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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37721

FusionGeneSummary for TENM2_RALGPS1

check button Fusion gene summary
Fusion gene informationFusion gene name: TENM2_RALGPS1
Fusion gene ID: 37721
HgeneTgene
Gene symbol

TENM2

RALGPS1

Gene ID

57451

9649

Gene nameteneurin transmembrane protein 2Ral GEF with PH domain and SH3 binding motif 1
SynonymsODZ2|TEN-M2|TNM2|ten-2RALGEF2|RALGPS1A
Cytomap

5q34

9q33.3

Type of geneprotein-codingprotein-coding
Descriptionteneurin-2neurestin alphaodd Oz/ten-m homolog 2odz, odd Oz/ten-m homolog 2protein Odd Oz/ten-m homolog 2tenascin-M2ras-specific guanine nucleotide-releasing factor RalGPS1Ral guanine nucleotide exchange factor RalGPS1ARalGEF 2ral GEF with PH domain and SH3-binding motif 1ral guanine nucleotide exchange factor 2ralA exchange factor RalGPS1
Modification date2018052320180519
UniProtAcc

Q9NT68

Q5JS13

Ensembl transtripts involved in fusion geneENST00000518659, ENST00000545108, 
ENST00000520393, ENST00000519204, 
ENST00000520394, ENST00000403607, 
ENST00000424082, ENST00000259351, 
ENST00000394022, ENST00000373436, 
ENST00000373434, ENST00000394011, 
ENST00000480993, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 6 X 5=210
# samples 27
** MAII scorelog2(2/8*10)=1.32192809488736log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TENM2 [Title/Abstract] AND RALGPS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRALGPS1

GO:0032485

regulation of Ral protein signal transduction

10747847


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDMESOTCGA-LK-A4NY-01ATENM2chr5

167420187

+RALGPS1chr9

129972974

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000518659ENST00000424082TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000518659ENST00000259351TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000518659ENST00000394022TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000518659ENST00000373436TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000518659ENST00000373434TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000518659ENST00000394011TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000518659ENST00000480993TENM2chr5

167420187

+RALGPS1chr9

129972974

+
Frame-shiftENST00000545108ENST00000424082TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000545108ENST00000259351TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000545108ENST00000394022TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000545108ENST00000373436TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000545108ENST00000373434TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000545108ENST00000394011TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000545108ENST00000480993TENM2chr5

167420187

+RALGPS1chr9

129972974

+
intron-3CDSENST00000520393ENST00000424082TENM2chr5

167420187

+RALGPS1chr9

129972974

+
intron-intronENST00000520393ENST00000259351TENM2chr5

167420187

+RALGPS1chr9

129972974

+
intron-intronENST00000520393ENST00000394022TENM2chr5

167420187

+RALGPS1chr9

129972974

+
intron-intronENST00000520393ENST00000373436TENM2chr5

167420187

+RALGPS1chr9

129972974

+
intron-intronENST00000520393ENST00000373434TENM2chr5

167420187

+RALGPS1chr9

129972974

+
intron-intronENST00000520393ENST00000394011TENM2chr5

167420187

+RALGPS1chr9

129972974

+
intron-intronENST00000520393ENST00000480993TENM2chr5

167420187

+RALGPS1chr9

129972974

+
Frame-shiftENST00000519204ENST00000424082TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000519204ENST00000259351TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000519204ENST00000394022TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000519204ENST00000373436TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000519204ENST00000373434TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000519204ENST00000394011TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000519204ENST00000480993TENM2chr5

167420187

+RALGPS1chr9

129972974

+
Frame-shiftENST00000520394ENST00000424082TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000520394ENST00000259351TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000520394ENST00000394022TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000520394ENST00000373436TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000520394ENST00000373434TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000520394ENST00000394011TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000520394ENST00000480993TENM2chr5

167420187

+RALGPS1chr9

129972974

+
Frame-shiftENST00000403607ENST00000424082TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000403607ENST00000259351TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000403607ENST00000394022TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000403607ENST00000373436TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000403607ENST00000373434TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000403607ENST00000394011TENM2chr5

167420187

+RALGPS1chr9

129972974

+
5CDS-intronENST00000403607ENST00000480993TENM2chr5

167420187

+RALGPS1chr9

129972974

+

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FusionProtFeatures for TENM2_RALGPS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TENM2

Q9NT68

RALGPS1

Q5JS13

Involved in neural development, regulating theestablishment of proper connectivity within the nervous system.Promotes the formation of filopodia and enlarged growth cone inneuronal cells. Induces homophilic cell-cell adhesion (Bysimilarity). May function as a cellular signal transducer.{ECO:0000250, ECO:0000269|PubMed:21724987}. Isoform 2: Acts as a ligand of the ADGRL1 receptor.Mediates axon guidance and heterophilic cell-cell adhesion.{ECO:0000269|PubMed:21724987}. Ten-2 intracellular domain: Induces gene transcriptioninhibition. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TENM2_RALGPS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TENM2_RALGPS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TENM2RALGPS1RALA, GRB2, NCK1, APP, C2orf88


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TENM2_RALGPS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TENM2_RALGPS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTENM2C0236969Substance-Related Disorders1CTD_human
TgeneRALGPS1C0005695Bladder Neoplasm1CTD_human