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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37683

FusionGeneSummary for TEAD4_CPM

check button Fusion gene summary
Fusion gene informationFusion gene name: TEAD4_CPM
Fusion gene ID: 37683
HgeneTgene
Gene symbol

TEAD4

CPM

Gene ID

7004

1368

Gene nameTEA domain transcription factor 4carboxypeptidase M
SynonymsEFTR-2|RTEF1|TCF13L1|TEF-3|TEF3|TEFR-1|hRTEF-1B-
Cytomap

12p13.33

12q15

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional enhancer factor TEF-3TEA domain family member 4related transcription enhancer factor 1Btranscription factor 13-like 1transcription factor RTEF-1transcriptional enhancer factor 1-relatedtranscriptional enhancer factor 3carboxypeptidase Mrenal carboxypeptidaseurinary carboxypeptidase B
Modification date2018052320180523
UniProtAcc

Q15561

P14384

Ensembl transtripts involved in fusion geneENST00000358409, ENST00000359864, 
ENST00000397122, 
ENST00000546373, 
ENST00000551568, ENST00000338356, 
ENST00000549691, 
Fusion gene scores* DoF score9 X 4 X 7=25238 X 10 X 8=3040
# samples 935
** MAII scorelog2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(35/3040*10)=-3.11864449649862
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TEAD4 [Title/Abstract] AND CPM [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTEAD4

GO:0035329

hippo signaling

18579750|19324877


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-D3-A3CC-06ATEAD4chr12

3069362

+CPMchr12

69326620

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000358409ENST00000546373TEAD4chr12

3069362

+CPMchr12

69326620

-
intron-5UTRENST00000358409ENST00000551568TEAD4chr12

3069362

+CPMchr12

69326620

-
intron-5UTRENST00000358409ENST00000338356TEAD4chr12

3069362

+CPMchr12

69326620

-
intron-intronENST00000358409ENST00000549691TEAD4chr12

3069362

+CPMchr12

69326620

-
intron-5UTRENST00000359864ENST00000546373TEAD4chr12

3069362

+CPMchr12

69326620

-
intron-5UTRENST00000359864ENST00000551568TEAD4chr12

3069362

+CPMchr12

69326620

-
intron-5UTRENST00000359864ENST00000338356TEAD4chr12

3069362

+CPMchr12

69326620

-
intron-intronENST00000359864ENST00000549691TEAD4chr12

3069362

+CPMchr12

69326620

-
intron-5UTRENST00000397122ENST00000546373TEAD4chr12

3069362

+CPMchr12

69326620

-
intron-5UTRENST00000397122ENST00000551568TEAD4chr12

3069362

+CPMchr12

69326620

-
intron-5UTRENST00000397122ENST00000338356TEAD4chr12

3069362

+CPMchr12

69326620

-
intron-intronENST00000397122ENST00000549691TEAD4chr12

3069362

+CPMchr12

69326620

-

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FusionProtFeatures for TEAD4_CPM


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TEAD4

Q15561

CPM

P14384

Transcription factor which plays a key role in the Hipposignaling pathway, a pathway involved in organ size control andtumor suppression by restricting proliferation and promotingapoptosis. The core of this pathway is composed of a kinasecascade wherein MST1/MST2, in complex with its regulatory proteinSAV1, phosphorylates and activates LATS1/2 in complex with itsregulatory protein MOB1, which in turn phosphorylates andinactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating geneexpression of YAP1 and WWTR1/TAZ, thereby regulating cellproliferation, migration and epithelial mesenchymal transition(EMT) induction. Binds specifically and non-cooperatively to theSph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activatestranscription. Binds to the M-CAT motif.{ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}. Specifically removes C-terminal basic residues (Arg orLys) from peptides and proteins. It is believed to play importantroles in the control of peptide hormone and growth factor activityat the cell surface, and in the membrane-localized degradation ofextracellular proteins. {ECO:0000269|PubMed:12457462}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TEAD4_CPM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TEAD4_CPM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TEAD4WWTR1, CCDC85B, VGLL1, GOLGA2, TRIM27, VPS52, TRAF1, PNMA1, KIAA0753, CCNDBP1, RABGEF1, CEP55, CEP70, LZTS2, SSX2IP, CCDC172, VGLL4, AMOTL1, LYPLA1, TEAD1, TEAD2, FN1, VASP, PARN, DLG3, YAP1, VTA1, SNX6, GNB1L, PDE4DIP, SKI, NCOR1, PFKMCPMELAVL1, CAPZA2, DBN1, FLNA, GAK, MYH9, PPP1CC, RAB7A, PDLIM7, ATP6AP2, SYNPO, MAPRE1, GOLT1B, LIMA1, ANLN, MYO19, ZSCAN12, ULBP1, FTH1, TBC1D22B, GTPBP3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TEAD4_CPM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TEAD4_CPM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCPMC0014175Endometriosis1CTD_human
TgeneCPMC0037116Silicosis1CTD_human