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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37704

FusionGeneSummary for TEF_CRYAB

check button Fusion gene summary
Fusion gene informationFusion gene name: TEF_CRYAB
Fusion gene ID: 37704
HgeneTgene
Gene symbol

TEF

CRYAB

Gene ID

7008

1410

Gene nameTEF, PAR bZIP transcription factorcrystallin alpha B
Synonyms-CMD1II|CRYA2|CTPP2|CTRCT16|HEL-S-101|HSPB5|MFM2
Cytomap

22q13.2

11q23.1

Type of geneprotein-codingprotein-coding
Descriptionthyrotroph embryonic factorthyrotrophic embryonic factoralpha-crystallin B chainepididymis secretory protein Li 101heat shock protein beta-5heat-shock 20 kD like-proteinrenal carcinoma antigen NY-REN-27rosenthal fiber component
Modification date2018052320180519
UniProtAcc

Q10587

P02511

Ensembl transtripts involved in fusion geneENST00000406644, ENST00000266304, 
ENST00000526180, ENST00000533280, 
ENST00000525823, ENST00000533475, 
ENST00000527950, ENST00000227251, 
ENST00000531198, ENST00000533971, 
Fusion gene scores* DoF score4 X 4 X 3=484 X 4 X 2=32
# samples 44
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TEF [Title/Abstract] AND CRYAB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCRYAB

GO:0032387

negative regulation of intracellular transport

14752512

TgeneCRYAB

GO:0032463

negative regulation of protein homooligomerization

23106396

TgeneCRYAB

GO:0043066

negative regulation of apoptotic process

14752512

TgeneCRYAB

GO:0051260

protein homooligomerization

16303126

TgeneCRYAB

GO:1905907

negative regulation of amyloid fibril formation

23106396


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF727201TEFchr22

41794533

+CRYABchr11

111782274

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000406644ENST00000526180TEFchr22

41794533

+CRYABchr11

111782274

-
3UTR-intronENST00000406644ENST00000533280TEFchr22

41794533

+CRYABchr11

111782274

-
3UTR-intronENST00000406644ENST00000525823TEFchr22

41794533

+CRYABchr11

111782274

-
3UTR-intronENST00000406644ENST00000533475TEFchr22

41794533

+CRYABchr11

111782274

-
3UTR-intronENST00000406644ENST00000527950TEFchr22

41794533

+CRYABchr11

111782274

-
3UTR-intronENST00000406644ENST00000227251TEFchr22

41794533

+CRYABchr11

111782274

-
3UTR-intronENST00000406644ENST00000531198TEFchr22

41794533

+CRYABchr11

111782274

-
3UTR-intronENST00000406644ENST00000533971TEFchr22

41794533

+CRYABchr11

111782274

-
3UTR-3CDSENST00000266304ENST00000526180TEFchr22

41794533

+CRYABchr11

111782274

-
3UTR-intronENST00000266304ENST00000533280TEFchr22

41794533

+CRYABchr11

111782274

-
3UTR-intronENST00000266304ENST00000525823TEFchr22

41794533

+CRYABchr11

111782274

-
3UTR-intronENST00000266304ENST00000533475TEFchr22

41794533

+CRYABchr11

111782274

-
3UTR-intronENST00000266304ENST00000527950TEFchr22

41794533

+CRYABchr11

111782274

-
3UTR-intronENST00000266304ENST00000227251TEFchr22

41794533

+CRYABchr11

111782274

-
3UTR-intronENST00000266304ENST00000531198TEFchr22

41794533

+CRYABchr11

111782274

-
3UTR-intronENST00000266304ENST00000533971TEFchr22

41794533

+CRYABchr11

111782274

-

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FusionProtFeatures for TEF_CRYAB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TEF

Q10587

CRYAB

P02511

Transcription factor that binds to and transactivatesthe TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'. May contribute to the transparency and refractive indexof the lens. Has chaperone-like activity, preventing aggregationof various proteins under a wide range of stress conditions.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TEF_CRYAB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TEF_CRYAB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TEF_CRYAB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TEF_CRYAB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTEFC0041696Unipolar Depression1PSYGENET
HgeneTEFC1269683Major Depressive Disorder1PSYGENET
TgeneCRYABC1837317Alpha-B Crystallinopathy3CTD_human;ORPHANET;UNIPROT
TgeneCRYABC3554649CARDIOMYOPATHY, DILATED, 1II2UNIPROT
TgeneCRYABC0007134Renal Cell Carcinoma1CTD_human
TgeneCRYABC0007137Squamous cell carcinoma1CTD_human
TgeneCRYABC0009375Colonic Neoplasms1CTD_human
TgeneCRYABC0014859Esophageal Neoplasms1CTD_human
TgeneCRYABC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCRYABC0026640Mouth Neoplasms1CTD_human
TgeneCRYABC0033578Prostatic Neoplasms1CTD_human
TgeneCRYABC0040411Tongue Neoplasms1CTD_human
TgeneCRYABC0086543Cataract1CTD_human;HPO
TgeneCRYABC0524851Neurodegenerative Disorders1CTD_human