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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37853

FusionGeneSummary for TFG_TFDP2

check button Fusion gene summary
Fusion gene informationFusion gene name: TFG_TFDP2
Fusion gene ID: 37853
HgeneTgene
Gene symbol

TFG

TFDP2

Gene ID

10342

7029

Gene nameTRK-fused genetranscription factor Dp-2
SynonymsHMSNP|SPG57|TF6|TRKT3DP2
Cytomap

3q12.2

3q23

Type of geneprotein-codingprotein-coding
Descriptionprotein TFGTRK-fused gene proteinTRKT3 oncogenetranscription factor Dp-2transcription factor Dp-2 (E2F dimerization partner 2)
Modification date2018052220180523
UniProtAcc

Q92734

Q14188

Ensembl transtripts involved in fusion geneENST00000418917, ENST00000490574, 
ENST00000240851, ENST00000476228, 
ENST00000481203, 		ENST00000499676, 
ENST00000489671, ENST00000486111, 
ENST00000477292, ENST00000495310, 
ENST00000467072, ENST00000317104, 
ENST00000310282, ENST00000479040, 
ENST00000397991, ENST00000464782, 
Fusion gene scores* DoF score8 X 7 X 3=1685 X 4 X 4=80
# samples 125
** MAII scorelog2(12/168*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TFG [Title/Abstract] AND TFDP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTFDP2

GO:0045892

negative regulation of transcription, DNA-templated

20176812

TgeneTFDP2

GO:0045944

positive regulation of transcription by RNA polymerase II

7739537


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-51-6867-01ATFGchr3

100438902

+TFDP2chr3

141663880

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000418917ENST00000499676TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000418917ENST00000489671TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000418917ENST00000486111TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000418917ENST00000477292TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000418917ENST00000495310TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000418917ENST00000467072TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000418917ENST00000317104TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000418917ENST00000310282TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000418917ENST00000479040TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000418917ENST00000397991TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000418917ENST00000464782TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-3UTRENST00000490574ENST00000499676TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000490574ENST00000489671TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000490574ENST00000486111TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000490574ENST00000477292TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000490574ENST00000495310TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000490574ENST00000467072TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000490574ENST00000317104TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000490574ENST00000310282TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000490574ENST00000479040TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000490574ENST00000397991TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000490574ENST00000464782TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-3UTRENST00000240851ENST00000499676TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000240851ENST00000489671TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000240851ENST00000486111TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000240851ENST00000477292TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000240851ENST00000495310TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000240851ENST00000467072TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000240851ENST00000317104TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000240851ENST00000310282TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000240851ENST00000479040TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000240851ENST00000397991TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000240851ENST00000464782TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-3UTRENST00000476228ENST00000499676TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000476228ENST00000489671TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000476228ENST00000486111TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000476228ENST00000477292TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000476228ENST00000495310TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000476228ENST00000467072TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000476228ENST00000317104TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000476228ENST00000310282TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000476228ENST00000479040TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000476228ENST00000397991TFGchr3

100438902

+TFDP2chr3

141663880

-
5CDS-intronENST00000476228ENST00000464782TFGchr3

100438902

+TFDP2chr3

141663880

-
intron-3UTRENST00000481203ENST00000499676TFGchr3

100438902

+TFDP2chr3

141663880

-
intron-intronENST00000481203ENST00000489671TFGchr3

100438902

+TFDP2chr3

141663880

-
intron-intronENST00000481203ENST00000486111TFGchr3

100438902

+TFDP2chr3

141663880

-
intron-intronENST00000481203ENST00000477292TFGchr3

100438902

+TFDP2chr3

141663880

-
intron-intronENST00000481203ENST00000495310TFGchr3

100438902

+TFDP2chr3

141663880

-
intron-intronENST00000481203ENST00000467072TFGchr3

100438902

+TFDP2chr3

141663880

-
intron-intronENST00000481203ENST00000317104TFGchr3

100438902

+TFDP2chr3

141663880

-
intron-intronENST00000481203ENST00000310282TFGchr3

100438902

+TFDP2chr3

141663880

-
intron-intronENST00000481203ENST00000479040TFGchr3

100438902

+TFDP2chr3

141663880

-
intron-intronENST00000481203ENST00000397991TFGchr3

100438902

+TFDP2chr3

141663880

-
intron-intronENST00000481203ENST00000464782TFGchr3

100438902

+TFDP2chr3

141663880

-

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FusionProtFeatures for TFG_TFDP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TFG

Q92734

TFDP2

Q14188

Plays a role in the normal dynamic function of theendoplasmic reticulum (ER) and its associated microtubules(PubMed:23479643, PubMed:27813252). {ECO:0000269|PubMed:23479643,ECO:0000269|PubMed:27813252}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TFG_TFDP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TFG_TFDP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TFGPLSCR1, C14orf1, GPRASP1, GBP2, ARL15, CRMP1, KIAA1377, TFG, GRB2, RAD21, TSG101, PPP1CA, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, TRAF3, CFTR, TRIM25, STAT5B, MYOT, PIN1, PALM2-AKAP2, BABAM1, BRE, EHBP1L1, ASB18, HSPA5, TRIM68, ANXA11, CSTF2, EWSR1, HNRNPF, MAGED1, SEC24A, RBPMS, ARHGEF16, SPG21, VPS37C, CEP55, BOLL, MAPK1IP1L, RIPPLY2, PEF1, CUL7, SEC13, IGHG1, SEC31A, SPINK5, PKP1, EIF1AX, VSIG8, S100A3, LRRC15, S100A7, FBXO11, HNRNPCL1, DSG4, SELENBP1, DUSP14, HEPHL1, HIST1H2AG, UNK, FEN1, NTRK1, IFI16, TMEM17, ANXA1, ATP6V1B2, ATP6V0A1, CLTA, FLOT2, RPL10A, CHMP1A, RARS, RPL4, ITSN1, TOP2A, NCOA4, SNX3, AURKB, CLINT1, IST1, URB1, PDCD6IP, RCL1, ATP5H, MTUS2, NIPBL, C3orf17, ABI3BP, FBXL6, CHMP2A, CHMP4A, PHF20, CHMP5, SCLY, CHMP3, DPM3, DGCR8, NAT10, CHMP1B, ERGIC1, BICC1, KLHL13, TOP1MT, CHMP4B, MITD1, PLBD2, UMAD1, MCM2, CRYAB, RCAN2, BRCA1TFDP2E2F6, E2F1, RB1, RBL1, E2F4, RBL2, LIN9, LIN37, LIN54, E2F5, E2F2, E2F3, PCGF6, L3MBTL2, COMMD8, RYBP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TFG_TFDP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TFG_TFDP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTFGC1858338Neuropathy, hereditary motor and sensory, Okinawa type1ORPHANET;UNIPROT
HgeneTFGC3714897SPASTIC PARAPLEGIA 57, AUTOSOMAL RECESSIVE1ORPHANET;UNIPROT
TgeneTFDP2C0345967Malignant mesothelioma1CTD_human