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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37662

FusionGeneSummary for TDRD3_TDRD3

check button Fusion gene summary
Fusion gene informationFusion gene name: TDRD3_TDRD3
Fusion gene ID: 37662
HgeneTgene
Gene symbol

TDRD3

TDRD3

Gene ID

81550

81550

Gene nametudor domain containing 3tudor domain containing 3
Synonyms--
Cytomap

13q21.2

13q21.2

Type of geneprotein-codingprotein-coding
Descriptiontudor domain-containing protein 3tudor domain-containing protein 3
Modification date2018052220180522
UniProtAcc

Q9H7E2

Q9H7E2

Ensembl transtripts involved in fusion geneENST00000196169, ENST00000377894, 
ENST00000535286, ENST00000377881, 
ENST00000463109, 
ENST00000196169, 
ENST00000377894, ENST00000535286, 
ENST00000377881, ENST00000463109, 
Fusion gene scores* DoF score6 X 5 X 4=1205 X 4 X 3=60
# samples 76
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/60*10)=0
Context

PubMed: TDRD3 [Title/Abstract] AND TDRD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ304940TDRD3chr13

61013822

-TDRD3chr13

61041516

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000196169ENST00000196169TDRD3chr13

61013822

-TDRD3chr13

61041516

-
intron-intronENST00000196169ENST00000377894TDRD3chr13

61013822

-TDRD3chr13

61041516

-
intron-intronENST00000196169ENST00000535286TDRD3chr13

61013822

-TDRD3chr13

61041516

-
intron-intronENST00000196169ENST00000377881TDRD3chr13

61013822

-TDRD3chr13

61041516

-
intron-intronENST00000196169ENST00000463109TDRD3chr13

61013822

-TDRD3chr13

61041516

-
intron-intronENST00000377894ENST00000196169TDRD3chr13

61013822

-TDRD3chr13

61041516

-
intron-intronENST00000377894ENST00000377894TDRD3chr13

61013822

-TDRD3chr13

61041516

-
intron-intronENST00000377894ENST00000535286TDRD3chr13

61013822

-TDRD3chr13

61041516

-
intron-intronENST00000377894ENST00000377881TDRD3chr13

61013822

-TDRD3chr13

61041516

-
intron-intronENST00000377894ENST00000463109TDRD3chr13

61013822

-TDRD3chr13

61041516

-
intron-intronENST00000535286ENST00000196169TDRD3chr13

61013822

-TDRD3chr13

61041516

-
intron-intronENST00000535286ENST00000377894TDRD3chr13

61013822

-TDRD3chr13

61041516

-
intron-intronENST00000535286ENST00000535286TDRD3chr13

61013822

-TDRD3chr13

61041516

-
intron-intronENST00000535286ENST00000377881TDRD3chr13

61013822

-TDRD3chr13

61041516

-
intron-intronENST00000535286ENST00000463109TDRD3chr13

61013822

-TDRD3chr13

61041516

-
intron-intronENST00000377881ENST00000196169TDRD3chr13

61013822

-TDRD3chr13

61041516

-
intron-intronENST00000377881ENST00000377894TDRD3chr13

61013822

-TDRD3chr13

61041516

-
intron-intronENST00000377881ENST00000535286TDRD3chr13

61013822

-TDRD3chr13

61041516

-
intron-intronENST00000377881ENST00000377881TDRD3chr13

61013822

-TDRD3chr13

61041516

-
intron-intronENST00000377881ENST00000463109TDRD3chr13

61013822

-TDRD3chr13

61041516

-
intron-intronENST00000463109ENST00000196169TDRD3chr13

61013822

-TDRD3chr13

61041516

-
intron-intronENST00000463109ENST00000377894TDRD3chr13

61013822

-TDRD3chr13

61041516

-
intron-intronENST00000463109ENST00000535286TDRD3chr13

61013822

-TDRD3chr13

61041516

-
intron-intronENST00000463109ENST00000377881TDRD3chr13

61013822

-TDRD3chr13

61041516

-
intron-intronENST00000463109ENST00000463109TDRD3chr13

61013822

-TDRD3chr13

61041516

-

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FusionProtFeatures for TDRD3_TDRD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TDRD3

Q9H7E2

TDRD3

Q9H7E2

Scaffolding protein that specifically recognizes andbinds dimethylarginine-containing proteins. In nucleus, acts as acoactivator: recognizes and binds asymmetric dimethylation on thecore histone tails associated with transcriptional activation(H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assemblyand/or disassembly of mRNA stress granules and in the regulationof translation of target mRNAs by binding Arg/Gly-rich motifs(GAR) in dimethylarginine-containing proteins.{ECO:0000269|PubMed:15955813, ECO:0000269|PubMed:18632687,ECO:0000269|PubMed:21172665}. Scaffolding protein that specifically recognizes andbinds dimethylarginine-containing proteins. In nucleus, acts as acoactivator: recognizes and binds asymmetric dimethylation on thecore histone tails associated with transcriptional activation(H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assemblyand/or disassembly of mRNA stress granules and in the regulationof translation of target mRNAs by binding Arg/Gly-rich motifs(GAR) in dimethylarginine-containing proteins.{ECO:0000269|PubMed:15955813, ECO:0000269|PubMed:18632687,ECO:0000269|PubMed:21172665}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TDRD3_TDRD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TDRD3_TDRD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TDRD3_TDRD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TDRD3_TDRD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource