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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37939

FusionGeneSummary for TG_CTNNB1

check button Fusion gene summary
Fusion gene informationFusion gene name: TG_CTNNB1
Fusion gene ID: 37939
HgeneTgene
Gene symbol

TG

CTNNB1

Gene ID

7038

1499

Gene namethyroglobulincatenin beta 1
SynonymsAITD3|TGNCTNNB|EVR7|MRD19|armadillo
Cytomap

8q24.22

3p22.1

Type of geneprotein-codingprotein-coding
Descriptionthyroglobulincatenin beta-1catenin (cadherin-associated protein), beta 1, 88kDa
Modification date2018052020180527
UniProtAcc

P01266

P35222

Ensembl transtripts involved in fusion geneENST00000377869, ENST00000220616, 
ENST00000542445, ENST00000519543, 
ENST00000522523, 
ENST00000471014, 
ENST00000405570, ENST00000396183, 
ENST00000349496, ENST00000453024, 
ENST00000396185, 
Fusion gene scores* DoF score10 X 12 X 3=3606 X 6 X 3=108
# samples 136
** MAII scorelog2(13/360*10)=-1.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TG [Title/Abstract] AND CTNNB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCTNNB1

GO:0008285

negative regulation of cell proliferation

12970740

TgeneCTNNB1

GO:0030997

regulation of centriole-centriole cohesion

18086858

TgeneCTNNB1

GO:0032355

response to estradiol

15304487

TgeneCTNNB1

GO:0033234

negative regulation of protein sumoylation

22155184

TgeneCTNNB1

GO:0043065

positive regulation of apoptotic process

12651860|12970740

TgeneCTNNB1

GO:0043525

positive regulation of neuron apoptotic process

19591802

TgeneCTNNB1

GO:0045893

positive regulation of transcription, DNA-templated

12970740|18787224

TgeneCTNNB1

GO:0045944

positive regulation of transcription by RNA polymerase II

9065402|11751639|12651860|14660579|18193033

TgeneCTNNB1

GO:0060070

canonical Wnt signaling pathway

10644691|12937339|19187541

TgeneCTNNB1

GO:0071681

cellular response to indole-3-methanol

10868478

TgeneCTNNB1

GO:0090279

regulation of calcium ion import

19996314

TgeneCTNNB1

GO:1904798

positive regulation of core promoter binding

22723415

TgeneCTNNB1

GO:2000008

regulation of protein localization to cell surface

19996314


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI003062TGchr8

133907316

-CTNNB1chr3

41279542

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000377869ENST00000471014TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000377869ENST00000405570TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000377869ENST00000396183TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000377869ENST00000349496TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000377869ENST00000453024TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000377869ENST00000396185TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000220616ENST00000471014TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000220616ENST00000405570TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000220616ENST00000396183TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000220616ENST00000349496TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000220616ENST00000453024TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000220616ENST00000396185TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000542445ENST00000471014TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000542445ENST00000405570TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000542445ENST00000396183TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000542445ENST00000349496TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000542445ENST00000453024TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000542445ENST00000396185TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000519543ENST00000471014TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000519543ENST00000405570TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000519543ENST00000396183TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000519543ENST00000349496TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000519543ENST00000453024TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000519543ENST00000396185TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000522523ENST00000471014TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000522523ENST00000405570TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000522523ENST00000396183TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000522523ENST00000349496TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000522523ENST00000453024TGchr8

133907316

-CTNNB1chr3

41279542

+
intron-intronENST00000522523ENST00000396185TGchr8

133907316

-CTNNB1chr3

41279542

+

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FusionProtFeatures for TG_CTNNB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TG

P01266

CTNNB1

P35222

Key downstream component of the canonical Wnt signalingpathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2,APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminalSer and Thr residues and ubiquitination of CTNNB1 via BTRC and itssubsequent degradation by the proteasome. In the presence of Wntligand, CTNNB1 is not ubiquitinated and accumulates in thenucleus, where it acts as a coactivator for transcription factorsof the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator ofcentrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1pathway of insulin internalization. Blocks anoikis of malignantkidney and intestinal epithelial cells and promotes theiranchorage-independent growth by down-regulating DAPK2. DisruptsPML function and PML-NB formation by inhibiting RANBP2-mediatedsumoylation of PML (PubMed:17524503, PubMed:18077326,PubMed:18086858, PubMed:18957423, PubMed:21262353,PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotesneurogenesis by maintaining sympathetic neuroblasts within thecell cycle (By similarity). {ECO:0000250|UniProtKB:Q02248,ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326,ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423,ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184,ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TG_CTNNB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TG_CTNNB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TG_CTNNB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TG_CTNNB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTGC0342194Thyroid Dyshormonogenesis 35CTD_human;UNIPROT
HgeneTGC0018021Goiter2CTD_human;HPO
HgeneTGC0013336Dwarfism1CTD_human
TgeneCTNNB1C0009375Colonic Neoplasms9CTD_human
TgeneCTNNB1C0206711Pilomatrixoma8CTD_human;HPO;ORPHANET;UNIPROT
TgeneCTNNB1C0009404Colorectal Neoplasms4CTD_human
TgeneCTNNB1C0001418Adenocarcinoma3CTD_human
TgeneCTNNB1C0023904Liver Neoplasms, Experimental3CTD_human
TgeneCTNNB1C0025149Medulloblastoma3CTD_human;HPO;UNIPROT
TgeneCTNNB1C1527249Colorectal Cancer3UNIPROT
TgeneCTNNB1C1879526Aberrant Crypt Foci3CTD_human
TgeneCTNNB1C2239176Liver carcinoma3CTD_human;HPO
TgeneCTNNB1C0001430Adenoma2CTD_human
TgeneCTNNB1C0023903Liver neoplasms2CTD_human
TgeneCTNNB1C0036341Schizophrenia2PSYGENET
TgeneCTNNB1C1458155Mammary Neoplasms2CTD_human
TgeneCTNNB1C0001624Adrenal Gland Neoplasms1CTD_human
TgeneCTNNB1C0007528Cecal Neoplasms1CTD_human
TgeneCTNNB1C0007873Uterine Cervical Neoplasm1CTD_human
TgeneCTNNB1C0010276Craniopharyngioma1CTD_human;ORPHANET
TgeneCTNNB1C0018923Hemangiosarcoma1CTD_human
TgeneCTNNB1C0021841Intestinal Neoplasms1CTD_human
TgeneCTNNB1C0023890Liver Cirrhosis1CTD_human
TgeneCTNNB1C0024121Lung Neoplasms1CTD_human
TgeneCTNNB1C0026846Muscular Atrophy1CTD_human
TgeneCTNNB1C0027626Neoplasm Invasiveness1CTD_human
TgeneCTNNB1C0027708Nephroblastoma1CTD_human
TgeneCTNNB1C0027746Nerve Degeneration1CTD_human
TgeneCTNNB1C0030297Pancreatic Neoplasm1CTD_human
TgeneCTNNB1C0031149Peritoneal Neoplasms1CTD_human
TgeneCTNNB1C0033578Prostatic Neoplasms1CTD_human
TgeneCTNNB1C0038325Stevens-Johnson Syndrome1CTD_human
TgeneCTNNB1C0206624Hepatoblastoma1CTD_human
TgeneCTNNB1C0206669Hepatocellular Adenoma1CTD_human
TgeneCTNNB1C0206686Adrenocortical carcinoma1CTD_human
TgeneCTNNB1C0232347No-Reflow Phenomenon1CTD_human
TgeneCTNNB1C0334634Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse1CTD_human
TgeneCTNNB1C0345967Malignant mesothelioma1CTD_human
TgeneCTNNB1C0376634Craniofacial Abnormalities1CTD_human
TgeneCTNNB1C0919267ovarian neoplasm1CTD_human
TgeneCTNNB1C3554449MENTAL RETARDATION, AUTOSOMAL DOMINANT 191ORPHANET;UNIPROT
TgeneCTNNB1C4277682Chemical and Drug Induced Liver Injury1CTD_human