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Fusion gene ID: 37677 |
FusionGeneSummary for TEAD2_NOSIP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TEAD2_NOSIP | Fusion gene ID: 37677 | Hgene | Tgene | Gene symbol | TEAD2 | NOSIP | Gene ID | 8463 | 51070 |
| Gene name | TEA domain transcription factor 2 | nitric oxide synthase interacting protein | |
| Synonyms | ETF|TEAD-2|TEF-4|TEF4 | CGI-25 | |
| Cytomap | 19q13.33 | 19q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcriptional enhancer factor TEF-4TEA domain family member 2 | nitric oxide synthase-interacting proteinE3 ubiquitin-protein ligase NOSIPRING-type E3 ubiquitin transferase NOSIPeNOS-interacting protein | |
| Modification date | 20180523 | 20180524 | |
| UniProtAcc | Q15562 | Q9Y314 | |
| Ensembl transtripts involved in fusion gene | ENST00000598810, ENST00000593945, ENST00000601519, ENST00000311227, ENST00000377214, ENST00000539846, ENST00000598397, | ENST00000339093, ENST00000596358, ENST00000391853, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 5 X 2 X 5=50 |
| # samples | 2 | 5 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(5/50*10)=0 | |
| Context | PubMed: TEAD2 [Title/Abstract] AND NOSIP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TEAD2 | GO:0035329 | hippo signaling | 18579750|19324877 |
| Tgene | NOSIP | GO:0043086 | negative regulation of catalytic activity | 11149895 |
| Tgene | NOSIP | GO:0051001 | negative regulation of nitric-oxide synthase activity | 11149895 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-BR-8060-01A | TEAD2 | chr19 | 49858405 | - | NOSIP | chr19 | 50060506 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000598810 | ENST00000339093 | TEAD2 | chr19 | 49858405 | - | NOSIP | chr19 | 50060506 | - |
| Frame-shift | ENST00000598810 | ENST00000596358 | TEAD2 | chr19 | 49858405 | - | NOSIP | chr19 | 50060506 | - |
| Frame-shift | ENST00000598810 | ENST00000391853 | TEAD2 | chr19 | 49858405 | - | NOSIP | chr19 | 50060506 | - |
| Frame-shift | ENST00000593945 | ENST00000339093 | TEAD2 | chr19 | 49858405 | - | NOSIP | chr19 | 50060506 | - |
| Frame-shift | ENST00000593945 | ENST00000596358 | TEAD2 | chr19 | 49858405 | - | NOSIP | chr19 | 50060506 | - |
| Frame-shift | ENST00000593945 | ENST00000391853 | TEAD2 | chr19 | 49858405 | - | NOSIP | chr19 | 50060506 | - |
| Frame-shift | ENST00000601519 | ENST00000339093 | TEAD2 | chr19 | 49858405 | - | NOSIP | chr19 | 50060506 | - |
| Frame-shift | ENST00000601519 | ENST00000596358 | TEAD2 | chr19 | 49858405 | - | NOSIP | chr19 | 50060506 | - |
| Frame-shift | ENST00000601519 | ENST00000391853 | TEAD2 | chr19 | 49858405 | - | NOSIP | chr19 | 50060506 | - |
| In-frame | ENST00000311227 | ENST00000339093 | TEAD2 | chr19 | 49858405 | - | NOSIP | chr19 | 50060506 | - |
| In-frame | ENST00000311227 | ENST00000596358 | TEAD2 | chr19 | 49858405 | - | NOSIP | chr19 | 50060506 | - |
| In-frame | ENST00000311227 | ENST00000391853 | TEAD2 | chr19 | 49858405 | - | NOSIP | chr19 | 50060506 | - |
| Frame-shift | ENST00000377214 | ENST00000339093 | TEAD2 | chr19 | 49858405 | - | NOSIP | chr19 | 50060506 | - |
| Frame-shift | ENST00000377214 | ENST00000596358 | TEAD2 | chr19 | 49858405 | - | NOSIP | chr19 | 50060506 | - |
| Frame-shift | ENST00000377214 | ENST00000391853 | TEAD2 | chr19 | 49858405 | - | NOSIP | chr19 | 50060506 | - |
| Frame-shift | ENST00000539846 | ENST00000339093 | TEAD2 | chr19 | 49858405 | - | NOSIP | chr19 | 50060506 | - |
| Frame-shift | ENST00000539846 | ENST00000596358 | TEAD2 | chr19 | 49858405 | - | NOSIP | chr19 | 50060506 | - |
| Frame-shift | ENST00000539846 | ENST00000391853 | TEAD2 | chr19 | 49858405 | - | NOSIP | chr19 | 50060506 | - |
| 5UTR-3CDS | ENST00000598397 | ENST00000339093 | TEAD2 | chr19 | 49858405 | - | NOSIP | chr19 | 50060506 | - |
| 5UTR-3CDS | ENST00000598397 | ENST00000596358 | TEAD2 | chr19 | 49858405 | - | NOSIP | chr19 | 50060506 | - |
| 5UTR-3CDS | ENST00000598397 | ENST00000391853 | TEAD2 | chr19 | 49858405 | - | NOSIP | chr19 | 50060506 | - |
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FusionProtFeatures for TEAD2_NOSIP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TEAD2 | NOSIP |
| Transcription factor which plays a key role in the Hipposignaling pathway, a pathway involved in organ size control andtumor suppression by restricting proliferation and promotingapoptosis. The core of this pathway is composed of a kinasecascade wherein MST1/MST2, in complex with its regulatory proteinSAV1, phosphorylates and activates LATS1/2 in complex with itsregulatory protein MOB1, which in turn phosphorylates andinactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating geneexpression of YAP1 and WWTR1/TAZ, thereby regulating cellproliferation, migration and epithelial mesenchymal transition(EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neuraldevelopment. Binds to the M-CAT motif.{ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}. | E3 ubiquitin-protein ligase that is essential for properdevelopment of the forebrain, the eye, and the face. Catalyzesmonoubiquitination of serine/threonine-protein phosphatase 2A(PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negativelyregulates nitric oxide production by inducing NOS1 and NOS3translocation to actin cytoskeleton and inhibiting their enzymaticactivity (PubMed:11149895, PubMed:15548660, PubMed:16135813).{ECO:0000250|UniProtKB:Q9D6T0, ECO:0000269|PubMed:11149895,ECO:0000269|PubMed:15548660, ECO:0000269|PubMed:16135813}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TEAD2_NOSIP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TEAD2_ENST00000311227_chr19_49858405_-_NOSIP_ENST00000339093_chr19_50060506_-_394aa MGEPRAGAALDDGSGWTGSEEGSEEGTGGSEGAGGDGGPDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLR TGKTRTRKQVSSHIQVLARRKSREIQSKLKDQVSKDKAFQTMATMSSAQLISAPSLQAKLGPTGPQASELFQFWSGGSGPPWNVPEPTRS SGAPGARSRRSFSGRPRRTMCGASWRRSRLSXAGPSTLSQPRPSRAPAQVTQMMSNLGPVWVLQVRTRTKCCPASGSRRXRPKPRPPSWR SRPARXPAPCQGSPCACRTXRPCTSHRXTAPWTAWGSSPAASATCVPXPATAXATPPPALCCGPLGLWSPSNAWRSXFGRTWWTLXLETN >In-frame_TEAD2_ENST00000311227_chr19_49858405_-_NOSIP_ENST00000596358_chr19_50060506_-_391aa MGEPRAGAALDDGSGWTGSEEGSEEGTGGSEGAGGDGGPDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLR TGKTRTRKQVSSHIQVLARRKSREIQSKLKDQVSKDKAFQTMATMSSAQLISAPSLQAKLGPTGPQASELFQFWSGGSGPPWNVPEPTRS SGAPGARSRRSFSGRPRRTMCGASWRRSRLSXAGPSTLSQPRPSRAPAQMMSNLGPVWVLQVRTRTKCCPASGSRRXRPKPRPPSWRSRP ARXPAPCQGSPCACRTXRPCTSHRXTAPWTAWGSSPAASATCVPXPATAXATPPPALCCGPLGLWSPSNAWRSXFGRTWWTLXLETNSQT >In-frame_TEAD2_ENST00000311227_chr19_49858405_-_NOSIP_ENST00000391853_chr19_50060506_-_391aa MGEPRAGAALDDGSGWTGSEEGSEEGTGGSEGAGGDGGPDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLR TGKTRTRKQVSSHIQVLARRKSREIQSKLKDQVSKDKAFQTMATMSSAQLISAPSLQAKLGPTGPQASELFQFWSGGSGPPWNVPEPTRS SGAPGARSRRSFSGRPRRTMCGASWRRSRLSXAGPSTLSQPRPSRAPAQMMSNLGPVWVLQVRTRTKCCPASGSRRXRPKPRPPSWRSRP ARXPAPCQGSPCACRTXRPCTSHRXTAPWTAWGSSPAASATCVPXPATAXATPPPALCCGPLGLWSPSNAWRSXFGRTWWTLXLETNSQT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TEAD2_ENST00000311227_chr19_49858405_-_NOSIP_ENST00000339093_chr19_50060506_-_1184nt ATGGGGGAACCCCGGGCTGGGGCCGCCCTGGACGATGGCAGCGGCTGGACGGGCAGTGAGGAAGGCAGTGAGGAGGGTACCGGCGGCAGT GAGGGGGCTGGGGGTGACGGGGGCCCGGATGCAGAGGGGGTGTGGAGCCCAGACATTGAGCAGAGCTTCCAGGAGGCCCTGGCCATCTAT CCACCCTGCGGCCGCCGGAAAATAATTTTGTCTGATGAAGGCAAGATGTATGGTCGGAATGAACTGATCGCCCGCTACATCAAGCTGAGA ACGGGGAAGACCCGAACTCGAAAACAGGTTTCTAGTCACATCCAGGTTTTGGCCCGAAGGAAATCAAGGGAAATCCAGTCCAAGTTGAAG GACCAGGTTTCCAAGGACAAGGCTTTCCAGACAATGGCAACCATGTCCTCTGCCCAGCTCATCTCCGCGCCTTCTCTGCAGGCCAAACTG GGTCCCACTGGTCCTCAGGCCTCTGAGCTTTTCCAGTTTTGGTCTGGAGGATCTGGGCCCCCCTGGAATGTTCCAGAGCCTACGAGAAGC AGCGGGGCACCCGGCGCGAGGAGCAGAAGGAGCTTCAGCGGGCGGCCTCGCAGGACCATGTGCGGGGCTTCCTGGAGAAGGAGTCGGCTA TCGTGAGCCGGCCCCTCAACCCTTTCACAGCCAAGGCCCTCTCGGGCACCAGCCCAGGTGACTCAGATGATGTCCAACCTGGGCCCAGTG TGGGTCCTCCAAGTAAGGACAAGGACAAAGTGCTGCCCAGCTTCTGGATCCCGTCGCTGACGCCCGAAGCCAAGGCCACCAAGCTGGAGA AGCCGTCCCGCACGGTGACCTGCCCCATGTCAGGGAAGCCCCTGCGCATGTCGGACCTGACGCCCGTGCACTTCACACCGCTAGACAGCT CCGTGGACCGCGTGGGGCTCATCACCCGCAGCGAGCGCTACGTGTGTGCCGTGACCCGCGACAGCCTGAGCAACGCCACCCCCTGCGCTG TGCTGCGGCCCTCTGGGGCTGTGGTCACCCTCGAATGCGTGGAGAAGCTGATTCGGAAGGACATGGTGGACCCTGTGACTGGAGACAAAC TCACAGACCGCGACATCATCGTGCTGCAGCGGGGCGGTACCGGCTTCGCGGGCTCCGGAGTGAAGCTGCAAGCGGAGAAATCACGGCCGG >In-frame_TEAD2_ENST00000311227_chr19_49858405_-_NOSIP_ENST00000596358_chr19_50060506_-_1175nt ATGGGGGAACCCCGGGCTGGGGCCGCCCTGGACGATGGCAGCGGCTGGACGGGCAGTGAGGAAGGCAGTGAGGAGGGTACCGGCGGCAGT GAGGGGGCTGGGGGTGACGGGGGCCCGGATGCAGAGGGGGTGTGGAGCCCAGACATTGAGCAGAGCTTCCAGGAGGCCCTGGCCATCTAT CCACCCTGCGGCCGCCGGAAAATAATTTTGTCTGATGAAGGCAAGATGTATGGTCGGAATGAACTGATCGCCCGCTACATCAAGCTGAGA ACGGGGAAGACCCGAACTCGAAAACAGGTTTCTAGTCACATCCAGGTTTTGGCCCGAAGGAAATCAAGGGAAATCCAGTCCAAGTTGAAG GACCAGGTTTCCAAGGACAAGGCTTTCCAGACAATGGCAACCATGTCCTCTGCCCAGCTCATCTCCGCGCCTTCTCTGCAGGCCAAACTG GGTCCCACTGGTCCTCAGGCCTCTGAGCTTTTCCAGTTTTGGTCTGGAGGATCTGGGCCCCCCTGGAATGTTCCAGAGCCTACGAGAAGC AGCGGGGCACCCGGCGCGAGGAGCAGAAGGAGCTTCAGCGGGCGGCCTCGCAGGACCATGTGCGGGGCTTCCTGGAGAAGGAGTCGGCTA TCGTGAGCCGGCCCCTCAACCCTTTCACAGCCAAGGCCCTCTCGGGCACCAGCCCAGATGATGTCCAACCTGGGCCCAGTGTGGGTCCTC CAAGTAAGGACAAGGACAAAGTGCTGCCCAGCTTCTGGATCCCGTCGCTGACGCCCGAAGCCAAGGCCACCAAGCTGGAGAAGCCGTCCC GCACGGTGACCTGCCCCATGTCAGGGAAGCCCCTGCGCATGTCGGACCTGACGCCCGTGCACTTCACACCGCTAGACAGCTCCGTGGACC GCGTGGGGCTCATCACCCGCAGCGAGCGCTACGTGTGTGCCGTGACCCGCGACAGCCTGAGCAACGCCACCCCCTGCGCTGTGCTGCGGC CCTCTGGGGCTGTGGTCACCCTCGAATGCGTGGAGAAGCTGATTCGGAAGGACATGGTGGACCCTGTGACTGGAGACAAACTCACAGACC GCGACATCATCGTGCTGCAGCGGGGCGGTACCGGCTTCGCGGGCTCCGGAGTGAAGCTGCAAGCGGAGAAATCACGGCCGGTGATGCAGG >In-frame_TEAD2_ENST00000311227_chr19_49858405_-_NOSIP_ENST00000391853_chr19_50060506_-_1175nt ATGGGGGAACCCCGGGCTGGGGCCGCCCTGGACGATGGCAGCGGCTGGACGGGCAGTGAGGAAGGCAGTGAGGAGGGTACCGGCGGCAGT GAGGGGGCTGGGGGTGACGGGGGCCCGGATGCAGAGGGGGTGTGGAGCCCAGACATTGAGCAGAGCTTCCAGGAGGCCCTGGCCATCTAT CCACCCTGCGGCCGCCGGAAAATAATTTTGTCTGATGAAGGCAAGATGTATGGTCGGAATGAACTGATCGCCCGCTACATCAAGCTGAGA ACGGGGAAGACCCGAACTCGAAAACAGGTTTCTAGTCACATCCAGGTTTTGGCCCGAAGGAAATCAAGGGAAATCCAGTCCAAGTTGAAG GACCAGGTTTCCAAGGACAAGGCTTTCCAGACAATGGCAACCATGTCCTCTGCCCAGCTCATCTCCGCGCCTTCTCTGCAGGCCAAACTG GGTCCCACTGGTCCTCAGGCCTCTGAGCTTTTCCAGTTTTGGTCTGGAGGATCTGGGCCCCCCTGGAATGTTCCAGAGCCTACGAGAAGC AGCGGGGCACCCGGCGCGAGGAGCAGAAGGAGCTTCAGCGGGCGGCCTCGCAGGACCATGTGCGGGGCTTCCTGGAGAAGGAGTCGGCTA TCGTGAGCCGGCCCCTCAACCCTTTCACAGCCAAGGCCCTCTCGGGCACCAGCCCAGATGATGTCCAACCTGGGCCCAGTGTGGGTCCTC CAAGTAAGGACAAGGACAAAGTGCTGCCCAGCTTCTGGATCCCGTCGCTGACGCCCGAAGCCAAGGCCACCAAGCTGGAGAAGCCGTCCC GCACGGTGACCTGCCCCATGTCAGGGAAGCCCCTGCGCATGTCGGACCTGACGCCCGTGCACTTCACACCGCTAGACAGCTCCGTGGACC GCGTGGGGCTCATCACCCGCAGCGAGCGCTACGTGTGTGCCGTGACCCGCGACAGCCTGAGCAACGCCACCCCCTGCGCTGTGCTGCGGC CCTCTGGGGCTGTGGTCACCCTCGAATGCGTGGAGAAGCTGATTCGGAAGGACATGGTGGACCCTGTGACTGGAGACAAACTCACAGACC GCGACATCATCGTGCTGCAGCGGGGCGGTACCGGCTTCGCGGGCTCCGGAGTGAAGCTGCAAGCGGAGAAATCACGGCCGGTGATGCAGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TEAD2_ENST00000311227_chr19_49858405_-_NOSIP_ENST00000339093_chr19_50060506_-_1315nt CCCACTTTTCCCAAACAAAGCTCCCGGCAACTTTCTCCCTCGCAGCGCCCCGCCCGCCCGCGGCTCCCCAGCCCCAGGCCGGGAGGCCCA GATGGGGGAACCCCGGGCTGGGGCCGCCCTGGACGATGGCAGCGGCTGGACGGGCAGTGAGGAAGGCAGTGAGGAGGGTACCGGCGGCAG TGAGGGGGCTGGGGGTGACGGGGGCCCGGATGCAGAGGGGGTGTGGAGCCCAGACATTGAGCAGAGCTTCCAGGAGGCCCTGGCCATCTA TCCACCCTGCGGCCGCCGGAAAATAATTTTGTCTGATGAAGGCAAGATGTATGGTCGGAATGAACTGATCGCCCGCTACATCAAGCTGAG AACGGGGAAGACCCGAACTCGAAAACAGGTTTCTAGTCACATCCAGGTTTTGGCCCGAAGGAAATCAAGGGAAATCCAGTCCAAGTTGAA GGACCAGGTTTCCAAGGACAAGGCTTTCCAGACAATGGCAACCATGTCCTCTGCCCAGCTCATCTCCGCGCCTTCTCTGCAGGCCAAACT GGGTCCCACTGGTCCTCAGGCCTCTGAGCTTTTCCAGTTTTGGTCTGGAGGATCTGGGCCCCCCTGGAATGTTCCAGAGCCTACGAGAAG CAGCGGGGCACCCGGCGCGAGGAGCAGAAGGAGCTTCAGCGGGCGGCCTCGCAGGACCATGTGCGGGGCTTCCTGGAGAAGGAGTCGGCT ATCGTGAGCCGGCCCCTCAACCCTTTCACAGCCAAGGCCCTCTCGGGCACCAGCCCAGGTGACTCAGATGATGTCCAACCTGGGCCCAGT GTGGGTCCTCCAAGTAAGGACAAGGACAAAGTGCTGCCCAGCTTCTGGATCCCGTCGCTGACGCCCGAAGCCAAGGCCACCAAGCTGGAG AAGCCGTCCCGCACGGTGACCTGCCCCATGTCAGGGAAGCCCCTGCGCATGTCGGACCTGACGCCCGTGCACTTCACACCGCTAGACAGC TCCGTGGACCGCGTGGGGCTCATCACCCGCAGCGAGCGCTACGTGTGTGCCGTGACCCGCGACAGCCTGAGCAACGCCACCCCCTGCGCT GTGCTGCGGCCCTCTGGGGCTGTGGTCACCCTCGAATGCGTGGAGAAGCTGATTCGGAAGGACATGGTGGACCCTGTGACTGGAGACAAA CTCACAGACCGCGACATCATCGTGCTGCAGCGGGGCGGTACCGGCTTCGCGGGCTCCGGAGTGAAGCTGCAAGCGGAGAAATCACGGCCG >In-frame_TEAD2_ENST00000311227_chr19_49858405_-_NOSIP_ENST00000596358_chr19_50060506_-_1306nt CCCACTTTTCCCAAACAAAGCTCCCGGCAACTTTCTCCCTCGCAGCGCCCCGCCCGCCCGCGGCTCCCCAGCCCCAGGCCGGGAGGCCCA GATGGGGGAACCCCGGGCTGGGGCCGCCCTGGACGATGGCAGCGGCTGGACGGGCAGTGAGGAAGGCAGTGAGGAGGGTACCGGCGGCAG TGAGGGGGCTGGGGGTGACGGGGGCCCGGATGCAGAGGGGGTGTGGAGCCCAGACATTGAGCAGAGCTTCCAGGAGGCCCTGGCCATCTA TCCACCCTGCGGCCGCCGGAAAATAATTTTGTCTGATGAAGGCAAGATGTATGGTCGGAATGAACTGATCGCCCGCTACATCAAGCTGAG AACGGGGAAGACCCGAACTCGAAAACAGGTTTCTAGTCACATCCAGGTTTTGGCCCGAAGGAAATCAAGGGAAATCCAGTCCAAGTTGAA GGACCAGGTTTCCAAGGACAAGGCTTTCCAGACAATGGCAACCATGTCCTCTGCCCAGCTCATCTCCGCGCCTTCTCTGCAGGCCAAACT GGGTCCCACTGGTCCTCAGGCCTCTGAGCTTTTCCAGTTTTGGTCTGGAGGATCTGGGCCCCCCTGGAATGTTCCAGAGCCTACGAGAAG CAGCGGGGCACCCGGCGCGAGGAGCAGAAGGAGCTTCAGCGGGCGGCCTCGCAGGACCATGTGCGGGGCTTCCTGGAGAAGGAGTCGGCT ATCGTGAGCCGGCCCCTCAACCCTTTCACAGCCAAGGCCCTCTCGGGCACCAGCCCAGATGATGTCCAACCTGGGCCCAGTGTGGGTCCT CCAAGTAAGGACAAGGACAAAGTGCTGCCCAGCTTCTGGATCCCGTCGCTGACGCCCGAAGCCAAGGCCACCAAGCTGGAGAAGCCGTCC CGCACGGTGACCTGCCCCATGTCAGGGAAGCCCCTGCGCATGTCGGACCTGACGCCCGTGCACTTCACACCGCTAGACAGCTCCGTGGAC CGCGTGGGGCTCATCACCCGCAGCGAGCGCTACGTGTGTGCCGTGACCCGCGACAGCCTGAGCAACGCCACCCCCTGCGCTGTGCTGCGG CCCTCTGGGGCTGTGGTCACCCTCGAATGCGTGGAGAAGCTGATTCGGAAGGACATGGTGGACCCTGTGACTGGAGACAAACTCACAGAC CGCGACATCATCGTGCTGCAGCGGGGCGGTACCGGCTTCGCGGGCTCCGGAGTGAAGCTGCAAGCGGAGAAATCACGGCCGGTGATGCAG >In-frame_TEAD2_ENST00000311227_chr19_49858405_-_NOSIP_ENST00000391853_chr19_50060506_-_1304nt CCCACTTTTCCCAAACAAAGCTCCCGGCAACTTTCTCCCTCGCAGCGCCCCGCCCGCCCGCGGCTCCCCAGCCCCAGGCCGGGAGGCCCA GATGGGGGAACCCCGGGCTGGGGCCGCCCTGGACGATGGCAGCGGCTGGACGGGCAGTGAGGAAGGCAGTGAGGAGGGTACCGGCGGCAG TGAGGGGGCTGGGGGTGACGGGGGCCCGGATGCAGAGGGGGTGTGGAGCCCAGACATTGAGCAGAGCTTCCAGGAGGCCCTGGCCATCTA TCCACCCTGCGGCCGCCGGAAAATAATTTTGTCTGATGAAGGCAAGATGTATGGTCGGAATGAACTGATCGCCCGCTACATCAAGCTGAG AACGGGGAAGACCCGAACTCGAAAACAGGTTTCTAGTCACATCCAGGTTTTGGCCCGAAGGAAATCAAGGGAAATCCAGTCCAAGTTGAA GGACCAGGTTTCCAAGGACAAGGCTTTCCAGACAATGGCAACCATGTCCTCTGCCCAGCTCATCTCCGCGCCTTCTCTGCAGGCCAAACT GGGTCCCACTGGTCCTCAGGCCTCTGAGCTTTTCCAGTTTTGGTCTGGAGGATCTGGGCCCCCCTGGAATGTTCCAGAGCCTACGAGAAG CAGCGGGGCACCCGGCGCGAGGAGCAGAAGGAGCTTCAGCGGGCGGCCTCGCAGGACCATGTGCGGGGCTTCCTGGAGAAGGAGTCGGCT ATCGTGAGCCGGCCCCTCAACCCTTTCACAGCCAAGGCCCTCTCGGGCACCAGCCCAGATGATGTCCAACCTGGGCCCAGTGTGGGTCCT CCAAGTAAGGACAAGGACAAAGTGCTGCCCAGCTTCTGGATCCCGTCGCTGACGCCCGAAGCCAAGGCCACCAAGCTGGAGAAGCCGTCC CGCACGGTGACCTGCCCCATGTCAGGGAAGCCCCTGCGCATGTCGGACCTGACGCCCGTGCACTTCACACCGCTAGACAGCTCCGTGGAC CGCGTGGGGCTCATCACCCGCAGCGAGCGCTACGTGTGTGCCGTGACCCGCGACAGCCTGAGCAACGCCACCCCCTGCGCTGTGCTGCGG CCCTCTGGGGCTGTGGTCACCCTCGAATGCGTGGAGAAGCTGATTCGGAAGGACATGGTGGACCCTGTGACTGGAGACAAACTCACAGAC CGCGACATCATCGTGCTGCAGCGGGGCGGTACCGGCTTCGCGGGCTCCGGAGTGAAGCTGCAAGCGGAGAAATCACGGCCGGTGATGCAG |
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FusionGenePPI for TEAD2_NOSIP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TEAD2 | NCOA1, VGLL1, NEDD4, ELAVL1, HSP90AA1, USF2, BCL2L15, MOV10, NXF1, TEAD4, KRAS, YAP1, SMARCA5, CHD4, SATB2, TRIM3, BAZ1A, CHD1L, HOXD13, PDS5A, RECQL, SMARCA1, ARID3B, ORC3, ATF3, CHAF1A, ORC2, CHAF1B, HELLS, KIF22, RCC1, DDX39A, H2AFY, SMC1A, CDC27, ORC4, SMPD4, TRIP12, ZFHX4, BTAF1, CASZ1, HOXB9, INTS3, LRWD1, MYBL2, NFATC1, NR2F1, NR2F2, POU2F1, SMARCAL1, SMC3, TRPS1, ZEB2, ZNF536, ABCF3, ADNP, DCUN1D5, DLX5, FOXK2, H2AFY2, HOXA10, HOXB13, LIN9, LRRC41, MECP2, NR3C1, POU2F2, RALY, SALL1, SATB1, TBX2, TFCP2, WWTR1, ZIC2, USP11, HUWE1, TGM1, NANOG, TEAD1, UBN2, HIRA, SUPT16H, RFC1 | NOSIP | EPOR, CUL3, KPNA1, NOS3, DDX42, HECW2, WWOX, POLL, SLC25A21, FAM212B, TNNC2, NEU2, HMCES, ATR, DDX17, NF1, MCM2, OTUB1, PPP2CA, PPP2CB, PPP2R1A, PPP2R2A, UBE2D3, EGFR, CUL5, PTPN11, FOXA1, G3BP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TEAD2_NOSIP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TEAD2_NOSIP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TEAD2 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
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