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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37868

FusionGeneSummary for TFRC_FN1

check button Fusion gene summary
Fusion gene informationFusion gene name: TFRC_FN1
Fusion gene ID: 37868
HgeneTgene
Gene symbol

TFRC

FN1

Gene ID

7037

2335

Gene nametransferrin receptorfibronectin 1
SynonymsCD71|IMD46|T9|TFR|TFR1|TR|TRFR|p90CIG|ED-B|FINC|FN|FNZ|GFND|GFND2|LETS|MSF|SMDCF
Cytomap

3q29

2q35

Type of geneprotein-codingprotein-coding
Descriptiontransferrin receptor protein 1fibronectincold-insoluble globulinmigration-stimulating factor
Modification date2018051920180527
UniProtAcc

P02786

P02751

Ensembl transtripts involved in fusion geneENST00000420415, ENST00000360110, 
ENST00000540528, ENST00000392396, 
ENST00000535031, ENST00000465288, 
ENST00000421182, ENST00000357867, 
ENST00000323926, ENST00000336916, 
ENST00000354785, ENST00000357009, 
ENST00000346544, ENST00000345488, 
ENST00000359671, ENST00000446046, 
ENST00000443816, ENST00000432072, 
ENST00000356005, ENST00000490833, 
ENST00000426059, 
Fusion gene scores* DoF score8 X 7 X 6=33620 X 22 X 3=1320
# samples 926
** MAII scorelog2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(26/1320*10)=-2.34395440121736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TFRC [Title/Abstract] AND FN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTFRC

GO:0030890

positive regulation of B cell proliferation

26642240

HgeneTFRC

GO:0031623

receptor internalization

26642240

HgeneTFRC

GO:0033572

transferrin transport

26642240

HgeneTFRC

GO:0035690

cellular response to drug

16254249

HgeneTFRC

GO:0042102

positive regulation of T cell proliferation

26642240

HgeneTFRC

GO:0045830

positive regulation of isotype switching

26642240

HgeneTFRC

GO:0097286

iron ion import

7556058

TgeneFN1

GO:0001932

regulation of protein phosphorylation

11792823

TgeneFN1

GO:0008284

positive regulation of cell proliferation

25834989

TgeneFN1

GO:0010628

positive regulation of gene expression

25834989

TgeneFN1

GO:0018149

peptide cross-linking

3997886

TgeneFN1

GO:0034446

substrate adhesion-dependent cell spreading

16236823

TgeneFN1

GO:0035987

endodermal cell differentiation

23154389

TgeneFN1

GO:0048146

positive regulation of fibroblast proliferation

25834989

TgeneFN1

GO:0051702

interaction with symbiont

12167537|12421310|19429745

TgeneFN1

GO:0052047

interaction with other organism via secreted substance involved in symbiotic interaction

17849409

TgeneFN1

GO:0070372

regulation of ERK1 and ERK2 cascade

11792823

TgeneFN1

GO:1904237

positive regulation of substrate-dependent cell migration, cell attachment to substrate

25834989

TgeneFN1

GO:2001202

negative regulation of transforming growth factor-beta secretion

25834989


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW854071TFRCchr3

195777316

-FN1chr2

216238086

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000420415ENST00000421182TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000420415ENST00000357867TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000420415ENST00000323926TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000420415ENST00000336916TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000420415ENST00000354785TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000420415ENST00000357009TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000420415ENST00000346544TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000420415ENST00000345488TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000420415ENST00000359671TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000420415ENST00000446046TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000420415ENST00000443816TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000420415ENST00000432072TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000420415ENST00000356005TFRCchr3

195777316

-FN1chr2

216238086

+
intron-intronENST00000420415ENST00000490833TFRCchr3

195777316

-FN1chr2

216238086

+
intron-intronENST00000420415ENST00000426059TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000360110ENST00000421182TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000360110ENST00000357867TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000360110ENST00000323926TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000360110ENST00000336916TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000360110ENST00000354785TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000360110ENST00000357009TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000360110ENST00000346544TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000360110ENST00000345488TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000360110ENST00000359671TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000360110ENST00000446046TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000360110ENST00000443816TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000360110ENST00000432072TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000360110ENST00000356005TFRCchr3

195777316

-FN1chr2

216238086

+
intron-intronENST00000360110ENST00000490833TFRCchr3

195777316

-FN1chr2

216238086

+
intron-intronENST00000360110ENST00000426059TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000540528ENST00000421182TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000540528ENST00000357867TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000540528ENST00000323926TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000540528ENST00000336916TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000540528ENST00000354785TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000540528ENST00000357009TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000540528ENST00000346544TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000540528ENST00000345488TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000540528ENST00000359671TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000540528ENST00000446046TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000540528ENST00000443816TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000540528ENST00000432072TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000540528ENST00000356005TFRCchr3

195777316

-FN1chr2

216238086

+
intron-intronENST00000540528ENST00000490833TFRCchr3

195777316

-FN1chr2

216238086

+
intron-intronENST00000540528ENST00000426059TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000392396ENST00000421182TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000392396ENST00000357867TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000392396ENST00000323926TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000392396ENST00000336916TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000392396ENST00000354785TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000392396ENST00000357009TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000392396ENST00000346544TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000392396ENST00000345488TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000392396ENST00000359671TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000392396ENST00000446046TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000392396ENST00000443816TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000392396ENST00000432072TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000392396ENST00000356005TFRCchr3

195777316

-FN1chr2

216238086

+
intron-intronENST00000392396ENST00000490833TFRCchr3

195777316

-FN1chr2

216238086

+
intron-intronENST00000392396ENST00000426059TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000535031ENST00000421182TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000535031ENST00000357867TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000535031ENST00000323926TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000535031ENST00000336916TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000535031ENST00000354785TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000535031ENST00000357009TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000535031ENST00000346544TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000535031ENST00000345488TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000535031ENST00000359671TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000535031ENST00000446046TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000535031ENST00000443816TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000535031ENST00000432072TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000535031ENST00000356005TFRCchr3

195777316

-FN1chr2

216238086

+
intron-intronENST00000535031ENST00000490833TFRCchr3

195777316

-FN1chr2

216238086

+
intron-intronENST00000535031ENST00000426059TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000465288ENST00000421182TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000465288ENST00000357867TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000465288ENST00000323926TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000465288ENST00000336916TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000465288ENST00000354785TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000465288ENST00000357009TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000465288ENST00000346544TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000465288ENST00000345488TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000465288ENST00000359671TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000465288ENST00000446046TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000465288ENST00000443816TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000465288ENST00000432072TFRCchr3

195777316

-FN1chr2

216238086

+
intron-3CDSENST00000465288ENST00000356005TFRCchr3

195777316

-FN1chr2

216238086

+
intron-intronENST00000465288ENST00000490833TFRCchr3

195777316

-FN1chr2

216238086

+
intron-intronENST00000465288ENST00000426059TFRCchr3

195777316

-FN1chr2

216238086

+

Top

FusionProtFeatures for TFRC_FN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TFRC

P02786

FN1

P02751

Cellular uptake of iron occurs via receptor-mediatedendocytosis of ligand-occupied transferrin receptor intospecialized endosomes. Endosomal acidification leads to ironrelease. The apotransferrin-receptor complex is then recycled tothe cell surface with a return to neutral pH and the concomitantloss of affinity of apotransferrin for its receptor. Transferrinreceptor is necessary for development of erythrocytes and thenervous system (By similarity). A second ligand, the heditaryhemochromatosis protein HFE, competes for binding with transferrinfor an overlapping C-terminal binding site. Positively regulates Tand B cell proliferation through iron uptake (PubMed:26642240).{ECO:0000250, ECO:0000269|PubMed:26642240,ECO:0000269|PubMed:3568132}. (Microbial infection) Acts as a receptor for new-worldarenaviruses: Guanarito, Junin and Machupo virus.{ECO:0000269|PubMed:17287727, ECO:0000269|PubMed:18268337}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TFRC_FN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TFRC_FN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TFRC_FN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneTFRCP02786DB01592IronTransferrin receptor protein 1small moleculeapproved
TgeneFN1P02751DB08888OcriplasminFibronectinbiotechapproved
TgeneFN1P02751DB01593ZincFibronectinsmall moleculeapproved|investigational

Top

RelatedDiseases for TFRC_FN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTFRCC0162316Iron deficiency anemia3CTD_human
HgeneTFRCC0012715Iron Metabolism Disorders2CTD_human
HgeneTFRCC0028754Obesity2CTD_human
HgeneTFRCC0079487Helicobacter Infections2CTD_human
HgeneTFRCC1458155Mammary Neoplasms2CTD_human
HgeneTFRCC0000786Spontaneous abortion1CTD_human
HgeneTFRCC0003756Arenaviridae Infections1CTD_human
HgeneTFRCC0005283beta Thalassemia1CTD_human
HgeneTFRCC0005695Bladder Neoplasm1CTD_human
HgeneTFRCC0007621Neoplastic Cell Transformation1CTD_human
HgeneTFRCC0009404Colorectal Neoplasms1CTD_human
HgeneTFRCC0017638Glioma1CTD_human
HgeneTFRCC0021368Inflammation1CTD_human
HgeneTFRCC0023434Chronic Lymphocytic Leukemia1CTD_human
HgeneTFRCC0024121Lung Neoplasms1CTD_human
HgeneTFRCC0024305Lymphoma, Non-Hodgkin1CTD_human
HgeneTFRCC0027055Myocardial Reperfusion Injury1CTD_human
HgeneTFRCC0032460Polycystic Ovary Syndrome1CTD_human
HgeneTFRCC0085110Severe Combined Immunodeficiency1CTD_human
HgeneTFRCC0151744Myocardial Ischemia1CTD_human
HgeneTFRCC4225219IMMUNODEFICIENCY 461ORPHANET;UNIPROT
TgeneFN1C0020538Hypertensive disease2CTD_human;HPO
TgeneFN1C0000786Spontaneous abortion1CTD_human
TgeneFN1C0003504Aortic Valve Insufficiency1CTD_human
TgeneFN1C0007621Neoplastic Cell Transformation1CTD_human
TgeneFN1C0010346Crohn Disease1CTD_human
TgeneFN1C0011849Diabetes Mellitus1CTD_human
TgeneFN1C0011881Diabetic Nephropathy1CTD_human
TgeneFN1C0017636Glioblastoma1CTD_human
TgeneFN1C0017668Focal glomerulosclerosis1CTD_human
TgeneFN1C0024667Animal Mammary Neoplasms1CTD_human
TgeneFN1C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneFN1C0027626Neoplasm Invasiveness1CTD_human
TgeneFN1C0034069Pulmonary Fibrosis1CTD_human
TgeneFN1C0036341Schizophrenia1PSYGENET
TgeneFN1C0085762Alcohol abuse1PSYGENET
TgeneFN1C0149721Left Ventricular Hypertrophy1CTD_human
TgeneFN1C0345967Malignant mesothelioma1CTD_human
TgeneFN1C1458155Mammary Neoplasms1CTD_human
TgeneFN1C1866075GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2 (disorder)1UNIPROT