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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37720

FusionGeneSummary for TENM1_GYPC

check button Fusion gene summary
Fusion gene informationFusion gene name: TENM1_GYPC
Fusion gene ID: 37720
HgeneTgene
Gene symbol

TENM1

GYPC

Gene ID

10178

2995

Gene nameteneurin transmembrane protein 1glycophorin C (Gerbich blood group)
SynonymsODZ1|ODZ3|TEN-M1|TNM|TNM1CD236|CD236R|GE|GE:GPC:GPD:GYPD|GPC|GPD|GYPD|PAS-2|PAS-2'
Cytomap

Xq25

2q14.3

Type of geneprotein-codingprotein-coding
Descriptionteneurin-1odz (odd Oz/ten-m, Drosophila) homolog 3odz, odd Oz/ten-m homolog 1odz, odd Oz/ten-m homolog 1(Drosophila)protein Odd Oz/ten-m homolog 1ten-1tenascin M1glycophorin-Cglycoconnectinglycophorin-Dglycoprotein betasialoglycoprotein D
Modification date2018052320180522
UniProtAcc

Q9UKZ4

P04921

Ensembl transtripts involved in fusion geneENST00000371130, ENST00000422452, 
ENST00000461429, 
ENST00000259254, 
ENST00000356887, ENST00000409836, 
ENST00000464053, 
Fusion gene scores* DoF score2 X 2 X 1=43 X 3 X 1=9
# samples 34
** MAII scorelog2(3/4*10)=2.90689059560852log2(4/9*10)=2.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TENM1 [Title/Abstract] AND GYPC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1N38988TENM1chrX

123554543

+GYPCchr2

127453519

+
ChiTaRS3.1N38974TENM1chrX

123554543

+GYPCchr2

127453519

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000371130ENST00000259254TENM1chrX

123554543

+GYPCchr2

127453519

+
intron-3CDSENST00000371130ENST00000356887TENM1chrX

123554543

+GYPCchr2

127453519

+
intron-3CDSENST00000371130ENST00000409836TENM1chrX

123554543

+GYPCchr2

127453519

+
intron-3UTRENST00000371130ENST00000464053TENM1chrX

123554543

+GYPCchr2

127453519

+
intron-3CDSENST00000422452ENST00000259254TENM1chrX

123554543

+GYPCchr2

127453519

+
intron-3CDSENST00000422452ENST00000356887TENM1chrX

123554543

+GYPCchr2

127453519

+
intron-3CDSENST00000422452ENST00000409836TENM1chrX

123554543

+GYPCchr2

127453519

+
intron-3UTRENST00000422452ENST00000464053TENM1chrX

123554543

+GYPCchr2

127453519

+
intron-3CDSENST00000461429ENST00000259254TENM1chrX

123554543

+GYPCchr2

127453519

+
intron-3CDSENST00000461429ENST00000356887TENM1chrX

123554543

+GYPCchr2

127453519

+
intron-3CDSENST00000461429ENST00000409836TENM1chrX

123554543

+GYPCchr2

127453519

+
intron-3UTRENST00000461429ENST00000464053TENM1chrX

123554543

+GYPCchr2

127453519

+

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FusionProtFeatures for TENM1_GYPC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TENM1

Q9UKZ4

GYPC

P04921

Involved in neural development, regulating theestablishment of proper connectivity within the nervous system.May function as a cellular signal transducer (By similarity).{ECO:0000250}. Teneurin C-terminal-associated peptide: Plays a role inthe regulation of neuroplasticity in the limbic system. Mediates arapid reorganization of actin- and tubulin-based cytoskeletonelements with an increase in dendritic arborization and spinedensity formation of neurons in the hippocampus and amygdala.Induces BDNF transcription inhibition in neurons. Activates themitogen-activated protein (MAP) kinase 2 (MEK2) and extracellularsignal-regulated kinase (ERK) cascade. Acts also as a bioactiveneuroprotective peptide on limbic neurons of the brain andregulates stress-induced behavior: attenuates alkalosis-associatednecrotic cell death and the effects of corticotropin-releasingfactor (CRF) on c-fos/FOS induction and on the reinstatement ofcocaine seeking (By similarity). {ECO:0000250}. Ten-1 intracellular domain: Induces gene transcriptionactivation. {ECO:0000250}. This protein is a minor sialoglycoprotein in humanerythrocyte membranes. The blood group Gerbich antigens andreceptors for Plasmodium falciparum merozoites are most likelylocated within the extracellular domain. Glycophorin-C plays animportant role in regulating the stability of red cells.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TENM1_GYPC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TENM1_GYPC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TENM1_GYPC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TENM1_GYPC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource