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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3786

FusionGeneSummary for BAD_MACROD1

check button Fusion gene summary
Fusion gene informationFusion gene name: BAD_MACROD1
Fusion gene ID: 3786
HgeneTgene
Gene symbol

BAD

MACROD1

Gene ID

572

28992

Gene nameBCL2 associated agonist of cell deathMACRO domain containing 1
SynonymsBBC2|BCL2L8LRP16
Cytomap

11q13.1

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionbcl2-associated agonist of cell deathBCL-X/BCL-2 binding proteinBCL2-antagonist of cell death proteinBCL2-binding component 6BCL2-binding proteinbcl-2-binding component 6bcl-2-like protein 8bcl-XL/Bcl-2-associated death promoterbcl2 antagonist of O-acetyl-ADP-ribose deacetylase MACROD1MACRO domain-containing protein 1[Protein ADP-ribosylglutamate] hydrolase
Modification date2018052320180519
UniProtAcc

Q92934

Q9BQ69

Ensembl transtripts involved in fusion geneENST00000394532, ENST00000309032, 
ENST00000544785, ENST00000394531, 
ENST00000255681, ENST00000538595, 
Fusion gene scores* DoF score4 X 3 X 4=486 X 4 X 6=144
# samples 46
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BAD [Title/Abstract] AND MACROD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBAD

GO:0006915

apoptotic process

19667065

HgeneBAD

GO:0043065

positive regulation of apoptotic process

9388232

HgeneBAD

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

18402937

HgeneBAD

GO:0045862

positive regulation of proteolysis

18387192

HgeneBAD

GO:0046931

pore complex assembly

19667065|21081150

HgeneBAD

GO:0071316

cellular response to nicotine

18676776

HgeneBAD

GO:0097202

activation of cysteine-type endopeptidase activity

18387192

TgeneMACROD1

GO:0042278

purine nucleoside metabolic process

21257746

TgeneMACROD1

GO:0051725

protein de-ADP-ribosylation

23474712


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-G2-A3VY-01ABADchr11

64051654

-MACROD1chr11

63919865

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000394532ENST00000255681BADchr11

64051654

-MACROD1chr11

63919865

-
5CDS-5UTRENST00000394532ENST00000538595BADchr11

64051654

-MACROD1chr11

63919865

-
Frame-shitENST00000309032ENST00000255681BADchr11

64051654

-MACROD1chr11

63919865

-
5CDS-5UTRENST00000309032ENST00000538595BADchr11

64051654

-MACROD1chr11

63919865

-
In-frameENST00000544785ENST00000255681BADchr11

64051654

-MACROD1chr11

63919865

-
5CDS-5UTRENST00000544785ENST00000538595BADchr11

64051654

-MACROD1chr11

63919865

-
In-frameENST00000394531ENST00000255681BADchr11

64051654

-MACROD1chr11

63919865

-
5CDS-5UTRENST00000394531ENST00000538595BADchr11

64051654

-MACROD1chr11

63919865

-

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FusionProtFeatures for BAD_MACROD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BAD

Q92934

MACROD1

Q9BQ69

Promotes cell death. Successfully competes for thebinding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the levelof heterodimerization of these proteins with BAX. Can reverse thedeath repressor activity of Bcl-X(L), but not that of Bcl-2 (Bysimilarity). Appears to act as a link between growth factorreceptor signaling and the apoptotic pathways. {ECO:0000250}. Removes ADP-ribose from glutamate residues in proteinsbearing a single ADP-ribose moiety. Inactive towards proteinsbearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, asignaling molecule generated by the deacetylation of acetylatedlysine residues in histones and other proteins. Plays a role inestrogen signaling. Binds to androgen receptor (AR) and amplifiesthe transactivation function of AR in response to androgen. Mayplay an important role in carcinogenesis and/or progression ofhormone-dependent cancers by feed-forward mechanism that activatesESR1 transactivation. Could be an ESR1 coactivator, providing apositive feedback regulatory loop for ESR1 signal transduction.Could be involved in invasive growth by down-regulating CDH1 inendometrial cancer cells. Enhances ESR1-mediated transcriptionactivity. {ECO:0000269|PubMed:17893710,ECO:0000269|PubMed:17914104, ECO:0000269|PubMed:19022849,ECO:0000269|PubMed:19403568, ECO:0000269|PubMed:21257746,ECO:0000269|PubMed:23474712}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMACROD1chr11:64051654chr11:63919865ENST00000255681-011141_32299225DomainMacro
TgeneMACROD1chr11:64051654chr11:63919865ENST00000255681-011159_16199225RegionSubstrate binding
TgeneMACROD1chr11:64051654chr11:63919865ENST00000255681-011172_17499225RegionSubstrate binding
TgeneMACROD1chr11:64051654chr11:63919865ENST00000255681-011179_18499225RegionSubstrate binding
TgeneMACROD1chr11:64051654chr11:63919865ENST00000255681-011267_27399225RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBADchr11:64051654chr11:63919865ENST00000309032-24110_12462169MotifNote=BH3
HgeneBADchr11:64051654chr11:63919865ENST00000394532-13110_12462169MotifNote=BH3


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FusionGeneSequence for BAD_MACROD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_BAD_ENST00000394532_chr11_64051654_-_MACROD1_ENST00000255681_chr11_63919865_-_62aa

>In-frame_BAD_ENST00000544785_chr11_64051654_-_MACROD1_ENST00000255681_chr11_63919865_-_62aa

>In-frame_BAD_ENST00000394531_chr11_64051654_-_MACROD1_ENST00000255681_chr11_63919865_-_62aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_BAD_ENST00000394532_chr11_64051654_-_MACROD1_ENST00000255681_chr11_63919865_-_187nt
ATGTTCCAGATCCCAGAGTTTGAGCCGAGTGAGCAGGAAGACTCCAGCTCTGCAGAGAGGGGCCTGGGCCCCAGCCCCGCAGGGGACGGG
CCCTCAGGCTCCGGCAAGCATCATCGCCAGGCCCCAGGCCTCCTGTGGGACGCCAGTCACCAGCAGGAGCAGCCAACCAGCAGCAGCCAT

>In-frame_BAD_ENST00000544785_chr11_64051654_-_MACROD1_ENST00000255681_chr11_63919865_-_187nt
ATGTTCCAGATCCCAGAGTTTGAGCCGAGTGAGCAGGAAGACTCCAGCTCTGCAGAGAGGGGCCTGGGCCCCAGCCCCGCAGGGGACGGG
CCCTCAGGCTCCGGCAAGCATCATCGCCAGGCCCCAGGCCTCCTGTGGGACGCCAGTCACCAGCAGGAGCAGCCAACCAGCAGCAGCCAT

>In-frame_BAD_ENST00000394531_chr11_64051654_-_MACROD1_ENST00000255681_chr11_63919865_-_187nt
ATGTTCCAGATCCCAGAGTTTGAGCCGAGTGAGCAGGAAGACTCCAGCTCTGCAGAGAGGGGCCTGGGCCCCAGCCCCGCAGGGGACGGG
CCCTCAGGCTCCGGCAAGCATCATCGCCAGGCCCCAGGCCTCCTGTGGGACGCCAGTCACCAGCAGGAGCAGCCAACCAGCAGCAGCCAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_BAD_ENST00000394532_chr11_64051654_-_MACROD1_ENST00000255681_chr11_63919865_-_1298nt
GGGCTTGGGGTGAGACCTGTGCGCCGTCACCACGGGCGGGGCGGGGCCTGGGTCCACCGGGGTTCTGAGGGGAGACTGAGGTCCTGAGCC
GACAGCCTCAGCTCCCTGCCAGGCCAGACCCGGCAGACAGATGAGGGCCCAGGAGGCCTGGCGGGCCTGGGGGCGCTACGGTGGGAGAGG
AAGCCAGGGGTACCTGCCTCTGCCTTCCAGGGCCACCGTTGGCCCCAGCTGTGCCTTGACTACGTAACATCTTGTCCTCACAGCCCAGAG
CATGTTCCAGATCCCAGAGTTTGAGCCGAGTGAGCAGGAAGACTCCAGCTCTGCAGAGAGGGGCCTGGGCCCCAGCCCCGCAGGGGACGG
GCCCTCAGGCTCCGGCAAGCATCATCGCCAGGCCCCAGGCCTCCTGTGGGACGCCAGTCACCAGCAGGAGCAGCCAACCAGCAGCAGCCA
TCATGGAGCCTTTCTGAAGGGCCTGAGTGACAAGCAGCGGGAGGAACATTACTTCTGCAAGGACTTTGTCAGGCTGAAGAAGATCCCGAC
ATGGAAGGAGATGGCGAAAGGGGTGGCTGTGAAGGTGGAGGAGCCCAGGTATAAAAAGGACAAGCAGCTCAATGAGAAAATCTCCCTGCT
CCGCAGCGACATCACCAAGCTGGAGGTGGACGCCATCGTCAACGCCGCCAACAGCTCCCTGCTCGGAGGCGGTGGCGTGGACGGCTGCAT
TCATCGGGCCGCCGGCCCCCTGCTTACCGACGAGTGCCGGACCCTGCAGAGCTGTAAGACTGGCAAGGCCAAGATCACCGGCGGCTATCG
GCTCCCGGCCAAGTACGTCATCCACACAGTGGGGCCCATCGCCTACGGGGAGCCCAGCGCCAGTCAGGCTGCCGAGCTCCGCAGCTGCTA
CCTGAGCAGTCTGGACCTGCTGCTGGAGCACCGGCTCCGCTCGGTGGCGTTCCCCTGCATCTCCACCGGCGTGTTTGGCTACCCCTGTGA
GGCGGCCGCCGAGATCGTGCTGGCCACGCTGCGAGAGTGGCTGGAGCAGCACAAGGACAAGGTGGACCGGCTGATCATCTGCGTGTTCCT
CGAGAAGGACGAGGACATCTACCGGAGCCGGCTCCCCCACTACTTCCCCGTGGCCTGAGGCTCCCGCAGCCCACCCTGACCGGGACTGAC
CCGCCTTCGGGACCCCGCTCCCAGCTCTGAGAGGTCGCCAAAGCCTGCAGCCTGGCCTGGGCCTGGCCACCCCTTCTTTCCCTCCGCGCC

>In-frame_BAD_ENST00000544785_chr11_64051654_-_MACROD1_ENST00000255681_chr11_63919865_-_1028nt
CATGTTCCAGATCCCAGAGTTTGAGCCGAGTGAGCAGGAAGACTCCAGCTCTGCAGAGAGGGGCCTGGGCCCCAGCCCCGCAGGGGACGG
GCCCTCAGGCTCCGGCAAGCATCATCGCCAGGCCCCAGGCCTCCTGTGGGACGCCAGTCACCAGCAGGAGCAGCCAACCAGCAGCAGCCA
TCATGGAGCCTTTCTGAAGGGCCTGAGTGACAAGCAGCGGGAGGAACATTACTTCTGCAAGGACTTTGTCAGGCTGAAGAAGATCCCGAC
ATGGAAGGAGATGGCGAAAGGGGTGGCTGTGAAGGTGGAGGAGCCCAGGTATAAAAAGGACAAGCAGCTCAATGAGAAAATCTCCCTGCT
CCGCAGCGACATCACCAAGCTGGAGGTGGACGCCATCGTCAACGCCGCCAACAGCTCCCTGCTCGGAGGCGGTGGCGTGGACGGCTGCAT
TCATCGGGCCGCCGGCCCCCTGCTTACCGACGAGTGCCGGACCCTGCAGAGCTGTAAGACTGGCAAGGCCAAGATCACCGGCGGCTATCG
GCTCCCGGCCAAGTACGTCATCCACACAGTGGGGCCCATCGCCTACGGGGAGCCCAGCGCCAGTCAGGCTGCCGAGCTCCGCAGCTGCTA
CCTGAGCAGTCTGGACCTGCTGCTGGAGCACCGGCTCCGCTCGGTGGCGTTCCCCTGCATCTCCACCGGCGTGTTTGGCTACCCCTGTGA
GGCGGCCGCCGAGATCGTGCTGGCCACGCTGCGAGAGTGGCTGGAGCAGCACAAGGACAAGGTGGACCGGCTGATCATCTGCGTGTTCCT
CGAGAAGGACGAGGACATCTACCGGAGCCGGCTCCCCCACTACTTCCCCGTGGCCTGAGGCTCCCGCAGCCCACCCTGACCGGGACTGAC
CCGCCTTCGGGACCCCGCTCCCAGCTCTGAGAGGTCGCCAAAGCCTGCAGCCTGGCCTGGGCCTGGCCACCCCTTCTTTCCCTCCGCGCC

>In-frame_BAD_ENST00000394531_chr11_64051654_-_MACROD1_ENST00000255681_chr11_63919865_-_1058nt
GGGGCCTCGAGATCGGGCTTGGGCCCAGAGCATGTTCCAGATCCCAGAGTTTGAGCCGAGTGAGCAGGAAGACTCCAGCTCTGCAGAGAG
GGGCCTGGGCCCCAGCCCCGCAGGGGACGGGCCCTCAGGCTCCGGCAAGCATCATCGCCAGGCCCCAGGCCTCCTGTGGGACGCCAGTCA
CCAGCAGGAGCAGCCAACCAGCAGCAGCCATCATGGAGCCTTTCTGAAGGGCCTGAGTGACAAGCAGCGGGAGGAACATTACTTCTGCAA
GGACTTTGTCAGGCTGAAGAAGATCCCGACATGGAAGGAGATGGCGAAAGGGGTGGCTGTGAAGGTGGAGGAGCCCAGGTATAAAAAGGA
CAAGCAGCTCAATGAGAAAATCTCCCTGCTCCGCAGCGACATCACCAAGCTGGAGGTGGACGCCATCGTCAACGCCGCCAACAGCTCCCT
GCTCGGAGGCGGTGGCGTGGACGGCTGCATTCATCGGGCCGCCGGCCCCCTGCTTACCGACGAGTGCCGGACCCTGCAGAGCTGTAAGAC
TGGCAAGGCCAAGATCACCGGCGGCTATCGGCTCCCGGCCAAGTACGTCATCCACACAGTGGGGCCCATCGCCTACGGGGAGCCCAGCGC
CAGTCAGGCTGCCGAGCTCCGCAGCTGCTACCTGAGCAGTCTGGACCTGCTGCTGGAGCACCGGCTCCGCTCGGTGGCGTTCCCCTGCAT
CTCCACCGGCGTGTTTGGCTACCCCTGTGAGGCGGCCGCCGAGATCGTGCTGGCCACGCTGCGAGAGTGGCTGGAGCAGCACAAGGACAA
GGTGGACCGGCTGATCATCTGCGTGTTCCTCGAGAAGGACGAGGACATCTACCGGAGCCGGCTCCCCCACTACTTCCCCGTGGCCTGAGG
CTCCCGCAGCCCACCCTGACCGGGACTGACCCGCCTTCGGGACCCCGCTCCCAGCTCTGAGAGGTCGCCAAAGCCTGCAGCCTGGCCTGG


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FusionGenePPI for BAD_MACROD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BADBCL2A1, MCL1, SFN, EWSR1, BCL2L2, BCL2L1, BCL2, YWHAQ, PRKCI, PIM2, YWHAE, YWHAB, YWHAH, S100A10, AKT1, PRKACA, RPS6KA1, RPS6KA5, YWHAZ, YWHAG, SUMO2, PPP1CA, BAX, SNCA, VCP, RAF1, PAK1, BRAF, ARAF, CREB3L3, CDKN1A, PRDX2, KEAP1, STEAP3, GIMAP5, PRKD1, PRKCE, NDUFA12, LIMK1, SORT1, SYNCRIP, APTX, CBY1MACROD1BAG3, PARP1, IKBKG, XRCC6, XRCC5, IKBKB, ERC1, EIF2AK2, HNRNPU, CSTF3, YBX1, DHX9, DDX21, PPP2R1A, PTP4A1, H2AFX, PARP2, SUPT16H, HIST2H3PS2, XPC, SSRP1, HBA2, EXOC3, CETN2, LIG3, HBE1, RPA1, PTPN6, PTPN7, DLD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BAD_MACROD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BAD_MACROD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBADC0033578Prostatic Neoplasms2CTD_human
HgeneBADC0007787Transient Ischemic Attack1CTD_human
HgeneBADC0023418leukemia1CTD_human