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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37639

FusionGeneSummary for TCTEX1D2_PRMT7

check button Fusion gene summary
Fusion gene informationFusion gene name: TCTEX1D2_PRMT7
Fusion gene ID: 37639
HgeneTgene
Gene symbol

TCTEX1D2

PRMT7

Gene ID

255758

54496

Gene nameTctex1 domain containing 2protein arginine methyltransferase 7
SynonymsSRTD17SBIDDS
Cytomap

3q29

16q22.1

Type of geneprotein-codingprotein-coding
Descriptiontctex1 domain-containing protein 2protein arginine N-methyltransferase 7[Myelin basic protein]-arginine N-methyltransferase PRMT7histone-arginine N-methyltransferase PRMT7
Modification date2018051920180523
UniProtAcc

Q8WW35

Q9NVM4

Ensembl transtripts involved in fusion geneENST00000491186, ENST00000325318, 
ENST00000449359, ENST00000564441, 
ENST00000441236, ENST00000348497, 
ENST00000339507, 
Fusion gene scores* DoF score2 X 2 X 1=44 X 4 X 4=64
# samples 24
** MAII scorelog2(2/4*10)=2.32192809488736log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TCTEX1D2 [Title/Abstract] AND PRMT7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePRMT7

GO:0016571

histone methylation

15494416

TgenePRMT7

GO:0018216

peptidyl-arginine methylation

15044439


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE159383TCTEX1D2chr3

196044151

+PRMT7chr16

68353614

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000491186ENST00000449359TCTEX1D2chr3

196044151

+PRMT7chr16

68353614

+
intron-intronENST00000491186ENST00000564441TCTEX1D2chr3

196044151

+PRMT7chr16

68353614

+
intron-intronENST00000491186ENST00000441236TCTEX1D2chr3

196044151

+PRMT7chr16

68353614

+
intron-intronENST00000491186ENST00000348497TCTEX1D2chr3

196044151

+PRMT7chr16

68353614

+
intron-intronENST00000491186ENST00000339507TCTEX1D2chr3

196044151

+PRMT7chr16

68353614

+
intron-intronENST00000325318ENST00000449359TCTEX1D2chr3

196044151

+PRMT7chr16

68353614

+
intron-intronENST00000325318ENST00000564441TCTEX1D2chr3

196044151

+PRMT7chr16

68353614

+
intron-intronENST00000325318ENST00000441236TCTEX1D2chr3

196044151

+PRMT7chr16

68353614

+
intron-intronENST00000325318ENST00000348497TCTEX1D2chr3

196044151

+PRMT7chr16

68353614

+
intron-intronENST00000325318ENST00000339507TCTEX1D2chr3

196044151

+PRMT7chr16

68353614

+

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FusionProtFeatures for TCTEX1D2_PRMT7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TCTEX1D2

Q8WW35

PRMT7

Q9NVM4

Required for proper retrograde ciliary transport.{ECO:0000269|PubMed:26044572}. Arginine methyltransferase that can both catalyze theformation of omega-N monomethylarginine (MMA) and symmetricaldimethylarginine (sDMA), with a preference for the formation ofMMA. Specifically mediates the symmetrical dimethylation ofarginine residues in the small nuclear ribonucleoproteins Sm D1(SNRPD1) and Sm D3 (SNRPD3); such methylation being required forthe assembly and biogenesis of snRNP core particles. Specificallymediates the symmetric dimethylation of histone H4 'Arg-3' to formH4R3me2s. Plays a role in gene imprinting by being recruited byCTCFL at the H19 imprinted control region (ICR) and methylatinghistone H4 to form H4R3me2s, possibly leading to recruit DNAmethyltransferases at these sites. May also play a role inembryonic stem cell (ESC) pluripotency. Also able to mediate thearginine methylation of histone H2A and myelin basic protein (MBP)in vitro; the relevance of such results is however unclear invivo. {ECO:0000269|PubMed:15044439, ECO:0000269|PubMed:15494416,ECO:0000269|PubMed:17709427, ECO:0000269|PubMed:19110445}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TCTEX1D2_PRMT7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TCTEX1D2_PRMT7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TCTEX1D2_PRMT7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TCTEX1D2_PRMT7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource