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Fusion gene ID: 37744 |
FusionGeneSummary for TERF2_COG4 |
Fusion gene summary |
Fusion gene information | Fusion gene name: TERF2_COG4 | Fusion gene ID: 37744 | Hgene | Tgene | Gene symbol | TERF2 | COG4 | Gene ID | 7014 | 25839 |
Gene name | telomeric repeat binding factor 2 | component of oligomeric golgi complex 4 | |
Synonyms | TRBF2|TRF2 | CDG2J|COD1 | |
Cytomap | 16q22.1 | 16q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | telomeric repeat-binding factor 2TTAGGG repeat-binding factor 2telomeric DNA-binding proteintelomeric repeat binding protein 2 | conserved oligomeric Golgi complex subunit 4COG complex subunit 4complexed with Dor1pconserved oligomeric Golgi complex protein 4 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q15554 | Q9H9E3 | |
Ensembl transtripts involved in fusion gene | ENST00000254942, ENST00000603068, ENST00000569611, ENST00000567296, | ENST00000323786, ENST00000393612, ENST00000564653, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 8 X 7 X 8=448 |
# samples | 2 | 12 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(12/448*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TERF2 [Title/Abstract] AND COG4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TERF2 | GO:0031627 | telomeric loop formation | 10338214 |
Hgene | TERF2 | GO:0032205 | negative regulation of telomere maintenance | 17055345 |
Hgene | TERF2 | GO:0032210 | regulation of telomere maintenance via telomerase | 23685356 |
Hgene | TERF2 | GO:0032211 | negative regulation of telomere maintenance via telomerase | 17055345 |
Hgene | TERF2 | GO:1903770 | negative regulation of beta-galactosidase activity | 11927518 |
Hgene | TERF2 | GO:1905778 | negative regulation of exonuclease activity | 15200954 |
Hgene | TERF2 | GO:1905839 | negative regulation of telomeric D-loop disassembly | 15200954 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-C8-A12Q-01A | TERF2 | chr16 | 69418483 | - | COG4 | chr16 | 70524295 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000254942 | ENST00000323786 | TERF2 | chr16 | 69418483 | - | COG4 | chr16 | 70524295 | - |
5CDS-intron | ENST00000254942 | ENST00000393612 | TERF2 | chr16 | 69418483 | - | COG4 | chr16 | 70524295 | - |
5CDS-intron | ENST00000254942 | ENST00000564653 | TERF2 | chr16 | 69418483 | - | COG4 | chr16 | 70524295 | - |
In-frame | ENST00000603068 | ENST00000323786 | TERF2 | chr16 | 69418483 | - | COG4 | chr16 | 70524295 | - |
5CDS-intron | ENST00000603068 | ENST00000393612 | TERF2 | chr16 | 69418483 | - | COG4 | chr16 | 70524295 | - |
5CDS-intron | ENST00000603068 | ENST00000564653 | TERF2 | chr16 | 69418483 | - | COG4 | chr16 | 70524295 | - |
5UTR-3CDS | ENST00000569611 | ENST00000323786 | TERF2 | chr16 | 69418483 | - | COG4 | chr16 | 70524295 | - |
5UTR-intron | ENST00000569611 | ENST00000393612 | TERF2 | chr16 | 69418483 | - | COG4 | chr16 | 70524295 | - |
5UTR-intron | ENST00000569611 | ENST00000564653 | TERF2 | chr16 | 69418483 | - | COG4 | chr16 | 70524295 | - |
In-frame | ENST00000567296 | ENST00000323786 | TERF2 | chr16 | 69418483 | - | COG4 | chr16 | 70524295 | - |
5CDS-intron | ENST00000567296 | ENST00000393612 | TERF2 | chr16 | 69418483 | - | COG4 | chr16 | 70524295 | - |
5CDS-intron | ENST00000567296 | ENST00000564653 | TERF2 | chr16 | 69418483 | - | COG4 | chr16 | 70524295 | - |
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FusionProtFeatures for TERF2_COG4 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
TERF2 | COG4 |
Binds the telomeric double-stranded 5'-TTAGGG-3' repeatand plays a central role in telomere maintenance and protectionagainst end-to-end fusion of chromosomes. In addition to itstelomeric DNA-binding role, required to recruit a number offactors and enzymes required for telomere protection, includingthe shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Componentof the shelterin complex (telosome) that is involved in theregulation of telomere length and protection. Shelterin associateswith arrays of double-stranded 5'-TTAGGG-3' repeats added bytelomerase and protects chromosome ends; without its protectiveactivity, telomeres are no longer hidden from the DNA damagesurveillance and chromosome ends are inappropriately processed byDNA repair pathways. Together with DCLRE1B/Apollo, plays a keyrole in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have beenproposed to protect chromosome ends from degradation and repair.Required both to recruit DCLRE1B/Apollo to telomeres and activatethe exonuclease activity of DCLRE1B/Apollo. Preferentially bindsto positive supercoiled DNA. Together with DCLRE1B/Apollo,required to control the amount of DNA topoisomerase (TOP1, TOP2Aand TOP2B) needed for telomere replication during fork passage andprevent aberrant telomere topology. Recruits TERF2IP/RAP1 totelomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.{ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:20655466,ECO:0000269|PubMed:9476899}. | Required for normal Golgi function. Plays a role inSNARE-pin assembly and Golgi-to-ER retrograde transport via itsinteraction with SCFD1. {ECO:0000269|PubMed:19536132}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TERF2 | chr16:69418483 | chr16:70524295 | ENST00000254942 | - | 3 | 10 | 55_72 | 202 | 543 | Compositional bias | Note=Arg-rich (basic) |
Hgene | TERF2 | chr16:69418483 | chr16:70524295 | ENST00000603068 | - | 3 | 10 | 55_72 | 160 | 501 | Compositional bias | Note=Arg-rich (basic) |
Tgene | >COG4 | chr16:69418483 | chr16:70524295 | ENST00000393612 | - | 0 | 8 | 618_740 | -1 | 338 | Region | Note=D domain |
Tgene | >COG4 | chr16:69418483 | chr16:70524295 | ENST00000393612 | - | 0 | 8 | 741_785 | -1 | 338 | Region | Note=E domain%3B essential for proper cell surface glycosylation |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >TERF2 | chr16:69418483 | chr16:70524295 | ENST00000254942 | - | 3 | 10 | 512_537 | 202 | 543 | DNA binding | H-T-H motif |
Hgene | >TERF2 | chr16:69418483 | chr16:70524295 | ENST00000603068 | - | 3 | 10 | 512_537 | 160 | 501 | DNA binding | H-T-H motif |
Hgene | >TERF2 | chr16:69418483 | chr16:70524295 | ENST00000254942 | - | 3 | 10 | 484_541 | 202 | 543 | Domain | HTH myb-type |
Hgene | >TERF2 | chr16:69418483 | chr16:70524295 | ENST00000603068 | - | 3 | 10 | 484_541 | 160 | 501 | Domain | HTH myb-type |
Hgene | >TERF2 | chr16:69418483 | chr16:70524295 | ENST00000254942 | - | 3 | 10 | 371_375 | 202 | 543 | Motif | Nuclear localization signal |
Hgene | >TERF2 | chr16:69418483 | chr16:70524295 | ENST00000603068 | - | 3 | 10 | 371_375 | 160 | 501 | Motif | Nuclear localization signal |
Hgene | >TERF2 | chr16:69418483 | chr16:70524295 | ENST00000254942 | - | 3 | 10 | 84_287 | 202 | 543 | Region | Note=TRFH dimerization |
Hgene | >TERF2 | chr16:69418483 | chr16:70524295 | ENST00000603068 | - | 3 | 10 | 84_287 | 160 | 501 | Region | Note=TRFH dimerization |
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FusionGeneSequence for TERF2_COG4 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_TERF2_ENST00000254942_chr16_69418483_-_COG4_ENST00000323786_chr16_70524295_-_443aa MAAGAGTAGPASGPGVVRDPAASQPRKRPGREGGEGARRSDTMAGGGGSSDGSGRAAGRRASRSSGRARRGRHEPGLGGPAERGAGEARL EEAVNRWVLKFYFHEALRAFRGSRYGDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEM IKTEFTLTEAVVESSRKLVKEAVTLNNVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSNKFRDLLQEGLTELNS TAIKPQVQPWINSFFSVSHNIEEEEFNDYEANDPWVQQFILNLEQQMAEFKASLSPVIYDSLTGLMTSLVAVELEKVVLKSTFNRLGGLQ >In-frame_TERF2_ENST00000603068_chr16_69418483_-_COG4_ENST00000323786_chr16_70524295_-_401aa MAGGGGSSDGSGRAAGRRASRSSGRARRGRHEPGLGGPAERGAGEARLEEAVNRWVLKFYFHEALRAFRGSRYGDFRQIRDIMQALLVRP LGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAVTLNNVEVCSENISTLKKTL ESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSNKFRDLLQEGLTELNSTAIKPQVQPWINSFFSVSHNIEEEEFNDYEANDPWVQQFILN LEQQMAEFKASLSPVIYDSLTGLMTSLVAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFARLSQMATILNLERVTEI >In-frame_TERF2_ENST00000567296_chr16_69418483_-_COG4_ENST00000323786_chr16_70524295_-_443aa MAAGAGTAGPASGPGVVRDPAASQPRKRPGREGGEGARRSDTMAGGGGSSDGSGRAAGRRASRSSGRARRGRHEPGLGGPAERGAGEARL EEAVNRWVLKFYFHEALRAFRGSRYGDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEM IKTEFTLTEAVVESSRKLVKEAVTLNNVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSNKFRDLLQEGLTELNS TAIKPQVQPWINSFFSVSHNIEEEEFNDYEANDPWVQQFILNLEQQMAEFKASLSPVIYDSLTGLMTSLVAVELEKVVLKSTFNRLGGLQ |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_TERF2_ENST00000254942_chr16_69418483_-_COG4_ENST00000323786_chr16_70524295_-_1329nt ATGGCCGCGGGAGCCGGGACGGCGGGCCCCGCTTCCGGCCCGGGCGTCGTGCGTGACCCAGCGGCGTCACAGCCGAGGAAGCGGCCCGGC CGGGAGGGCGGGGAGGGCGCGCGGCGATCGGACACGATGGCGGGAGGAGGCGGGAGTAGCGACGGCAGCGGGCGGGCAGCTGGCAGGCGG GCGTCCCGCAGTAGCGGGCGGGCCCGGCGGGGGCGCCACGAGCCGGGGCTGGGGGGCCCGGCGGAGCGCGGCGCGGGGGAGGCACGGCTG GAAGAGGCAGTCAATCGCTGGGTGCTCAAGTTCTACTTCCACGAGGCGCTGCGGGCCTTTCGGGGTAGCCGGTACGGGGACTTCAGACAG ATCCGGGACATCATGCAGGCTTTGCTTGTCAGGCCCTTGGGGAAGGAGCACACCGTGTCCCGATTGCTGCGGGTTATGCAGTGTCTGTCG CGGATTGAAGAAGGGGAAAATTTAGACTGTTCCTTTGATATGGAGGCTGAGCTCACACCACTGGAATCAGCTATCAATGTGCTGGAGATG ATTAAAACGGAATTTACACTGACAGAAGCAGTGGTCGAATCCAGTAGAAAACTGGTCAAGGAAGCTGTGACTCTGAACAACGTGGAAGTC TGCAGTGAAAACATCTCCACTCTGAAGAAGACACTGGAGAGTGACTGCACCAAGCTCTTCAGCCAGGGCATTGGAGGGGAGCAGGCCCAG GCCAAGTTTGACAGCTGCCTTTCTGACTTGGCCGCCGTGTCCAACAAATTCCGAGACCTCTTGCAGGAAGGGCTGACGGAGCTCAACAGC ACAGCCATCAAGCCACAGGTGCAGCCTTGGATCAACAGCTTTTTCTCCGTCTCCCACAACATCGAGGAGGAAGAATTCAATGACTATGAG GCCAACGACCCTTGGGTACAACAGTTCATCCTTAACCTGGAGCAGCAAATGGCAGAGTTCAAGGCCAGCCTGTCCCCGGTCATCTACGAC AGCCTAACCGGCCTCATGACTAGCCTTGTTGCCGTCGAGTTGGAGAAAGTGGTGCTGAAATCCACCTTTAACCGGCTGGGTGGTCTGCAG TTTGACAAGGAGCTGAGGTCGCTCATTGCCTACCTTACCACGGTGACCACCTGGACCATCCGAGACAAGTTTGCCCGGCTCTCCCAGATG GCCACCATCCTCAATCTGGAGCGGGTGACCGAGATCCTCGATTACTGGGGACCCAATTCCGGCCCATTGACGTGGCGCCTCACCCCTGCT >In-frame_TERF2_ENST00000603068_chr16_69418483_-_COG4_ENST00000323786_chr16_70524295_-_1203nt ATGGCGGGAGGAGGCGGGAGTAGCGACGGCAGCGGGCGGGCAGCTGGCAGGCGGGCGTCCCGCAGTAGCGGGCGGGCCCGGCGGGGGCGC CACGAGCCGGGGCTGGGGGGCCCGGCGGAGCGCGGCGCGGGGGAGGCACGGCTGGAAGAGGCAGTCAATCGCTGGGTGCTCAAGTTCTAC TTCCACGAGGCGCTGCGGGCCTTTCGGGGTAGCCGGTACGGGGACTTCAGACAGATCCGGGACATCATGCAGGCTTTGCTTGTCAGGCCC TTGGGGAAGGAGCACACCGTGTCCCGATTGCTGCGGGTTATGCAGTGTCTGTCGCGGATTGAAGAAGGGGAAAATTTAGACTGTTCCTTT GATATGGAGGCTGAGCTCACACCACTGGAATCAGCTATCAATGTGCTGGAGATGATTAAAACGGAATTTACACTGACAGAAGCAGTGGTC GAATCCAGTAGAAAACTGGTCAAGGAAGCTGTGACTCTGAACAACGTGGAAGTCTGCAGTGAAAACATCTCCACTCTGAAGAAGACACTG GAGAGTGACTGCACCAAGCTCTTCAGCCAGGGCATTGGAGGGGAGCAGGCCCAGGCCAAGTTTGACAGCTGCCTTTCTGACTTGGCCGCC GTGTCCAACAAATTCCGAGACCTCTTGCAGGAAGGGCTGACGGAGCTCAACAGCACAGCCATCAAGCCACAGGTGCAGCCTTGGATCAAC AGCTTTTTCTCCGTCTCCCACAACATCGAGGAGGAAGAATTCAATGACTATGAGGCCAACGACCCTTGGGTACAACAGTTCATCCTTAAC CTGGAGCAGCAAATGGCAGAGTTCAAGGCCAGCCTGTCCCCGGTCATCTACGACAGCCTAACCGGCCTCATGACTAGCCTTGTTGCCGTC GAGTTGGAGAAAGTGGTGCTGAAATCCACCTTTAACCGGCTGGGTGGTCTGCAGTTTGACAAGGAGCTGAGGTCGCTCATTGCCTACCTT ACCACGGTGACCACCTGGACCATCCGAGACAAGTTTGCCCGGCTCTCCCAGATGGCCACCATCCTCAATCTGGAGCGGGTGACCGAGATC CTCGATTACTGGGGACCCAATTCCGGCCCATTGACGTGGCGCCTCACCCCTGCTGAAGTGCGCCAGGTGCTGGCCCTGCGGATAGACTTC >In-frame_TERF2_ENST00000567296_chr16_69418483_-_COG4_ENST00000323786_chr16_70524295_-_1329nt ATGGCCGCGGGAGCCGGGACGGCGGGCCCCGCTTCCGGCCCGGGCGTCGTGCGTGACCCAGCGGCGTCACAGCCGAGGAAGCGGCCCGGC CGGGAGGGCGGGGAGGGCGCGCGGCGATCGGACACGATGGCGGGAGGAGGCGGGAGTAGCGACGGCAGCGGGCGGGCAGCTGGCAGGCGG GCGTCCCGCAGTAGCGGGCGGGCCCGGCGGGGGCGCCACGAGCCGGGGCTGGGGGGCCCGGCGGAGCGCGGCGCGGGGGAGGCACGGCTG GAAGAGGCAGTCAATCGCTGGGTGCTCAAGTTCTACTTCCACGAGGCGCTGCGGGCCTTTCGGGGTAGCCGGTACGGGGACTTCAGACAG ATCCGGGACATCATGCAGGCTTTGCTTGTCAGGCCCTTGGGGAAGGAGCACACCGTGTCCCGATTGCTGCGGGTTATGCAGTGTCTGTCG CGGATTGAAGAAGGGGAAAATTTAGACTGTTCCTTTGATATGGAGGCTGAGCTCACACCACTGGAATCAGCTATCAATGTGCTGGAGATG ATTAAAACGGAATTTACACTGACAGAAGCAGTGGTCGAATCCAGTAGAAAACTGGTCAAGGAAGCTGTGACTCTGAACAACGTGGAAGTC TGCAGTGAAAACATCTCCACTCTGAAGAAGACACTGGAGAGTGACTGCACCAAGCTCTTCAGCCAGGGCATTGGAGGGGAGCAGGCCCAG GCCAAGTTTGACAGCTGCCTTTCTGACTTGGCCGCCGTGTCCAACAAATTCCGAGACCTCTTGCAGGAAGGGCTGACGGAGCTCAACAGC ACAGCCATCAAGCCACAGGTGCAGCCTTGGATCAACAGCTTTTTCTCCGTCTCCCACAACATCGAGGAGGAAGAATTCAATGACTATGAG GCCAACGACCCTTGGGTACAACAGTTCATCCTTAACCTGGAGCAGCAAATGGCAGAGTTCAAGGCCAGCCTGTCCCCGGTCATCTACGAC AGCCTAACCGGCCTCATGACTAGCCTTGTTGCCGTCGAGTTGGAGAAAGTGGTGCTGAAATCCACCTTTAACCGGCTGGGTGGTCTGCAG TTTGACAAGGAGCTGAGGTCGCTCATTGCCTACCTTACCACGGTGACCACCTGGACCATCCGAGACAAGTTTGCCCGGCTCTCCCAGATG GCCACCATCCTCAATCTGGAGCGGGTGACCGAGATCCTCGATTACTGGGGACCCAATTCCGGCCCATTGACGTGGCGCCTCACCCCTGCT |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_TERF2_ENST00000254942_chr16_69418483_-_COG4_ENST00000323786_chr16_70524295_-_1787nt GGAACGCTGTTTCTATCATGGCCGCGGGAGCCGGGACGGCGGGCCCCGCTTCCGGCCCGGGCGTCGTGCGTGACCCAGCGGCGTCACAGC CGAGGAAGCGGCCCGGCCGGGAGGGCGGGGAGGGCGCGCGGCGATCGGACACGATGGCGGGAGGAGGCGGGAGTAGCGACGGCAGCGGGC GGGCAGCTGGCAGGCGGGCGTCCCGCAGTAGCGGGCGGGCCCGGCGGGGGCGCCACGAGCCGGGGCTGGGGGGCCCGGCGGAGCGCGGCG CGGGGGAGGCACGGCTGGAAGAGGCAGTCAATCGCTGGGTGCTCAAGTTCTACTTCCACGAGGCGCTGCGGGCCTTTCGGGGTAGCCGGT ACGGGGACTTCAGACAGATCCGGGACATCATGCAGGCTTTGCTTGTCAGGCCCTTGGGGAAGGAGCACACCGTGTCCCGATTGCTGCGGG TTATGCAGTGTCTGTCGCGGATTGAAGAAGGGGAAAATTTAGACTGTTCCTTTGATATGGAGGCTGAGCTCACACCACTGGAATCAGCTA TCAATGTGCTGGAGATGATTAAAACGGAATTTACACTGACAGAAGCAGTGGTCGAATCCAGTAGAAAACTGGTCAAGGAAGCTGTGACTC TGAACAACGTGGAAGTCTGCAGTGAAAACATCTCCACTCTGAAGAAGACACTGGAGAGTGACTGCACCAAGCTCTTCAGCCAGGGCATTG GAGGGGAGCAGGCCCAGGCCAAGTTTGACAGCTGCCTTTCTGACTTGGCCGCCGTGTCCAACAAATTCCGAGACCTCTTGCAGGAAGGGC TGACGGAGCTCAACAGCACAGCCATCAAGCCACAGGTGCAGCCTTGGATCAACAGCTTTTTCTCCGTCTCCCACAACATCGAGGAGGAAG AATTCAATGACTATGAGGCCAACGACCCTTGGGTACAACAGTTCATCCTTAACCTGGAGCAGCAAATGGCAGAGTTCAAGGCCAGCCTGT CCCCGGTCATCTACGACAGCCTAACCGGCCTCATGACTAGCCTTGTTGCCGTCGAGTTGGAGAAAGTGGTGCTGAAATCCACCTTTAACC GGCTGGGTGGTCTGCAGTTTGACAAGGAGCTGAGGTCGCTCATTGCCTACCTTACCACGGTGACCACCTGGACCATCCGAGACAAGTTTG CCCGGCTCTCCCAGATGGCCACCATCCTCAATCTGGAGCGGGTGACCGAGATCCTCGATTACTGGGGACCCAATTCCGGCCCATTGACGT GGCGCCTCACCCCTGCTGAAGTGCGCCAGGTGCTGGCCCTGCGGATAGACTTCCGCAGTGAAGATATCAAGAGGCTGCGCCTGTAGCTGC CTGGATGAGCACACCTGGCTCATCACACTTGCAGGCCTGTTCCCTAAGGGGCCCCAGCCAAGGAGCTGAGCGAGGCTGTCTGGCTTGGGG GAGATCTGACAGCCCAGACCTTTCTACGGCTGGCAGCAGAGAAACAAAGTCTGGACCCACTCCATGCTCTGCCCTCAGACCTGGCCAGGT GATGCTCTGGGGGCAGCATCTCCCCACCGAGAGAAGCGGGCTCCTAATGAGGTGGGAAAGCCACGGCAGGCAGCGAGCAGCCCAGGCCAG CTTTCTGCATGGATGGTCAGTCTCTTGCCCTCAAACACTACAGCAAACAAGCTACCCCTGCCAGTCCTAGACAACTTGGGTACATCTGGG >In-frame_TERF2_ENST00000603068_chr16_69418483_-_COG4_ENST00000323786_chr16_70524295_-_1769nt TGGCCGCGGGAGCCGGGACGGCGGGCCCCGCTTCCGGCCCGGGCGTCGTGCGTGACCCAGCGGCGTCACAGCCGAGGAAGCGGCCCGGCC GGGAGGGCGGGGAGGGCGCGCGGCGATCGGACACGATGGCGGGAGGAGGCGGGAGTAGCGACGGCAGCGGGCGGGCAGCTGGCAGGCGGG CGTCCCGCAGTAGCGGGCGGGCCCGGCGGGGGCGCCACGAGCCGGGGCTGGGGGGCCCGGCGGAGCGCGGCGCGGGGGAGGCACGGCTGG AAGAGGCAGTCAATCGCTGGGTGCTCAAGTTCTACTTCCACGAGGCGCTGCGGGCCTTTCGGGGTAGCCGGTACGGGGACTTCAGACAGA TCCGGGACATCATGCAGGCTTTGCTTGTCAGGCCCTTGGGGAAGGAGCACACCGTGTCCCGATTGCTGCGGGTTATGCAGTGTCTGTCGC GGATTGAAGAAGGGGAAAATTTAGACTGTTCCTTTGATATGGAGGCTGAGCTCACACCACTGGAATCAGCTATCAATGTGCTGGAGATGA TTAAAACGGAATTTACACTGACAGAAGCAGTGGTCGAATCCAGTAGAAAACTGGTCAAGGAAGCTGTGACTCTGAACAACGTGGAAGTCT GCAGTGAAAACATCTCCACTCTGAAGAAGACACTGGAGAGTGACTGCACCAAGCTCTTCAGCCAGGGCATTGGAGGGGAGCAGGCCCAGG CCAAGTTTGACAGCTGCCTTTCTGACTTGGCCGCCGTGTCCAACAAATTCCGAGACCTCTTGCAGGAAGGGCTGACGGAGCTCAACAGCA CAGCCATCAAGCCACAGGTGCAGCCTTGGATCAACAGCTTTTTCTCCGTCTCCCACAACATCGAGGAGGAAGAATTCAATGACTATGAGG CCAACGACCCTTGGGTACAACAGTTCATCCTTAACCTGGAGCAGCAAATGGCAGAGTTCAAGGCCAGCCTGTCCCCGGTCATCTACGACA GCCTAACCGGCCTCATGACTAGCCTTGTTGCCGTCGAGTTGGAGAAAGTGGTGCTGAAATCCACCTTTAACCGGCTGGGTGGTCTGCAGT TTGACAAGGAGCTGAGGTCGCTCATTGCCTACCTTACCACGGTGACCACCTGGACCATCCGAGACAAGTTTGCCCGGCTCTCCCAGATGG CCACCATCCTCAATCTGGAGCGGGTGACCGAGATCCTCGATTACTGGGGACCCAATTCCGGCCCATTGACGTGGCGCCTCACCCCTGCTG AAGTGCGCCAGGTGCTGGCCCTGCGGATAGACTTCCGCAGTGAAGATATCAAGAGGCTGCGCCTGTAGCTGCCTGGATGAGCACACCTGG CTCATCACACTTGCAGGCCTGTTCCCTAAGGGGCCCCAGCCAAGGAGCTGAGCGAGGCTGTCTGGCTTGGGGGAGATCTGACAGCCCAGA CCTTTCTACGGCTGGCAGCAGAGAAACAAAGTCTGGACCCACTCCATGCTCTGCCCTCAGACCTGGCCAGGTGATGCTCTGGGGGCAGCA TCTCCCCACCGAGAGAAGCGGGCTCCTAATGAGGTGGGAAAGCCACGGCAGGCAGCGAGCAGCCCAGGCCAGCTTTCTGCATGGATGGTC AGTCTCTTGCCCTCAAACACTACAGCAAACAAGCTACCCCTGCCAGTCCTAGACAACTTGGGTACATCTGGGGACCTAGCAGTTAGGCTT >In-frame_TERF2_ENST00000567296_chr16_69418483_-_COG4_ENST00000323786_chr16_70524295_-_1787nt GGAACGCTGTTTCTATCATGGCCGCGGGAGCCGGGACGGCGGGCCCCGCTTCCGGCCCGGGCGTCGTGCGTGACCCAGCGGCGTCACAGC CGAGGAAGCGGCCCGGCCGGGAGGGCGGGGAGGGCGCGCGGCGATCGGACACGATGGCGGGAGGAGGCGGGAGTAGCGACGGCAGCGGGC GGGCAGCTGGCAGGCGGGCGTCCCGCAGTAGCGGGCGGGCCCGGCGGGGGCGCCACGAGCCGGGGCTGGGGGGCCCGGCGGAGCGCGGCG CGGGGGAGGCACGGCTGGAAGAGGCAGTCAATCGCTGGGTGCTCAAGTTCTACTTCCACGAGGCGCTGCGGGCCTTTCGGGGTAGCCGGT ACGGGGACTTCAGACAGATCCGGGACATCATGCAGGCTTTGCTTGTCAGGCCCTTGGGGAAGGAGCACACCGTGTCCCGATTGCTGCGGG TTATGCAGTGTCTGTCGCGGATTGAAGAAGGGGAAAATTTAGACTGTTCCTTTGATATGGAGGCTGAGCTCACACCACTGGAATCAGCTA TCAATGTGCTGGAGATGATTAAAACGGAATTTACACTGACAGAAGCAGTGGTCGAATCCAGTAGAAAACTGGTCAAGGAAGCTGTGACTC TGAACAACGTGGAAGTCTGCAGTGAAAACATCTCCACTCTGAAGAAGACACTGGAGAGTGACTGCACCAAGCTCTTCAGCCAGGGCATTG GAGGGGAGCAGGCCCAGGCCAAGTTTGACAGCTGCCTTTCTGACTTGGCCGCCGTGTCCAACAAATTCCGAGACCTCTTGCAGGAAGGGC TGACGGAGCTCAACAGCACAGCCATCAAGCCACAGGTGCAGCCTTGGATCAACAGCTTTTTCTCCGTCTCCCACAACATCGAGGAGGAAG AATTCAATGACTATGAGGCCAACGACCCTTGGGTACAACAGTTCATCCTTAACCTGGAGCAGCAAATGGCAGAGTTCAAGGCCAGCCTGT CCCCGGTCATCTACGACAGCCTAACCGGCCTCATGACTAGCCTTGTTGCCGTCGAGTTGGAGAAAGTGGTGCTGAAATCCACCTTTAACC GGCTGGGTGGTCTGCAGTTTGACAAGGAGCTGAGGTCGCTCATTGCCTACCTTACCACGGTGACCACCTGGACCATCCGAGACAAGTTTG CCCGGCTCTCCCAGATGGCCACCATCCTCAATCTGGAGCGGGTGACCGAGATCCTCGATTACTGGGGACCCAATTCCGGCCCATTGACGT GGCGCCTCACCCCTGCTGAAGTGCGCCAGGTGCTGGCCCTGCGGATAGACTTCCGCAGTGAAGATATCAAGAGGCTGCGCCTGTAGCTGC CTGGATGAGCACACCTGGCTCATCACACTTGCAGGCCTGTTCCCTAAGGGGCCCCAGCCAAGGAGCTGAGCGAGGCTGTCTGGCTTGGGG GAGATCTGACAGCCCAGACCTTTCTACGGCTGGCAGCAGAGAAACAAAGTCTGGACCCACTCCATGCTCTGCCCTCAGACCTGGCCAGGT GATGCTCTGGGGGCAGCATCTCCCCACCGAGAGAAGCGGGCTCCTAATGAGGTGGGAAAGCCACGGCAGGCAGCGAGCAGCCCAGGCCAG CTTTCTGCATGGATGGTCAGTCTCTTGCCCTCAAACACTACAGCAAACAAGCTACCCCTGCCAGTCCTAGACAACTTGGGTACATCTGGG |
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FusionGenePPI for TERF2_COG4 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TERF2 | BLM, WRN, TINF2, RAD50, XRCC5, TERF2IP, XRCC6, MRE11A, NBN, MUS81, DCLRE1B, ORC1, ORC2, ORC3, ORC6, SLX4, BRCA1, PRMT1, ZC3HAV1L, RBM15B, POT1, PLAT, KPNA2, TERF1, STUB1, YY1, RBM33, PABPC4, MCCC2, CSNK2B, BMP2K, CYFIP1, DDX3X, SF3B4, S100A8, HSPA4, ACTN1, MCM7, DDB1, PRDX4, RASGEF1C, CDK9, FBXO21, BAIAP2L1, CHD8, TOX4, CLK3, SEC16A, DNAJB11, TLN1, MYO10, ABCD1, S100A7, HSP90AB2P, KPNB1, USP9X, CSNK2A2, PLOD2, RING1, ZNF281, FOXJ3, LARP7, IRS4, SAP30BP, DST, UGDH, ERH, PITRM1, MYH10, ATP2B1, ATP2B3, CARM1, SLTM, NT5DC2, THRAP3, CALD1, HSP90B1, ACLY, PRPS1L1, IDH3A, HSPH1, MACROD2, BAG3, TNKS, CCNT1, MYH9, TBPL1, RPS8, KCTD15, PLOD1, TBX1, RSBN1L, TRPC5, GTF2A2, POLD1, SYNE1, POLDIP3, RPS6, AP2A2, ZNF703, G3BP2, SEC24B, CCNT2, OSBPL11, SKIV2L2, ZGPAT, CHD7, KIAA1429, MACF1, SMC3, C20orf27, PCMT1, GANAB, PRMT5, KIAA2022, TDRD6, SYNE2, CENPF, TAF2, RYR2, ATN1, CDC37, CDK13, RNF40, UTRN, DMD, RALGAPA1, DNAJA2, GTF2A1, DHX33, KIF13B, ARHGAP20, MCM3AP, RAVER1, EDC3, U2AF2, PRDX3, IVD, LDOC1L, ARMC6, SRSF11, SNRNP70, MARK3, PFKL, CLASRP, DKC1, FXR2, DARS2, SDF2L1, TBC1D15, CLPB, USP15, PAXBP1, HSPA4L, REPIN1, DHX40, LLGL1, MYOM2, BRD2, KIAA0430, ZC3H13, NFRKB, DHX37, REV3L, SRRM2, MECP2, TCOF1, PYCR2, NME4, DUSP11, BCKDK, TRIM47, SNX22, WDR5, EEFSEC, AASS, GPATCH8, OSBPL9, ZKSCAN4, TFIP11, CYLC2, PCBP1, ACD, TERF2, SIAH1, ELAVL1, HMGN1, RNF113A, NCL, RPRD1B, HMGN2, RPL13, H2AFX, CCDC137, ASS1, WDR4, LYAR, DDX21, HDGFRP2, ZC3H18, HEXIM1, HEXIM2, SRSF6, NASP, HMGB1, NAIF1, CTBP1, LANCL2, MAGOHB, BANP, TOR1AIP1, SET, PTMA, TALDO1, APEX1, DDX24, OCM2, PPM1G, HMGN4, SP100, NUMA1, HMGN3, DDX39A, ANXA5, TMSB10, NXNL1, AFAP1L2, GNMT, REST, TFAP4, TEP1, HSP90AA1, TOP2A, SF3B2, TOP3A, HMGA1, VCP, ATM, RPA3, RPA2, RPA1, EP300, BMI1, PRPF40A, CCDC106, TEX264, FBL, TADA2B, CHAMP1, NUMB, PIK3R3, HIST1H2BG, PIAS1, UBE2I, RNF4, AKTIP, PPP1CA, ARL4D, XAGE1B, FGFRL1, ARL4C, HEXA, PTRF, UCHL1 | COG4 | COG1, COG2, COG5, COG7, COG3, APC, SEPT2, CUL4B, COG8, RPS20, VCP, COG6, EGFR, BSG, CD274, VSIG2, CA14, TEKT4, SCN2B, NTRK1, HDAC1, PDK1, SMEK1, CCDC40, PSMC5, TMCO3, NUP54, CCDC59, COMMD8, VSIG1, OPRM1, SIGLECL1, RAB30, MTNR1B |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Tgene | COG4 | chr16:69418483 | chr16:70524295 | ENST00000393612 | - | 0 | 8 | 2_84 | -1 | 338 | SCFD1 |
Tgene | COG4 | chr16:69418483 | chr16:70524295 | ENST00000393612 | - | 0 | 8 | 85_153 | -1 | 338 | STX5 |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TERF2_COG4 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TERF2_COG4 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TERF2 | C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | CTD_human |
Tgene | COG4 | C0032927 | Precancerous Conditions | 1 | CTD_human |
Tgene | COG4 | C3150736 | CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIj | 1 | CTD_human;ORPHANET;UNIPROT |