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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37902

FusionGeneSummary for TGFBI_ZYX

check button Fusion gene summary
Fusion gene informationFusion gene name: TGFBI_ZYX
Fusion gene ID: 37902
HgeneTgene
Gene symbol

TGFBI

ZYX

Gene ID

7045

7791

Gene nametransforming growth factor beta inducedzyxin
SynonymsBIGH3|CDB1|CDG2|CDGG1|CSD|CSD1|CSD2|CSD3|EBMD|LCD1ESP-2|HED-2
Cytomap

5q31.1

7q34

Type of geneprotein-codingprotein-coding
Descriptiontransforming growth factor-beta-induced protein ig-h3RGD-CAPRGD-containing collagen-associated proteinbeta ig-h3betaig-h3kerato-epithelintransforming growth factor beta-induced 68kDatransforming growth factor, beta-induced, 68kDzyxinzyxin-2
Modification date2018052720180522
UniProtAcc

Q15582

Q15942

Ensembl transtripts involved in fusion geneENST00000442011, ENST00000305126, 
ENST00000508076, ENST00000504185, 
ENST00000322764, ENST00000449423, 
ENST00000392910, ENST00000477373, 
Fusion gene scores* DoF score9 X 8 X 4=2886 X 7 X 1=42
# samples 107
** MAII scorelog2(10/288*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/42*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TGFBI [Title/Abstract] AND ZYX [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW239032TGFBIchr5

135383072

+ZYXchr7

143085700

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000442011ENST00000322764TGFBIchr5

135383072

+ZYXchr7

143085700

+
Frame-shitENST00000442011ENST00000449423TGFBIchr5

135383072

+ZYXchr7

143085700

+
Frame-shitENST00000442011ENST00000392910TGFBIchr5

135383072

+ZYXchr7

143085700

+
5CDS-intronENST00000442011ENST00000477373TGFBIchr5

135383072

+ZYXchr7

143085700

+
Frame-shitENST00000305126ENST00000322764TGFBIchr5

135383072

+ZYXchr7

143085700

+
Frame-shitENST00000305126ENST00000449423TGFBIchr5

135383072

+ZYXchr7

143085700

+
Frame-shitENST00000305126ENST00000392910TGFBIchr5

135383072

+ZYXchr7

143085700

+
5CDS-intronENST00000305126ENST00000477373TGFBIchr5

135383072

+ZYXchr7

143085700

+
intron-3CDSENST00000508076ENST00000322764TGFBIchr5

135383072

+ZYXchr7

143085700

+
intron-3CDSENST00000508076ENST00000449423TGFBIchr5

135383072

+ZYXchr7

143085700

+
intron-3CDSENST00000508076ENST00000392910TGFBIchr5

135383072

+ZYXchr7

143085700

+
intron-intronENST00000508076ENST00000477373TGFBIchr5

135383072

+ZYXchr7

143085700

+
intron-3CDSENST00000504185ENST00000322764TGFBIchr5

135383072

+ZYXchr7

143085700

+
intron-3CDSENST00000504185ENST00000449423TGFBIchr5

135383072

+ZYXchr7

143085700

+
intron-3CDSENST00000504185ENST00000392910TGFBIchr5

135383072

+ZYXchr7

143085700

+
intron-intronENST00000504185ENST00000477373TGFBIchr5

135383072

+ZYXchr7

143085700

+

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FusionProtFeatures for TGFBI_ZYX


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TGFBI

Q15582

ZYX

Q15942

Adhesion plaque protein. Binds alpha-actinin and the CRPprotein. Important for targeting TES and ENA/VASP family membersto focal adhesions and for the formation of actin-rich structures.May be a component of a signal transduction pathway that mediatesadhesion-stimulated changes in gene expression (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TGFBI_ZYX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TGFBI_ZYX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TGFBI_ZYX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneZYXQ15942DB11638ArtenimolZyxinsmall moleculeapproved|investigational

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RelatedDiseases for TGFBI_ZYX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTGFBIC1690006Lattice corneal dystrophy Type I12CTD_human;ORPHANET;UNIPROT
HgeneTGFBIC1641846Groenouw corneal dystrophy type I (disorder)7CTD_human;ORPHANET;UNIPROT
HgeneTGFBIC1275685Avellino corneal dystrophy6CTD_human;ORPHANET;UNIPROT
HgeneTGFBIC0339278Reis-Bucklers' corneal dystrophy5CTD_human;ORPHANET;UNIPROT
HgeneTGFBIC1837974Corneal Dystrophy, Lattice Type IIIA5CTD_human;UNIPROT
HgeneTGFBIC1562894Thiel-Behnke corneal dystrophy4CTD_human;ORPHANET;UNIPROT
HgeneTGFBIC0000786Spontaneous abortion1CTD_human
HgeneTGFBIC0011881Diabetic Nephropathy1CTD_human
HgeneTGFBIC0521723Corneal dystrophy, epithelial basement membrane1CTD_human;ORPHANET;UNIPROT