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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3795

FusionGeneSummary for BAG4_LETM2

check button Fusion gene summary
Fusion gene informationFusion gene name: BAG4_LETM2
Fusion gene ID: 3795
HgeneTgene
Gene symbol

BAG4

LETM2

Gene ID

9530

137994

Gene nameBCL2 associated athanogene 4leucine zipper and EF-hand containing transmembrane protein 2
SynonymsBAG-4|SODDSLC55A2
Cytomap

8p11.23

8p11.23

Type of geneprotein-codingprotein-coding
DescriptionBAG family molecular chaperone regulator 4bcl-2-associated athanogene 4silencer of death domainsLETM1 domain-containing protein LETM2, mitochondrialLETM1 and EF-hand domain-containing protein 2leucine zipper-EF-hand containing transmembrane protein 1-like proteinleucine zipper-EF-hand containing transmembrane protein 2
Modification date2018052220180523
UniProtAcc

O95429

Q2VYF4

Ensembl transtripts involved in fusion geneENST00000521282, ENST00000432471, 
ENST00000287322, 
ENST00000519476, 
ENST00000297720, ENST00000524874, 
ENST00000379957, ENST00000523983, 
ENST00000527710, ENST00000528827, 
Fusion gene scores* DoF score8 X 3 X 4=9611 X 3 X 7=231
# samples 811
** MAII scorelog2(8/96*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/231*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BAG4 [Title/Abstract] AND LETM2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBAG4

GO:0071356

cellular response to tumor necrosis factor

21712384


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-66-2789-01ABAG4chr8

38050313

+LETM2chr8

38257790

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000521282ENST00000519476BAG4chr8

38050313

+LETM2chr8

38257790

+
3UTR-intronENST00000521282ENST00000297720BAG4chr8

38050313

+LETM2chr8

38257790

+
3UTR-intronENST00000521282ENST00000524874BAG4chr8

38050313

+LETM2chr8

38257790

+
3UTR-intronENST00000521282ENST00000379957BAG4chr8

38050313

+LETM2chr8

38257790

+
3UTR-intronENST00000521282ENST00000523983BAG4chr8

38050313

+LETM2chr8

38257790

+
3UTR-intronENST00000521282ENST00000527710BAG4chr8

38050313

+LETM2chr8

38257790

+
3UTR-intronENST00000521282ENST00000528827BAG4chr8

38050313

+LETM2chr8

38257790

+
intron-intronENST00000432471ENST00000519476BAG4chr8

38050313

+LETM2chr8

38257790

+
intron-intronENST00000432471ENST00000297720BAG4chr8

38050313

+LETM2chr8

38257790

+
intron-intronENST00000432471ENST00000524874BAG4chr8

38050313

+LETM2chr8

38257790

+
intron-intronENST00000432471ENST00000379957BAG4chr8

38050313

+LETM2chr8

38257790

+
intron-intronENST00000432471ENST00000523983BAG4chr8

38050313

+LETM2chr8

38257790

+
intron-intronENST00000432471ENST00000527710BAG4chr8

38050313

+LETM2chr8

38257790

+
intron-intronENST00000432471ENST00000528827BAG4chr8

38050313

+LETM2chr8

38257790

+
5CDS-intronENST00000287322ENST00000519476BAG4chr8

38050313

+LETM2chr8

38257790

+
5CDS-intronENST00000287322ENST00000297720BAG4chr8

38050313

+LETM2chr8

38257790

+
5CDS-intronENST00000287322ENST00000524874BAG4chr8

38050313

+LETM2chr8

38257790

+
5CDS-intronENST00000287322ENST00000379957BAG4chr8

38050313

+LETM2chr8

38257790

+
5CDS-intronENST00000287322ENST00000523983BAG4chr8

38050313

+LETM2chr8

38257790

+
5CDS-intronENST00000287322ENST00000527710BAG4chr8

38050313

+LETM2chr8

38257790

+
5CDS-intronENST00000287322ENST00000528827BAG4chr8

38050313

+LETM2chr8

38257790

+

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FusionProtFeatures for BAG4_LETM2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BAG4

O95429

LETM2

Q2VYF4

Inhibits the chaperone activity of HSP70/HSC70 bypromoting substrate release (By similarity). Prevents constitutiveTNFRSF1A signaling. Negative regulator of PRKN translocation todamaged mitochondria. {ECO:0000250, ECO:0000269|PubMed:24270810}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BAG4_LETM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BAG4_LETM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BAG4APOBEC1, HSP90AA1, HSPA4, TNFRSF1A, TNFRSF25, HSPA8, ELAVL1, CUL3, CUL4A, CUL5, CUL2, CUL1, COPS5, DCUN1D1, CAND1, NEDD8, MCL1, DCP1A, DCP1B, HSPA2, STUB1, MLF2, DNAJB6, DNAJB1, EDC3, HSPA1B, HSPA1L, DNAJC9, DNAJB12, DDX6, CD93, DNAJC7, MOV10, NXF1, FBXW11, BEX1, IL24, LYPD3, BCAS3, NAT2, ATAD2, BAP1, KLK5, RNF20, SCGB3A1, THRSP, CASZ1, CCL5, DIRAS3, EPSTI1, FAM84B, GLCE, IL13RA2, KLK9, PDLIM2, ERRFI1, KLK7, MTA3, PRDM14, RASL10B, ITIH5, MRC2, RHOBTB2, MCM2, WWP2, C3orf38, HSF1, DNAJC13, BCORL1, KLHL18, HSF2, ZNF318, GMNN, ENDOG, WNK1, FLYWCH2, ZNF703, BRCA2, QRICH1, EDC4, YAP1, SF3A3, DNAJB5, NMT1LETM2APP, FBXW7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BAG4_LETM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BAG4_LETM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource