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Fusion gene ID: 37675 |
FusionGeneSummary for TEAD1_WDR41 |
Fusion gene summary |
Fusion gene information | Fusion gene name: TEAD1_WDR41 | Fusion gene ID: 37675 | Hgene | Tgene | Gene symbol | TEAD1 | WDR41 | Gene ID | 7003 | 55255 |
Gene name | TEA domain transcription factor 1 | WD repeat domain 41 | |
Synonyms | AA|NTEF-1|REF1|TCF-13|TCF13|TEAD-1|TEF-1 | MSTP048 | |
Cytomap | 11p15.3 | 5q13.3-q14.1 | |
Type of gene | protein-coding | protein-coding | |
Description | transcriptional enhancer factor TEF-1TEA domain family member 1 (SV40 transcriptional enhancer factor)protein GT-IICtranscription factor 13transcriptional enhancer factor 1 | WD repeat-containing protein 41 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | P28347 | Q9HAD4 | |
Ensembl transtripts involved in fusion gene | ENST00000361905, ENST00000527636, ENST00000527575, ENST00000334310, ENST00000361985, ENST00000526600, | ENST00000512033, ENST00000296679, ENST00000414719, ENST00000507029, | |
Fusion gene scores | * DoF score | 12 X 7 X 10=840 | 3 X 4 X 2=24 |
# samples | 15 | 4 | |
** MAII score | log2(15/840*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TEAD1 [Title/Abstract] AND WDR41 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TEAD1 | GO:0035329 | hippo signaling | 18579750|19324877 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF753132 | TEAD1 | chr11 | 12960678 | + | WDR41 | chr5 | 76733290 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000361905 | ENST00000512033 | TEAD1 | chr11 | 12960678 | + | WDR41 | chr5 | 76733290 | + |
3UTR-intron | ENST00000361905 | ENST00000296679 | TEAD1 | chr11 | 12960678 | + | WDR41 | chr5 | 76733290 | + |
3UTR-intron | ENST00000361905 | ENST00000414719 | TEAD1 | chr11 | 12960678 | + | WDR41 | chr5 | 76733290 | + |
3UTR-intron | ENST00000361905 | ENST00000507029 | TEAD1 | chr11 | 12960678 | + | WDR41 | chr5 | 76733290 | + |
intron-intron | ENST00000527636 | ENST00000512033 | TEAD1 | chr11 | 12960678 | + | WDR41 | chr5 | 76733290 | + |
intron-intron | ENST00000527636 | ENST00000296679 | TEAD1 | chr11 | 12960678 | + | WDR41 | chr5 | 76733290 | + |
intron-intron | ENST00000527636 | ENST00000414719 | TEAD1 | chr11 | 12960678 | + | WDR41 | chr5 | 76733290 | + |
intron-intron | ENST00000527636 | ENST00000507029 | TEAD1 | chr11 | 12960678 | + | WDR41 | chr5 | 76733290 | + |
intron-intron | ENST00000527575 | ENST00000512033 | TEAD1 | chr11 | 12960678 | + | WDR41 | chr5 | 76733290 | + |
intron-intron | ENST00000527575 | ENST00000296679 | TEAD1 | chr11 | 12960678 | + | WDR41 | chr5 | 76733290 | + |
intron-intron | ENST00000527575 | ENST00000414719 | TEAD1 | chr11 | 12960678 | + | WDR41 | chr5 | 76733290 | + |
intron-intron | ENST00000527575 | ENST00000507029 | TEAD1 | chr11 | 12960678 | + | WDR41 | chr5 | 76733290 | + |
intron-intron | ENST00000334310 | ENST00000512033 | TEAD1 | chr11 | 12960678 | + | WDR41 | chr5 | 76733290 | + |
intron-intron | ENST00000334310 | ENST00000296679 | TEAD1 | chr11 | 12960678 | + | WDR41 | chr5 | 76733290 | + |
intron-intron | ENST00000334310 | ENST00000414719 | TEAD1 | chr11 | 12960678 | + | WDR41 | chr5 | 76733290 | + |
intron-intron | ENST00000334310 | ENST00000507029 | TEAD1 | chr11 | 12960678 | + | WDR41 | chr5 | 76733290 | + |
3UTR-intron | ENST00000361985 | ENST00000512033 | TEAD1 | chr11 | 12960678 | + | WDR41 | chr5 | 76733290 | + |
3UTR-intron | ENST00000361985 | ENST00000296679 | TEAD1 | chr11 | 12960678 | + | WDR41 | chr5 | 76733290 | + |
3UTR-intron | ENST00000361985 | ENST00000414719 | TEAD1 | chr11 | 12960678 | + | WDR41 | chr5 | 76733290 | + |
3UTR-intron | ENST00000361985 | ENST00000507029 | TEAD1 | chr11 | 12960678 | + | WDR41 | chr5 | 76733290 | + |
3UTR-intron | ENST00000526600 | ENST00000512033 | TEAD1 | chr11 | 12960678 | + | WDR41 | chr5 | 76733290 | + |
3UTR-intron | ENST00000526600 | ENST00000296679 | TEAD1 | chr11 | 12960678 | + | WDR41 | chr5 | 76733290 | + |
3UTR-intron | ENST00000526600 | ENST00000414719 | TEAD1 | chr11 | 12960678 | + | WDR41 | chr5 | 76733290 | + |
3UTR-intron | ENST00000526600 | ENST00000507029 | TEAD1 | chr11 | 12960678 | + | WDR41 | chr5 | 76733290 | + |
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FusionProtFeatures for TEAD1_WDR41 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
TEAD1 | WDR41 |
Transcription factor which plays a key role in the Hipposignaling pathway, a pathway involved in organ size control andtumor suppression by restricting proliferation and promotingapoptosis. The core of this pathway is composed of a kinasecascade wherein MST1/MST2, in complex with its regulatory proteinSAV1, phosphorylates and activates LATS1/2 in complex with itsregulatory protein MOB1, which in turn phosphorylates andinactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating geneexpression of YAP1 and WWTR1/TAZ, thereby regulating cellproliferation, migration and epithelial mesenchymal transition(EMT) induction. Binds specifically and cooperatively to the SPHand GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activatestranscription in vivo in a cell-specific manner. The activationfunction appears to be mediated by a limiting cell-specifictranscriptional intermediary factor (TIF). Involved in cardiacdevelopment. Binds to the M-CAT motif.{ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}. | Non-catalytic component of the C9orf72-SMCR8 complex, acomplex that has guanine nucleotide exchange factor (GEF) activityand regulates autophagy (PubMed:27193190, PubMed:27103069,PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complexpromotes the exchange of GDP to GTP, converting inactive GDP-boundRAB8A and RAB39B into their active GTP-bound form, therebypromoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagyinitiation by interacting with the ATG1/ULK1 kinase complex andinhibiting its protein kinase activity (PubMed:27103069,PubMed:27617292). {ECO:0000269|PubMed:27103069,ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27617292,ECO:0000269|PubMed:28195531}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TEAD1_WDR41 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TEAD1_WDR41 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TEAD1_WDR41 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TEAD1_WDR41 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TEAD1 | C1862382 | SVEINSSON CHORIORETINAL ATROPHY | 1 | CTD_human;ORPHANET;UNIPROT |