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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37780

FusionGeneSummary for TET3_MNS1

check button Fusion gene summary
Fusion gene informationFusion gene name: TET3_MNS1
Fusion gene ID: 37780
HgeneTgene
Gene symbol

TET3

MNS1

Gene ID

200424

55329

Gene nametet methylcytosine dioxygenase 3meiosis specific nuclear structural 1
SynonymshCG_40738SPATA40
Cytomap

2p13.1

15q21.3

Type of geneprotein-codingprotein-coding
Descriptionmethylcytosine dioxygenase TET3probable methylcytosine dioxygenase TET3putative methylcytosine dioxygenasetet oncogene family member 3meiosis-specific nuclear structural protein 1spermatogenesis associated 40
Modification date2018052320180523
UniProtAcc

O43151

Q8NEH6

Ensembl transtripts involved in fusion geneENST00000409262, ENST00000260453, 
ENST00000566386, 
Fusion gene scores* DoF score10 X 6 X 8=4802 X 1 X 1=2
# samples 152
** MAII scorelog2(15/480*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/2*10)=3.32192809488736
Context

PubMed: TET3 [Title/Abstract] AND MNS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-HC-7231-01ATET3chr2

74230293

+MNS1chr15

56756445

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000409262ENST00000260453TET3chr2

74230293

+MNS1chr15

56756445

-
intron-intronENST00000409262ENST00000566386TET3chr2

74230293

+MNS1chr15

56756445

-

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FusionProtFeatures for TET3_MNS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TET3

O43151

MNS1

Q8NEH6

Dioxygenase that catalyzes the conversion of themodified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigeneticchromatin reprogramming in the zygote following fertilization.Also mediates subsequent conversion of 5hmC into 5-formylcytosine(5fC), and conversion of 5fC to 5-carboxylcytosine (5caC).Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes thefirst step in cytosine demethylation (By similarity). Selectivelybinds to the promoter region of target genes and contributes toregulate the expression of numerous developmental genes(PubMed:23217707). In zygotes, DNA demethylation occursselectively in the paternal pronucleus before the first celldivision, while the adjacent maternal pronucleus and certainpaternally-imprinted loci are protected from this process.Participates in DNA demethylation in the paternal pronucleus bymediating conversion of 5mC into 5hmC, 5fC and 5caC. Does notmediate DNA demethylation of maternal pronucleus because of thepresence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role inDNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites ofactive genes, thereby promoting histone H2B GlcNAcylation by OGT(PubMed:23353889). {ECO:0000250|UniProtKB:Q8BG87,ECO:0000269|PubMed:23217707, ECO:0000269|PubMed:23353889}. May play a role in the control of meiotic division andgerm cell differentiation through regulation of pairing andrecombination during meiosis. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TET3_MNS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TET3_MNS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TET3APP, VPRBP, DDB1, BAG3, LTN1MNS1EWSR1, KDM1A, MNS1, CCDC93, RAB28, UBE2N, HSF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TET3_MNS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TET3_MNS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTET3C1510586Autism Spectrum Disorders1CTD_human