FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 3766

FusionGeneSummary for BAAT_ALDOB

check button Fusion gene summary
Fusion gene informationFusion gene name: BAAT_ALDOB
Fusion gene ID: 3766
HgeneTgene
Gene symbol

BAAT

ALDOB

Gene ID

570

229

Gene namebile acid-CoA:amino acid N-acyltransferasealdolase, fructose-bisphosphate B
SynonymsBACAT|BATALDB|ALDO2
Cytomap

9q31.1

9q31.1

Type of geneprotein-codingprotein-coding
Descriptionbile acid-CoA:amino acid N-acyltransferasebile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)long-chain fatty-acyl-CoA hydrolasefructose-bisphosphate aldolase Baldolase 2aldolase B, fructose-bisphosphatasealdolase B, fructose-bisphosphateliver-type aldolase
Modification date2018052320180519
UniProtAcc

Q14032

P05062

Ensembl transtripts involved in fusion geneENST00000259407, ENST00000395051, 
ENST00000374855, ENST00000468981, 
Fusion gene scores* DoF score2 X 2 X 1=47 X 6 X 3=126
# samples 27
** MAII scorelog2(2/4*10)=2.32192809488736log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BAAT [Title/Abstract] AND ALDOB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBAAT

GO:0002152

bile acid conjugation

8034703|12810727

HgeneBAAT

GO:0006544

glycine metabolic process

8034703

HgeneBAAT

GO:0006637

acyl-CoA metabolic process

12810727

HgeneBAAT

GO:0006699

bile acid biosynthetic process

8034703|12810727

HgeneBAAT

GO:0019530

taurine metabolic process

8034703

TgeneALDOB

GO:0006096

glycolytic process

10625657

TgeneALDOB

GO:0006116

NADH oxidation

17576770

TgeneALDOB

GO:0030388

fructose 1,6-bisphosphate metabolic process

9244396|10625657


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-MR-A520-01ABAATchr9

104145752

-ALDOBchr9

104193179

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000259407ENST00000374855BAATchr9

104145752

-ALDOBchr9

104193179

-
5UTR-intronENST00000259407ENST00000468981BAATchr9

104145752

-ALDOBchr9

104193179

-
intron-5UTRENST00000395051ENST00000374855BAATchr9

104145752

-ALDOBchr9

104193179

-
intron-intronENST00000395051ENST00000468981BAATchr9

104145752

-ALDOBchr9

104193179

-

Top

FusionProtFeatures for BAAT_ALDOB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BAAT

Q14032

ALDOB

P05062

Involved in bile acid metabolism. In liver hepatocytescatalyzes the second step in the conjugation of C24 bile acids(choloneates) to glycine and taurine before excretion into bilecanaliculi. The major components of bile are cholic acid andchenodeoxycholic acid. In a first step the bile acids areconverted to an acyl-CoA thioester, either in peroxisomes (primarybile acids deriving from the cholesterol pathway), or cytoplasmicat the endoplasmic reticulum (secondary bile acids). May catalyzethe conjugation of primary or secondary bile acids, or both. Theconjugation increases the detergent properties of bile acids inthe intestine, which facilitates lipid and fat-soluble vitaminabsorption. In turn, bile acids are deconjugated by bacteria inthe intestine and are recycled back to the liver for reconjugation(secondary bile acids). May also act as an acyl-CoA thioesterasethat regulates intracellular levels of free fatty acids. In vitro,catalyzes the hydrolysis of long- and very long-chain saturatedacyl-CoAs to the free fatty acid and coenzyme A (CoASH), andconjugates glycine to these acyl-CoAs.{ECO:0000269|PubMed:12810727, ECO:0000269|PubMed:8034703}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for BAAT_ALDOB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for BAAT_ALDOB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BAATPEX5, GOLGA8EP, GOLGA8F, GOLGA8DP, STAU1ALDOBATP6V1E1, APP, BBS1, BBS2, BBS4, BBS7, MUC20, TXN2, HIVEP1, ALDOA, AGXT2, RPE, SUMO3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for BAAT_ALDOB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneBAATQ14032DB00145GlycineBile acid-CoA:amino acid N-acyltransferase {ECO:0000303|PubMed:8034703}small moleculeapproved|nutraceutical|vet_approved

Top

RelatedDiseases for BAAT_ALDOB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBAATC1843139Hypercholanemia, Familial1CTD_human;ORPHANET;UNIPROT
TgeneALDOBC0016751Hereditary fructose intolerance syndrome9CTD_human;HPO;ORPHANET;UNIPROT
TgeneALDOBC0038356Stomach Neoplasms1CTD_human
TgeneALDOBC0241910Hepatitis, Autoimmune1CTD_human
TgeneALDOBC0242184Hypoxia1CTD_human
TgeneALDOBC4277682Chemical and Drug Induced Liver Injury1CTD_human