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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37976

FusionGeneSummary for THBS2_THBS2

check button Fusion gene summary
Fusion gene informationFusion gene name: THBS2_THBS2
Fusion gene ID: 37976
HgeneTgene
Gene symbol

THBS2

THBS2

Gene ID

7058

7058

Gene namethrombospondin 2thrombospondin 2
SynonymsTSP2TSP2
Cytomap

6q27

6q27

Type of geneprotein-codingprotein-coding
Descriptionthrombospondin-2thrombospondin-2
Modification date2018052220180522
UniProtAcc

P35442

P35442

Ensembl transtripts involved in fusion geneENST00000366787, ENST00000488355, 
ENST00000366787, ENST00000488355, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 1=9
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: THBS2 [Title/Abstract] AND THBS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTHBS2

GO:0016525

negative regulation of angiogenesis

20714802

TgeneTHBS2

GO:0016525

negative regulation of angiogenesis

20714802


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI954258THBS2chr6

169644422

+THBS2chr6

169641560

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000366787ENST00000366787THBS2chr6

169644422

+THBS2chr6

169641560

+
intron-intronENST00000366787ENST00000488355THBS2chr6

169644422

+THBS2chr6

169641560

+
intron-intronENST00000488355ENST00000366787THBS2chr6

169644422

+THBS2chr6

169641560

+
intron-intronENST00000488355ENST00000488355THBS2chr6

169644422

+THBS2chr6

169641560

+

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FusionProtFeatures for THBS2_THBS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
THBS2

P35442

THBS2

P35442

Adhesive glycoprotein that mediates cell-to-cell andcell-to-matrix interactions. Ligand for CD36 mediatingantiangiogenic properties. {ECO:0000269|PubMed:20714802}. Adhesive glycoprotein that mediates cell-to-cell andcell-to-matrix interactions. Ligand for CD36 mediatingantiangiogenic properties. {ECO:0000269|PubMed:20714802}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for THBS2_THBS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for THBS2_THBS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for THBS2_THBS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for THBS2_THBS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTHBS2C0011849Diabetes Mellitus1CTD_human
HgeneTHBS2C0011875Diabetic Angiopathies1CTD_human
TgeneTHBS2C0011849Diabetes Mellitus1CTD_human
TgeneTHBS2C0011875Diabetic Angiopathies1CTD_human