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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37684

FusionGeneSummary for TEAD4_DCAF10

check button Fusion gene summary
Fusion gene informationFusion gene name: TEAD4_DCAF10
Fusion gene ID: 37684
HgeneTgene
Gene symbol

TEAD4

DCAF10

Gene ID

7004

79269

Gene nameTEA domain transcription factor 4DDB1 and CUL4 associated factor 10
SynonymsEFTR-2|RTEF1|TCF13L1|TEF-3|TEF3|TEFR-1|hRTEF-1BWDR32
Cytomap

12p13.33

9p13.2

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional enhancer factor TEF-3TEA domain family member 4related transcription enhancer factor 1Btranscription factor 13-like 1transcription factor RTEF-1transcriptional enhancer factor 1-relatedtranscriptional enhancer factor 3DDB1- and CUL4-associated factor 10WD repeat domain 32WD repeat-containing protein 32
Modification date2018052320180519
UniProtAcc

Q15561

Q5QP82

Ensembl transtripts involved in fusion geneENST00000358409, ENST00000359864, 
ENST00000397122, 
ENST00000377724, 
ENST00000242323, ENST00000483167, 
Fusion gene scores* DoF score9 X 4 X 7=2523 X 4 X 3=36
# samples 94
** MAII scorelog2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TEAD4 [Title/Abstract] AND DCAF10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTEAD4

GO:0035329

hippo signaling

18579750|19324877


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-BR-6709-01ATEAD4chr12

3069206

+DCAF10chr9

37854777

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000358409ENST00000377724TEAD4chr12

3069206

+DCAF10chr9

37854777

+
5UTR-3CDSENST00000358409ENST00000242323TEAD4chr12

3069206

+DCAF10chr9

37854777

+
5UTR-intronENST00000358409ENST00000483167TEAD4chr12

3069206

+DCAF10chr9

37854777

+
5UTR-3CDSENST00000359864ENST00000377724TEAD4chr12

3069206

+DCAF10chr9

37854777

+
5UTR-3CDSENST00000359864ENST00000242323TEAD4chr12

3069206

+DCAF10chr9

37854777

+
5UTR-intronENST00000359864ENST00000483167TEAD4chr12

3069206

+DCAF10chr9

37854777

+
5UTR-3CDSENST00000397122ENST00000377724TEAD4chr12

3069206

+DCAF10chr9

37854777

+
5UTR-3CDSENST00000397122ENST00000242323TEAD4chr12

3069206

+DCAF10chr9

37854777

+
5UTR-intronENST00000397122ENST00000483167TEAD4chr12

3069206

+DCAF10chr9

37854777

+

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FusionProtFeatures for TEAD4_DCAF10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TEAD4

Q15561

DCAF10

Q5QP82

Transcription factor which plays a key role in the Hipposignaling pathway, a pathway involved in organ size control andtumor suppression by restricting proliferation and promotingapoptosis. The core of this pathway is composed of a kinasecascade wherein MST1/MST2, in complex with its regulatory proteinSAV1, phosphorylates and activates LATS1/2 in complex with itsregulatory protein MOB1, which in turn phosphorylates andinactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating geneexpression of YAP1 and WWTR1/TAZ, thereby regulating cellproliferation, migration and epithelial mesenchymal transition(EMT) induction. Binds specifically and non-cooperatively to theSph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activatestranscription. Binds to the M-CAT motif.{ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}. May function as a substrate receptor for CUL4-DDB1 E3ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TEAD4_DCAF10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TEAD4_DCAF10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TEAD4WWTR1, CCDC85B, VGLL1, GOLGA2, TRIM27, VPS52, TRAF1, PNMA1, KIAA0753, CCNDBP1, RABGEF1, CEP55, CEP70, LZTS2, SSX2IP, CCDC172, VGLL4, AMOTL1, LYPLA1, TEAD1, TEAD2, FN1, VASP, PARN, DLG3, YAP1, VTA1, SNX6, GNB1L, PDE4DIP, SKI, NCOR1, PFKMDCAF10SLX4, DDB1, CUL4A, DDA1, COPS6, AGO1, DIRAS3, SNX11, HDAC7, ACTR8, EIF3I, TRUB2, GNAZ, SCRN2, PPP2R2C, SRPK2, CUL4B, JRKL, COPS7A, CCT6B, CCT3, MTUS2, CCT2, CCT4, PRIM1, TCP1, CIR1, STK16, CCT7, PRIM2, NECAB2, RGS20, NKIRAS2, PTPN7, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TEAD4_DCAF10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TEAD4_DCAF10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource