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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37717

FusionGeneSummary for TELO2_TELO2

check button Fusion gene summary
Fusion gene informationFusion gene name: TELO2_TELO2
Fusion gene ID: 37717
HgeneTgene
Gene symbol

TELO2

TELO2

Gene ID

9894

9894

Gene nametelomere maintenance 2telomere maintenance 2
SynonymsCLK2|TEL2|YHFSCLK2|TEL2|YHFS
Cytomap

16p13.3

16p13.3

Type of geneprotein-codingprotein-coding
Descriptiontelomere length regulation protein TEL2 homologTEL2, telomere maintenance 2, homologprotein clk-2 homologtelomere length regulation protein TEL2 homologTEL2, telomere maintenance 2, homologprotein clk-2 homolog
Modification date2018052320180523
UniProtAcc

Q9Y4R8

Q9Y4R8

Ensembl transtripts involved in fusion geneENST00000262319, ENST00000564507, 
ENST00000262319, ENST00000564507, 
Fusion gene scores* DoF score2 X 2 X 1=43 X 3 X 2=18
# samples 23
** MAII scorelog2(2/4*10)=2.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TELO2 [Title/Abstract] AND TELO2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF844011TELO2chr16

1552664

+TELO2chr16

1552738

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000262319ENST00000262319TELO2chr16

1552664

+TELO2chr16

1552738

-
5CDS-3UTRENST00000262319ENST00000564507TELO2chr16

1552664

+TELO2chr16

1552738

-
3UTR-3CDSENST00000564507ENST00000262319TELO2chr16

1552664

+TELO2chr16

1552738

-
3UTR-3UTRENST00000564507ENST00000564507TELO2chr16

1552664

+TELO2chr16

1552738

-

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FusionProtFeatures for TELO2_TELO2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TELO2

Q9Y4R8

TELO2

Q9Y4R8

Regulator of the DNA damage response (DDR). Part of theTTT complex that is required to stabilize protein levels of thephosphatidylinositol 3-kinase-related protein kinase (PIKK) familyproteins. The TTT complex is involved in the cellular resistanceto DNA damage stresses, like ionizing radiation (IR), ultraviolet(UV) and mitomycin C (MMC). Together with the TTT complex andHSP90 may participate in the proper folding of newly synthesizedPIKKs. Promotes assembly, stabilizes and maintains the activity ofmTORC1 and mTORC2 complexes, which regulate cell growth andsurvival in response to nutrient and hormonal signals. May beinvolved in telomere length regulation.{ECO:0000269|PubMed:12670948, ECO:0000269|PubMed:20810650}. Regulator of the DNA damage response (DDR). Part of theTTT complex that is required to stabilize protein levels of thephosphatidylinositol 3-kinase-related protein kinase (PIKK) familyproteins. The TTT complex is involved in the cellular resistanceto DNA damage stresses, like ionizing radiation (IR), ultraviolet(UV) and mitomycin C (MMC). Together with the TTT complex andHSP90 may participate in the proper folding of newly synthesizedPIKKs. Promotes assembly, stabilizes and maintains the activity ofmTORC1 and mTORC2 complexes, which regulate cell growth andsurvival in response to nutrient and hormonal signals. May beinvolved in telomere length regulation.{ECO:0000269|PubMed:12670948, ECO:0000269|PubMed:20810650}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TELO2_TELO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TELO2_TELO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TELO2_TELO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TELO2_TELO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource