. During splicing of PTPRC/CD45 is proposed tosequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in restingT-cells. Involved in cyclin-D1/CCND1 mRNA stability probably byacting as component of the SNARP complex which associates withboth the 3'end of the CCND1 gene and its mRNA. Involved inresponse to DNA damage. Is excluced from DNA damage sites in amanner that parallels transcription inhibition; the function mayinvolve the SNARP complex. Initially thought to play a role intranscriptional coactivation through its association with the TRAPcomplex; however, it is not regarded as a stable Mediator complexsubunit. Cooperatively with HELZ2, enhances the transcriptionalactivation mediated by PPARG, maybe through the stabilization ofthe PPARG binding to DNA in presence of ligand. May play a role inthe terminal stage of adipocyte differentiation. Plays a role inthe positive regulation of the circadian clock. Acts as acoactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes itstranscriptional activator activity and binding to circadian targetgenes (PubMed:24043798). {ECO:0000269\|PubMed:20123736,ECO:0000269\|PubMed:20932480, ECO:0000269\|PubMed:22424773,ECO:0000269\|PubMed:23525231, ECO:0000269\|PubMed:24043798}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for THRAP3_MAP7D1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for THRAP3_MAP7D1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
THRAP3	RNPS1, TRIP6, CLEC3B, RUNX1T1, LXN, CDK8, VDR, MED1, PARP1, H3F3A, TERF2, POT1, SMN1, TRA, YWHAG, SREK1, ARRB1, ARRB2, CAND1, RBM14, HNRNPU, DDX21, PRPF6, S100A9, PRPF3, NCSTN, SF3B2, SAP18, SFPQ, PHGDH, DHX9, IK, SF3A1, SNRPA1, DEK, SRSF11, SF3B6, HNRNPM, ACIN1, EEF1A1, SF3B3, PSIP1, DDX5, SART1, PSAP, ESR1, BARD1, MDC1, PAXIP1, MAGOH, EIF4A3, SMURF1, ALB, CSNK2A1, PAN2, LMNA, HDAC11, CLK3, SRPK2, SRPK1, CLK2, SRPK3, APBB1, NEDD4, PIN1, WWOX, ASB3, ASB18, LGR4, CSNK2A2, DROSHA, IVNS1ABP, SART3, TP53, CBX1, CUL7, OBSL1, EZH2, SUZ12, RNF2, BMI1, LUZP4, SPIN1, TRA2A, PRMT8, LUC7L, LUC7L2, SNIP1, WHSC1, FBXW11, NTRK1, PUF60, RPS19, SSRP1, BCLAF1, MED4, CLK1, XPO1, HIST1H3E, AHSA1, THOC1, PLK2, GAN, FOXK2, FOXL2, ALKBH3, MCM5, U2AF2, PNN, SNRNP70, TNFRSF13B, C11orf57, CHCHD10, APOBEC3D, CAMKV, LLGL2, CYLD, COQ2, COX15, DLD, DLST, PARK7, PDHA1, VDAC1, TRIM25, UBE2A, TES	MAP7D1	APOA1, RBM48, GPRASP1, COPS6, USP20, NEURL4, ATN1, HECW2, CTDSP2, LTBR, NTRK1, SRPK2, CEP170, KIAA0753, CEP162, SPICE1, DCTN1, LCA5, POC1A, TUBA1C, LDHD, FOXL1, FBXW7, POU5F1, FBXL5, SSSCA1, P4HA2, DKK3, APP, TNFRSF19, SKAP1, INO80B

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for THRAP3_MAP7D1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for THRAP3_MAP7D1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 38017

FusionGeneSummary for THRAP3_MAP7D1

FusionProtFeatures for THRAP3_MAP7D1

FusionGeneSequence for THRAP3_MAP7D1

FusionGenePPI for THRAP3_MAP7D1

RelatedDrugs for THRAP3_MAP7D1

RelatedDiseases for THRAP3_MAP7D1