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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37998

FusionGeneSummary for THOC5_PATZ1

check button Fusion gene summary
Fusion gene informationFusion gene name: THOC5_PATZ1
Fusion gene ID: 37998
HgeneTgene
Gene symbol

THOC5

PATZ1

Gene ID

8563

23598

Gene nameTHO complex 5POZ/BTB and AT hook containing zinc finger 1
SynonymsC22orf19|Fmip|PK1.3|fSAP79MAZR|PATZ|RIAZ|ZBTB19|ZNF278|ZSG|dJ400N23
Cytomap

22q12.2

22q12.2

Type of geneprotein-codingprotein-coding
DescriptionTHO complex subunit 5 homologFms-interacting proteinNF2/meningioma region protein pK1.3PP39.2functional spliceosome-associated protein 79hTREX90placental protein 39.2POZ-, AT hook-, and zinc finger-containing protein 1BTB-POZ domain zinc finger transcription factorMAZ-related factorPOZ-AT hook-zinc finger proteinprotein kinase A RI subunit alpha-associated proteinzinc finger and BTB domain-containing protein 19z
Modification date2018052320180519
UniProtAcc

Q13769

Q9HBE1

Ensembl transtripts involved in fusion geneENST00000490103, ENST00000397871, 
ENST00000397872, ENST00000397873, 
ENST00000266269, ENST00000405309, 
ENST00000351933, ENST00000215919, 
Fusion gene scores* DoF score8 X 8 X 6=3845 X 5 X 3=75
# samples 87
** MAII scorelog2(8/384*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/75*10)=-0.0995356735509144
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: THOC5 [Title/Abstract] AND PATZ1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTHOC5

GO:0006406

mRNA export from nucleus

17190602

HgeneTHOC5

GO:0030224

monocyte differentiation

19015024

HgeneTHOC5

GO:0046784

viral mRNA export from host cell nucleus

18974867


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF743471THOC5chr22

29935393

-PATZ1chr22

31735096

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000490103ENST00000266269THOC5chr22

29935393

-PATZ1chr22

31735096

+
intron-intronENST00000490103ENST00000405309THOC5chr22

29935393

-PATZ1chr22

31735096

+
intron-intronENST00000490103ENST00000351933THOC5chr22

29935393

-PATZ1chr22

31735096

+
intron-intronENST00000490103ENST00000215919THOC5chr22

29935393

-PATZ1chr22

31735096

+
intron-intronENST00000397871ENST00000266269THOC5chr22

29935393

-PATZ1chr22

31735096

+
intron-intronENST00000397871ENST00000405309THOC5chr22

29935393

-PATZ1chr22

31735096

+
intron-intronENST00000397871ENST00000351933THOC5chr22

29935393

-PATZ1chr22

31735096

+
intron-intronENST00000397871ENST00000215919THOC5chr22

29935393

-PATZ1chr22

31735096

+
intron-intronENST00000397872ENST00000266269THOC5chr22

29935393

-PATZ1chr22

31735096

+
intron-intronENST00000397872ENST00000405309THOC5chr22

29935393

-PATZ1chr22

31735096

+
intron-intronENST00000397872ENST00000351933THOC5chr22

29935393

-PATZ1chr22

31735096

+
intron-intronENST00000397872ENST00000215919THOC5chr22

29935393

-PATZ1chr22

31735096

+
intron-intronENST00000397873ENST00000266269THOC5chr22

29935393

-PATZ1chr22

31735096

+
intron-intronENST00000397873ENST00000405309THOC5chr22

29935393

-PATZ1chr22

31735096

+
intron-intronENST00000397873ENST00000351933THOC5chr22

29935393

-PATZ1chr22

31735096

+
intron-intronENST00000397873ENST00000215919THOC5chr22

29935393

-PATZ1chr22

31735096

+

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FusionProtFeatures for THOC5_PATZ1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
THOC5

Q13769

PATZ1

Q9HBE1

Acts as component of the THO subcomplex of the TREXcomplex which is thought to couple mRNA transcription, processingand nuclear export, and which specifically associates with splicedmRNA and not with unspliced pre-mRNA. TREX is recruited to splicedmRNAs by a transcription-independent mechanism, binds to mRNAupstream of the exon-junction complex (EJC) and is recruited in asplicing- and cap-dependent manner to a region near the 5' end ofthe mRNA where it functions in mRNA export to the cytoplasm viathe TAP/NFX1 pathway. The TREX complex is essential for the exportof Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAsand infectious virus production. THOC5 in conjunction withALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export ofHSP70 mRNA; both proteins enhance the RNA binding activity of NXF1and are required for NXF1 localization to the nuclear rim.Involved in transcription elongation and genome stability.Involved in alternative polyadenylation site choice by recruitingCPSF6 to 5' region of target genes; probably mediates associationof the TREX and CFIm complexes. Regulates the expression of myeloid transcriptionfactors CEBPA, CEBPB and GAB2 by enhancing the levels ofphosphatidylinositol 3,4,5-trisphosphate. May be involved in thedifferentiation of granulocytes and adipocytes. Essential forhematopoietic primitive cell survival and plays an integral rolein monocytic development. Transcriptional repressor.{ECO:0000269|PubMed:10713105}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for THOC5_PATZ1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for THOC5_PATZ1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for THOC5_PATZ1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for THOC5_PATZ1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource