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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 37999

FusionGeneSummary for THOC5_PIBF1

check button Fusion gene summary
Fusion gene informationFusion gene name: THOC5_PIBF1
Fusion gene ID: 37999
HgeneTgene
Gene symbol

THOC5

PIBF1

Gene ID

8563

10464

Gene nameTHO complex 5progesterone immunomodulatory binding factor 1
SynonymsC22orf19|Fmip|PK1.3|fSAP79C13orf24|CEP90|JBTS33|PIBF
Cytomap

22q12.2

13q21.33-q22.1

Type of geneprotein-codingprotein-coding
DescriptionTHO complex subunit 5 homologFms-interacting proteinNF2/meningioma region protein pK1.3PP39.2functional spliceosome-associated protein 79hTREX90placental protein 39.2progesterone-induced-blocking factor 1centrosomal protein of 90 kDa
Modification date2018052320180519
UniProtAcc

Q13769

Q8WXW3

Ensembl transtripts involved in fusion geneENST00000490103, ENST00000397871, 
ENST00000397872, ENST00000397873, 
ENST00000326291, ENST00000489922, 
Fusion gene scores* DoF score8 X 8 X 6=3848 X 7 X 9=504
# samples 810
** MAII scorelog2(8/384*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/504*10)=-2.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: THOC5 [Title/Abstract] AND PIBF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTHOC5

GO:0006406

mRNA export from nucleus

17190602

HgeneTHOC5

GO:0030224

monocyte differentiation

19015024

HgeneTHOC5

GO:0046784

viral mRNA export from host cell nucleus

18974867

TgenePIBF1

GO:0031393

negative regulation of prostaglandin biosynthetic process

3863495

TgenePIBF1

GO:0032695

negative regulation of interleukin-12 production

14634107

TgenePIBF1

GO:0032733

positive regulation of interleukin-10 production

14634107

TgenePIBF1

GO:0032815

negative regulation of natural killer cell activation

12516630

TgenePIBF1

GO:0042531

positive regulation of tyrosine phosphorylation of STAT protein

16393965

TgenePIBF1

GO:0042532

negative regulation of tyrosine phosphorylation of STAT protein

16393965

TgenePIBF1

GO:0042976

activation of Janus kinase activity

16393965


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-GU-AATP-01ATHOC5chr22

29916987

-PIBF1chr13

73505303

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000490103ENST00000326291THOC5chr22

29916987

-PIBF1chr13

73505303

+
5CDS-intronENST00000490103ENST00000489922THOC5chr22

29916987

-PIBF1chr13

73505303

+
Frame-shiftENST00000397871ENST00000326291THOC5chr22

29916987

-PIBF1chr13

73505303

+
5CDS-intronENST00000397871ENST00000489922THOC5chr22

29916987

-PIBF1chr13

73505303

+
In-frameENST00000397872ENST00000326291THOC5chr22

29916987

-PIBF1chr13

73505303

+
5CDS-intronENST00000397872ENST00000489922THOC5chr22

29916987

-PIBF1chr13

73505303

+
Frame-shiftENST00000397873ENST00000326291THOC5chr22

29916987

-PIBF1chr13

73505303

+
5CDS-intronENST00000397873ENST00000489922THOC5chr22

29916987

-PIBF1chr13

73505303

+

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FusionProtFeatures for THOC5_PIBF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
THOC5

Q13769

PIBF1

Q8WXW3

Acts as component of the THO subcomplex of the TREXcomplex which is thought to couple mRNA transcription, processingand nuclear export, and which specifically associates with splicedmRNA and not with unspliced pre-mRNA. TREX is recruited to splicedmRNAs by a transcription-independent mechanism, binds to mRNAupstream of the exon-junction complex (EJC) and is recruited in asplicing- and cap-dependent manner to a region near the 5' end ofthe mRNA where it functions in mRNA export to the cytoplasm viathe TAP/NFX1 pathway. The TREX complex is essential for the exportof Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAsand infectious virus production. THOC5 in conjunction withALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export ofHSP70 mRNA; both proteins enhance the RNA binding activity of NXF1and are required for NXF1 localization to the nuclear rim.Involved in transcription elongation and genome stability.Involved in alternative polyadenylation site choice by recruitingCPSF6 to 5' region of target genes; probably mediates associationof the TREX and CFIm complexes. Regulates the expression of myeloid transcriptionfactors CEBPA, CEBPB and GAB2 by enhancing the levels ofphosphatidylinositol 3,4,5-trisphosphate. May be involved in thedifferentiation of granulocytes and adipocytes. Essential forhematopoietic primitive cell survival and plays an integral rolein monocytic development. Plays a role in ciliogenesis.{ECO:0000269|PubMed:26167768}. Isoform 1: Pericentriolar protein required to maintainmitotic spindle pole integrity (PubMed:21224392). Required for thecentrosomal accumulation of PCM1 and the recruitment of centriolarsatellite proteins such as BBS4. Via association with PCM1 may beinvolved in primary cilia formation (PubMed:23110211). Requiredfor CEP63 centrosomal localization and its interaction with WDR62.Together with CEP63 promotes centriole duplication. Promotes thecentrosomal localization of CDK2 (PubMed:26297806).{ECO:0000269|PubMed:21224392, ECO:0000269|PubMed:23110211,ECO:0000269|PubMed:26297806}. Isoform 4: The secreted form is a mediator ofprogesterone that by acting on the phospholipase A2 enzymeinterferes with arachidonic acid metabolism, induces a Th2 biasedimmune response, and by controlling decidual naturakl killer cells(NK) activity exerts an anti-abortive effect (PubMed:14634107,PubMed:3863495, PubMed:12516630). Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. ActivatesSTAT6 and inhibits STAT4 phosphorylation. Signaling via a notidentified receptor seems to implicate IL4R and a GPI-anchoredprotein (PubMed:16393965, PubMed:25218441).{ECO:0000269|PubMed:12516630, ECO:0000269|PubMed:14634107,ECO:0000269|PubMed:16393965, ECO:0000269|PubMed:25218441,ECO:0000269|PubMed:3863495, ECO:0000305|PubMed:11407300}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTHOC5chr22:29916987chr13:73505303ENST00000397871-13207_10425684MotifNuclear localization signal
HgeneTHOC5chr22:29916987chr13:73505303ENST00000397872-14217_10425684MotifNuclear localization signal
HgeneTHOC5chr22:29916987chr13:73505303ENST00000397873-14217_10425684MotifNuclear localization signal
HgeneTHOC5chr22:29916987chr13:73505303ENST00000490103-13207_10425684MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePIBF1chr22:29916987chr13:73505303ENST00000326291+12181_184576758RegionSufficient for NK inhibitory function
TgenePIBF1chr22:29916987chr13:73505303ENST00000326291+12181_419576758RegionMediates modulation of Th2 dominant cytokine production


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FusionGeneSequence for THOC5_PIBF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_THOC5_ENST00000490103_chr22_29916987_-_PIBF1_ENST00000326291_chr13_73505303_+_607aa
MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQELQRLMAEIQDLKSRGGKDVAIEIEERRIQ
SCVHFMTLKKLNRLAHIRLKKGRDQTHEAKQKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTM
GDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYV
LFVQATAYGQACDKTLSVAIEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVL
HLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGVHLARRVLQLEKQNSLILKDLEHR
KDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHREELAAMKQI

>In-frame_THOC5_ENST00000397872_chr22_29916987_-_PIBF1_ENST00000326291_chr13_73505303_+_607aa
MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQELQRLMAEIQDLKSRGGKDVAIEIEERRIQ
SCVHFMTLKKLNRLAHIRLKKGRDQTHEAKQKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTM
GDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYV
LFVQATAYGQACDKTLSVAIEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVL
HLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGVHLARRVLQLEKQNSLILKDLEHR
KDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHREELAAMKQI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_THOC5_ENST00000490103_chr22_29916987_-_PIBF1_ENST00000326291_chr13_73505303_+_1821nt
ATGTCATCAGAATCGAGCAAAAAACGGAAGCCCAAAGTGATCCGAAGCGATGGAGCCCCAGCTGAAGGAAAGCGGAATCGATCTGACACC
GAGCAGGAAGGTAAATACTACAGTGAGGAGGCCGAGGTGGATCTGCGGGACCCTGGCAGAGACTATGAGTTATACAAGTACACCTGCCAG
GAGCTACAGAGGCTGATGGCTGAGATCCAAGACCTGAAGAGCAGGGGTGGCAAGGATGTGGCAATAGAAATAGAAGAACGGAGGATCCAG
AGCTGTGTGCATTTCATGACTCTAAAGAAGCTTAACCGATTAGCCCACATCAGGTTGAAGAAAGGAAGAGATCAGACCCACGAGGCTAAG
CAGAAAGTAGATGCCTATCATCTGCAGCTCCAGAACCTGTTGTATGAGGTGATGCACCTACAGAAGGAGATCACCAAATGTTTGGAGTTT
AAGTCAAAGCATGAAGAAATTGATCTGGTCAGTTTAGAGGAGTTTTATAAGGAGGCTCCACCAGATATCAGCAAGGCCGAAGTCACCATG
GGAGACCCTCACCAGCAAACACTGGCACGTCTGGACTGGGAGCTGGAGCAGCGGAAAAGGCTGGCAGAGAAGTACCGAGAGTGCCTATCT
AACAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACCTGAGCAGCCTCCAGCCCCGCCTCAACAGCATCATGCAGGCTTCC
CTTCCGGTGCAGGAGTACCTGTTTATGCCATTCGACCAGGCTCACAAGCAGTATGAGACAGCCAGACACCTGCCGCCTCCCCTCTATGTC
CTCTTTGTTCAGGCCACTGCGTATGGGCAGGCCTGTGATAAGACGTTATCTGTGGCAATCGAAGGCAGTGTGGATGAAGCCAAGGCTCTG
TTCAAACCTCCAGAGGACTCCCAAGATGACGAGAGTGACTCAGATGCCGAGGAGGAGCAGACTACGAAGCGCCGGAGACCCACACTGGGG
GTTCAGTTGGACGACAAACGCAAGGAGATGCTGAAGAGGCACCCACTGTCTGTCATGCTCGACCTGAAGTGCAAAGATGACAGTGTGCTT
CACCTGACTTTCTACTACCTCATGAACCTCAACATCATGACAGTAAAAGCCAAAGTGACAACTGCCATGGAGCTGATCACCCCCATCAGT
GCAGGTGACTTGCTGTCTCCTGACTCAGTCCTGAGTTGCTTGTATCCTGGGGATCATGGAAAGAAAACTCCGAATCCAGCCAATCAGTAT
CAGTTTGATAAAGTTGGTGTTCACTTGGCAAGAAGAGTGCTTCAATTAGAAAAACAAAACTCGCTGATTTTAAAAGATCTGGAACATCGA
AAGGACCAAGTAACACAGCTTTCACAAGAGCTTGACAGAGCCAATTCGCTATTAAACCAGACTCAACAGCCTTACAGGTATCTCATTGAA
TCAGTGCGTCAGAGAGATTCTAAGATTGATTCACTGACGGAATCTATTGCACAACTTGAGAAAGATGTCAGCAACTTAAATAAAGAAAAG
TCAGCTTTACTACAGACGAAGAATCAAATGGCATTAGATTTAGAACAACTTCTAAATCATCGTGAGGAATTGGCAGCAATGAAACAGATT
CTCGTTAAGATGCATAGTAAACATTCTGAGAACAGCTTACTTCTCACTAAAACAGAACCAAAACATGTGACAGAAAATCAGAAATCAAAG
ACTTTGAATGTGCCTAAAGAGCATGAAGACAATATATTTACACCTAAACCAACACTCTTTACTAAAAAAGAAGCACCTGAGTGGTCTAAG

>In-frame_THOC5_ENST00000397872_chr22_29916987_-_PIBF1_ENST00000326291_chr13_73505303_+_1821nt
ATGTCATCAGAATCGAGCAAAAAACGGAAGCCCAAAGTGATCCGAAGCGATGGAGCCCCAGCTGAAGGAAAGCGGAATCGATCTGACACC
GAGCAGGAAGGTAAATACTACAGTGAGGAGGCCGAGGTGGATCTGCGGGACCCTGGCAGAGACTATGAGTTATACAAGTACACCTGCCAG
GAGCTACAGAGGCTGATGGCTGAGATCCAAGACCTGAAGAGCAGGGGTGGCAAGGATGTGGCAATAGAAATAGAAGAACGGAGGATCCAG
AGCTGTGTGCATTTCATGACTCTAAAGAAGCTTAACCGATTAGCCCACATCAGGTTGAAGAAAGGAAGAGATCAGACCCACGAGGCTAAG
CAGAAAGTAGATGCCTATCATCTGCAGCTCCAGAACCTGTTGTATGAGGTGATGCACCTACAGAAGGAGATCACCAAATGTTTGGAGTTT
AAGTCAAAGCATGAAGAAATTGATCTGGTCAGTTTAGAGGAGTTTTATAAGGAGGCTCCACCAGATATCAGCAAGGCCGAAGTCACCATG
GGAGACCCTCACCAGCAAACACTGGCACGTCTGGACTGGGAGCTGGAGCAGCGGAAAAGGCTGGCAGAGAAGTACCGAGAGTGCCTATCT
AACAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACCTGAGCAGCCTCCAGCCCCGCCTCAACAGCATCATGCAGGCTTCC
CTTCCGGTGCAGGAGTACCTGTTTATGCCATTCGACCAGGCTCACAAGCAGTATGAGACAGCCAGACACCTGCCGCCTCCCCTCTATGTC
CTCTTTGTTCAGGCCACTGCGTATGGGCAGGCCTGTGATAAGACGTTATCTGTGGCAATCGAAGGCAGTGTGGATGAAGCCAAGGCTCTG
TTCAAACCTCCAGAGGACTCCCAAGATGACGAGAGTGACTCAGATGCCGAGGAGGAGCAGACTACGAAGCGCCGGAGACCCACACTGGGG
GTTCAGTTGGACGACAAACGCAAGGAGATGCTGAAGAGGCACCCACTGTCTGTCATGCTCGACCTGAAGTGCAAAGATGACAGTGTGCTT
CACCTGACTTTCTACTACCTCATGAACCTCAACATCATGACAGTAAAAGCCAAAGTGACAACTGCCATGGAGCTGATCACCCCCATCAGT
GCAGGTGACTTGCTGTCTCCTGACTCAGTCCTGAGTTGCTTGTATCCTGGGGATCATGGAAAGAAAACTCCGAATCCAGCCAATCAGTAT
CAGTTTGATAAAGTTGGTGTTCACTTGGCAAGAAGAGTGCTTCAATTAGAAAAACAAAACTCGCTGATTTTAAAAGATCTGGAACATCGA
AAGGACCAAGTAACACAGCTTTCACAAGAGCTTGACAGAGCCAATTCGCTATTAAACCAGACTCAACAGCCTTACAGGTATCTCATTGAA
TCAGTGCGTCAGAGAGATTCTAAGATTGATTCACTGACGGAATCTATTGCACAACTTGAGAAAGATGTCAGCAACTTAAATAAAGAAAAG
TCAGCTTTACTACAGACGAAGAATCAAATGGCATTAGATTTAGAACAACTTCTAAATCATCGTGAGGAATTGGCAGCAATGAAACAGATT
CTCGTTAAGATGCATAGTAAACATTCTGAGAACAGCTTACTTCTCACTAAAACAGAACCAAAACATGTGACAGAAAATCAGAAATCAAAG
ACTTTGAATGTGCCTAAAGAGCATGAAGACAATATATTTACACCTAAACCAACACTCTTTACTAAAAAAGAAGCACCTGAGTGGTCTAAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_THOC5_ENST00000490103_chr22_29916987_-_PIBF1_ENST00000326291_chr13_73505303_+_2478nt
GCTTCCGGTCGGCCGCCCCTTCCTTACTTCCGGTTCTCTATGGTGCGCGGGCAAGCTTTGCTCCGCCTCCGGCAGTGGCTTACTCCCGGT
GCCAGGTTCTTGGAGCTGTGAGGAGGAACAACCATGTCATCAGAATCGAGCAAAAAACGGAAGCCCAAAGTGATCCGAAGCGATGGAGCC
CCAGCTGAAGGAAAGCGGAATCGATCTGACACCGAGCAGGAAGGTAAATACTACAGTGAGGAGGCCGAGGTGGATCTGCGGGACCCTGGC
AGAGACTATGAGTTATACAAGTACACCTGCCAGGAGCTACAGAGGCTGATGGCTGAGATCCAAGACCTGAAGAGCAGGGGTGGCAAGGAT
GTGGCAATAGAAATAGAAGAACGGAGGATCCAGAGCTGTGTGCATTTCATGACTCTAAAGAAGCTTAACCGATTAGCCCACATCAGGTTG
AAGAAAGGAAGAGATCAGACCCACGAGGCTAAGCAGAAAGTAGATGCCTATCATCTGCAGCTCCAGAACCTGTTGTATGAGGTGATGCAC
CTACAGAAGGAGATCACCAAATGTTTGGAGTTTAAGTCAAAGCATGAAGAAATTGATCTGGTCAGTTTAGAGGAGTTTTATAAGGAGGCT
CCACCAGATATCAGCAAGGCCGAAGTCACCATGGGAGACCCTCACCAGCAAACACTGGCACGTCTGGACTGGGAGCTGGAGCAGCGGAAA
AGGCTGGCAGAGAAGTACCGAGAGTGCCTATCTAACAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACCTGAGCAGCCTC
CAGCCCCGCCTCAACAGCATCATGCAGGCTTCCCTTCCGGTGCAGGAGTACCTGTTTATGCCATTCGACCAGGCTCACAAGCAGTATGAG
ACAGCCAGACACCTGCCGCCTCCCCTCTATGTCCTCTTTGTTCAGGCCACTGCGTATGGGCAGGCCTGTGATAAGACGTTATCTGTGGCA
ATCGAAGGCAGTGTGGATGAAGCCAAGGCTCTGTTCAAACCTCCAGAGGACTCCCAAGATGACGAGAGTGACTCAGATGCCGAGGAGGAG
CAGACTACGAAGCGCCGGAGACCCACACTGGGGGTTCAGTTGGACGACAAACGCAAGGAGATGCTGAAGAGGCACCCACTGTCTGTCATG
CTCGACCTGAAGTGCAAAGATGACAGTGTGCTTCACCTGACTTTCTACTACCTCATGAACCTCAACATCATGACAGTAAAAGCCAAAGTG
ACAACTGCCATGGAGCTGATCACCCCCATCAGTGCAGGTGACTTGCTGTCTCCTGACTCAGTCCTGAGTTGCTTGTATCCTGGGGATCAT
GGAAAGAAAACTCCGAATCCAGCCAATCAGTATCAGTTTGATAAAGTTGGTGTTCACTTGGCAAGAAGAGTGCTTCAATTAGAAAAACAA
AACTCGCTGATTTTAAAAGATCTGGAACATCGAAAGGACCAAGTAACACAGCTTTCACAAGAGCTTGACAGAGCCAATTCGCTATTAAAC
CAGACTCAACAGCCTTACAGGTATCTCATTGAATCAGTGCGTCAGAGAGATTCTAAGATTGATTCACTGACGGAATCTATTGCACAACTT
GAGAAAGATGTCAGCAACTTAAATAAAGAAAAGTCAGCTTTACTACAGACGAAGAATCAAATGGCATTAGATTTAGAACAACTTCTAAAT
CATCGTGAGGAATTGGCAGCAATGAAACAGATTCTCGTTAAGATGCATAGTAAACATTCTGAGAACAGCTTACTTCTCACTAAAACAGAA
CCAAAACATGTGACAGAAAATCAGAAATCAAAGACTTTGAATGTGCCTAAAGAGCATGAAGACAATATATTTACACCTAAACCAACACTC
TTTACTAAAAAAGAAGCACCTGAGTGGTCTAAGAAACAAAAGATGAAGACCTAGTGTTTTGGATGGGAAGCACCTGTAGACCATTATATA
CTCCTGAAGTTCTTTTTCTGATGGAAAACAAAATTCAGCTTAATCGTGTACTCAGCATTTTTTAAATAACAATGTTTATTTGAACTAATA
TTAAATTAACAAATTCAGTGTAATCAAAATGTGTAAAGAACAATCAATATACTTTATTTTTTTTTCTATTTTATAAAATAAATATATATG
CTATGCTTTAAATTTTGGAGCTTTCATAAATGTTCAATGCATTTTAAGTGTGTGGCTTATAAATATTTTGGTATTTTTCTATACTACGTA
AATTCTGAGTTTAAATGTCATACACAAATACTAAGACACTTTGCATTTTTAAAAATTAAGAATCATTTGTGAAGTCCACTACGAGGTACT
TCAAAAGCCCAGTAATGGTGGTCAGATACCATGTAGATGGATACAGATTGTTGACTCTTTTGAAGTTGTTTTTTTCTTATATTTTATATT

>In-frame_THOC5_ENST00000397872_chr22_29916987_-_PIBF1_ENST00000326291_chr13_73505303_+_2690nt
GGGCAGTGGGGCTGGGAGATGGGGCGGGGCTGGGCGCTCCGGGACTGAGGTGCTGATCGCCCAAAGGGCGCCCCTGGGCTGGGGTCTGAC
CCGGCTTCTCCTCCCTCACTACCCGCGGTCCCCGGCCTCTCGGCGCTGCGCTGTTACCTCATCCGAAAAGTGTTCGCTGCAGCATCCTCA
GGCTTCACGTTGGAGCCTCTTGATTGTGGTGTTCAGCATTATTTAAGATCACCTATGCATCATCTGAAGCCACAGTCCCAGGTCATCTTC
ATCACCTTCCCCAGTGGAATGCCTCCTGTGTTAAAGCCCACAACAACCCCTGTGGAGGAACAACCATGTCATCAGAATCGAGCAAAAAAC
GGAAGCCCAAAGTGATCCGAAGCGATGGAGCCCCAGCTGAAGGAAAGCGGAATCGATCTGACACCGAGCAGGAAGGTAAATACTACAGTG
AGGAGGCCGAGGTGGATCTGCGGGACCCTGGCAGAGACTATGAGTTATACAAGTACACCTGCCAGGAGCTACAGAGGCTGATGGCTGAGA
TCCAAGACCTGAAGAGCAGGGGTGGCAAGGATGTGGCAATAGAAATAGAAGAACGGAGGATCCAGAGCTGTGTGCATTTCATGACTCTAA
AGAAGCTTAACCGATTAGCCCACATCAGGTTGAAGAAAGGAAGAGATCAGACCCACGAGGCTAAGCAGAAAGTAGATGCCTATCATCTGC
AGCTCCAGAACCTGTTGTATGAGGTGATGCACCTACAGAAGGAGATCACCAAATGTTTGGAGTTTAAGTCAAAGCATGAAGAAATTGATC
TGGTCAGTTTAGAGGAGTTTTATAAGGAGGCTCCACCAGATATCAGCAAGGCCGAAGTCACCATGGGAGACCCTCACCAGCAAACACTGG
CACGTCTGGACTGGGAGCTGGAGCAGCGGAAAAGGCTGGCAGAGAAGTACCGAGAGTGCCTATCTAACAAGGAGAAGATTCTCAAGGAGA
TTGAGGTGAAGAAGGAGTACCTGAGCAGCCTCCAGCCCCGCCTCAACAGCATCATGCAGGCTTCCCTTCCGGTGCAGGAGTACCTGTTTA
TGCCATTCGACCAGGCTCACAAGCAGTATGAGACAGCCAGACACCTGCCGCCTCCCCTCTATGTCCTCTTTGTTCAGGCCACTGCGTATG
GGCAGGCCTGTGATAAGACGTTATCTGTGGCAATCGAAGGCAGTGTGGATGAAGCCAAGGCTCTGTTCAAACCTCCAGAGGACTCCCAAG
ATGACGAGAGTGACTCAGATGCCGAGGAGGAGCAGACTACGAAGCGCCGGAGACCCACACTGGGGGTTCAGTTGGACGACAAACGCAAGG
AGATGCTGAAGAGGCACCCACTGTCTGTCATGCTCGACCTGAAGTGCAAAGATGACAGTGTGCTTCACCTGACTTTCTACTACCTCATGA
ACCTCAACATCATGACAGTAAAAGCCAAAGTGACAACTGCCATGGAGCTGATCACCCCCATCAGTGCAGGTGACTTGCTGTCTCCTGACT
CAGTCCTGAGTTGCTTGTATCCTGGGGATCATGGAAAGAAAACTCCGAATCCAGCCAATCAGTATCAGTTTGATAAAGTTGGTGTTCACT
TGGCAAGAAGAGTGCTTCAATTAGAAAAACAAAACTCGCTGATTTTAAAAGATCTGGAACATCGAAAGGACCAAGTAACACAGCTTTCAC
AAGAGCTTGACAGAGCCAATTCGCTATTAAACCAGACTCAACAGCCTTACAGGTATCTCATTGAATCAGTGCGTCAGAGAGATTCTAAGA
TTGATTCACTGACGGAATCTATTGCACAACTTGAGAAAGATGTCAGCAACTTAAATAAAGAAAAGTCAGCTTTACTACAGACGAAGAATC
AAATGGCATTAGATTTAGAACAACTTCTAAATCATCGTGAGGAATTGGCAGCAATGAAACAGATTCTCGTTAAGATGCATAGTAAACATT
CTGAGAACAGCTTACTTCTCACTAAAACAGAACCAAAACATGTGACAGAAAATCAGAAATCAAAGACTTTGAATGTGCCTAAAGAGCATG
AAGACAATATATTTACACCTAAACCAACACTCTTTACTAAAAAAGAAGCACCTGAGTGGTCTAAGAAACAAAAGATGAAGACCTAGTGTT
TTGGATGGGAAGCACCTGTAGACCATTATATACTCCTGAAGTTCTTTTTCTGATGGAAAACAAAATTCAGCTTAATCGTGTACTCAGCAT
TTTTTAAATAACAATGTTTATTTGAACTAATATTAAATTAACAAATTCAGTGTAATCAAAATGTGTAAAGAACAATCAATATACTTTATT
TTTTTTTCTATTTTATAAAATAAATATATATGCTATGCTTTAAATTTTGGAGCTTTCATAAATGTTCAATGCATTTTAAGTGTGTGGCTT
ATAAATATTTTGGTATTTTTCTATACTACGTAAATTCTGAGTTTAAATGTCATACACAAATACTAAGACACTTTGCATTTTTAAAAATTA
AGAATCATTTGTGAAGTCCACTACGAGGTACTTCAAAAGCCCAGTAATGGTGGTCAGATACCATGTAGATGGATACAGATTGTTGACTCT


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FusionGenePPI for THOC5_PIBF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
THOC5DDX39B, ALYREF, THOC2, THOC1, THOC3, THOC6, THOC7, SMAD4, NCBP1, NXF1, DDX23, ZC3H15, XPO4, ZKSCAN5, VIM, RRP9, UTRN, ZPR1, ZNF606, TJP2, UBR7, LIG4, LSM3, PPIL1, ZNF830, CSNK2A1, RNF2, LUZP4, HSPB1, TJP1, FMNL1, GTF2F1, PDGFRA, RPL6, RPL22, RPL27A, HSF2, BCLAF1, C17orf85, NEMF, EIF4A3, ZC3H11A, DDX39A, KIF1C, MRPS27, SIRT1, CCDC9, CHTOP, WDR74, MAGOHB, DDX24, KIAA1522, MYO1G, ZC3H14, KLF16, FYTTD1, POLDIP3, SERPINB12, IMP4, C19orf47, MRPL12, SARNPPIBF1MAP3K2, APP, SAV1, SHMT2, NXF1, SLC25A41, PPP1R21, C17orf59, NTRK1, CEP63, KIAA0753, CCDC14, MED4, CEP290, CEP162, PCM1, SSX2IP, OFD1, CEP120, SPICE1, CEP128, CEP135, CEP89, CNTRL, NIN, ODF2, POC5, LCA5, SASS6, ITPKB, PCNT, FGFR1OP, MAPRE1, BORA, KIF7, PTPN22, TPTE2, TSNAXIP1, VAT1L, CPNE2, LRRCC1, EXOC3, PTPRQ, AHI1, EEA1, SNX27, ATP2B2, CEP131, SLC9A3R2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneTHOC5chr22:29916987chr13:73505303ENST00000397871-13202_144425684CSF1R
HgeneTHOC5chr22:29916987chr13:73505303ENST00000397872-14212_144425684CSF1R
HgeneTHOC5chr22:29916987chr13:73505303ENST00000397873-14212_144425684CSF1R
HgeneTHOC5chr22:29916987chr13:73505303ENST00000490103-13202_144425684CSF1R
HgeneTHOC5chr22:29916987chr13:73505303ENST00000397871-13202_199425684THOC7
HgeneTHOC5chr22:29916987chr13:73505303ENST00000397872-14212_199425684THOC7
HgeneTHOC5chr22:29916987chr13:73505303ENST00000397873-14212_199425684THOC7
HgeneTHOC5chr22:29916987chr13:73505303ENST00000490103-13202_199425684THOC7


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for THOC5_PIBF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for THOC5_PIBF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePIBF1C0000821Threatened abortion1CTD_human