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Fusion gene ID: 37913 |
FusionGeneSummary for TGFBR3_LRTM1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TGFBR3_LRTM1 | Fusion gene ID: 37913 | Hgene | Tgene | Gene symbol | TGFBR3 | LRTM1 | Gene ID | 7049 | 57408 |
| Gene name | transforming growth factor beta receptor 3 | leucine rich repeats and transmembrane domains 1 | |
| Synonyms | BGCAN|betaglycan | HT017 | |
| Cytomap | 1p22.1 | 3p14.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transforming growth factor beta receptor type 3TGF-beta receptor type 3TGF-beta receptor type IIITGFR-3betaglycan proteoglycantransforming growth factor beta receptor III | leucine-rich repeat and transmembrane domain-containing protein 1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q03167 | Q9HBL6 | |
| Ensembl transtripts involved in fusion gene | ENST00000212355, ENST00000370399, ENST00000525962, ENST00000468996, | ENST00000273286, ENST00000493075, | |
| Fusion gene scores | * DoF score | 6 X 5 X 4=120 | 3 X 2 X 3=18 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TGFBR3 [Title/Abstract] AND LRTM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TGFBR3 | GO:0001837 | epithelial to mesenchymal transition | 18184661 |
| Hgene | TGFBR3 | GO:0007179 | transforming growth factor beta receptor signaling pathway | 12958365 |
| Hgene | TGFBR3 | GO:0030509 | BMP signaling pathway | 18184661 |
| Hgene | TGFBR3 | GO:0032354 | response to follicle-stimulating hormone | 14557487 |
| Hgene | TGFBR3 | GO:0034695 | response to prostaglandin E | 14557487 |
| Hgene | TGFBR3 | GO:0034699 | response to luteinizing hormone | 14557487 |
| Hgene | TGFBR3 | GO:0051271 | negative regulation of cellular component movement | 17999987 |
| Hgene | TGFBR3 | GO:0060317 | cardiac epithelial to mesenchymal transition | 18184661 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-30-1861-01A | TGFBR3 | chr1 | 92174220 | - | LRTM1 | chr3 | 54959242 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000212355 | ENST00000273286 | TGFBR3 | chr1 | 92174220 | - | LRTM1 | chr3 | 54959242 | - |
| 5CDS-5UTR | ENST00000212355 | ENST00000493075 | TGFBR3 | chr1 | 92174220 | - | LRTM1 | chr3 | 54959242 | - |
| Frame-shift | ENST00000370399 | ENST00000273286 | TGFBR3 | chr1 | 92174220 | - | LRTM1 | chr3 | 54959242 | - |
| 5CDS-5UTR | ENST00000370399 | ENST00000493075 | TGFBR3 | chr1 | 92174220 | - | LRTM1 | chr3 | 54959242 | - |
| In-frame | ENST00000525962 | ENST00000273286 | TGFBR3 | chr1 | 92174220 | - | LRTM1 | chr3 | 54959242 | - |
| 5CDS-5UTR | ENST00000525962 | ENST00000493075 | TGFBR3 | chr1 | 92174220 | - | LRTM1 | chr3 | 54959242 | - |
| intron-3CDS | ENST00000468996 | ENST00000273286 | TGFBR3 | chr1 | 92174220 | - | LRTM1 | chr3 | 54959242 | - |
| intron-5UTR | ENST00000468996 | ENST00000493075 | TGFBR3 | chr1 | 92174220 | - | LRTM1 | chr3 | 54959242 | - |
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FusionProtFeatures for TGFBR3_LRTM1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TGFBR3 | LRTM1 |
| Binds to TGF-beta. Could be involved in capturing andretaining TGF-beta for presentation to the signaling receptors. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TGFBR3_LRTM1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TGFBR3_ENST00000525962_chr1_92174220_-_LRTM1_ENST00000273286_chr3_54959242_-_1106aa MTSHYVIAIFALMSSCLATAGPEPGALCELSPVSASHPVQALMESFTVLSGCASRGTTGLPQEVHVLNLRTAGQGPGQLQREVTLHLNPI SSVHIHHKSVVFLLNSPHPLVWHLKTERLATGVSRLFLVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSFTELKIA RNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLEVVKNLI LILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLRLENNAE EMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQGSVDI ALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSGWPDGY EDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVSVTKAEQ ELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKMEKHPQKL PKCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKGELLLFSSVIVLLQVVCSCPDKCYCQSSTNFVDCSQQGLAEIPSHLPP QTRTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTS LGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQ PCPLPAPDPVSSQAQWPGSAHGVVLRPPENHNAGERELLECELKPKPRPANLRHAIATVIITGVVCGIVCLMMLAAAIYGCTYAAITAQY |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TGFBR3_ENST00000525962_chr1_92174220_-_LRTM1_ENST00000273286_chr3_54959242_-_3318nt ATGACTTCCCATTATGTGATTGCCATCTTTGCCCTGATGAGCTCCTGTTTAGCCACTGCAGGTCCAGAGCCTGGTGCACTGTGTGAACTG TCACCTGTCAGTGCCTCCCATCCTGTCCAGGCCTTGATGGAGAGCTTCACTGTTTTGTCAGGCTGTGCCAGCAGAGGCACAACTGGGCTG CCACAGGAGGTGCATGTCCTGAATCTCCGCACTGCAGGCCAGGGGCCTGGCCAGCTACAGAGAGAGGTCACACTTCACCTGAATCCCATC TCCTCAGTCCACATCCACCACAAGTCTGTTGTGTTCCTGCTCAACTCCCCACACCCCCTGGTGTGGCATCTGAAGACAGAGAGACTTGCC ACTGGGGTCTCCAGACTGTTTTTGGTGTCTGAGGGTTCTGTGGTCCAGTTTTCATCAGCAAACTTCTCCTTGACAGCAGAAACAGAAGAA AGGAACTTCCCCCATGGAAATGAACATCTGTTAAATTGGGCCCGAAAAGAGTATGGAGCAGTTACTTCATTCACCGAACTCAAGATAGCA AGAAACATTTATATTAAAGTGGGGGAAGATCAAGTGTTCCCTCCAAAGTGCAACATAGGGAAGAATTTTCTCTCACTCAATTACCTTGCT GAGTACCTTCAACCCAAAGCAGCAGAAGGGTGTGTGATGTCCAGCCAGCCCCAGAATGAGGAAGTACACATCATCGAGCTAATCACCCCC AACTCTAACCCCTACAGTGCTTTCCAGGTGGATATAACAATTGATATAAGACCTTCTCAAGAGGATCTTGAAGTGGTCAAAAATCTCATC CTGATCTTGAAGTGCAAAAAGTCTGTCAACTGGGTGATCAAATCTTTTGATGTTAAGGGAAGCCTGAAAATTATTGCTCCTAACAGTATT GGCTTTGGAAAAGAGAGTGAAAGATCTATGACAATGACCAAATCAATAAGAGATGACATTCCTTCAACCCAAGGGAATCTGGTGAAGTGG GCTTTGGACAATGGCTATAGTCCAATAACTTCATACACAATGGCTCCTGTGGCTAATAGATTTCATCTTCGGCTTGAAAATAATGCAGAG GAGATGGGAGATGAGGAAGTCCACACTATTCCTCCTGAGCTACGGATCCTGCTGGACCCTGGTGCCCTGCCTGCCCTGCAGAACCCGCCC ATCCGGGGAGGGGAAGGCCAAAATGGAGGCCTTCCGTTTCCTTTCCCAGATATTTCCAGGAGAGTCTGGAATGAAGAGGGAGAAGATGGG CTCCCTCGGCCAAAGGACCCTGTCATTCCCAGCATACAACTGTTTCCTGGTCTCAGAGAGCCAGAAGAGGTGCAAGGGAGCGTGGATATT GCCCTGTCTGTCAAATGTGACAATGAGAAGATGATCGTGGCTGTAGAAAAAGATTCTTTTCAGGCCAGTGGCTACTCGGGGATGGACGTC ACCCTGTTGGATCCTACCTGCAAGGCCAAGATGAATGGCACACACTTTGTTTTGGAGTCTCCTCTGAATGGCTGCGGTACTCGGCCCCGG TGGTCAGCCCTTGATGGTGTGGTCTACTATAACTCCATTGTGATACAGGTTCCAGCCCTTGGGGACAGTAGTGGTTGGCCAGATGGTTAT GAAGATCTGGAGTCAGGTGATAATGGATTTCCGGGAGATATGGATGAAGGAGATGCTTCCCTGTTCACCCGACCTGAAATCGTGGTGTTT AATTGCAGCCTTCAGCAGGTGAGGAACCCCAGCAGCTTCCAGGAACAGCCCCACGGAAACATCACCTTCAACATGGAGCTATACAACACT GACCTCTTTTTGGTGCCCTCCCAGGGCGTCTTCTCTGTGCCAGAGAATGGACACGTTTATGTTGAGGTATCTGTTACTAAGGCTGAACAA GAACTGGGATTTGCCATCCAAACGTGCTTTATCTCTCCATATTCGAACCCTGATAGGATGTCTCATTACACCATTATTGAGAATATTTGT CCTAAAGATGAATCTGTGAAATTCTACAGTCCCAAGAGAGTGCACTTTCCTATCCCGCAAGCTGACATGGATAAGAAGCGATTCAGCTTT GTCTTCAAGCCTGTCTTCAACACCTCACTGCTCTTTCTACAGTGTGAGCTGACGCTGTGTACGAAGATGGAGAAGCACCCCCAGAAGTTG CCTAAGTGTGTGCCTCCTGACGAAGCCTGCACCTCGCTGGACGCCTCGATAATCTGGGCCATGATGCAGAATAAGAAGACGTTCACTAAG CCCCTTGCTGTGATCCACCATGAAGCAGAATCTAAAGGTGAACTGCTCCTGTTTTCCAGTGTGATTGTCCTGCTCCAGGTGGTATGCAGC TGCCCGGACAAGTGTTACTGTCAGTCATCTACAAATTTTGTAGACTGCAGCCAGCAGGGTCTGGCCGAAATCCCTTCCCATTTACCTCCT CAGACTCGAACGCTGCATTTACAAGATAATCAGATACACCATCTTCCTGCTTTTGCATTTAGGTCAGTGCCATGGCTCATGACCTTAAAC TTGTCCAACAATTCCCTTTCAAATCTGGCCCCTGGAGCTTTCCATGGGCTTCAGCACTTGCAGGTTTTAAATCTAACCCAGAATTCACTC CTTTCCCTGGAAAGCAGACTTTTCCATTCCCTCCCTCAGCTGAGGGAGCTTGATTTGTCATCAAACAACATAAGCCACCTTCCCACATCC TTGGGAGAGACTTGGGAGAACCTAACTATACTTGCGGTTCAACAAAACCAGCTTCAGCAGCTTGATCGAGCGCTCCTGGAATCCATGCCC AGTGTGAGGCTTTTACTTCTCAAGGACAACCTCTGGAAATGCAATTGCCACTTGCTCGGTCTTAAACTCTGGCTGGAGAAATTTGTCTAT AAAGGGGGACTAACAGACGGCATCATCTGTGAATCACCAGACACCTGGAAGGGAAAGGACCTCCTTAGGATCCCTCATGAGCTGTACCAG CCCTGCCCTCTTCCTGCTCCTGATCCAGTGTCCTCGCAGGCTCAGTGGCCCGGCTCTGCCCACGGTGTGGTCCTGAGGCCTCCTGAGAAC CACAACGCGGGGGAGCGAGAACTCTTGGAGTGCGAGCTCAAACCCAAGCCAAGGCCGGCCAACCTGCGTCATGCCATTGCCACTGTCATC ATCACTGGCGTTGTGTGTGGGATTGTGTGTCTCATGATGTTGGCAGCTGCCATCTATGGCTGCACCTATGCGGCAATCACAGCCCAGTAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TGFBR3_ENST00000525962_chr1_92174220_-_LRTM1_ENST00000273286_chr3_54959242_-_3602nt GATTGTCTGTGCTCTGAGCAGGCTGAAGTGACTGGACGAGACGCACTGTTGGAGAAATAAAAATGACTTCCCATTATGTGATTGCCATCT TTGCCCTGATGAGCTCCTGTTTAGCCACTGCAGGTCCAGAGCCTGGTGCACTGTGTGAACTGTCACCTGTCAGTGCCTCCCATCCTGTCC AGGCCTTGATGGAGAGCTTCACTGTTTTGTCAGGCTGTGCCAGCAGAGGCACAACTGGGCTGCCACAGGAGGTGCATGTCCTGAATCTCC GCACTGCAGGCCAGGGGCCTGGCCAGCTACAGAGAGAGGTCACACTTCACCTGAATCCCATCTCCTCAGTCCACATCCACCACAAGTCTG TTGTGTTCCTGCTCAACTCCCCACACCCCCTGGTGTGGCATCTGAAGACAGAGAGACTTGCCACTGGGGTCTCCAGACTGTTTTTGGTGT CTGAGGGTTCTGTGGTCCAGTTTTCATCAGCAAACTTCTCCTTGACAGCAGAAACAGAAGAAAGGAACTTCCCCCATGGAAATGAACATC TGTTAAATTGGGCCCGAAAAGAGTATGGAGCAGTTACTTCATTCACCGAACTCAAGATAGCAAGAAACATTTATATTAAAGTGGGGGAAG ATCAAGTGTTCCCTCCAAAGTGCAACATAGGGAAGAATTTTCTCTCACTCAATTACCTTGCTGAGTACCTTCAACCCAAAGCAGCAGAAG GGTGTGTGATGTCCAGCCAGCCCCAGAATGAGGAAGTACACATCATCGAGCTAATCACCCCCAACTCTAACCCCTACAGTGCTTTCCAGG TGGATATAACAATTGATATAAGACCTTCTCAAGAGGATCTTGAAGTGGTCAAAAATCTCATCCTGATCTTGAAGTGCAAAAAGTCTGTCA ACTGGGTGATCAAATCTTTTGATGTTAAGGGAAGCCTGAAAATTATTGCTCCTAACAGTATTGGCTTTGGAAAAGAGAGTGAAAGATCTA TGACAATGACCAAATCAATAAGAGATGACATTCCTTCAACCCAAGGGAATCTGGTGAAGTGGGCTTTGGACAATGGCTATAGTCCAATAA CTTCATACACAATGGCTCCTGTGGCTAATAGATTTCATCTTCGGCTTGAAAATAATGCAGAGGAGATGGGAGATGAGGAAGTCCACACTA TTCCTCCTGAGCTACGGATCCTGCTGGACCCTGGTGCCCTGCCTGCCCTGCAGAACCCGCCCATCCGGGGAGGGGAAGGCCAAAATGGAG GCCTTCCGTTTCCTTTCCCAGATATTTCCAGGAGAGTCTGGAATGAAGAGGGAGAAGATGGGCTCCCTCGGCCAAAGGACCCTGTCATTC CCAGCATACAACTGTTTCCTGGTCTCAGAGAGCCAGAAGAGGTGCAAGGGAGCGTGGATATTGCCCTGTCTGTCAAATGTGACAATGAGA AGATGATCGTGGCTGTAGAAAAAGATTCTTTTCAGGCCAGTGGCTACTCGGGGATGGACGTCACCCTGTTGGATCCTACCTGCAAGGCCA AGATGAATGGCACACACTTTGTTTTGGAGTCTCCTCTGAATGGCTGCGGTACTCGGCCCCGGTGGTCAGCCCTTGATGGTGTGGTCTACT ATAACTCCATTGTGATACAGGTTCCAGCCCTTGGGGACAGTAGTGGTTGGCCAGATGGTTATGAAGATCTGGAGTCAGGTGATAATGGAT TTCCGGGAGATATGGATGAAGGAGATGCTTCCCTGTTCACCCGACCTGAAATCGTGGTGTTTAATTGCAGCCTTCAGCAGGTGAGGAACC CCAGCAGCTTCCAGGAACAGCCCCACGGAAACATCACCTTCAACATGGAGCTATACAACACTGACCTCTTTTTGGTGCCCTCCCAGGGCG TCTTCTCTGTGCCAGAGAATGGACACGTTTATGTTGAGGTATCTGTTACTAAGGCTGAACAAGAACTGGGATTTGCCATCCAAACGTGCT TTATCTCTCCATATTCGAACCCTGATAGGATGTCTCATTACACCATTATTGAGAATATTTGTCCTAAAGATGAATCTGTGAAATTCTACA GTCCCAAGAGAGTGCACTTTCCTATCCCGCAAGCTGACATGGATAAGAAGCGATTCAGCTTTGTCTTCAAGCCTGTCTTCAACACCTCAC TGCTCTTTCTACAGTGTGAGCTGACGCTGTGTACGAAGATGGAGAAGCACCCCCAGAAGTTGCCTAAGTGTGTGCCTCCTGACGAAGCCT GCACCTCGCTGGACGCCTCGATAATCTGGGCCATGATGCAGAATAAGAAGACGTTCACTAAGCCCCTTGCTGTGATCCACCATGAAGCAG AATCTAAAGGTGAACTGCTCCTGTTTTCCAGTGTGATTGTCCTGCTCCAGGTGGTATGCAGCTGCCCGGACAAGTGTTACTGTCAGTCAT CTACAAATTTTGTAGACTGCAGCCAGCAGGGTCTGGCCGAAATCCCTTCCCATTTACCTCCTCAGACTCGAACGCTGCATTTACAAGATA ATCAGATACACCATCTTCCTGCTTTTGCATTTAGGTCAGTGCCATGGCTCATGACCTTAAACTTGTCCAACAATTCCCTTTCAAATCTGG CCCCTGGAGCTTTCCATGGGCTTCAGCACTTGCAGGTTTTAAATCTAACCCAGAATTCACTCCTTTCCCTGGAAAGCAGACTTTTCCATT CCCTCCCTCAGCTGAGGGAGCTTGATTTGTCATCAAACAACATAAGCCACCTTCCCACATCCTTGGGAGAGACTTGGGAGAACCTAACTA TACTTGCGGTTCAACAAAACCAGCTTCAGCAGCTTGATCGAGCGCTCCTGGAATCCATGCCCAGTGTGAGGCTTTTACTTCTCAAGGACA ACCTCTGGAAATGCAATTGCCACTTGCTCGGTCTTAAACTCTGGCTGGAGAAATTTGTCTATAAAGGGGGACTAACAGACGGCATCATCT GTGAATCACCAGACACCTGGAAGGGAAAGGACCTCCTTAGGATCCCTCATGAGCTGTACCAGCCCTGCCCTCTTCCTGCTCCTGATCCAG TGTCCTCGCAGGCTCAGTGGCCCGGCTCTGCCCACGGTGTGGTCCTGAGGCCTCCTGAGAACCACAACGCGGGGGAGCGAGAACTCTTGG AGTGCGAGCTCAAACCCAAGCCAAGGCCGGCCAACCTGCGTCATGCCATTGCCACTGTCATCATCACTGGCGTTGTGTGTGGGATTGTGT GTCTCATGATGTTGGCAGCTGCCATCTATGGCTGCACCTATGCGGCAATCACAGCCCAGTACCATGGGGGACCCTTGGCTCAAACCAATG ATCCTGGGAAGGTGGAAGAAAAAGAGCGATTTGACAGCTCACCAGCCTGAGAGCTTTTGTCTCAAATAGGATTGGTCATTGCAGGCCAGA AGATAGTGTCTGAGTAGGGCTGATGTGTTTCCTGTTAGTCTGATTTTGCTTTTGCCAAAAGACAAAAAAAAAAAAAAAAAAAAAAAGAAA AAAAAAAGATGTGTCTGTAAAAAATATTTCTGGGGAGGAATTTATGTTGCGATTTTTAAAATACTATAGGTAAAATAAAGATGATACTTG |
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FusionGenePPI for TGFBR3_LRTM1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TGFBR3 | TGFBR2, TGFB1, ELAVL1, NRP1, KLK11, ITM2B, ATP1B3, FGF1, GPR183, ATP1B4, PTCH1, SIAE, PIP5K1A, CAMKV, DEFA5, ST8SIA4, FAM19A4, DKKL1, CANT1, DEFA1 | LRTM1 | PITHD1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TGFBR3_LRTM1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TGFBR3_LRTM1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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