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Fusion gene ID: 37703 |
FusionGeneSummary for TEC_PASD1 |
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Fusion gene information | Fusion gene name: TEC_PASD1 | Fusion gene ID: 37703 | Hgene | Tgene | Gene symbol | TEC | PASD1 | Gene ID | 79651 | 139135 |
Gene name | rhomboid 5 homolog 2 | PAS domain containing repressor 1 | |
Synonyms | RHBDL5|RHBDL6|TEC|TOC|TOCG|iRhom2 | CT63|CT64|OXTES1 | |
Cytomap | 17q25.1 | Xq28 | |
Type of gene | protein-coding | protein-coding | |
Description | inactive rhomboid protein 2rhomboid family member 2rhomboid veinlet-like protein 5rhomboid veinlet-like protein 6 | circadian clock protein PASD1PAS domain containing 1cancer/testis antigen 63 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P42680 | Q8IV76 | |
Ensembl transtripts involved in fusion gene | ENST00000381501, ENST00000511471, | ENST00000370357, | |
Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 3 X 2 X 3=18 |
# samples | 4 | 3 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TEC [Title/Abstract] AND PASD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PASD1 | GO:0042754 | negative regulation of circadian rhythm | 25936801 |
Tgene | PASD1 | GO:0045892 | negative regulation of transcription, DNA-templated | 25936801 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-GM-A2DH-01A | TEC | chr4 | 48271769 | - | PASD1 | chrX | 150789402 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000381501 | ENST00000370357 | TEC | chr4 | 48271769 | - | PASD1 | chrX | 150789402 | + |
intron-3CDS | ENST00000511471 | ENST00000370357 | TEC | chr4 | 48271769 | - | PASD1 | chrX | 150789402 | + |
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FusionProtFeatures for TEC_PASD1 |
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Hgene | Tgene |
TEC | PASD1 |
Non-receptor tyrosine kinase that contributes tosignaling from many receptors and participates as a signaltransducer in multiple downstream pathways, including regulationof the actin cytoskeleton. Plays a redundant role to ITK inregulation of the adaptive immune response. Regulates thedevelopment, function and differentiation of conventional T-cellsand nonconventional NKT-cells. Required for TCR-dependent IL2 geneinduction. Phosphorylates DOK1, one CD28-specific substrate, andcontributes to CD28-signaling. Mediates signals that negativelyregulate IL2RA expression induced by TCR cross-linking. Plays aredundant role to BTK in BCR-signaling for B-cell development andactivation, especially by phosphorylating STAP1, a BCR-signalingprotein. Required in mast cells for efficient cytokine production.Involved in both growth and differentiation mechanisms of myeloidcells through activation by the granulocyte colony-stimulatingfactor CSF3, a critical cytokine to promoting the growth,differentiation, and functional activation of myeloid cells.Participates in platelet signaling downstream of integrinactivation. Cooperates with JAK2 through reciprocalphosphorylation to mediate cytokine-driven activation of FOStranscription. GRB10, a negative modifier of the FOS activationpathway, is another substrate of TEC. TEC is involved in Gprotein-coupled receptor- and integrin-mediated signalings inblood platelets. Plays a role in hepatocyte proliferation andliver regeneration and is involved in HGF-induced ERK signalingpathway. TEC regulates also FGF2 unconventional secretion(endoplasmic reticulum (ER)/Golgi-independent mechanism) undervarious physiological conditions through phosphorylation of FGF2'Tyr-215'. May also be involved in the regulation of osteoclastdifferentiation. {ECO:0000269|PubMed:10518561,ECO:0000269|PubMed:19883687, ECO:0000269|PubMed:20230531,ECO:0000269|PubMed:9753425}. | Functions as a suppressor of the biological clock thatdrives the daily circadian rhythms of cells throughout the body(PubMed:25936801). Acts as a nuclear repressor of the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of thecore clock components (PubMed:25936801). Inhibits circadian clockfunction in cancer cells, when overexpressed (PubMed:25936801).{ECO:0000269|PubMed:25936801}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TEC_PASD1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TEC_PASD1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TEC | PRLR, VAV1, RAC1, JAK1, JAK2, PIK3R2, LYN, KIT, DOK1, WAS, SOCS1, GNA12, GNA13, ARHGEF12, IKBKG, FASLG, SHC1, MED28, GRB2, ERBB2, RPE, SORT1 | PASD1 | APP |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TEC_PASD1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TEC_PASD1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |