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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 37762

FusionGeneSummary for TET1_ASCC1

check button Fusion gene summary
Fusion gene informationFusion gene name: TET1_ASCC1
Fusion gene ID: 37762
HgeneTgene
Gene symbol

TET1

ASCC1

Gene ID

80312

51008

Gene nametet methylcytosine dioxygenase 1activating signal cointegrator 1 complex subunit 1
SynonymsCXXC6|LCX|bA119F7.1ASC1p50|CGI-18|SMABF2|p50
Cytomap

10q21.3

10q22.1

Type of geneprotein-codingprotein-coding
Descriptionmethylcytosine dioxygenase TET1CXXC finger 6CXXC zinc finger 6CXXC-type zinc finger protein 6TET1 splice variant VP_DE4TET1 splice variant VP_DE456leukemia-associated protein with a CXXC domainten-eleven translocation 1 gene proteinten-eleven tranactivating signal cointegrator 1 complex subunit 1ASC-1 complex subunit P50trip4 complex subunit p50
Modification date2018052320180520
UniProtAcc

Q8NFU7

Q8N9N2

Ensembl transtripts involved in fusion geneENST00000373644, ENST00000394919, 
ENST00000342444, ENST00000317168, 
ENST00000545550, ENST00000317126, 
ENST00000394915, ENST00000492502, 
Fusion gene scores* DoF score6 X 9 X 5=2706 X 5 X 4=120
# samples 96
** MAII scorelog2(9/270*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TET1 [Title/Abstract] AND ASCC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneASCC1

GO:0006355

regulation of transcription, DNA-templated

12077347


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A7-A0CJ-01ATET1chr10

70360791

+ASCC1chr10

73921432

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000373644ENST00000394919TET1chr10

70360791

+ASCC1chr10

73921432

-
In-frameENST00000373644ENST00000342444TET1chr10

70360791

+ASCC1chr10

73921432

-
In-frameENST00000373644ENST00000317168TET1chr10

70360791

+ASCC1chr10

73921432

-
In-frameENST00000373644ENST00000545550TET1chr10

70360791

+ASCC1chr10

73921432

-
In-frameENST00000373644ENST00000317126TET1chr10

70360791

+ASCC1chr10

73921432

-
In-frameENST00000373644ENST00000394915TET1chr10

70360791

+ASCC1chr10

73921432

-
5CDS-intronENST00000373644ENST00000492502TET1chr10

70360791

+ASCC1chr10

73921432

-

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FusionProtFeatures for TET1_ASCC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TET1

Q8NFU7

ASCC1

Q8N9N2

Dioxygenase that catalyzes the conversion of themodified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNAdemethylation. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine(5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probablyconstitutes the first step in cytosine demethylation. Methylationat the C5 position of cytosine bases is an epigenetic modificationof the mammalian genome which plays an important role intranscriptional regulation. In addition to its role in DNAdemethylation, plays a more general role in chromatin regulation.Preferentially binds to CpG-rich sequences at promoters of bothtranscriptionally active and Polycomb-repressed genes. Involved inthe recruitment of the O-GlcNAc transferase OGT to CpG-richtranscription start sites of active genes, thereby promotinghistone H2B GlcNAcylation by OGT. Also involved in transcriptionrepression of a subset of genes through recruitment oftranscriptional repressors to promoters. Involved in the balancebetween pluripotency and lineage commitment of cells it plays arole in embryonic stem cells maintenance and inner cell mass cellspecification. Plays an important role in the tumorigenicity ofglioblastoma cells. TET1-mediated production of 5hmC acts as arecruitment signal for the CHTOP-methylosome complex to selectivesites on the chromosome, where it methylates H4R3 and activatesthe transcription of genes involved in glioblastomagenesis(PubMed:25284789). {ECO:0000269|PubMed:12124344,ECO:0000269|PubMed:19372391, ECO:0000269|PubMed:19372393,ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21778364,ECO:0000269|PubMed:25284789}. Enhances NF-kappa-B, SRF and AP1 transactivation. Incells responding to gastrin-activated paracrine signals, it isinvolved in the induction of SERPINB2 expression by gastrin. Mayalso play a role in the development of neuromuscular junction.{ECO:0000269|PubMed:19074642, ECO:0000269|PubMed:26924529}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTET1chr10:70360791chr10:73921432ENST00000373644+312584_6256562137Zinc fingerCXXC-type

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTET1chr10:70360791chr10:73921432ENST00000373644+3122043_20456562137Region2-oxoglutarate binding
HgeneTET1chr10:70360791chr10:73921432ENST00000373644+3122049_20516562137RegionSubstrate binding
HgeneTET1chr10:70360791chr10:73921432ENST00000373644+312528_6746562137RegionNote=Sufficient for binding to genomic CpG islands
TgeneASCC1chr10:70360791chr10:73921432ENST00000317126-41086_148163358DomainKH
TgeneASCC1chr10:70360791chr10:73921432ENST00000317168-41086_148163358DomainKH
TgeneASCC1chr10:70360791chr10:73921432ENST00000342444-51386_148191666DomainKH
TgeneASCC1chr10:70360791chr10:73921432ENST00000394915-51286_148191401DomainKH
TgeneASCC1chr10:70360791chr10:73921432ENST00000394919-41086_148163358DomainKH


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FusionGeneSequence for TET1_ASCC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TET1_ENST00000373644_chr10_70360791_+_ASCC1_ENST00000394919_chr10_73921432_-_851aa
MSRSRHARPSRLVRKEDVNKKKKNSQLRKTTKGANKNVASVKTLSPGKLKQLIQERDVKKKTEPKPPVPVRSLLTRAGAARMNLDRTEVL
FQNPESLTCNGFTMALRSTSLSRRLSQPPLVVAKSKKVPLSKGLEKQHDCDYKILPALGVKHSENDSVPMQDTQVLPDIETLIGVQNPSL
LKGKSQETTQFWSQRVEDSKINIPTHSGPAAEILPGPLEGTRCGEGLFSEETLNDTSGSPKMFAQDTVCAPFPQRATPKVTSQGNPSIQL
EELGSRVESLKLSDSYLDPIKSEHDCYPTSSLNKVIPDLNLRNCLALGGSTSPTSVIKFLLAGSKQATLGAKPDHQEAFEATANQQEVSD
TTSFLGQAFGAIPHQWELPGADPVHGEALGETPDLPEIPGAIPVQGEVFGTILDQQETLGMSGSVVPDLPVFLPVPPNPIATFNAPSKWP
EPQSTVSYGLAVQGAIQILPLGSGHTPQSSSNSEKNSLPPVMAISNVENEKQVHISFLPANTQGFPLAPERGLFHASLGIAQLSQAGPSK
SDRGSSQVSVTSTVHVVNTTVVTMPVPMVSTSSSSYTTLLPTLEKKKRKRCGVCEPCQQKTNCGECTYCKNRKNSHQICKKRKCEELKKK
PSVVVPLEVIKENKRPQREKKPKVLKDHGVDSSIFQNPKKLHLTIGMLVLLSEEEIQQTCEMLQQCKEEFINDISGGKPLEVEMAGIEYM
NDDPGMVDVLYAKVHMKDGSNRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNAEGRYNLYTAEGKYIFKERESFDGRNI

>In-frame_TET1_ENST00000373644_chr10_70360791_+_ASCC1_ENST00000342444_chr10_73921432_-_866aa
MSRSRHARPSRLVRKEDVNKKKKNSQLRKTTKGANKNVASVKTLSPGKLKQLIQERDVKKKTEPKPPVPVRSLLTRAGAARMNLDRTEVL
FQNPESLTCNGFTMALRSTSLSRRLSQPPLVVAKSKKVPLSKGLEKQHDCDYKILPALGVKHSENDSVPMQDTQVLPDIETLIGVQNPSL
LKGKSQETTQFWSQRVEDSKINIPTHSGPAAEILPGPLEGTRCGEGLFSEETLNDTSGSPKMFAQDTVCAPFPQRATPKVTSQGNPSIQL
EELGSRVESLKLSDSYLDPIKSEHDCYPTSSLNKVIPDLNLRNCLALGGSTSPTSVIKFLLAGSKQATLGAKPDHQEAFEATANQQEVSD
TTSFLGQAFGAIPHQWELPGADPVHGEALGETPDLPEIPGAIPVQGEVFGTILDQQETLGMSGSVVPDLPVFLPVPPNPIATFNAPSKWP
EPQSTVSYGLAVQGAIQILPLGSGHTPQSSSNSEKNSLPPVMAISNVENEKQVHISFLPANTQGFPLAPERGLFHASLGIAQLSQAGPSK
SDRGSSQVSVTSTVHVVNTTVVTMPVPMVSTSSSSYTTLLPTLEKKKRKRCGVCEPCQQKTNCGECTYCKNRKNSHQICKKRKCEELKKK
PSVVVPLEVIKENKRPQREKKPKVLKDHGVDSSIFQNPKKLHLTIGMLVLLSEEEIQQTCEMLQQCKEEFINDISGGKPLEVEMAGIEYM
NDDPGMVDVLYAKVHMKDGSNRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNAEGRYNLYTAEGKYIFKERESFDGRNI

>In-frame_TET1_ENST00000373644_chr10_70360791_+_ASCC1_ENST00000317168_chr10_73921432_-_851aa
MSRSRHARPSRLVRKEDVNKKKKNSQLRKTTKGANKNVASVKTLSPGKLKQLIQERDVKKKTEPKPPVPVRSLLTRAGAARMNLDRTEVL
FQNPESLTCNGFTMALRSTSLSRRLSQPPLVVAKSKKVPLSKGLEKQHDCDYKILPALGVKHSENDSVPMQDTQVLPDIETLIGVQNPSL
LKGKSQETTQFWSQRVEDSKINIPTHSGPAAEILPGPLEGTRCGEGLFSEETLNDTSGSPKMFAQDTVCAPFPQRATPKVTSQGNPSIQL
EELGSRVESLKLSDSYLDPIKSEHDCYPTSSLNKVIPDLNLRNCLALGGSTSPTSVIKFLLAGSKQATLGAKPDHQEAFEATANQQEVSD
TTSFLGQAFGAIPHQWELPGADPVHGEALGETPDLPEIPGAIPVQGEVFGTILDQQETLGMSGSVVPDLPVFLPVPPNPIATFNAPSKWP
EPQSTVSYGLAVQGAIQILPLGSGHTPQSSSNSEKNSLPPVMAISNVENEKQVHISFLPANTQGFPLAPERGLFHASLGIAQLSQAGPSK
SDRGSSQVSVTSTVHVVNTTVVTMPVPMVSTSSSSYTTLLPTLEKKKRKRCGVCEPCQQKTNCGECTYCKNRKNSHQICKKRKCEELKKK
PSVVVPLEVIKENKRPQREKKPKVLKDHGVDSSIFQNPKKLHLTIGMLVLLSEEEIQQTCEMLQQCKEEFINDISGGKPLEVEMAGIEYM
NDDPGMVDVLYAKVHMKDGSNRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNAEGRYNLYTAEGKYIFKERESFDGRNI

>In-frame_TET1_ENST00000373644_chr10_70360791_+_ASCC1_ENST00000545550_chr10_73921432_-_851aa
MSRSRHARPSRLVRKEDVNKKKKNSQLRKTTKGANKNVASVKTLSPGKLKQLIQERDVKKKTEPKPPVPVRSLLTRAGAARMNLDRTEVL
FQNPESLTCNGFTMALRSTSLSRRLSQPPLVVAKSKKVPLSKGLEKQHDCDYKILPALGVKHSENDSVPMQDTQVLPDIETLIGVQNPSL
LKGKSQETTQFWSQRVEDSKINIPTHSGPAAEILPGPLEGTRCGEGLFSEETLNDTSGSPKMFAQDTVCAPFPQRATPKVTSQGNPSIQL
EELGSRVESLKLSDSYLDPIKSEHDCYPTSSLNKVIPDLNLRNCLALGGSTSPTSVIKFLLAGSKQATLGAKPDHQEAFEATANQQEVSD
TTSFLGQAFGAIPHQWELPGADPVHGEALGETPDLPEIPGAIPVQGEVFGTILDQQETLGMSGSVVPDLPVFLPVPPNPIATFNAPSKWP
EPQSTVSYGLAVQGAIQILPLGSGHTPQSSSNSEKNSLPPVMAISNVENEKQVHISFLPANTQGFPLAPERGLFHASLGIAQLSQAGPSK
SDRGSSQVSVTSTVHVVNTTVVTMPVPMVSTSSSSYTTLLPTLEKKKRKRCGVCEPCQQKTNCGECTYCKNRKNSHQICKKRKCEELKKK
PSVVVPLEVIKENKRPQREKKPKVLKDHGVDSSIFQNPKKLHLTIGMLVLLSEEEIQQTCEMLQQCKEEFINDISGGKPLEVEMAGIEYM
NDDPGMVDVLYAKVHMKDGSNRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNAEGRYNLYTAEGKYIFKERESFDGRNI

>In-frame_TET1_ENST00000373644_chr10_70360791_+_ASCC1_ENST00000317126_chr10_73921432_-_851aa
MSRSRHARPSRLVRKEDVNKKKKNSQLRKTTKGANKNVASVKTLSPGKLKQLIQERDVKKKTEPKPPVPVRSLLTRAGAARMNLDRTEVL
FQNPESLTCNGFTMALRSTSLSRRLSQPPLVVAKSKKVPLSKGLEKQHDCDYKILPALGVKHSENDSVPMQDTQVLPDIETLIGVQNPSL
LKGKSQETTQFWSQRVEDSKINIPTHSGPAAEILPGPLEGTRCGEGLFSEETLNDTSGSPKMFAQDTVCAPFPQRATPKVTSQGNPSIQL
EELGSRVESLKLSDSYLDPIKSEHDCYPTSSLNKVIPDLNLRNCLALGGSTSPTSVIKFLLAGSKQATLGAKPDHQEAFEATANQQEVSD
TTSFLGQAFGAIPHQWELPGADPVHGEALGETPDLPEIPGAIPVQGEVFGTILDQQETLGMSGSVVPDLPVFLPVPPNPIATFNAPSKWP
EPQSTVSYGLAVQGAIQILPLGSGHTPQSSSNSEKNSLPPVMAISNVENEKQVHISFLPANTQGFPLAPERGLFHASLGIAQLSQAGPSK
SDRGSSQVSVTSTVHVVNTTVVTMPVPMVSTSSSSYTTLLPTLEKKKRKRCGVCEPCQQKTNCGECTYCKNRKNSHQICKKRKCEELKKK
PSVVVPLEVIKENKRPQREKKPKVLKDHGVDSSIFQNPKKLHLTIGMLVLLSEEEIQQTCEMLQQCKEEFINDISGGKPLEVEMAGIEYM
NDDPGMVDVLYAKVHMKDGSNRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNAEGRYNLYTAEGKYIFKERESFDGRNI

>In-frame_TET1_ENST00000373644_chr10_70360791_+_ASCC1_ENST00000394915_chr10_73921432_-_866aa
MSRSRHARPSRLVRKEDVNKKKKNSQLRKTTKGANKNVASVKTLSPGKLKQLIQERDVKKKTEPKPPVPVRSLLTRAGAARMNLDRTEVL
FQNPESLTCNGFTMALRSTSLSRRLSQPPLVVAKSKKVPLSKGLEKQHDCDYKILPALGVKHSENDSVPMQDTQVLPDIETLIGVQNPSL
LKGKSQETTQFWSQRVEDSKINIPTHSGPAAEILPGPLEGTRCGEGLFSEETLNDTSGSPKMFAQDTVCAPFPQRATPKVTSQGNPSIQL
EELGSRVESLKLSDSYLDPIKSEHDCYPTSSLNKVIPDLNLRNCLALGGSTSPTSVIKFLLAGSKQATLGAKPDHQEAFEATANQQEVSD
TTSFLGQAFGAIPHQWELPGADPVHGEALGETPDLPEIPGAIPVQGEVFGTILDQQETLGMSGSVVPDLPVFLPVPPNPIATFNAPSKWP
EPQSTVSYGLAVQGAIQILPLGSGHTPQSSSNSEKNSLPPVMAISNVENEKQVHISFLPANTQGFPLAPERGLFHASLGIAQLSQAGPSK
SDRGSSQVSVTSTVHVVNTTVVTMPVPMVSTSSSSYTTLLPTLEKKKRKRCGVCEPCQQKTNCGECTYCKNRKNSHQICKKRKCEELKKK
PSVVVPLEVIKENKRPQREKKPKVLKDHGVDSSIFQNPKKLHLTIGMLVLLSEEEIQQTCEMLQQCKEEFINDISGGKPLEVEMAGIEYM
NDDPGMVDVLYAKVHMKDGSNRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNAEGRYNLYTAEGKYIFKERESFDGRNI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TET1_ENST00000373644_chr10_70360791_+_ASCC1_ENST00000394919_chr10_73921432_-_2553nt
ATGTCTCGATCCCGCCATGCAAGGCCTTCCAGATTAGTCAGGAAGGAAGATGTAAACAAAAAAAAGAAAAACAGCCAACTACGAAAGACA
ACCAAGGGAGCCAACAAAAATGTGGCATCAGTCAAGACTTTAAGCCCTGGAAAATTAAAGCAATTAATTCAAGAAAGAGATGTTAAGAAA
AAAACAGAACCTAAACCACCCGTGCCAGTCAGAAGCCTTCTGACAAGAGCTGGAGCAGCACGCATGAATTTGGATAGGACTGAGGTTCTT
TTTCAGAACCCAGAGTCCTTAACCTGCAATGGGTTTACAATGGCGCTACGAAGCACCTCTCTTAGCAGGCGACTCTCCCAACCCCCACTG
GTCGTAGCCAAATCCAAAAAGGTTCCACTTTCTAAGGGTTTAGAAAAGCAACATGATTGTGATTATAAGATACTCCCTGCTTTGGGAGTA
AAGCACTCAGAAAATGATTCGGTTCCAATGCAAGACACCCAAGTCCTTCCTGATATAGAGACTCTAATTGGTGTACAAAATCCCTCTTTA
CTTAAAGGTAAGAGCCAAGAGACAACTCAGTTTTGGTCCCAAAGAGTTGAGGATTCCAAGATCAATATCCCTACCCACAGTGGCCCTGCA
GCTGAGATCCTTCCTGGGCCACTGGAAGGGACACGCTGTGGTGAAGGACTATTCTCTGAAGAGACATTGAATGATACCAGTGGTTCCCCA
AAAATGTTTGCTCAGGACACAGTGTGTGCTCCTTTTCCCCAAAGAGCAACCCCCAAAGTTACCTCTCAAGGAAACCCCAGCATTCAGTTA
GAAGAGTTGGGTTCACGAGTAGAATCTCTTAAGTTATCTGATTCTTACCTGGATCCCATTAAAAGTGAACATGATTGCTACCCCACCTCC
AGTCTTAATAAGGTTATACCTGACTTGAACCTTAGAAACTGCTTGGCTCTTGGTGGGTCTACGTCTCCTACCTCTGTAATAAAATTCCTC
TTGGCAGGCTCAAAACAAGCGACCCTTGGTGCTAAACCAGATCATCAAGAGGCCTTCGAAGCTACTGCAAATCAACAGGAAGTTTCTGAT
ACCACCTCTTTCCTAGGACAGGCCTTTGGTGCTATCCCACATCAATGGGAACTTCCTGGTGCTGACCCAGTTCATGGTGAGGCCCTGGGT
GAGACCCCAGATCTACCAGAGATTCCTGGTGCTATTCCAGTCCAAGGAGAGGTCTTTGGTACTATTTTAGACCAACAAGAAACTCTTGGT
ATGAGTGGGAGTGTTGTCCCAGACTTGCCTGTCTTCCTTCCTGTTCCTCCAAATCCAATTGCTACCTTTAATGCTCCTTCCAAATGGCCT
GAGCCCCAAAGCACTGTCTCATATGGACTTGCAGTCCAGGGTGCTATACAGATTTTGCCTTTGGGCTCAGGACACACTCCTCAATCATCA
TCAAACTCAGAGAAAAATTCATTACCTCCAGTAATGGCTATAAGCAATGTAGAAAATGAGAAGCAGGTTCATATAAGCTTCCTGCCAGCT
AACACTCAGGGGTTCCCATTAGCCCCTGAGAGAGGACTCTTCCATGCTTCACTGGGTATAGCCCAACTCTCTCAGGCTGGTCCTAGCAAA
TCAGACAGAGGGAGCTCCCAGGTCAGTGTAACCAGCACAGTTCATGTTGTCAACACCACAGTGGTGACTATGCCAGTGCCAATGGTCAGT
ACCTCCTCTTCTTCCTATACCACTTTGCTACCGACTTTGGAAAAGAAGAAAAGAAAGCGATGTGGGGTCTGTGAACCCTGCCAGCAGAAG
ACCAACTGTGGTGAATGCACTTACTGCAAGAACAGAAAGAACAGCCATCAGATCTGTAAGAAAAGAAAATGTGAGGAGCTGAAAAAGAAA
CCATCTGTTGTTGTGCCTCTGGAGGTTATAAAGGAAAACAAGAGGCCCCAGAGGGAAAAGAAGCCCAAAGTTTTAAAGGATCATGGGGTT
GACAGCAGCATTTTCCAGAATCCTAAAAAGCTTCATCTAACTATTGGGATGTTGGTGCTTTTGAGTGAGGAAGAGATCCAGCAGACATGT
GAGATGCTACAGCAGTGTAAAGAGGAATTCATTAATGATATTTCTGGGGGTAAACCCCTAGAAGTGGAGATGGCAGGGATAGAATACATG
AATGATGATCCTGGCATGGTGGATGTTCTTTACGCCAAAGTCCATATGAAAGATGGCTCCAACAGGCTACAAGAATTAGTTGATCGAGTG
CTGGAACGTTTTCAGGCATCTGGACTAATAGTGAAAGAGTGGAATAGTGTGAAACTGCATGCTACAGTTATGAATACACTATTCAGGAAA
GACCCCAATGCTGAAGGCAGGTACAATCTCTACACAGCGGAAGGCAAATATATCTTCAAGGAAAGAGAATCATTTGATGGCCGAAATATT
TTAAAGTTGTTTGAGAACTTCTACTTTGGCTCCCTAAAGCTGAATTCAATTCACATCTCTCAGAGGTTCACCGTAGACAGCTTTGGAAAC

>In-frame_TET1_ENST00000373644_chr10_70360791_+_ASCC1_ENST00000342444_chr10_73921432_-_2598nt
ATGTCTCGATCCCGCCATGCAAGGCCTTCCAGATTAGTCAGGAAGGAAGATGTAAACAAAAAAAAGAAAAACAGCCAACTACGAAAGACA
ACCAAGGGAGCCAACAAAAATGTGGCATCAGTCAAGACTTTAAGCCCTGGAAAATTAAAGCAATTAATTCAAGAAAGAGATGTTAAGAAA
AAAACAGAACCTAAACCACCCGTGCCAGTCAGAAGCCTTCTGACAAGAGCTGGAGCAGCACGCATGAATTTGGATAGGACTGAGGTTCTT
TTTCAGAACCCAGAGTCCTTAACCTGCAATGGGTTTACAATGGCGCTACGAAGCACCTCTCTTAGCAGGCGACTCTCCCAACCCCCACTG
GTCGTAGCCAAATCCAAAAAGGTTCCACTTTCTAAGGGTTTAGAAAAGCAACATGATTGTGATTATAAGATACTCCCTGCTTTGGGAGTA
AAGCACTCAGAAAATGATTCGGTTCCAATGCAAGACACCCAAGTCCTTCCTGATATAGAGACTCTAATTGGTGTACAAAATCCCTCTTTA
CTTAAAGGTAAGAGCCAAGAGACAACTCAGTTTTGGTCCCAAAGAGTTGAGGATTCCAAGATCAATATCCCTACCCACAGTGGCCCTGCA
GCTGAGATCCTTCCTGGGCCACTGGAAGGGACACGCTGTGGTGAAGGACTATTCTCTGAAGAGACATTGAATGATACCAGTGGTTCCCCA
AAAATGTTTGCTCAGGACACAGTGTGTGCTCCTTTTCCCCAAAGAGCAACCCCCAAAGTTACCTCTCAAGGAAACCCCAGCATTCAGTTA
GAAGAGTTGGGTTCACGAGTAGAATCTCTTAAGTTATCTGATTCTTACCTGGATCCCATTAAAAGTGAACATGATTGCTACCCCACCTCC
AGTCTTAATAAGGTTATACCTGACTTGAACCTTAGAAACTGCTTGGCTCTTGGTGGGTCTACGTCTCCTACCTCTGTAATAAAATTCCTC
TTGGCAGGCTCAAAACAAGCGACCCTTGGTGCTAAACCAGATCATCAAGAGGCCTTCGAAGCTACTGCAAATCAACAGGAAGTTTCTGAT
ACCACCTCTTTCCTAGGACAGGCCTTTGGTGCTATCCCACATCAATGGGAACTTCCTGGTGCTGACCCAGTTCATGGTGAGGCCCTGGGT
GAGACCCCAGATCTACCAGAGATTCCTGGTGCTATTCCAGTCCAAGGAGAGGTCTTTGGTACTATTTTAGACCAACAAGAAACTCTTGGT
ATGAGTGGGAGTGTTGTCCCAGACTTGCCTGTCTTCCTTCCTGTTCCTCCAAATCCAATTGCTACCTTTAATGCTCCTTCCAAATGGCCT
GAGCCCCAAAGCACTGTCTCATATGGACTTGCAGTCCAGGGTGCTATACAGATTTTGCCTTTGGGCTCAGGACACACTCCTCAATCATCA
TCAAACTCAGAGAAAAATTCATTACCTCCAGTAATGGCTATAAGCAATGTAGAAAATGAGAAGCAGGTTCATATAAGCTTCCTGCCAGCT
AACACTCAGGGGTTCCCATTAGCCCCTGAGAGAGGACTCTTCCATGCTTCACTGGGTATAGCCCAACTCTCTCAGGCTGGTCCTAGCAAA
TCAGACAGAGGGAGCTCCCAGGTCAGTGTAACCAGCACAGTTCATGTTGTCAACACCACAGTGGTGACTATGCCAGTGCCAATGGTCAGT
ACCTCCTCTTCTTCCTATACCACTTTGCTACCGACTTTGGAAAAGAAGAAAAGAAAGCGATGTGGGGTCTGTGAACCCTGCCAGCAGAAG
ACCAACTGTGGTGAATGCACTTACTGCAAGAACAGAAAGAACAGCCATCAGATCTGTAAGAAAAGAAAATGTGAGGAGCTGAAAAAGAAA
CCATCTGTTGTTGTGCCTCTGGAGGTTATAAAGGAAAACAAGAGGCCCCAGAGGGAAAAGAAGCCCAAAGTTTTAAAGGATCATGGGGTT
GACAGCAGCATTTTCCAGAATCCTAAAAAGCTTCATCTAACTATTGGGATGTTGGTGCTTTTGAGTGAGGAAGAGATCCAGCAGACATGT
GAGATGCTACAGCAGTGTAAAGAGGAATTCATTAATGATATTTCTGGGGGTAAACCCCTAGAAGTGGAGATGGCAGGGATAGAATACATG
AATGATGATCCTGGCATGGTGGATGTTCTTTACGCCAAAGTCCATATGAAAGATGGCTCCAACAGGCTACAAGAATTAGTTGATCGAGTG
CTGGAACGTTTTCAGGCATCTGGACTAATAGTGAAAGAGTGGAATAGTGTGAAACTGCATGCTACAGTTATGAATACACTATTCAGGAAA
GACCCCAATGCTGAAGGCAGGTACAATCTCTACACAGCGGAAGGCAAATATATCTTCAAGGAAAGAGAATCATTTGATGGCCGAAATATT
TTAAAGAGCTTTGCCTTGTTGCCCAGGCTGGAGTACAATGATGCAATCTCCGCTCACTGCAACCTGTGCCTCCCGGGTTCAAGTGATTCT

>In-frame_TET1_ENST00000373644_chr10_70360791_+_ASCC1_ENST00000317168_chr10_73921432_-_2553nt
ATGTCTCGATCCCGCCATGCAAGGCCTTCCAGATTAGTCAGGAAGGAAGATGTAAACAAAAAAAAGAAAAACAGCCAACTACGAAAGACA
ACCAAGGGAGCCAACAAAAATGTGGCATCAGTCAAGACTTTAAGCCCTGGAAAATTAAAGCAATTAATTCAAGAAAGAGATGTTAAGAAA
AAAACAGAACCTAAACCACCCGTGCCAGTCAGAAGCCTTCTGACAAGAGCTGGAGCAGCACGCATGAATTTGGATAGGACTGAGGTTCTT
TTTCAGAACCCAGAGTCCTTAACCTGCAATGGGTTTACAATGGCGCTACGAAGCACCTCTCTTAGCAGGCGACTCTCCCAACCCCCACTG
GTCGTAGCCAAATCCAAAAAGGTTCCACTTTCTAAGGGTTTAGAAAAGCAACATGATTGTGATTATAAGATACTCCCTGCTTTGGGAGTA
AAGCACTCAGAAAATGATTCGGTTCCAATGCAAGACACCCAAGTCCTTCCTGATATAGAGACTCTAATTGGTGTACAAAATCCCTCTTTA
CTTAAAGGTAAGAGCCAAGAGACAACTCAGTTTTGGTCCCAAAGAGTTGAGGATTCCAAGATCAATATCCCTACCCACAGTGGCCCTGCA
GCTGAGATCCTTCCTGGGCCACTGGAAGGGACACGCTGTGGTGAAGGACTATTCTCTGAAGAGACATTGAATGATACCAGTGGTTCCCCA
AAAATGTTTGCTCAGGACACAGTGTGTGCTCCTTTTCCCCAAAGAGCAACCCCCAAAGTTACCTCTCAAGGAAACCCCAGCATTCAGTTA
GAAGAGTTGGGTTCACGAGTAGAATCTCTTAAGTTATCTGATTCTTACCTGGATCCCATTAAAAGTGAACATGATTGCTACCCCACCTCC
AGTCTTAATAAGGTTATACCTGACTTGAACCTTAGAAACTGCTTGGCTCTTGGTGGGTCTACGTCTCCTACCTCTGTAATAAAATTCCTC
TTGGCAGGCTCAAAACAAGCGACCCTTGGTGCTAAACCAGATCATCAAGAGGCCTTCGAAGCTACTGCAAATCAACAGGAAGTTTCTGAT
ACCACCTCTTTCCTAGGACAGGCCTTTGGTGCTATCCCACATCAATGGGAACTTCCTGGTGCTGACCCAGTTCATGGTGAGGCCCTGGGT
GAGACCCCAGATCTACCAGAGATTCCTGGTGCTATTCCAGTCCAAGGAGAGGTCTTTGGTACTATTTTAGACCAACAAGAAACTCTTGGT
ATGAGTGGGAGTGTTGTCCCAGACTTGCCTGTCTTCCTTCCTGTTCCTCCAAATCCAATTGCTACCTTTAATGCTCCTTCCAAATGGCCT
GAGCCCCAAAGCACTGTCTCATATGGACTTGCAGTCCAGGGTGCTATACAGATTTTGCCTTTGGGCTCAGGACACACTCCTCAATCATCA
TCAAACTCAGAGAAAAATTCATTACCTCCAGTAATGGCTATAAGCAATGTAGAAAATGAGAAGCAGGTTCATATAAGCTTCCTGCCAGCT
AACACTCAGGGGTTCCCATTAGCCCCTGAGAGAGGACTCTTCCATGCTTCACTGGGTATAGCCCAACTCTCTCAGGCTGGTCCTAGCAAA
TCAGACAGAGGGAGCTCCCAGGTCAGTGTAACCAGCACAGTTCATGTTGTCAACACCACAGTGGTGACTATGCCAGTGCCAATGGTCAGT
ACCTCCTCTTCTTCCTATACCACTTTGCTACCGACTTTGGAAAAGAAGAAAAGAAAGCGATGTGGGGTCTGTGAACCCTGCCAGCAGAAG
ACCAACTGTGGTGAATGCACTTACTGCAAGAACAGAAAGAACAGCCATCAGATCTGTAAGAAAAGAAAATGTGAGGAGCTGAAAAAGAAA
CCATCTGTTGTTGTGCCTCTGGAGGTTATAAAGGAAAACAAGAGGCCCCAGAGGGAAAAGAAGCCCAAAGTTTTAAAGGATCATGGGGTT
GACAGCAGCATTTTCCAGAATCCTAAAAAGCTTCATCTAACTATTGGGATGTTGGTGCTTTTGAGTGAGGAAGAGATCCAGCAGACATGT
GAGATGCTACAGCAGTGTAAAGAGGAATTCATTAATGATATTTCTGGGGGTAAACCCCTAGAAGTGGAGATGGCAGGGATAGAATACATG
AATGATGATCCTGGCATGGTGGATGTTCTTTACGCCAAAGTCCATATGAAAGATGGCTCCAACAGGCTACAAGAATTAGTTGATCGAGTG
CTGGAACGTTTTCAGGCATCTGGACTAATAGTGAAAGAGTGGAATAGTGTGAAACTGCATGCTACAGTTATGAATACACTATTCAGGAAA
GACCCCAATGCTGAAGGCAGGTACAATCTCTACACAGCGGAAGGCAAATATATCTTCAAGGAAAGAGAATCATTTGATGGCCGAAATATT
TTAAAGTTGTTTGAGAACTTCTACTTTGGCTCCCTAAAGCTGAATTCAATTCACATCTCTCAGAGGTTCACCGTAGACAGCTTTGGAAAC

>In-frame_TET1_ENST00000373644_chr10_70360791_+_ASCC1_ENST00000545550_chr10_73921432_-_2553nt
ATGTCTCGATCCCGCCATGCAAGGCCTTCCAGATTAGTCAGGAAGGAAGATGTAAACAAAAAAAAGAAAAACAGCCAACTACGAAAGACA
ACCAAGGGAGCCAACAAAAATGTGGCATCAGTCAAGACTTTAAGCCCTGGAAAATTAAAGCAATTAATTCAAGAAAGAGATGTTAAGAAA
AAAACAGAACCTAAACCACCCGTGCCAGTCAGAAGCCTTCTGACAAGAGCTGGAGCAGCACGCATGAATTTGGATAGGACTGAGGTTCTT
TTTCAGAACCCAGAGTCCTTAACCTGCAATGGGTTTACAATGGCGCTACGAAGCACCTCTCTTAGCAGGCGACTCTCCCAACCCCCACTG
GTCGTAGCCAAATCCAAAAAGGTTCCACTTTCTAAGGGTTTAGAAAAGCAACATGATTGTGATTATAAGATACTCCCTGCTTTGGGAGTA
AAGCACTCAGAAAATGATTCGGTTCCAATGCAAGACACCCAAGTCCTTCCTGATATAGAGACTCTAATTGGTGTACAAAATCCCTCTTTA
CTTAAAGGTAAGAGCCAAGAGACAACTCAGTTTTGGTCCCAAAGAGTTGAGGATTCCAAGATCAATATCCCTACCCACAGTGGCCCTGCA
GCTGAGATCCTTCCTGGGCCACTGGAAGGGACACGCTGTGGTGAAGGACTATTCTCTGAAGAGACATTGAATGATACCAGTGGTTCCCCA
AAAATGTTTGCTCAGGACACAGTGTGTGCTCCTTTTCCCCAAAGAGCAACCCCCAAAGTTACCTCTCAAGGAAACCCCAGCATTCAGTTA
GAAGAGTTGGGTTCACGAGTAGAATCTCTTAAGTTATCTGATTCTTACCTGGATCCCATTAAAAGTGAACATGATTGCTACCCCACCTCC
AGTCTTAATAAGGTTATACCTGACTTGAACCTTAGAAACTGCTTGGCTCTTGGTGGGTCTACGTCTCCTACCTCTGTAATAAAATTCCTC
TTGGCAGGCTCAAAACAAGCGACCCTTGGTGCTAAACCAGATCATCAAGAGGCCTTCGAAGCTACTGCAAATCAACAGGAAGTTTCTGAT
ACCACCTCTTTCCTAGGACAGGCCTTTGGTGCTATCCCACATCAATGGGAACTTCCTGGTGCTGACCCAGTTCATGGTGAGGCCCTGGGT
GAGACCCCAGATCTACCAGAGATTCCTGGTGCTATTCCAGTCCAAGGAGAGGTCTTTGGTACTATTTTAGACCAACAAGAAACTCTTGGT
ATGAGTGGGAGTGTTGTCCCAGACTTGCCTGTCTTCCTTCCTGTTCCTCCAAATCCAATTGCTACCTTTAATGCTCCTTCCAAATGGCCT
GAGCCCCAAAGCACTGTCTCATATGGACTTGCAGTCCAGGGTGCTATACAGATTTTGCCTTTGGGCTCAGGACACACTCCTCAATCATCA
TCAAACTCAGAGAAAAATTCATTACCTCCAGTAATGGCTATAAGCAATGTAGAAAATGAGAAGCAGGTTCATATAAGCTTCCTGCCAGCT
AACACTCAGGGGTTCCCATTAGCCCCTGAGAGAGGACTCTTCCATGCTTCACTGGGTATAGCCCAACTCTCTCAGGCTGGTCCTAGCAAA
TCAGACAGAGGGAGCTCCCAGGTCAGTGTAACCAGCACAGTTCATGTTGTCAACACCACAGTGGTGACTATGCCAGTGCCAATGGTCAGT
ACCTCCTCTTCTTCCTATACCACTTTGCTACCGACTTTGGAAAAGAAGAAAAGAAAGCGATGTGGGGTCTGTGAACCCTGCCAGCAGAAG
ACCAACTGTGGTGAATGCACTTACTGCAAGAACAGAAAGAACAGCCATCAGATCTGTAAGAAAAGAAAATGTGAGGAGCTGAAAAAGAAA
CCATCTGTTGTTGTGCCTCTGGAGGTTATAAAGGAAAACAAGAGGCCCCAGAGGGAAAAGAAGCCCAAAGTTTTAAAGGATCATGGGGTT
GACAGCAGCATTTTCCAGAATCCTAAAAAGCTTCATCTAACTATTGGGATGTTGGTGCTTTTGAGTGAGGAAGAGATCCAGCAGACATGT
GAGATGCTACAGCAGTGTAAAGAGGAATTCATTAATGATATTTCTGGGGGTAAACCCCTAGAAGTGGAGATGGCAGGGATAGAATACATG
AATGATGATCCTGGCATGGTGGATGTTCTTTACGCCAAAGTCCATATGAAAGATGGCTCCAACAGGCTACAAGAATTAGTTGATCGAGTG
CTGGAACGTTTTCAGGCATCTGGACTAATAGTGAAAGAGTGGAATAGTGTGAAACTGCATGCTACAGTTATGAATACACTATTCAGGAAA
GACCCCAATGCTGAAGGCAGGTACAATCTCTACACAGCGGAAGGCAAATATATCTTCAAGGAAAGAGAATCATTTGATGGCCGAAATATT
TTAAAGTTGTTTGAGAACTTCTACTTTGGCTCCCTAAAGCTGAATTCAATTCACATCTCTCAGAGGTTCACCGTAGACAGCTTTGGAAAC

>In-frame_TET1_ENST00000373644_chr10_70360791_+_ASCC1_ENST00000317126_chr10_73921432_-_2553nt
ATGTCTCGATCCCGCCATGCAAGGCCTTCCAGATTAGTCAGGAAGGAAGATGTAAACAAAAAAAAGAAAAACAGCCAACTACGAAAGACA
ACCAAGGGAGCCAACAAAAATGTGGCATCAGTCAAGACTTTAAGCCCTGGAAAATTAAAGCAATTAATTCAAGAAAGAGATGTTAAGAAA
AAAACAGAACCTAAACCACCCGTGCCAGTCAGAAGCCTTCTGACAAGAGCTGGAGCAGCACGCATGAATTTGGATAGGACTGAGGTTCTT
TTTCAGAACCCAGAGTCCTTAACCTGCAATGGGTTTACAATGGCGCTACGAAGCACCTCTCTTAGCAGGCGACTCTCCCAACCCCCACTG
GTCGTAGCCAAATCCAAAAAGGTTCCACTTTCTAAGGGTTTAGAAAAGCAACATGATTGTGATTATAAGATACTCCCTGCTTTGGGAGTA
AAGCACTCAGAAAATGATTCGGTTCCAATGCAAGACACCCAAGTCCTTCCTGATATAGAGACTCTAATTGGTGTACAAAATCCCTCTTTA
CTTAAAGGTAAGAGCCAAGAGACAACTCAGTTTTGGTCCCAAAGAGTTGAGGATTCCAAGATCAATATCCCTACCCACAGTGGCCCTGCA
GCTGAGATCCTTCCTGGGCCACTGGAAGGGACACGCTGTGGTGAAGGACTATTCTCTGAAGAGACATTGAATGATACCAGTGGTTCCCCA
AAAATGTTTGCTCAGGACACAGTGTGTGCTCCTTTTCCCCAAAGAGCAACCCCCAAAGTTACCTCTCAAGGAAACCCCAGCATTCAGTTA
GAAGAGTTGGGTTCACGAGTAGAATCTCTTAAGTTATCTGATTCTTACCTGGATCCCATTAAAAGTGAACATGATTGCTACCCCACCTCC
AGTCTTAATAAGGTTATACCTGACTTGAACCTTAGAAACTGCTTGGCTCTTGGTGGGTCTACGTCTCCTACCTCTGTAATAAAATTCCTC
TTGGCAGGCTCAAAACAAGCGACCCTTGGTGCTAAACCAGATCATCAAGAGGCCTTCGAAGCTACTGCAAATCAACAGGAAGTTTCTGAT
ACCACCTCTTTCCTAGGACAGGCCTTTGGTGCTATCCCACATCAATGGGAACTTCCTGGTGCTGACCCAGTTCATGGTGAGGCCCTGGGT
GAGACCCCAGATCTACCAGAGATTCCTGGTGCTATTCCAGTCCAAGGAGAGGTCTTTGGTACTATTTTAGACCAACAAGAAACTCTTGGT
ATGAGTGGGAGTGTTGTCCCAGACTTGCCTGTCTTCCTTCCTGTTCCTCCAAATCCAATTGCTACCTTTAATGCTCCTTCCAAATGGCCT
GAGCCCCAAAGCACTGTCTCATATGGACTTGCAGTCCAGGGTGCTATACAGATTTTGCCTTTGGGCTCAGGACACACTCCTCAATCATCA
TCAAACTCAGAGAAAAATTCATTACCTCCAGTAATGGCTATAAGCAATGTAGAAAATGAGAAGCAGGTTCATATAAGCTTCCTGCCAGCT
AACACTCAGGGGTTCCCATTAGCCCCTGAGAGAGGACTCTTCCATGCTTCACTGGGTATAGCCCAACTCTCTCAGGCTGGTCCTAGCAAA
TCAGACAGAGGGAGCTCCCAGGTCAGTGTAACCAGCACAGTTCATGTTGTCAACACCACAGTGGTGACTATGCCAGTGCCAATGGTCAGT
ACCTCCTCTTCTTCCTATACCACTTTGCTACCGACTTTGGAAAAGAAGAAAAGAAAGCGATGTGGGGTCTGTGAACCCTGCCAGCAGAAG
ACCAACTGTGGTGAATGCACTTACTGCAAGAACAGAAAGAACAGCCATCAGATCTGTAAGAAAAGAAAATGTGAGGAGCTGAAAAAGAAA
CCATCTGTTGTTGTGCCTCTGGAGGTTATAAAGGAAAACAAGAGGCCCCAGAGGGAAAAGAAGCCCAAAGTTTTAAAGGATCATGGGGTT
GACAGCAGCATTTTCCAGAATCCTAAAAAGCTTCATCTAACTATTGGGATGTTGGTGCTTTTGAGTGAGGAAGAGATCCAGCAGACATGT
GAGATGCTACAGCAGTGTAAAGAGGAATTCATTAATGATATTTCTGGGGGTAAACCCCTAGAAGTGGAGATGGCAGGGATAGAATACATG
AATGATGATCCTGGCATGGTGGATGTTCTTTACGCCAAAGTCCATATGAAAGATGGCTCCAACAGGCTACAAGAATTAGTTGATCGAGTG
CTGGAACGTTTTCAGGCATCTGGACTAATAGTGAAAGAGTGGAATAGTGTGAAACTGCATGCTACAGTTATGAATACACTATTCAGGAAA
GACCCCAATGCTGAAGGCAGGTACAATCTCTACACAGCGGAAGGCAAATATATCTTCAAGGAAAGAGAATCATTTGATGGCCGAAATATT
TTAAAGTTGTTTGAGAACTTCTACTTTGGCTCCCTAAAGCTGAATTCAATTCACATCTCTCAGAGGTTCACCGTAGACAGCTTTGGAAAC

>In-frame_TET1_ENST00000373644_chr10_70360791_+_ASCC1_ENST00000394915_chr10_73921432_-_2598nt
ATGTCTCGATCCCGCCATGCAAGGCCTTCCAGATTAGTCAGGAAGGAAGATGTAAACAAAAAAAAGAAAAACAGCCAACTACGAAAGACA
ACCAAGGGAGCCAACAAAAATGTGGCATCAGTCAAGACTTTAAGCCCTGGAAAATTAAAGCAATTAATTCAAGAAAGAGATGTTAAGAAA
AAAACAGAACCTAAACCACCCGTGCCAGTCAGAAGCCTTCTGACAAGAGCTGGAGCAGCACGCATGAATTTGGATAGGACTGAGGTTCTT
TTTCAGAACCCAGAGTCCTTAACCTGCAATGGGTTTACAATGGCGCTACGAAGCACCTCTCTTAGCAGGCGACTCTCCCAACCCCCACTG
GTCGTAGCCAAATCCAAAAAGGTTCCACTTTCTAAGGGTTTAGAAAAGCAACATGATTGTGATTATAAGATACTCCCTGCTTTGGGAGTA
AAGCACTCAGAAAATGATTCGGTTCCAATGCAAGACACCCAAGTCCTTCCTGATATAGAGACTCTAATTGGTGTACAAAATCCCTCTTTA
CTTAAAGGTAAGAGCCAAGAGACAACTCAGTTTTGGTCCCAAAGAGTTGAGGATTCCAAGATCAATATCCCTACCCACAGTGGCCCTGCA
GCTGAGATCCTTCCTGGGCCACTGGAAGGGACACGCTGTGGTGAAGGACTATTCTCTGAAGAGACATTGAATGATACCAGTGGTTCCCCA
AAAATGTTTGCTCAGGACACAGTGTGTGCTCCTTTTCCCCAAAGAGCAACCCCCAAAGTTACCTCTCAAGGAAACCCCAGCATTCAGTTA
GAAGAGTTGGGTTCACGAGTAGAATCTCTTAAGTTATCTGATTCTTACCTGGATCCCATTAAAAGTGAACATGATTGCTACCCCACCTCC
AGTCTTAATAAGGTTATACCTGACTTGAACCTTAGAAACTGCTTGGCTCTTGGTGGGTCTACGTCTCCTACCTCTGTAATAAAATTCCTC
TTGGCAGGCTCAAAACAAGCGACCCTTGGTGCTAAACCAGATCATCAAGAGGCCTTCGAAGCTACTGCAAATCAACAGGAAGTTTCTGAT
ACCACCTCTTTCCTAGGACAGGCCTTTGGTGCTATCCCACATCAATGGGAACTTCCTGGTGCTGACCCAGTTCATGGTGAGGCCCTGGGT
GAGACCCCAGATCTACCAGAGATTCCTGGTGCTATTCCAGTCCAAGGAGAGGTCTTTGGTACTATTTTAGACCAACAAGAAACTCTTGGT
ATGAGTGGGAGTGTTGTCCCAGACTTGCCTGTCTTCCTTCCTGTTCCTCCAAATCCAATTGCTACCTTTAATGCTCCTTCCAAATGGCCT
GAGCCCCAAAGCACTGTCTCATATGGACTTGCAGTCCAGGGTGCTATACAGATTTTGCCTTTGGGCTCAGGACACACTCCTCAATCATCA
TCAAACTCAGAGAAAAATTCATTACCTCCAGTAATGGCTATAAGCAATGTAGAAAATGAGAAGCAGGTTCATATAAGCTTCCTGCCAGCT
AACACTCAGGGGTTCCCATTAGCCCCTGAGAGAGGACTCTTCCATGCTTCACTGGGTATAGCCCAACTCTCTCAGGCTGGTCCTAGCAAA
TCAGACAGAGGGAGCTCCCAGGTCAGTGTAACCAGCACAGTTCATGTTGTCAACACCACAGTGGTGACTATGCCAGTGCCAATGGTCAGT
ACCTCCTCTTCTTCCTATACCACTTTGCTACCGACTTTGGAAAAGAAGAAAAGAAAGCGATGTGGGGTCTGTGAACCCTGCCAGCAGAAG
ACCAACTGTGGTGAATGCACTTACTGCAAGAACAGAAAGAACAGCCATCAGATCTGTAAGAAAAGAAAATGTGAGGAGCTGAAAAAGAAA
CCATCTGTTGTTGTGCCTCTGGAGGTTATAAAGGAAAACAAGAGGCCCCAGAGGGAAAAGAAGCCCAAAGTTTTAAAGGATCATGGGGTT
GACAGCAGCATTTTCCAGAATCCTAAAAAGCTTCATCTAACTATTGGGATGTTGGTGCTTTTGAGTGAGGAAGAGATCCAGCAGACATGT
GAGATGCTACAGCAGTGTAAAGAGGAATTCATTAATGATATTTCTGGGGGTAAACCCCTAGAAGTGGAGATGGCAGGGATAGAATACATG
AATGATGATCCTGGCATGGTGGATGTTCTTTACGCCAAAGTCCATATGAAAGATGGCTCCAACAGGCTACAAGAATTAGTTGATCGAGTG
CTGGAACGTTTTCAGGCATCTGGACTAATAGTGAAAGAGTGGAATAGTGTGAAACTGCATGCTACAGTTATGAATACACTATTCAGGAAA
GACCCCAATGCTGAAGGCAGGTACAATCTCTACACAGCGGAAGGCAAATATATCTTCAAGGAAAGAGAATCATTTGATGGCCGAAATATT
TTAAAGAGCTTTGCCTTGTTGCCCAGGCTGGAGTACAATGATGCAATCTCCGCTCACTGCAACCTGTGCCTCCCGGGTTCAAGTGATTCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_TET1_ENST00000373644_chr10_70360791_+_ASCC1_ENST00000394919_chr10_73921432_-_3576nt
GGCGCGAGTTGGAAAGTTTGCCCGAGGGCTGGTGCAGGCTTGGAGCTGGGGGCCGTGCGCTGCCCTGGGAATGTGACCCGGCCAGCGACC
AAAACCTTGTGTGACTGAGCTGAAGAGCAGTGCATCCAGATTCTCCTCAGAAGTGAGACTTTCCAAAGGACCAATGACTCTGTTTCCTGC
GCCCTTTCATTTTTTCCTACTCTGTAGCTATGTCTCGATCCCGCCATGCAAGGCCTTCCAGATTAGTCAGGAAGGAAGATGTAAACAAAA
AAAAGAAAAACAGCCAACTACGAAAGACAACCAAGGGAGCCAACAAAAATGTGGCATCAGTCAAGACTTTAAGCCCTGGAAAATTAAAGC
AATTAATTCAAGAAAGAGATGTTAAGAAAAAAACAGAACCTAAACCACCCGTGCCAGTCAGAAGCCTTCTGACAAGAGCTGGAGCAGCAC
GCATGAATTTGGATAGGACTGAGGTTCTTTTTCAGAACCCAGAGTCCTTAACCTGCAATGGGTTTACAATGGCGCTACGAAGCACCTCTC
TTAGCAGGCGACTCTCCCAACCCCCACTGGTCGTAGCCAAATCCAAAAAGGTTCCACTTTCTAAGGGTTTAGAAAAGCAACATGATTGTG
ATTATAAGATACTCCCTGCTTTGGGAGTAAAGCACTCAGAAAATGATTCGGTTCCAATGCAAGACACCCAAGTCCTTCCTGATATAGAGA
CTCTAATTGGTGTACAAAATCCCTCTTTACTTAAAGGTAAGAGCCAAGAGACAACTCAGTTTTGGTCCCAAAGAGTTGAGGATTCCAAGA
TCAATATCCCTACCCACAGTGGCCCTGCAGCTGAGATCCTTCCTGGGCCACTGGAAGGGACACGCTGTGGTGAAGGACTATTCTCTGAAG
AGACATTGAATGATACCAGTGGTTCCCCAAAAATGTTTGCTCAGGACACAGTGTGTGCTCCTTTTCCCCAAAGAGCAACCCCCAAAGTTA
CCTCTCAAGGAAACCCCAGCATTCAGTTAGAAGAGTTGGGTTCACGAGTAGAATCTCTTAAGTTATCTGATTCTTACCTGGATCCCATTA
AAAGTGAACATGATTGCTACCCCACCTCCAGTCTTAATAAGGTTATACCTGACTTGAACCTTAGAAACTGCTTGGCTCTTGGTGGGTCTA
CGTCTCCTACCTCTGTAATAAAATTCCTCTTGGCAGGCTCAAAACAAGCGACCCTTGGTGCTAAACCAGATCATCAAGAGGCCTTCGAAG
CTACTGCAAATCAACAGGAAGTTTCTGATACCACCTCTTTCCTAGGACAGGCCTTTGGTGCTATCCCACATCAATGGGAACTTCCTGGTG
CTGACCCAGTTCATGGTGAGGCCCTGGGTGAGACCCCAGATCTACCAGAGATTCCTGGTGCTATTCCAGTCCAAGGAGAGGTCTTTGGTA
CTATTTTAGACCAACAAGAAACTCTTGGTATGAGTGGGAGTGTTGTCCCAGACTTGCCTGTCTTCCTTCCTGTTCCTCCAAATCCAATTG
CTACCTTTAATGCTCCTTCCAAATGGCCTGAGCCCCAAAGCACTGTCTCATATGGACTTGCAGTCCAGGGTGCTATACAGATTTTGCCTT
TGGGCTCAGGACACACTCCTCAATCATCATCAAACTCAGAGAAAAATTCATTACCTCCAGTAATGGCTATAAGCAATGTAGAAAATGAGA
AGCAGGTTCATATAAGCTTCCTGCCAGCTAACACTCAGGGGTTCCCATTAGCCCCTGAGAGAGGACTCTTCCATGCTTCACTGGGTATAG
CCCAACTCTCTCAGGCTGGTCCTAGCAAATCAGACAGAGGGAGCTCCCAGGTCAGTGTAACCAGCACAGTTCATGTTGTCAACACCACAG
TGGTGACTATGCCAGTGCCAATGGTCAGTACCTCCTCTTCTTCCTATACCACTTTGCTACCGACTTTGGAAAAGAAGAAAAGAAAGCGAT
GTGGGGTCTGTGAACCCTGCCAGCAGAAGACCAACTGTGGTGAATGCACTTACTGCAAGAACAGAAAGAACAGCCATCAGATCTGTAAGA
AAAGAAAATGTGAGGAGCTGAAAAAGAAACCATCTGTTGTTGTGCCTCTGGAGGTTATAAAGGAAAACAAGAGGCCCCAGAGGGAAAAGA
AGCCCAAAGTTTTAAAGGATCATGGGGTTGACAGCAGCATTTTCCAGAATCCTAAAAAGCTTCATCTAACTATTGGGATGTTGGTGCTTT
TGAGTGAGGAAGAGATCCAGCAGACATGTGAGATGCTACAGCAGTGTAAAGAGGAATTCATTAATGATATTTCTGGGGGTAAACCCCTAG
AAGTGGAGATGGCAGGGATAGAATACATGAATGATGATCCTGGCATGGTGGATGTTCTTTACGCCAAAGTCCATATGAAAGATGGCTCCA
ACAGGCTACAAGAATTAGTTGATCGAGTGCTGGAACGTTTTCAGGCATCTGGACTAATAGTGAAAGAGTGGAATAGTGTGAAACTGCATG
CTACAGTTATGAATACACTATTCAGGAAAGACCCCAATGCTGAAGGCAGGTACAATCTCTACACAGCGGAAGGCAAATATATCTTCAAGG
AAAGAGAATCATTTGATGGCCGAAATATTTTAAAGTTGTTTGAGAACTTCTACTTTGGCTCCCTAAAGCTGAATTCAATTCACATCTCTC
AGAGGTTCACCGTAGACAGCTTTGGAAACTACGCTTCCTGTGGACAAATTGACTTCTCCTGAGGTGGATCTTGGAAAGCACTAGAAACTA
AACATCTTCACCAGGTGCTGAAGAAAAGTGTCTTCGTTTTAATTGCCAAGCAGGGATGTGGACATTTGGATGGTGACTTTCCTGGGTGGT
TCCCCATAGATTCACCATTGCCTCTAATGGTGTCTACACCCGTCATACTACCAGCTGAGATGGTGGTGGGCATAAGGAGAATTTGTGCCT
ATAACCCTTAGTGTGTTCTGGTTTTTTTTCTTTTAATTTTTAAATTGTCGTAAAATACTCATAAAACATACTGTCTTCACCATTTTTAAG
TGCACAGTTCAGTAACGTTAACTGTTAATACATTCATAATGCTGTGTGGCCGTCACCGCCGTCCATCTCCATAGGCTTCTCAGCTTGTAA
AATGGAAACTGTACCCATTAAACAGTAATTCCCACTCCTCCCAGCCCCCGCAGCCACCATTCTGCTTTCTGTCTCTCTGGTTTTGACTAT
TCTCAGTATCTCATATAAGTGGAATCATACAGTGACTTGTCTTTTTGTGACTGGCTTATTTCACTTAGCATAATGTCCTCAAGGTTCATC
CATGTTGTGTCAGGTGACAGGATTTCCTTCCTGTATTATACATATAATGGAATGTTCCGTTACATGTGCGTACCACACTCTGTTCCTCCA
TCAGTGAACACTTGGCTTGCTTCCTCTTGACTATTGGGAGTAGTGCTAATACAGACACGGGGGTGCAAATATCTCTTTGAGACTCTGCCT

>In-frame_TET1_ENST00000373644_chr10_70360791_+_ASCC1_ENST00000342444_chr10_73921432_-_3772nt
GGCGCGAGTTGGAAAGTTTGCCCGAGGGCTGGTGCAGGCTTGGAGCTGGGGGCCGTGCGCTGCCCTGGGAATGTGACCCGGCCAGCGACC
AAAACCTTGTGTGACTGAGCTGAAGAGCAGTGCATCCAGATTCTCCTCAGAAGTGAGACTTTCCAAAGGACCAATGACTCTGTTTCCTGC
GCCCTTTCATTTTTTCCTACTCTGTAGCTATGTCTCGATCCCGCCATGCAAGGCCTTCCAGATTAGTCAGGAAGGAAGATGTAAACAAAA
AAAAGAAAAACAGCCAACTACGAAAGACAACCAAGGGAGCCAACAAAAATGTGGCATCAGTCAAGACTTTAAGCCCTGGAAAATTAAAGC
AATTAATTCAAGAAAGAGATGTTAAGAAAAAAACAGAACCTAAACCACCCGTGCCAGTCAGAAGCCTTCTGACAAGAGCTGGAGCAGCAC
GCATGAATTTGGATAGGACTGAGGTTCTTTTTCAGAACCCAGAGTCCTTAACCTGCAATGGGTTTACAATGGCGCTACGAAGCACCTCTC
TTAGCAGGCGACTCTCCCAACCCCCACTGGTCGTAGCCAAATCCAAAAAGGTTCCACTTTCTAAGGGTTTAGAAAAGCAACATGATTGTG
ATTATAAGATACTCCCTGCTTTGGGAGTAAAGCACTCAGAAAATGATTCGGTTCCAATGCAAGACACCCAAGTCCTTCCTGATATAGAGA
CTCTAATTGGTGTACAAAATCCCTCTTTACTTAAAGGTAAGAGCCAAGAGACAACTCAGTTTTGGTCCCAAAGAGTTGAGGATTCCAAGA
TCAATATCCCTACCCACAGTGGCCCTGCAGCTGAGATCCTTCCTGGGCCACTGGAAGGGACACGCTGTGGTGAAGGACTATTCTCTGAAG
AGACATTGAATGATACCAGTGGTTCCCCAAAAATGTTTGCTCAGGACACAGTGTGTGCTCCTTTTCCCCAAAGAGCAACCCCCAAAGTTA
CCTCTCAAGGAAACCCCAGCATTCAGTTAGAAGAGTTGGGTTCACGAGTAGAATCTCTTAAGTTATCTGATTCTTACCTGGATCCCATTA
AAAGTGAACATGATTGCTACCCCACCTCCAGTCTTAATAAGGTTATACCTGACTTGAACCTTAGAAACTGCTTGGCTCTTGGTGGGTCTA
CGTCTCCTACCTCTGTAATAAAATTCCTCTTGGCAGGCTCAAAACAAGCGACCCTTGGTGCTAAACCAGATCATCAAGAGGCCTTCGAAG
CTACTGCAAATCAACAGGAAGTTTCTGATACCACCTCTTTCCTAGGACAGGCCTTTGGTGCTATCCCACATCAATGGGAACTTCCTGGTG
CTGACCCAGTTCATGGTGAGGCCCTGGGTGAGACCCCAGATCTACCAGAGATTCCTGGTGCTATTCCAGTCCAAGGAGAGGTCTTTGGTA
CTATTTTAGACCAACAAGAAACTCTTGGTATGAGTGGGAGTGTTGTCCCAGACTTGCCTGTCTTCCTTCCTGTTCCTCCAAATCCAATTG
CTACCTTTAATGCTCCTTCCAAATGGCCTGAGCCCCAAAGCACTGTCTCATATGGACTTGCAGTCCAGGGTGCTATACAGATTTTGCCTT
TGGGCTCAGGACACACTCCTCAATCATCATCAAACTCAGAGAAAAATTCATTACCTCCAGTAATGGCTATAAGCAATGTAGAAAATGAGA
AGCAGGTTCATATAAGCTTCCTGCCAGCTAACACTCAGGGGTTCCCATTAGCCCCTGAGAGAGGACTCTTCCATGCTTCACTGGGTATAG
CCCAACTCTCTCAGGCTGGTCCTAGCAAATCAGACAGAGGGAGCTCCCAGGTCAGTGTAACCAGCACAGTTCATGTTGTCAACACCACAG
TGGTGACTATGCCAGTGCCAATGGTCAGTACCTCCTCTTCTTCCTATACCACTTTGCTACCGACTTTGGAAAAGAAGAAAAGAAAGCGAT
GTGGGGTCTGTGAACCCTGCCAGCAGAAGACCAACTGTGGTGAATGCACTTACTGCAAGAACAGAAAGAACAGCCATCAGATCTGTAAGA
AAAGAAAATGTGAGGAGCTGAAAAAGAAACCATCTGTTGTTGTGCCTCTGGAGGTTATAAAGGAAAACAAGAGGCCCCAGAGGGAAAAGA
AGCCCAAAGTTTTAAAGGATCATGGGGTTGACAGCAGCATTTTCCAGAATCCTAAAAAGCTTCATCTAACTATTGGGATGTTGGTGCTTT
TGAGTGAGGAAGAGATCCAGCAGACATGTGAGATGCTACAGCAGTGTAAAGAGGAATTCATTAATGATATTTCTGGGGGTAAACCCCTAG
AAGTGGAGATGGCAGGGATAGAATACATGAATGATGATCCTGGCATGGTGGATGTTCTTTACGCCAAAGTCCATATGAAAGATGGCTCCA
ACAGGCTACAAGAATTAGTTGATCGAGTGCTGGAACGTTTTCAGGCATCTGGACTAATAGTGAAAGAGTGGAATAGTGTGAAACTGCATG
CTACAGTTATGAATACACTATTCAGGAAAGACCCCAATGCTGAAGGCAGGTACAATCTCTACACAGCGGAAGGCAAATATATCTTCAAGG
AAAGAGAATCATTTGATGGCCGAAATATTTTAAAGAGCTTTGCCTTGTTGCCCAGGCTGGAGTACAATGATGCAATCTCCGCTCACTGCA
ACCTGTGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGTCTCTGATGCATATTCTCAGAGCC
TACCAGGAAAATCCTAGAATCGAGAAGGGCTTGGGACACAGAGAGCTAGTGGTTGTTTGAGAACTTCTACTTTGGCTCCCTAAAGCTGAA
TTCAATTCACATCTCTCAGAGGTTCACCGTAGACAGCTTTGGAAACTACGCTTCCTGTGGACAAATTGACTTCTCCTGAGGTGGATCTTG
GAAAGCACTAGAAACTAAACATCTTCACCAGGTGCTGAAGAAAAGTGTCTTCGTTTTAATTGCCAAGCAGGGATGTGGACATTTGGATGG
TGACTTTCCTGGGTGGTTCCCCATAGATTCACCATTGCCTCTAATGGTGTCTACACCCGTCATACTACCAGCTGAGATGGTGGTGGGCAT
AAGGAGAATTTGTGCCTATAACCCTTAGTGTGTTCTGGTTTTTTTTCTTTTAATTTTTAAATTGTCGTAAAATACTCATAAAACATACTG
TCTTCACCATTTTTAAGTGCACAGTTCAGTAACGTTAACTGTTAATACATTCATAATGCTGTGTGGCCGTCACCGCCGTCCATCTCCATA
GGCTTCTCAGCTTGTAAAATGGAAACTGTACCCATTAAACAGTAATTCCCACTCCTCCCAGCCCCCGCAGCCACCATTCTGCTTTCTGTC
TCTCTGGTTTTGACTATTCTCAGTATCTCATATAAGTGGAATCATACAGTGACTTGTCTTTTTGTGACTGGCTTATTTCACTTAGCATAA
TGTCCTCAAGGTTCATCCATGTTGTGTCAGGTGACAGGATTTCCTTCCTGTATTATACATATAATGGAATGTTCCGTTACATGTGCGTAC
CACACTCTGTTCCTCCATCAGTGAACACTTGGCTTGCTTCCTCTTGACTATTGGGAGTAGTGCTAATACAGACACGGGGGTGCAAATATC

>In-frame_TET1_ENST00000373644_chr10_70360791_+_ASCC1_ENST00000317168_chr10_73921432_-_3575nt
GGCGCGAGTTGGAAAGTTTGCCCGAGGGCTGGTGCAGGCTTGGAGCTGGGGGCCGTGCGCTGCCCTGGGAATGTGACCCGGCCAGCGACC
AAAACCTTGTGTGACTGAGCTGAAGAGCAGTGCATCCAGATTCTCCTCAGAAGTGAGACTTTCCAAAGGACCAATGACTCTGTTTCCTGC
GCCCTTTCATTTTTTCCTACTCTGTAGCTATGTCTCGATCCCGCCATGCAAGGCCTTCCAGATTAGTCAGGAAGGAAGATGTAAACAAAA
AAAAGAAAAACAGCCAACTACGAAAGACAACCAAGGGAGCCAACAAAAATGTGGCATCAGTCAAGACTTTAAGCCCTGGAAAATTAAAGC
AATTAATTCAAGAAAGAGATGTTAAGAAAAAAACAGAACCTAAACCACCCGTGCCAGTCAGAAGCCTTCTGACAAGAGCTGGAGCAGCAC
GCATGAATTTGGATAGGACTGAGGTTCTTTTTCAGAACCCAGAGTCCTTAACCTGCAATGGGTTTACAATGGCGCTACGAAGCACCTCTC
TTAGCAGGCGACTCTCCCAACCCCCACTGGTCGTAGCCAAATCCAAAAAGGTTCCACTTTCTAAGGGTTTAGAAAAGCAACATGATTGTG
ATTATAAGATACTCCCTGCTTTGGGAGTAAAGCACTCAGAAAATGATTCGGTTCCAATGCAAGACACCCAAGTCCTTCCTGATATAGAGA
CTCTAATTGGTGTACAAAATCCCTCTTTACTTAAAGGTAAGAGCCAAGAGACAACTCAGTTTTGGTCCCAAAGAGTTGAGGATTCCAAGA
TCAATATCCCTACCCACAGTGGCCCTGCAGCTGAGATCCTTCCTGGGCCACTGGAAGGGACACGCTGTGGTGAAGGACTATTCTCTGAAG
AGACATTGAATGATACCAGTGGTTCCCCAAAAATGTTTGCTCAGGACACAGTGTGTGCTCCTTTTCCCCAAAGAGCAACCCCCAAAGTTA
CCTCTCAAGGAAACCCCAGCATTCAGTTAGAAGAGTTGGGTTCACGAGTAGAATCTCTTAAGTTATCTGATTCTTACCTGGATCCCATTA
AAAGTGAACATGATTGCTACCCCACCTCCAGTCTTAATAAGGTTATACCTGACTTGAACCTTAGAAACTGCTTGGCTCTTGGTGGGTCTA
CGTCTCCTACCTCTGTAATAAAATTCCTCTTGGCAGGCTCAAAACAAGCGACCCTTGGTGCTAAACCAGATCATCAAGAGGCCTTCGAAG
CTACTGCAAATCAACAGGAAGTTTCTGATACCACCTCTTTCCTAGGACAGGCCTTTGGTGCTATCCCACATCAATGGGAACTTCCTGGTG
CTGACCCAGTTCATGGTGAGGCCCTGGGTGAGACCCCAGATCTACCAGAGATTCCTGGTGCTATTCCAGTCCAAGGAGAGGTCTTTGGTA
CTATTTTAGACCAACAAGAAACTCTTGGTATGAGTGGGAGTGTTGTCCCAGACTTGCCTGTCTTCCTTCCTGTTCCTCCAAATCCAATTG
CTACCTTTAATGCTCCTTCCAAATGGCCTGAGCCCCAAAGCACTGTCTCATATGGACTTGCAGTCCAGGGTGCTATACAGATTTTGCCTT
TGGGCTCAGGACACACTCCTCAATCATCATCAAACTCAGAGAAAAATTCATTACCTCCAGTAATGGCTATAAGCAATGTAGAAAATGAGA
AGCAGGTTCATATAAGCTTCCTGCCAGCTAACACTCAGGGGTTCCCATTAGCCCCTGAGAGAGGACTCTTCCATGCTTCACTGGGTATAG
CCCAACTCTCTCAGGCTGGTCCTAGCAAATCAGACAGAGGGAGCTCCCAGGTCAGTGTAACCAGCACAGTTCATGTTGTCAACACCACAG
TGGTGACTATGCCAGTGCCAATGGTCAGTACCTCCTCTTCTTCCTATACCACTTTGCTACCGACTTTGGAAAAGAAGAAAAGAAAGCGAT
GTGGGGTCTGTGAACCCTGCCAGCAGAAGACCAACTGTGGTGAATGCACTTACTGCAAGAACAGAAAGAACAGCCATCAGATCTGTAAGA
AAAGAAAATGTGAGGAGCTGAAAAAGAAACCATCTGTTGTTGTGCCTCTGGAGGTTATAAAGGAAAACAAGAGGCCCCAGAGGGAAAAGA
AGCCCAAAGTTTTAAAGGATCATGGGGTTGACAGCAGCATTTTCCAGAATCCTAAAAAGCTTCATCTAACTATTGGGATGTTGGTGCTTT
TGAGTGAGGAAGAGATCCAGCAGACATGTGAGATGCTACAGCAGTGTAAAGAGGAATTCATTAATGATATTTCTGGGGGTAAACCCCTAG
AAGTGGAGATGGCAGGGATAGAATACATGAATGATGATCCTGGCATGGTGGATGTTCTTTACGCCAAAGTCCATATGAAAGATGGCTCCA
ACAGGCTACAAGAATTAGTTGATCGAGTGCTGGAACGTTTTCAGGCATCTGGACTAATAGTGAAAGAGTGGAATAGTGTGAAACTGCATG
CTACAGTTATGAATACACTATTCAGGAAAGACCCCAATGCTGAAGGCAGGTACAATCTCTACACAGCGGAAGGCAAATATATCTTCAAGG
AAAGAGAATCATTTGATGGCCGAAATATTTTAAAGTTGTTTGAGAACTTCTACTTTGGCTCCCTAAAGCTGAATTCAATTCACATCTCTC
AGAGGTTCACCGTAGACAGCTTTGGAAACTACGCTTCCTGTGGACAAATTGACTTCTCCTGAGGTGGATCTTGGAAAGCACTAGAAACTA
AACATCTTCACCAGGTGCTGAAGAAAAGTGTCTTCGTTTTAATTGCCAAGCAGGGATGTGGACATTTGGATGGTGACTTTCCTGGGTGGT
TCCCCATAGATTCACCATTGCCTCTAATGGTGTCTACACCCGTCATACTACCAGCTGAGATGGTGGTGGGCATAAGGAGAATTTGTGCCT
ATAACCCTTAGTGTGTTCTGGTTTTTTTTCTTTTAATTTTTAAATTGTCGTAAAATACTCATAAAACATACTGTCTTCACCATTTTTAAG
TGCACAGTTCAGTAACGTTAACTGTTAATACATTCATAATGCTGTGTGGCCGTCACCGCCGTCCATCTCCATAGGCTTCTCAGCTTGTAA
AATGGAAACTGTACCCATTAAACAGTAATTCCCACTCCTCCCAGCCCCCGCAGCCACCATTCTGCTTTCTGTCTCTCTGGTTTTGACTAT
TCTCAGTATCTCATATAAGTGGAATCATACAGTGACTTGTCTTTTTGTGACTGGCTTATTTCACTTAGCATAATGTCCTCAAGGTTCATC
CATGTTGTGTCAGGTGACAGGATTTCCTTCCTGTATTATACATATAATGGAATGTTCCGTTACATGTGCGTACCACACTCTGTTCCTCCA
TCAGTGAACACTTGGCTTGCTTCCTCTTGACTATTGGGAGTAGTGCTAATACAGACACGGGGGTGCAAATATCTCTTTGAGACTCTGCCT

>In-frame_TET1_ENST00000373644_chr10_70360791_+_ASCC1_ENST00000545550_chr10_73921432_-_2842nt
GGCGCGAGTTGGAAAGTTTGCCCGAGGGCTGGTGCAGGCTTGGAGCTGGGGGCCGTGCGCTGCCCTGGGAATGTGACCCGGCCAGCGACC
AAAACCTTGTGTGACTGAGCTGAAGAGCAGTGCATCCAGATTCTCCTCAGAAGTGAGACTTTCCAAAGGACCAATGACTCTGTTTCCTGC
GCCCTTTCATTTTTTCCTACTCTGTAGCTATGTCTCGATCCCGCCATGCAAGGCCTTCCAGATTAGTCAGGAAGGAAGATGTAAACAAAA
AAAAGAAAAACAGCCAACTACGAAAGACAACCAAGGGAGCCAACAAAAATGTGGCATCAGTCAAGACTTTAAGCCCTGGAAAATTAAAGC
AATTAATTCAAGAAAGAGATGTTAAGAAAAAAACAGAACCTAAACCACCCGTGCCAGTCAGAAGCCTTCTGACAAGAGCTGGAGCAGCAC
GCATGAATTTGGATAGGACTGAGGTTCTTTTTCAGAACCCAGAGTCCTTAACCTGCAATGGGTTTACAATGGCGCTACGAAGCACCTCTC
TTAGCAGGCGACTCTCCCAACCCCCACTGGTCGTAGCCAAATCCAAAAAGGTTCCACTTTCTAAGGGTTTAGAAAAGCAACATGATTGTG
ATTATAAGATACTCCCTGCTTTGGGAGTAAAGCACTCAGAAAATGATTCGGTTCCAATGCAAGACACCCAAGTCCTTCCTGATATAGAGA
CTCTAATTGGTGTACAAAATCCCTCTTTACTTAAAGGTAAGAGCCAAGAGACAACTCAGTTTTGGTCCCAAAGAGTTGAGGATTCCAAGA
TCAATATCCCTACCCACAGTGGCCCTGCAGCTGAGATCCTTCCTGGGCCACTGGAAGGGACACGCTGTGGTGAAGGACTATTCTCTGAAG
AGACATTGAATGATACCAGTGGTTCCCCAAAAATGTTTGCTCAGGACACAGTGTGTGCTCCTTTTCCCCAAAGAGCAACCCCCAAAGTTA
CCTCTCAAGGAAACCCCAGCATTCAGTTAGAAGAGTTGGGTTCACGAGTAGAATCTCTTAAGTTATCTGATTCTTACCTGGATCCCATTA
AAAGTGAACATGATTGCTACCCCACCTCCAGTCTTAATAAGGTTATACCTGACTTGAACCTTAGAAACTGCTTGGCTCTTGGTGGGTCTA
CGTCTCCTACCTCTGTAATAAAATTCCTCTTGGCAGGCTCAAAACAAGCGACCCTTGGTGCTAAACCAGATCATCAAGAGGCCTTCGAAG
CTACTGCAAATCAACAGGAAGTTTCTGATACCACCTCTTTCCTAGGACAGGCCTTTGGTGCTATCCCACATCAATGGGAACTTCCTGGTG
CTGACCCAGTTCATGGTGAGGCCCTGGGTGAGACCCCAGATCTACCAGAGATTCCTGGTGCTATTCCAGTCCAAGGAGAGGTCTTTGGTA
CTATTTTAGACCAACAAGAAACTCTTGGTATGAGTGGGAGTGTTGTCCCAGACTTGCCTGTCTTCCTTCCTGTTCCTCCAAATCCAATTG
CTACCTTTAATGCTCCTTCCAAATGGCCTGAGCCCCAAAGCACTGTCTCATATGGACTTGCAGTCCAGGGTGCTATACAGATTTTGCCTT
TGGGCTCAGGACACACTCCTCAATCATCATCAAACTCAGAGAAAAATTCATTACCTCCAGTAATGGCTATAAGCAATGTAGAAAATGAGA
AGCAGGTTCATATAAGCTTCCTGCCAGCTAACACTCAGGGGTTCCCATTAGCCCCTGAGAGAGGACTCTTCCATGCTTCACTGGGTATAG
CCCAACTCTCTCAGGCTGGTCCTAGCAAATCAGACAGAGGGAGCTCCCAGGTCAGTGTAACCAGCACAGTTCATGTTGTCAACACCACAG
TGGTGACTATGCCAGTGCCAATGGTCAGTACCTCCTCTTCTTCCTATACCACTTTGCTACCGACTTTGGAAAAGAAGAAAAGAAAGCGAT
GTGGGGTCTGTGAACCCTGCCAGCAGAAGACCAACTGTGGTGAATGCACTTACTGCAAGAACAGAAAGAACAGCCATCAGATCTGTAAGA
AAAGAAAATGTGAGGAGCTGAAAAAGAAACCATCTGTTGTTGTGCCTCTGGAGGTTATAAAGGAAAACAAGAGGCCCCAGAGGGAAAAGA
AGCCCAAAGTTTTAAAGGATCATGGGGTTGACAGCAGCATTTTCCAGAATCCTAAAAAGCTTCATCTAACTATTGGGATGTTGGTGCTTT
TGAGTGAGGAAGAGATCCAGCAGACATGTGAGATGCTACAGCAGTGTAAAGAGGAATTCATTAATGATATTTCTGGGGGTAAACCCCTAG
AAGTGGAGATGGCAGGGATAGAATACATGAATGATGATCCTGGCATGGTGGATGTTCTTTACGCCAAAGTCCATATGAAAGATGGCTCCA
ACAGGCTACAAGAATTAGTTGATCGAGTGCTGGAACGTTTTCAGGCATCTGGACTAATAGTGAAAGAGTGGAATAGTGTGAAACTGCATG
CTACAGTTATGAATACACTATTCAGGAAAGACCCCAATGCTGAAGGCAGGTACAATCTCTACACAGCGGAAGGCAAATATATCTTCAAGG
AAAGAGAATCATTTGATGGCCGAAATATTTTAAAGTTGTTTGAGAACTTCTACTTTGGCTCCCTAAAGCTGAATTCAATTCACATCTCTC
AGAGGTTCACCGTAGACAGCTTTGGAAACTACGCTTCCTGTGGACAAATTGACTTCTCCTGAGGTGGATCTTGGAAAGCACTAGAAACTA

>In-frame_TET1_ENST00000373644_chr10_70360791_+_ASCC1_ENST00000317126_chr10_73921432_-_2842nt
GGCGCGAGTTGGAAAGTTTGCCCGAGGGCTGGTGCAGGCTTGGAGCTGGGGGCCGTGCGCTGCCCTGGGAATGTGACCCGGCCAGCGACC
AAAACCTTGTGTGACTGAGCTGAAGAGCAGTGCATCCAGATTCTCCTCAGAAGTGAGACTTTCCAAAGGACCAATGACTCTGTTTCCTGC
GCCCTTTCATTTTTTCCTACTCTGTAGCTATGTCTCGATCCCGCCATGCAAGGCCTTCCAGATTAGTCAGGAAGGAAGATGTAAACAAAA
AAAAGAAAAACAGCCAACTACGAAAGACAACCAAGGGAGCCAACAAAAATGTGGCATCAGTCAAGACTTTAAGCCCTGGAAAATTAAAGC
AATTAATTCAAGAAAGAGATGTTAAGAAAAAAACAGAACCTAAACCACCCGTGCCAGTCAGAAGCCTTCTGACAAGAGCTGGAGCAGCAC
GCATGAATTTGGATAGGACTGAGGTTCTTTTTCAGAACCCAGAGTCCTTAACCTGCAATGGGTTTACAATGGCGCTACGAAGCACCTCTC
TTAGCAGGCGACTCTCCCAACCCCCACTGGTCGTAGCCAAATCCAAAAAGGTTCCACTTTCTAAGGGTTTAGAAAAGCAACATGATTGTG
ATTATAAGATACTCCCTGCTTTGGGAGTAAAGCACTCAGAAAATGATTCGGTTCCAATGCAAGACACCCAAGTCCTTCCTGATATAGAGA
CTCTAATTGGTGTACAAAATCCCTCTTTACTTAAAGGTAAGAGCCAAGAGACAACTCAGTTTTGGTCCCAAAGAGTTGAGGATTCCAAGA
TCAATATCCCTACCCACAGTGGCCCTGCAGCTGAGATCCTTCCTGGGCCACTGGAAGGGACACGCTGTGGTGAAGGACTATTCTCTGAAG
AGACATTGAATGATACCAGTGGTTCCCCAAAAATGTTTGCTCAGGACACAGTGTGTGCTCCTTTTCCCCAAAGAGCAACCCCCAAAGTTA
CCTCTCAAGGAAACCCCAGCATTCAGTTAGAAGAGTTGGGTTCACGAGTAGAATCTCTTAAGTTATCTGATTCTTACCTGGATCCCATTA
AAAGTGAACATGATTGCTACCCCACCTCCAGTCTTAATAAGGTTATACCTGACTTGAACCTTAGAAACTGCTTGGCTCTTGGTGGGTCTA
CGTCTCCTACCTCTGTAATAAAATTCCTCTTGGCAGGCTCAAAACAAGCGACCCTTGGTGCTAAACCAGATCATCAAGAGGCCTTCGAAG
CTACTGCAAATCAACAGGAAGTTTCTGATACCACCTCTTTCCTAGGACAGGCCTTTGGTGCTATCCCACATCAATGGGAACTTCCTGGTG
CTGACCCAGTTCATGGTGAGGCCCTGGGTGAGACCCCAGATCTACCAGAGATTCCTGGTGCTATTCCAGTCCAAGGAGAGGTCTTTGGTA
CTATTTTAGACCAACAAGAAACTCTTGGTATGAGTGGGAGTGTTGTCCCAGACTTGCCTGTCTTCCTTCCTGTTCCTCCAAATCCAATTG
CTACCTTTAATGCTCCTTCCAAATGGCCTGAGCCCCAAAGCACTGTCTCATATGGACTTGCAGTCCAGGGTGCTATACAGATTTTGCCTT
TGGGCTCAGGACACACTCCTCAATCATCATCAAACTCAGAGAAAAATTCATTACCTCCAGTAATGGCTATAAGCAATGTAGAAAATGAGA
AGCAGGTTCATATAAGCTTCCTGCCAGCTAACACTCAGGGGTTCCCATTAGCCCCTGAGAGAGGACTCTTCCATGCTTCACTGGGTATAG
CCCAACTCTCTCAGGCTGGTCCTAGCAAATCAGACAGAGGGAGCTCCCAGGTCAGTGTAACCAGCACAGTTCATGTTGTCAACACCACAG
TGGTGACTATGCCAGTGCCAATGGTCAGTACCTCCTCTTCTTCCTATACCACTTTGCTACCGACTTTGGAAAAGAAGAAAAGAAAGCGAT
GTGGGGTCTGTGAACCCTGCCAGCAGAAGACCAACTGTGGTGAATGCACTTACTGCAAGAACAGAAAGAACAGCCATCAGATCTGTAAGA
AAAGAAAATGTGAGGAGCTGAAAAAGAAACCATCTGTTGTTGTGCCTCTGGAGGTTATAAAGGAAAACAAGAGGCCCCAGAGGGAAAAGA
AGCCCAAAGTTTTAAAGGATCATGGGGTTGACAGCAGCATTTTCCAGAATCCTAAAAAGCTTCATCTAACTATTGGGATGTTGGTGCTTT
TGAGTGAGGAAGAGATCCAGCAGACATGTGAGATGCTACAGCAGTGTAAAGAGGAATTCATTAATGATATTTCTGGGGGTAAACCCCTAG
AAGTGGAGATGGCAGGGATAGAATACATGAATGATGATCCTGGCATGGTGGATGTTCTTTACGCCAAAGTCCATATGAAAGATGGCTCCA
ACAGGCTACAAGAATTAGTTGATCGAGTGCTGGAACGTTTTCAGGCATCTGGACTAATAGTGAAAGAGTGGAATAGTGTGAAACTGCATG
CTACAGTTATGAATACACTATTCAGGAAAGACCCCAATGCTGAAGGCAGGTACAATCTCTACACAGCGGAAGGCAAATATATCTTCAAGG
AAAGAGAATCATTTGATGGCCGAAATATTTTAAAGTTGTTTGAGAACTTCTACTTTGGCTCCCTAAAGCTGAATTCAATTCACATCTCTC
AGAGGTTCACCGTAGACAGCTTTGGAAACTACGCTTCCTGTGGACAAATTGACTTCTCCTGAGGTGGATCTTGGAAAGCACTAGAAACTA

>In-frame_TET1_ENST00000373644_chr10_70360791_+_ASCC1_ENST00000394915_chr10_73921432_-_2807nt
GGCGCGAGTTGGAAAGTTTGCCCGAGGGCTGGTGCAGGCTTGGAGCTGGGGGCCGTGCGCTGCCCTGGGAATGTGACCCGGCCAGCGACC
AAAACCTTGTGTGACTGAGCTGAAGAGCAGTGCATCCAGATTCTCCTCAGAAGTGAGACTTTCCAAAGGACCAATGACTCTGTTTCCTGC
GCCCTTTCATTTTTTCCTACTCTGTAGCTATGTCTCGATCCCGCCATGCAAGGCCTTCCAGATTAGTCAGGAAGGAAGATGTAAACAAAA
AAAAGAAAAACAGCCAACTACGAAAGACAACCAAGGGAGCCAACAAAAATGTGGCATCAGTCAAGACTTTAAGCCCTGGAAAATTAAAGC
AATTAATTCAAGAAAGAGATGTTAAGAAAAAAACAGAACCTAAACCACCCGTGCCAGTCAGAAGCCTTCTGACAAGAGCTGGAGCAGCAC
GCATGAATTTGGATAGGACTGAGGTTCTTTTTCAGAACCCAGAGTCCTTAACCTGCAATGGGTTTACAATGGCGCTACGAAGCACCTCTC
TTAGCAGGCGACTCTCCCAACCCCCACTGGTCGTAGCCAAATCCAAAAAGGTTCCACTTTCTAAGGGTTTAGAAAAGCAACATGATTGTG
ATTATAAGATACTCCCTGCTTTGGGAGTAAAGCACTCAGAAAATGATTCGGTTCCAATGCAAGACACCCAAGTCCTTCCTGATATAGAGA
CTCTAATTGGTGTACAAAATCCCTCTTTACTTAAAGGTAAGAGCCAAGAGACAACTCAGTTTTGGTCCCAAAGAGTTGAGGATTCCAAGA
TCAATATCCCTACCCACAGTGGCCCTGCAGCTGAGATCCTTCCTGGGCCACTGGAAGGGACACGCTGTGGTGAAGGACTATTCTCTGAAG
AGACATTGAATGATACCAGTGGTTCCCCAAAAATGTTTGCTCAGGACACAGTGTGTGCTCCTTTTCCCCAAAGAGCAACCCCCAAAGTTA
CCTCTCAAGGAAACCCCAGCATTCAGTTAGAAGAGTTGGGTTCACGAGTAGAATCTCTTAAGTTATCTGATTCTTACCTGGATCCCATTA
AAAGTGAACATGATTGCTACCCCACCTCCAGTCTTAATAAGGTTATACCTGACTTGAACCTTAGAAACTGCTTGGCTCTTGGTGGGTCTA
CGTCTCCTACCTCTGTAATAAAATTCCTCTTGGCAGGCTCAAAACAAGCGACCCTTGGTGCTAAACCAGATCATCAAGAGGCCTTCGAAG
CTACTGCAAATCAACAGGAAGTTTCTGATACCACCTCTTTCCTAGGACAGGCCTTTGGTGCTATCCCACATCAATGGGAACTTCCTGGTG
CTGACCCAGTTCATGGTGAGGCCCTGGGTGAGACCCCAGATCTACCAGAGATTCCTGGTGCTATTCCAGTCCAAGGAGAGGTCTTTGGTA
CTATTTTAGACCAACAAGAAACTCTTGGTATGAGTGGGAGTGTTGTCCCAGACTTGCCTGTCTTCCTTCCTGTTCCTCCAAATCCAATTG
CTACCTTTAATGCTCCTTCCAAATGGCCTGAGCCCCAAAGCACTGTCTCATATGGACTTGCAGTCCAGGGTGCTATACAGATTTTGCCTT
TGGGCTCAGGACACACTCCTCAATCATCATCAAACTCAGAGAAAAATTCATTACCTCCAGTAATGGCTATAAGCAATGTAGAAAATGAGA
AGCAGGTTCATATAAGCTTCCTGCCAGCTAACACTCAGGGGTTCCCATTAGCCCCTGAGAGAGGACTCTTCCATGCTTCACTGGGTATAG
CCCAACTCTCTCAGGCTGGTCCTAGCAAATCAGACAGAGGGAGCTCCCAGGTCAGTGTAACCAGCACAGTTCATGTTGTCAACACCACAG
TGGTGACTATGCCAGTGCCAATGGTCAGTACCTCCTCTTCTTCCTATACCACTTTGCTACCGACTTTGGAAAAGAAGAAAAGAAAGCGAT
GTGGGGTCTGTGAACCCTGCCAGCAGAAGACCAACTGTGGTGAATGCACTTACTGCAAGAACAGAAAGAACAGCCATCAGATCTGTAAGA
AAAGAAAATGTGAGGAGCTGAAAAAGAAACCATCTGTTGTTGTGCCTCTGGAGGTTATAAAGGAAAACAAGAGGCCCCAGAGGGAAAAGA
AGCCCAAAGTTTTAAAGGATCATGGGGTTGACAGCAGCATTTTCCAGAATCCTAAAAAGCTTCATCTAACTATTGGGATGTTGGTGCTTT
TGAGTGAGGAAGAGATCCAGCAGACATGTGAGATGCTACAGCAGTGTAAAGAGGAATTCATTAATGATATTTCTGGGGGTAAACCCCTAG
AAGTGGAGATGGCAGGGATAGAATACATGAATGATGATCCTGGCATGGTGGATGTTCTTTACGCCAAAGTCCATATGAAAGATGGCTCCA
ACAGGCTACAAGAATTAGTTGATCGAGTGCTGGAACGTTTTCAGGCATCTGGACTAATAGTGAAAGAGTGGAATAGTGTGAAACTGCATG
CTACAGTTATGAATACACTATTCAGGAAAGACCCCAATGCTGAAGGCAGGTACAATCTCTACACAGCGGAAGGCAAATATATCTTCAAGG
AAAGAGAATCATTTGATGGCCGAAATATTTTAAAGAGCTTTGCCTTGTTGCCCAGGCTGGAGTACAATGATGCAATCTCCGCTCACTGCA
ACCTGTGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGTCTCTGATGCATATTCTCAGAGCC


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FusionGenePPI for TET1_ASCC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TET1MBD3, VPRBP, DDB1ASCC1NCOA6, ELAVL1, UFSP2, ESR1, EP300, NCOA1, TRAF2, ALKBH3, IGKC, ASCC3, IGHG2, IGHG1, ASCC2, TRIP4, SERPINB3, PNMA2, CPA4, FGB, C3, IGLL5, FGG, CALML5, XPO1, CSNK2A2, SOD1, AURKA, FGFR1OP, SMC6, SKA1, CSRP1, SERPINB4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTET1chr10:70360791chr10:73921432ENST00000373644+3121580_15936562137DNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TET1_ASCC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TET1_ASCC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTET1C0033975Psychotic Disorders1PSYGENET
HgeneTET1C0036341Schizophrenia1PSYGENET
HgeneTET1C0349204Nonorganic psychosis1PSYGENET
HgeneTET1C1510586Autism Spectrum Disorders1CTD_human