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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37792

FusionGeneSummary for TEX26_SNRPN

check button Fusion gene summary
Fusion gene informationFusion gene name: TEX26_SNRPN
Fusion gene ID: 37792
HgeneTgene
Gene symbol

TEX26

SNRPN

Gene ID

122046

6638

Gene nametestis expressed 26small nuclear ribonucleoprotein polypeptide N
SynonymsC13orf26HCERN3|PWCR|RT-LI|SM-D|SMN|SNRNP-N|SNURF-SNRPN|sm-N
Cytomap

13q12.3

15q11.2

Type of geneprotein-codingprotein-coding
Descriptiontestis-expressed protein 26testis-expressed sequence 26 proteinsmall nuclear ribonucleoprotein-associated protein NSM protein Nsm protein Dtissue-specific splicing protein
Modification date2018052320180523
UniProtAcc

Q8N6G2

P63162

Ensembl transtripts involved in fusion geneENST00000380473, ENST00000530916, 
ENST00000400098, ENST00000400100, 
ENST00000400097, ENST00000553597, 
ENST00000390687, ENST00000346403, 
ENST00000554227, ENST00000577565, 
ENST00000444203, 
Fusion gene scores* DoF score1 X 1 X 1=17 X 10 X 2=140
# samples 111
** MAII scorelog2(1/1*10)=3.32192809488736log2(11/140*10)=-0.347923303420307
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TEX26 [Title/Abstract] AND SNRPN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU609006TEX26chr13

31548983

-SNRPNchr15

25247443

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000380473ENST00000400098TEX26chr13

31548983

-SNRPNchr15

25247443

+
intron-intronENST00000380473ENST00000400100TEX26chr13

31548983

-SNRPNchr15

25247443

+
intron-intronENST00000380473ENST00000400097TEX26chr13

31548983

-SNRPNchr15

25247443

+
intron-intronENST00000380473ENST00000553597TEX26chr13

31548983

-SNRPNchr15

25247443

+
intron-intronENST00000380473ENST00000390687TEX26chr13

31548983

-SNRPNchr15

25247443

+
intron-intronENST00000380473ENST00000346403TEX26chr13

31548983

-SNRPNchr15

25247443

+
intron-intronENST00000380473ENST00000554227TEX26chr13

31548983

-SNRPNchr15

25247443

+
intron-intronENST00000380473ENST00000577565TEX26chr13

31548983

-SNRPNchr15

25247443

+
intron-intronENST00000380473ENST00000444203TEX26chr13

31548983

-SNRPNchr15

25247443

+
intron-intronENST00000530916ENST00000400098TEX26chr13

31548983

-SNRPNchr15

25247443

+
intron-intronENST00000530916ENST00000400100TEX26chr13

31548983

-SNRPNchr15

25247443

+
intron-intronENST00000530916ENST00000400097TEX26chr13

31548983

-SNRPNchr15

25247443

+
intron-intronENST00000530916ENST00000553597TEX26chr13

31548983

-SNRPNchr15

25247443

+
intron-intronENST00000530916ENST00000390687TEX26chr13

31548983

-SNRPNchr15

25247443

+
intron-intronENST00000530916ENST00000346403TEX26chr13

31548983

-SNRPNchr15

25247443

+
intron-intronENST00000530916ENST00000554227TEX26chr13

31548983

-SNRPNchr15

25247443

+
intron-intronENST00000530916ENST00000577565TEX26chr13

31548983

-SNRPNchr15

25247443

+
intron-intronENST00000530916ENST00000444203TEX26chr13

31548983

-SNRPNchr15

25247443

+

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FusionProtFeatures for TEX26_SNRPN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TEX26

Q8N6G2

SNRPN

P63162

May be involved in tissue-specific alternative RNAprocessing events.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TEX26_SNRPN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TEX26_SNRPN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TEX26_SNRPN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TEX26_SNRPN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource