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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37940

FusionGeneSummary for TG_FNBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: TG_FNBP1
Fusion gene ID: 37940
HgeneTgene
Gene symbol

TG

FNBP1

Gene ID

7038

23048

Gene namethyroglobulinformin binding protein 1
SynonymsAITD3|TGNFBP17
Cytomap

8q24.22

9q34.11

Type of geneprotein-codingprotein-coding
Descriptionthyroglobulinformin-binding protein 1formin-binding protein 17
Modification date2018052020180529
UniProtAcc

P01266

Q96RU3

Ensembl transtripts involved in fusion geneENST00000377869, ENST00000220616, 
ENST00000542445, ENST00000519543, 
ENST00000522523, 
ENST00000446176, 
ENST00000420781, ENST00000355681, 
ENST00000443566, ENST00000478129, 
Fusion gene scores* DoF score10 X 12 X 3=3608 X 10 X 3=240
# samples 1314
** MAII scorelog2(13/360*10)=-1.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/240*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TG [Title/Abstract] AND FNBP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG999952TGchr8

133918253

-FNBP1chr9

132803774

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000377869ENST00000446176TGchr8

133918253

-FNBP1chr9

132803774

-
intron-intronENST00000377869ENST00000420781TGchr8

133918253

-FNBP1chr9

132803774

-
intron-intronENST00000377869ENST00000355681TGchr8

133918253

-FNBP1chr9

132803774

-
intron-intronENST00000377869ENST00000443566TGchr8

133918253

-FNBP1chr9

132803774

-
intron-intronENST00000377869ENST00000478129TGchr8

133918253

-FNBP1chr9

132803774

-
intron-intronENST00000220616ENST00000446176TGchr8

133918253

-FNBP1chr9

132803774

-
intron-intronENST00000220616ENST00000420781TGchr8

133918253

-FNBP1chr9

132803774

-
intron-intronENST00000220616ENST00000355681TGchr8

133918253

-FNBP1chr9

132803774

-
intron-intronENST00000220616ENST00000443566TGchr8

133918253

-FNBP1chr9

132803774

-
intron-intronENST00000220616ENST00000478129TGchr8

133918253

-FNBP1chr9

132803774

-
intron-intronENST00000542445ENST00000446176TGchr8

133918253

-FNBP1chr9

132803774

-
intron-intronENST00000542445ENST00000420781TGchr8

133918253

-FNBP1chr9

132803774

-
intron-intronENST00000542445ENST00000355681TGchr8

133918253

-FNBP1chr9

132803774

-
intron-intronENST00000542445ENST00000443566TGchr8

133918253

-FNBP1chr9

132803774

-
intron-intronENST00000542445ENST00000478129TGchr8

133918253

-FNBP1chr9

132803774

-
intron-intronENST00000519543ENST00000446176TGchr8

133918253

-FNBP1chr9

132803774

-
intron-intronENST00000519543ENST00000420781TGchr8

133918253

-FNBP1chr9

132803774

-
intron-intronENST00000519543ENST00000355681TGchr8

133918253

-FNBP1chr9

132803774

-
intron-intronENST00000519543ENST00000443566TGchr8

133918253

-FNBP1chr9

132803774

-
intron-intronENST00000519543ENST00000478129TGchr8

133918253

-FNBP1chr9

132803774

-
intron-intronENST00000522523ENST00000446176TGchr8

133918253

-FNBP1chr9

132803774

-
intron-intronENST00000522523ENST00000420781TGchr8

133918253

-FNBP1chr9

132803774

-
intron-intronENST00000522523ENST00000355681TGchr8

133918253

-FNBP1chr9

132803774

-
intron-intronENST00000522523ENST00000443566TGchr8

133918253

-FNBP1chr9

132803774

-
intron-intronENST00000522523ENST00000478129TGchr8

133918253

-FNBP1chr9

132803774

-

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FusionProtFeatures for TG_FNBP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TG

P01266

FNBP1

Q96RU3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TG_FNBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TG_FNBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TG_FNBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TG_FNBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTGC0342194Thyroid Dyshormonogenesis 35CTD_human;UNIPROT
HgeneTGC0018021Goiter2CTD_human;HPO
HgeneTGC0013336Dwarfism1CTD_human