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Fusion gene ID: 37999 |
FusionGeneSummary for THOC5_PIBF1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: THOC5_PIBF1 | Fusion gene ID: 37999 | Hgene | Tgene | Gene symbol | THOC5 | PIBF1 | Gene ID | 8563 | 10464 |
Gene name | THO complex 5 | progesterone immunomodulatory binding factor 1 | |
Synonyms | C22orf19|Fmip|PK1.3|fSAP79 | C13orf24|CEP90|JBTS33|PIBF | |
Cytomap | 22q12.2 | 13q21.33-q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | THO complex subunit 5 homologFms-interacting proteinNF2/meningioma region protein pK1.3PP39.2functional spliceosome-associated protein 79hTREX90placental protein 39.2 | progesterone-induced-blocking factor 1centrosomal protein of 90 kDa | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q13769 | Q8WXW3 | |
Ensembl transtripts involved in fusion gene | ENST00000490103, ENST00000397871, ENST00000397872, ENST00000397873, | ENST00000326291, ENST00000489922, | |
Fusion gene scores | * DoF score | 8 X 8 X 6=384 | 8 X 7 X 9=504 |
# samples | 8 | 10 | |
** MAII score | log2(8/384*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/504*10)=-2.33342373372519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: THOC5 [Title/Abstract] AND PIBF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | THOC5 | GO:0006406 | mRNA export from nucleus | 17190602 |
Hgene | THOC5 | GO:0030224 | monocyte differentiation | 19015024 |
Hgene | THOC5 | GO:0046784 | viral mRNA export from host cell nucleus | 18974867 |
Tgene | PIBF1 | GO:0031393 | negative regulation of prostaglandin biosynthetic process | 3863495 |
Tgene | PIBF1 | GO:0032695 | negative regulation of interleukin-12 production | 14634107 |
Tgene | PIBF1 | GO:0032733 | positive regulation of interleukin-10 production | 14634107 |
Tgene | PIBF1 | GO:0032815 | negative regulation of natural killer cell activation | 12516630 |
Tgene | PIBF1 | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein | 16393965 |
Tgene | PIBF1 | GO:0042532 | negative regulation of tyrosine phosphorylation of STAT protein | 16393965 |
Tgene | PIBF1 | GO:0042976 | activation of Janus kinase activity | 16393965 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BLCA | TCGA-GU-AATP-01A | THOC5 | chr22 | 29916987 | - | PIBF1 | chr13 | 73505303 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000490103 | ENST00000326291 | THOC5 | chr22 | 29916987 | - | PIBF1 | chr13 | 73505303 | + |
5CDS-intron | ENST00000490103 | ENST00000489922 | THOC5 | chr22 | 29916987 | - | PIBF1 | chr13 | 73505303 | + |
Frame-shift | ENST00000397871 | ENST00000326291 | THOC5 | chr22 | 29916987 | - | PIBF1 | chr13 | 73505303 | + |
5CDS-intron | ENST00000397871 | ENST00000489922 | THOC5 | chr22 | 29916987 | - | PIBF1 | chr13 | 73505303 | + |
In-frame | ENST00000397872 | ENST00000326291 | THOC5 | chr22 | 29916987 | - | PIBF1 | chr13 | 73505303 | + |
5CDS-intron | ENST00000397872 | ENST00000489922 | THOC5 | chr22 | 29916987 | - | PIBF1 | chr13 | 73505303 | + |
Frame-shift | ENST00000397873 | ENST00000326291 | THOC5 | chr22 | 29916987 | - | PIBF1 | chr13 | 73505303 | + |
5CDS-intron | ENST00000397873 | ENST00000489922 | THOC5 | chr22 | 29916987 | - | PIBF1 | chr13 | 73505303 | + |
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FusionProtFeatures for THOC5_PIBF1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
THOC5 | PIBF1 |
Acts as component of the THO subcomplex of the TREXcomplex which is thought to couple mRNA transcription, processingand nuclear export, and which specifically associates with splicedmRNA and not with unspliced pre-mRNA. TREX is recruited to splicedmRNAs by a transcription-independent mechanism, binds to mRNAupstream of the exon-junction complex (EJC) and is recruited in asplicing- and cap-dependent manner to a region near the 5' end ofthe mRNA where it functions in mRNA export to the cytoplasm viathe TAP/NFX1 pathway. The TREX complex is essential for the exportof Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAsand infectious virus production. THOC5 in conjunction withALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export ofHSP70 mRNA; both proteins enhance the RNA binding activity of NXF1and are required for NXF1 localization to the nuclear rim.Involved in transcription elongation and genome stability.Involved in alternative polyadenylation site choice by recruitingCPSF6 to 5' region of target genes; probably mediates associationof the TREX and CFIm complexes. Regulates the expression of myeloid transcriptionfactors CEBPA, CEBPB and GAB2 by enhancing the levels ofphosphatidylinositol 3,4,5-trisphosphate. May be involved in thedifferentiation of granulocytes and adipocytes. Essential forhematopoietic primitive cell survival and plays an integral rolein monocytic development. | Plays a role in ciliogenesis.{ECO:0000269|PubMed:26167768}. Isoform 1: Pericentriolar protein required to maintainmitotic spindle pole integrity (PubMed:21224392). Required for thecentrosomal accumulation of PCM1 and the recruitment of centriolarsatellite proteins such as BBS4. Via association with PCM1 may beinvolved in primary cilia formation (PubMed:23110211). Requiredfor CEP63 centrosomal localization and its interaction with WDR62.Together with CEP63 promotes centriole duplication. Promotes thecentrosomal localization of CDK2 (PubMed:26297806).{ECO:0000269|PubMed:21224392, ECO:0000269|PubMed:23110211,ECO:0000269|PubMed:26297806}. Isoform 4: The secreted form is a mediator ofprogesterone that by acting on the phospholipase A2 enzymeinterferes with arachidonic acid metabolism, induces a Th2 biasedimmune response, and by controlling decidual naturakl killer cells(NK) activity exerts an anti-abortive effect (PubMed:14634107,PubMed:3863495, PubMed:12516630). Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. ActivatesSTAT6 and inhibits STAT4 phosphorylation. Signaling via a notidentified receptor seems to implicate IL4R and a GPI-anchoredprotein (PubMed:16393965, PubMed:25218441).{ECO:0000269|PubMed:12516630, ECO:0000269|PubMed:14634107,ECO:0000269|PubMed:16393965, ECO:0000269|PubMed:25218441,ECO:0000269|PubMed:3863495, ECO:0000305|PubMed:11407300}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | THOC5 | chr22:29916987 | chr13:73505303 | ENST00000397871 | - | 13 | 20 | 7_10 | 425 | 684 | Motif | Nuclear localization signal |
Hgene | THOC5 | chr22:29916987 | chr13:73505303 | ENST00000397872 | - | 14 | 21 | 7_10 | 425 | 684 | Motif | Nuclear localization signal |
Hgene | THOC5 | chr22:29916987 | chr13:73505303 | ENST00000397873 | - | 14 | 21 | 7_10 | 425 | 684 | Motif | Nuclear localization signal |
Hgene | THOC5 | chr22:29916987 | chr13:73505303 | ENST00000490103 | - | 13 | 20 | 7_10 | 425 | 684 | Motif | Nuclear localization signal |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | PIBF1 | chr22:29916987 | chr13:73505303 | ENST00000326291 | + | 12 | 18 | 1_184 | 576 | 758 | Region | Sufficient for NK inhibitory function |
Tgene | PIBF1 | chr22:29916987 | chr13:73505303 | ENST00000326291 | + | 12 | 18 | 1_419 | 576 | 758 | Region | Mediates modulation of Th2 dominant cytokine production |
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FusionGeneSequence for THOC5_PIBF1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_THOC5_ENST00000490103_chr22_29916987_-_PIBF1_ENST00000326291_chr13_73505303_+_607aa MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQELQRLMAEIQDLKSRGGKDVAIEIEERRIQ SCVHFMTLKKLNRLAHIRLKKGRDQTHEAKQKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTM GDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYV LFVQATAYGQACDKTLSVAIEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVL HLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGVHLARRVLQLEKQNSLILKDLEHR KDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHREELAAMKQI >In-frame_THOC5_ENST00000397872_chr22_29916987_-_PIBF1_ENST00000326291_chr13_73505303_+_607aa MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQELQRLMAEIQDLKSRGGKDVAIEIEERRIQ SCVHFMTLKKLNRLAHIRLKKGRDQTHEAKQKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTM GDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYV LFVQATAYGQACDKTLSVAIEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVL HLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGVHLARRVLQLEKQNSLILKDLEHR KDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHREELAAMKQI |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_THOC5_ENST00000490103_chr22_29916987_-_PIBF1_ENST00000326291_chr13_73505303_+_1821nt ATGTCATCAGAATCGAGCAAAAAACGGAAGCCCAAAGTGATCCGAAGCGATGGAGCCCCAGCTGAAGGAAAGCGGAATCGATCTGACACC GAGCAGGAAGGTAAATACTACAGTGAGGAGGCCGAGGTGGATCTGCGGGACCCTGGCAGAGACTATGAGTTATACAAGTACACCTGCCAG GAGCTACAGAGGCTGATGGCTGAGATCCAAGACCTGAAGAGCAGGGGTGGCAAGGATGTGGCAATAGAAATAGAAGAACGGAGGATCCAG AGCTGTGTGCATTTCATGACTCTAAAGAAGCTTAACCGATTAGCCCACATCAGGTTGAAGAAAGGAAGAGATCAGACCCACGAGGCTAAG CAGAAAGTAGATGCCTATCATCTGCAGCTCCAGAACCTGTTGTATGAGGTGATGCACCTACAGAAGGAGATCACCAAATGTTTGGAGTTT AAGTCAAAGCATGAAGAAATTGATCTGGTCAGTTTAGAGGAGTTTTATAAGGAGGCTCCACCAGATATCAGCAAGGCCGAAGTCACCATG GGAGACCCTCACCAGCAAACACTGGCACGTCTGGACTGGGAGCTGGAGCAGCGGAAAAGGCTGGCAGAGAAGTACCGAGAGTGCCTATCT AACAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACCTGAGCAGCCTCCAGCCCCGCCTCAACAGCATCATGCAGGCTTCC CTTCCGGTGCAGGAGTACCTGTTTATGCCATTCGACCAGGCTCACAAGCAGTATGAGACAGCCAGACACCTGCCGCCTCCCCTCTATGTC CTCTTTGTTCAGGCCACTGCGTATGGGCAGGCCTGTGATAAGACGTTATCTGTGGCAATCGAAGGCAGTGTGGATGAAGCCAAGGCTCTG TTCAAACCTCCAGAGGACTCCCAAGATGACGAGAGTGACTCAGATGCCGAGGAGGAGCAGACTACGAAGCGCCGGAGACCCACACTGGGG GTTCAGTTGGACGACAAACGCAAGGAGATGCTGAAGAGGCACCCACTGTCTGTCATGCTCGACCTGAAGTGCAAAGATGACAGTGTGCTT CACCTGACTTTCTACTACCTCATGAACCTCAACATCATGACAGTAAAAGCCAAAGTGACAACTGCCATGGAGCTGATCACCCCCATCAGT GCAGGTGACTTGCTGTCTCCTGACTCAGTCCTGAGTTGCTTGTATCCTGGGGATCATGGAAAGAAAACTCCGAATCCAGCCAATCAGTAT CAGTTTGATAAAGTTGGTGTTCACTTGGCAAGAAGAGTGCTTCAATTAGAAAAACAAAACTCGCTGATTTTAAAAGATCTGGAACATCGA AAGGACCAAGTAACACAGCTTTCACAAGAGCTTGACAGAGCCAATTCGCTATTAAACCAGACTCAACAGCCTTACAGGTATCTCATTGAA TCAGTGCGTCAGAGAGATTCTAAGATTGATTCACTGACGGAATCTATTGCACAACTTGAGAAAGATGTCAGCAACTTAAATAAAGAAAAG TCAGCTTTACTACAGACGAAGAATCAAATGGCATTAGATTTAGAACAACTTCTAAATCATCGTGAGGAATTGGCAGCAATGAAACAGATT CTCGTTAAGATGCATAGTAAACATTCTGAGAACAGCTTACTTCTCACTAAAACAGAACCAAAACATGTGACAGAAAATCAGAAATCAAAG ACTTTGAATGTGCCTAAAGAGCATGAAGACAATATATTTACACCTAAACCAACACTCTTTACTAAAAAAGAAGCACCTGAGTGGTCTAAG >In-frame_THOC5_ENST00000397872_chr22_29916987_-_PIBF1_ENST00000326291_chr13_73505303_+_1821nt ATGTCATCAGAATCGAGCAAAAAACGGAAGCCCAAAGTGATCCGAAGCGATGGAGCCCCAGCTGAAGGAAAGCGGAATCGATCTGACACC GAGCAGGAAGGTAAATACTACAGTGAGGAGGCCGAGGTGGATCTGCGGGACCCTGGCAGAGACTATGAGTTATACAAGTACACCTGCCAG GAGCTACAGAGGCTGATGGCTGAGATCCAAGACCTGAAGAGCAGGGGTGGCAAGGATGTGGCAATAGAAATAGAAGAACGGAGGATCCAG AGCTGTGTGCATTTCATGACTCTAAAGAAGCTTAACCGATTAGCCCACATCAGGTTGAAGAAAGGAAGAGATCAGACCCACGAGGCTAAG CAGAAAGTAGATGCCTATCATCTGCAGCTCCAGAACCTGTTGTATGAGGTGATGCACCTACAGAAGGAGATCACCAAATGTTTGGAGTTT AAGTCAAAGCATGAAGAAATTGATCTGGTCAGTTTAGAGGAGTTTTATAAGGAGGCTCCACCAGATATCAGCAAGGCCGAAGTCACCATG GGAGACCCTCACCAGCAAACACTGGCACGTCTGGACTGGGAGCTGGAGCAGCGGAAAAGGCTGGCAGAGAAGTACCGAGAGTGCCTATCT AACAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACCTGAGCAGCCTCCAGCCCCGCCTCAACAGCATCATGCAGGCTTCC CTTCCGGTGCAGGAGTACCTGTTTATGCCATTCGACCAGGCTCACAAGCAGTATGAGACAGCCAGACACCTGCCGCCTCCCCTCTATGTC CTCTTTGTTCAGGCCACTGCGTATGGGCAGGCCTGTGATAAGACGTTATCTGTGGCAATCGAAGGCAGTGTGGATGAAGCCAAGGCTCTG TTCAAACCTCCAGAGGACTCCCAAGATGACGAGAGTGACTCAGATGCCGAGGAGGAGCAGACTACGAAGCGCCGGAGACCCACACTGGGG GTTCAGTTGGACGACAAACGCAAGGAGATGCTGAAGAGGCACCCACTGTCTGTCATGCTCGACCTGAAGTGCAAAGATGACAGTGTGCTT CACCTGACTTTCTACTACCTCATGAACCTCAACATCATGACAGTAAAAGCCAAAGTGACAACTGCCATGGAGCTGATCACCCCCATCAGT GCAGGTGACTTGCTGTCTCCTGACTCAGTCCTGAGTTGCTTGTATCCTGGGGATCATGGAAAGAAAACTCCGAATCCAGCCAATCAGTAT CAGTTTGATAAAGTTGGTGTTCACTTGGCAAGAAGAGTGCTTCAATTAGAAAAACAAAACTCGCTGATTTTAAAAGATCTGGAACATCGA AAGGACCAAGTAACACAGCTTTCACAAGAGCTTGACAGAGCCAATTCGCTATTAAACCAGACTCAACAGCCTTACAGGTATCTCATTGAA TCAGTGCGTCAGAGAGATTCTAAGATTGATTCACTGACGGAATCTATTGCACAACTTGAGAAAGATGTCAGCAACTTAAATAAAGAAAAG TCAGCTTTACTACAGACGAAGAATCAAATGGCATTAGATTTAGAACAACTTCTAAATCATCGTGAGGAATTGGCAGCAATGAAACAGATT CTCGTTAAGATGCATAGTAAACATTCTGAGAACAGCTTACTTCTCACTAAAACAGAACCAAAACATGTGACAGAAAATCAGAAATCAAAG ACTTTGAATGTGCCTAAAGAGCATGAAGACAATATATTTACACCTAAACCAACACTCTTTACTAAAAAAGAAGCACCTGAGTGGTCTAAG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_THOC5_ENST00000490103_chr22_29916987_-_PIBF1_ENST00000326291_chr13_73505303_+_2478nt GCTTCCGGTCGGCCGCCCCTTCCTTACTTCCGGTTCTCTATGGTGCGCGGGCAAGCTTTGCTCCGCCTCCGGCAGTGGCTTACTCCCGGT GCCAGGTTCTTGGAGCTGTGAGGAGGAACAACCATGTCATCAGAATCGAGCAAAAAACGGAAGCCCAAAGTGATCCGAAGCGATGGAGCC CCAGCTGAAGGAAAGCGGAATCGATCTGACACCGAGCAGGAAGGTAAATACTACAGTGAGGAGGCCGAGGTGGATCTGCGGGACCCTGGC AGAGACTATGAGTTATACAAGTACACCTGCCAGGAGCTACAGAGGCTGATGGCTGAGATCCAAGACCTGAAGAGCAGGGGTGGCAAGGAT GTGGCAATAGAAATAGAAGAACGGAGGATCCAGAGCTGTGTGCATTTCATGACTCTAAAGAAGCTTAACCGATTAGCCCACATCAGGTTG AAGAAAGGAAGAGATCAGACCCACGAGGCTAAGCAGAAAGTAGATGCCTATCATCTGCAGCTCCAGAACCTGTTGTATGAGGTGATGCAC CTACAGAAGGAGATCACCAAATGTTTGGAGTTTAAGTCAAAGCATGAAGAAATTGATCTGGTCAGTTTAGAGGAGTTTTATAAGGAGGCT CCACCAGATATCAGCAAGGCCGAAGTCACCATGGGAGACCCTCACCAGCAAACACTGGCACGTCTGGACTGGGAGCTGGAGCAGCGGAAA AGGCTGGCAGAGAAGTACCGAGAGTGCCTATCTAACAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACCTGAGCAGCCTC CAGCCCCGCCTCAACAGCATCATGCAGGCTTCCCTTCCGGTGCAGGAGTACCTGTTTATGCCATTCGACCAGGCTCACAAGCAGTATGAG ACAGCCAGACACCTGCCGCCTCCCCTCTATGTCCTCTTTGTTCAGGCCACTGCGTATGGGCAGGCCTGTGATAAGACGTTATCTGTGGCA ATCGAAGGCAGTGTGGATGAAGCCAAGGCTCTGTTCAAACCTCCAGAGGACTCCCAAGATGACGAGAGTGACTCAGATGCCGAGGAGGAG CAGACTACGAAGCGCCGGAGACCCACACTGGGGGTTCAGTTGGACGACAAACGCAAGGAGATGCTGAAGAGGCACCCACTGTCTGTCATG CTCGACCTGAAGTGCAAAGATGACAGTGTGCTTCACCTGACTTTCTACTACCTCATGAACCTCAACATCATGACAGTAAAAGCCAAAGTG ACAACTGCCATGGAGCTGATCACCCCCATCAGTGCAGGTGACTTGCTGTCTCCTGACTCAGTCCTGAGTTGCTTGTATCCTGGGGATCAT GGAAAGAAAACTCCGAATCCAGCCAATCAGTATCAGTTTGATAAAGTTGGTGTTCACTTGGCAAGAAGAGTGCTTCAATTAGAAAAACAA AACTCGCTGATTTTAAAAGATCTGGAACATCGAAAGGACCAAGTAACACAGCTTTCACAAGAGCTTGACAGAGCCAATTCGCTATTAAAC CAGACTCAACAGCCTTACAGGTATCTCATTGAATCAGTGCGTCAGAGAGATTCTAAGATTGATTCACTGACGGAATCTATTGCACAACTT GAGAAAGATGTCAGCAACTTAAATAAAGAAAAGTCAGCTTTACTACAGACGAAGAATCAAATGGCATTAGATTTAGAACAACTTCTAAAT CATCGTGAGGAATTGGCAGCAATGAAACAGATTCTCGTTAAGATGCATAGTAAACATTCTGAGAACAGCTTACTTCTCACTAAAACAGAA CCAAAACATGTGACAGAAAATCAGAAATCAAAGACTTTGAATGTGCCTAAAGAGCATGAAGACAATATATTTACACCTAAACCAACACTC TTTACTAAAAAAGAAGCACCTGAGTGGTCTAAGAAACAAAAGATGAAGACCTAGTGTTTTGGATGGGAAGCACCTGTAGACCATTATATA CTCCTGAAGTTCTTTTTCTGATGGAAAACAAAATTCAGCTTAATCGTGTACTCAGCATTTTTTAAATAACAATGTTTATTTGAACTAATA TTAAATTAACAAATTCAGTGTAATCAAAATGTGTAAAGAACAATCAATATACTTTATTTTTTTTTCTATTTTATAAAATAAATATATATG CTATGCTTTAAATTTTGGAGCTTTCATAAATGTTCAATGCATTTTAAGTGTGTGGCTTATAAATATTTTGGTATTTTTCTATACTACGTA AATTCTGAGTTTAAATGTCATACACAAATACTAAGACACTTTGCATTTTTAAAAATTAAGAATCATTTGTGAAGTCCACTACGAGGTACT TCAAAAGCCCAGTAATGGTGGTCAGATACCATGTAGATGGATACAGATTGTTGACTCTTTTGAAGTTGTTTTTTTCTTATATTTTATATT >In-frame_THOC5_ENST00000397872_chr22_29916987_-_PIBF1_ENST00000326291_chr13_73505303_+_2690nt GGGCAGTGGGGCTGGGAGATGGGGCGGGGCTGGGCGCTCCGGGACTGAGGTGCTGATCGCCCAAAGGGCGCCCCTGGGCTGGGGTCTGAC CCGGCTTCTCCTCCCTCACTACCCGCGGTCCCCGGCCTCTCGGCGCTGCGCTGTTACCTCATCCGAAAAGTGTTCGCTGCAGCATCCTCA GGCTTCACGTTGGAGCCTCTTGATTGTGGTGTTCAGCATTATTTAAGATCACCTATGCATCATCTGAAGCCACAGTCCCAGGTCATCTTC ATCACCTTCCCCAGTGGAATGCCTCCTGTGTTAAAGCCCACAACAACCCCTGTGGAGGAACAACCATGTCATCAGAATCGAGCAAAAAAC GGAAGCCCAAAGTGATCCGAAGCGATGGAGCCCCAGCTGAAGGAAAGCGGAATCGATCTGACACCGAGCAGGAAGGTAAATACTACAGTG AGGAGGCCGAGGTGGATCTGCGGGACCCTGGCAGAGACTATGAGTTATACAAGTACACCTGCCAGGAGCTACAGAGGCTGATGGCTGAGA TCCAAGACCTGAAGAGCAGGGGTGGCAAGGATGTGGCAATAGAAATAGAAGAACGGAGGATCCAGAGCTGTGTGCATTTCATGACTCTAA AGAAGCTTAACCGATTAGCCCACATCAGGTTGAAGAAAGGAAGAGATCAGACCCACGAGGCTAAGCAGAAAGTAGATGCCTATCATCTGC AGCTCCAGAACCTGTTGTATGAGGTGATGCACCTACAGAAGGAGATCACCAAATGTTTGGAGTTTAAGTCAAAGCATGAAGAAATTGATC TGGTCAGTTTAGAGGAGTTTTATAAGGAGGCTCCACCAGATATCAGCAAGGCCGAAGTCACCATGGGAGACCCTCACCAGCAAACACTGG CACGTCTGGACTGGGAGCTGGAGCAGCGGAAAAGGCTGGCAGAGAAGTACCGAGAGTGCCTATCTAACAAGGAGAAGATTCTCAAGGAGA TTGAGGTGAAGAAGGAGTACCTGAGCAGCCTCCAGCCCCGCCTCAACAGCATCATGCAGGCTTCCCTTCCGGTGCAGGAGTACCTGTTTA TGCCATTCGACCAGGCTCACAAGCAGTATGAGACAGCCAGACACCTGCCGCCTCCCCTCTATGTCCTCTTTGTTCAGGCCACTGCGTATG GGCAGGCCTGTGATAAGACGTTATCTGTGGCAATCGAAGGCAGTGTGGATGAAGCCAAGGCTCTGTTCAAACCTCCAGAGGACTCCCAAG ATGACGAGAGTGACTCAGATGCCGAGGAGGAGCAGACTACGAAGCGCCGGAGACCCACACTGGGGGTTCAGTTGGACGACAAACGCAAGG AGATGCTGAAGAGGCACCCACTGTCTGTCATGCTCGACCTGAAGTGCAAAGATGACAGTGTGCTTCACCTGACTTTCTACTACCTCATGA ACCTCAACATCATGACAGTAAAAGCCAAAGTGACAACTGCCATGGAGCTGATCACCCCCATCAGTGCAGGTGACTTGCTGTCTCCTGACT CAGTCCTGAGTTGCTTGTATCCTGGGGATCATGGAAAGAAAACTCCGAATCCAGCCAATCAGTATCAGTTTGATAAAGTTGGTGTTCACT TGGCAAGAAGAGTGCTTCAATTAGAAAAACAAAACTCGCTGATTTTAAAAGATCTGGAACATCGAAAGGACCAAGTAACACAGCTTTCAC AAGAGCTTGACAGAGCCAATTCGCTATTAAACCAGACTCAACAGCCTTACAGGTATCTCATTGAATCAGTGCGTCAGAGAGATTCTAAGA TTGATTCACTGACGGAATCTATTGCACAACTTGAGAAAGATGTCAGCAACTTAAATAAAGAAAAGTCAGCTTTACTACAGACGAAGAATC AAATGGCATTAGATTTAGAACAACTTCTAAATCATCGTGAGGAATTGGCAGCAATGAAACAGATTCTCGTTAAGATGCATAGTAAACATT CTGAGAACAGCTTACTTCTCACTAAAACAGAACCAAAACATGTGACAGAAAATCAGAAATCAAAGACTTTGAATGTGCCTAAAGAGCATG AAGACAATATATTTACACCTAAACCAACACTCTTTACTAAAAAAGAAGCACCTGAGTGGTCTAAGAAACAAAAGATGAAGACCTAGTGTT TTGGATGGGAAGCACCTGTAGACCATTATATACTCCTGAAGTTCTTTTTCTGATGGAAAACAAAATTCAGCTTAATCGTGTACTCAGCAT TTTTTAAATAACAATGTTTATTTGAACTAATATTAAATTAACAAATTCAGTGTAATCAAAATGTGTAAAGAACAATCAATATACTTTATT TTTTTTTCTATTTTATAAAATAAATATATATGCTATGCTTTAAATTTTGGAGCTTTCATAAATGTTCAATGCATTTTAAGTGTGTGGCTT ATAAATATTTTGGTATTTTTCTATACTACGTAAATTCTGAGTTTAAATGTCATACACAAATACTAAGACACTTTGCATTTTTAAAAATTA AGAATCATTTGTGAAGTCCACTACGAGGTACTTCAAAAGCCCAGTAATGGTGGTCAGATACCATGTAGATGGATACAGATTGTTGACTCT |
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FusionGenePPI for THOC5_PIBF1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
THOC5 | DDX39B, ALYREF, THOC2, THOC1, THOC3, THOC6, THOC7, SMAD4, NCBP1, NXF1, DDX23, ZC3H15, XPO4, ZKSCAN5, VIM, RRP9, UTRN, ZPR1, ZNF606, TJP2, UBR7, LIG4, LSM3, PPIL1, ZNF830, CSNK2A1, RNF2, LUZP4, HSPB1, TJP1, FMNL1, GTF2F1, PDGFRA, RPL6, RPL22, RPL27A, HSF2, BCLAF1, C17orf85, NEMF, EIF4A3, ZC3H11A, DDX39A, KIF1C, MRPS27, SIRT1, CCDC9, CHTOP, WDR74, MAGOHB, DDX24, KIAA1522, MYO1G, ZC3H14, KLF16, FYTTD1, POLDIP3, SERPINB12, IMP4, C19orf47, MRPL12, SARNP | PIBF1 | MAP3K2, APP, SAV1, SHMT2, NXF1, SLC25A41, PPP1R21, C17orf59, NTRK1, CEP63, KIAA0753, CCDC14, MED4, CEP290, CEP162, PCM1, SSX2IP, OFD1, CEP120, SPICE1, CEP128, CEP135, CEP89, CNTRL, NIN, ODF2, POC5, LCA5, SASS6, ITPKB, PCNT, FGFR1OP, MAPRE1, BORA, KIF7, PTPN22, TPTE2, TSNAXIP1, VAT1L, CPNE2, LRRCC1, EXOC3, PTPRQ, AHI1, EEA1, SNX27, ATP2B2, CEP131, SLC9A3R2 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Hgene | THOC5 | chr22:29916987 | chr13:73505303 | ENST00000397871 | - | 13 | 20 | 2_144 | 425 | 684 | CSF1R |
Hgene | THOC5 | chr22:29916987 | chr13:73505303 | ENST00000397872 | - | 14 | 21 | 2_144 | 425 | 684 | CSF1R |
Hgene | THOC5 | chr22:29916987 | chr13:73505303 | ENST00000397873 | - | 14 | 21 | 2_144 | 425 | 684 | CSF1R |
Hgene | THOC5 | chr22:29916987 | chr13:73505303 | ENST00000490103 | - | 13 | 20 | 2_144 | 425 | 684 | CSF1R |
Hgene | THOC5 | chr22:29916987 | chr13:73505303 | ENST00000397871 | - | 13 | 20 | 2_199 | 425 | 684 | THOC7 |
Hgene | THOC5 | chr22:29916987 | chr13:73505303 | ENST00000397872 | - | 14 | 21 | 2_199 | 425 | 684 | THOC7 |
Hgene | THOC5 | chr22:29916987 | chr13:73505303 | ENST00000397873 | - | 14 | 21 | 2_199 | 425 | 684 | THOC7 |
Hgene | THOC5 | chr22:29916987 | chr13:73505303 | ENST00000490103 | - | 13 | 20 | 2_199 | 425 | 684 | THOC7 |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for THOC5_PIBF1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for THOC5_PIBF1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PIBF1 | C0000821 | Threatened abortion | 1 | CTD_human |