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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37682

FusionGeneSummary for TEAD4_CD82

check button Fusion gene summary
Fusion gene informationFusion gene name: TEAD4_CD82
Fusion gene ID: 37682
HgeneTgene
Gene symbol

TEAD4

CD82

Gene ID

7004

3732

Gene nameTEA domain transcription factor 4CD82 molecule
SynonymsEFTR-2|RTEF1|TCF13L1|TEF-3|TEF3|TEFR-1|hRTEF-1B4F9|C33|GR15|IA4|KAI1|R2|SAR2|ST6|TSPAN27
Cytomap

12p13.33

11p11.2

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional enhancer factor TEF-3TEA domain family member 4related transcription enhancer factor 1Btranscription factor 13-like 1transcription factor RTEF-1transcriptional enhancer factor 1-relatedtranscriptional enhancer factor 3CD82 antigenC33 antigeninducible membrane protein R2kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))metastasis suppressor Kangai-1tetraspanin-27tspan-27
Modification date2018052320180523
UniProtAcc

Q15561

P27701

Ensembl transtripts involved in fusion geneENST00000358409, ENST00000359864, 
ENST00000397122, 
ENST00000227155, 
ENST00000342935, ENST00000530931, 
Fusion gene scores* DoF score9 X 4 X 7=2525 X 3 X 4=60
# samples 95
** MAII scorelog2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TEAD4 [Title/Abstract] AND CD82 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTEAD4

GO:0035329

hippo signaling

18579750|19324877


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-BR-8485-01ATEAD4chr12

3069206

+CD82chr11

44609025

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000358409ENST00000227155TEAD4chr12

3069206

+CD82chr11

44609025

+
5UTR-5UTRENST00000358409ENST00000342935TEAD4chr12

3069206

+CD82chr11

44609025

+
5UTR-intronENST00000358409ENST00000530931TEAD4chr12

3069206

+CD82chr11

44609025

+
5UTR-5UTRENST00000359864ENST00000227155TEAD4chr12

3069206

+CD82chr11

44609025

+
5UTR-5UTRENST00000359864ENST00000342935TEAD4chr12

3069206

+CD82chr11

44609025

+
5UTR-intronENST00000359864ENST00000530931TEAD4chr12

3069206

+CD82chr11

44609025

+
5UTR-5UTRENST00000397122ENST00000227155TEAD4chr12

3069206

+CD82chr11

44609025

+
5UTR-5UTRENST00000397122ENST00000342935TEAD4chr12

3069206

+CD82chr11

44609025

+
5UTR-intronENST00000397122ENST00000530931TEAD4chr12

3069206

+CD82chr11

44609025

+

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FusionProtFeatures for TEAD4_CD82


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TEAD4

Q15561

CD82

P27701

Transcription factor which plays a key role in the Hipposignaling pathway, a pathway involved in organ size control andtumor suppression by restricting proliferation and promotingapoptosis. The core of this pathway is composed of a kinasecascade wherein MST1/MST2, in complex with its regulatory proteinSAV1, phosphorylates and activates LATS1/2 in complex with itsregulatory protein MOB1, which in turn phosphorylates andinactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating geneexpression of YAP1 and WWTR1/TAZ, thereby regulating cellproliferation, migration and epithelial mesenchymal transition(EMT) induction. Binds specifically and non-cooperatively to theSph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activatestranscription. Binds to the M-CAT motif.{ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}. Associates with CD4 or CD8 and delivers costimulatorysignals for the TCR/CD3 pathway.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TEAD4_CD82


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TEAD4_CD82


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TEAD4WWTR1, CCDC85B, VGLL1, GOLGA2, TRIM27, VPS52, TRAF1, PNMA1, KIAA0753, CCNDBP1, RABGEF1, CEP55, CEP70, LZTS2, SSX2IP, CCDC172, VGLL4, AMOTL1, LYPLA1, TEAD1, TEAD2, FN1, VASP, PARN, DLG3, YAP1, VTA1, SNX6, GNB1L, PDE4DIP, SKI, NCOR1, PFKMCD82CD151, CD9, ERBB2, ERBB3, IGSF8, CD46, PTGFRN, CD63, HLA-DRA, HLA-DMB, HLA-DOB, HBEGF, CD4, CD19, ITGAL, EGFR, AMFR, LGALS3BP, GGT1, CD81, CD53, CREB3, NFKB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TEAD4_CD82


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TEAD4_CD82


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCD82C0000786Spontaneous abortion1CTD_human
TgeneCD82C0027626Neoplasm Invasiveness1CTD_human
TgeneCD82C0027627Neoplasm Metastasis1CTD_human