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Fusion gene ID: 37625 |
FusionGeneSummary for TCL1A_VPS8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TCL1A_VPS8 | Fusion gene ID: 37625 | Hgene | Tgene | Gene symbol | TCL1A | VPS8 | Gene ID | 8115 | 23355 |
| Gene name | T cell leukemia/lymphoma 1A | VPS8, CORVET complex subunit | |
| Synonyms | TCL1 | KIAA0804 | |
| Cytomap | 14q32.13 | 3q27.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | T-cell leukemia/lymphoma protein 1AT-cell lymphoma-1oncogene TCL-1oncogene TCL1protein p14 TCL1 | vacuolar protein sorting-associated protein 8 homologvacuolar protein sorting 8 homolog | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | P56279 | Q8N3P4 | |
| Ensembl transtripts involved in fusion gene | ENST00000554012, ENST00000402399, ENST00000556450, ENST00000555202, | ENST00000437079, ENST00000287546, ENST00000436792, ENST00000446204, ENST00000424463, ENST00000463687, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 5 X 5 X 4=100 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(4/100*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TCL1A [Title/Abstract] AND VPS8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TCL1A | GO:0008284 | positive regulation of cell proliferation | 10983986 |
| Hgene | TCL1A | GO:0010918 | positive regulation of mitochondrial membrane potential | 10983986 |
| Hgene | TCL1A | GO:0032461 | positive regulation of protein oligomerization | 10983986 |
| Hgene | TCL1A | GO:0043066 | negative regulation of apoptotic process | 10983986 |
| Hgene | TCL1A | GO:0070207 | protein homotrimerization | 10983986 |
| Hgene | TCL1A | GO:0071356 | cellular response to tumor necrosis factor | 10983986 |
| Hgene | TCL1A | GO:0071902 | positive regulation of protein serine/threonine kinase activity | 10983986 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | X82240 | TCL1A | chr14 | 96176304 | - | VPS8 | chr3 | 184708737 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000554012 | ENST00000437079 | TCL1A | chr14 | 96176304 | - | VPS8 | chr3 | 184708737 | - |
| 5CDS-intron | ENST00000554012 | ENST00000287546 | TCL1A | chr14 | 96176304 | - | VPS8 | chr3 | 184708737 | - |
| 5CDS-intron | ENST00000554012 | ENST00000436792 | TCL1A | chr14 | 96176304 | - | VPS8 | chr3 | 184708737 | - |
| 5CDS-intron | ENST00000554012 | ENST00000446204 | TCL1A | chr14 | 96176304 | - | VPS8 | chr3 | 184708737 | - |
| 5CDS-intron | ENST00000554012 | ENST00000424463 | TCL1A | chr14 | 96176304 | - | VPS8 | chr3 | 184708737 | - |
| 5CDS-intron | ENST00000554012 | ENST00000463687 | TCL1A | chr14 | 96176304 | - | VPS8 | chr3 | 184708737 | - |
| 5CDS-intron | ENST00000402399 | ENST00000437079 | TCL1A | chr14 | 96176304 | - | VPS8 | chr3 | 184708737 | - |
| 5CDS-intron | ENST00000402399 | ENST00000287546 | TCL1A | chr14 | 96176304 | - | VPS8 | chr3 | 184708737 | - |
| 5CDS-intron | ENST00000402399 | ENST00000436792 | TCL1A | chr14 | 96176304 | - | VPS8 | chr3 | 184708737 | - |
| 5CDS-intron | ENST00000402399 | ENST00000446204 | TCL1A | chr14 | 96176304 | - | VPS8 | chr3 | 184708737 | - |
| 5CDS-intron | ENST00000402399 | ENST00000424463 | TCL1A | chr14 | 96176304 | - | VPS8 | chr3 | 184708737 | - |
| 5CDS-intron | ENST00000402399 | ENST00000463687 | TCL1A | chr14 | 96176304 | - | VPS8 | chr3 | 184708737 | - |
| intron-intron | ENST00000556450 | ENST00000437079 | TCL1A | chr14 | 96176304 | - | VPS8 | chr3 | 184708737 | - |
| intron-intron | ENST00000556450 | ENST00000287546 | TCL1A | chr14 | 96176304 | - | VPS8 | chr3 | 184708737 | - |
| intron-intron | ENST00000556450 | ENST00000436792 | TCL1A | chr14 | 96176304 | - | VPS8 | chr3 | 184708737 | - |
| intron-intron | ENST00000556450 | ENST00000446204 | TCL1A | chr14 | 96176304 | - | VPS8 | chr3 | 184708737 | - |
| intron-intron | ENST00000556450 | ENST00000424463 | TCL1A | chr14 | 96176304 | - | VPS8 | chr3 | 184708737 | - |
| intron-intron | ENST00000556450 | ENST00000463687 | TCL1A | chr14 | 96176304 | - | VPS8 | chr3 | 184708737 | - |
| intron-intron | ENST00000555202 | ENST00000437079 | TCL1A | chr14 | 96176304 | - | VPS8 | chr3 | 184708737 | - |
| intron-intron | ENST00000555202 | ENST00000287546 | TCL1A | chr14 | 96176304 | - | VPS8 | chr3 | 184708737 | - |
| intron-intron | ENST00000555202 | ENST00000436792 | TCL1A | chr14 | 96176304 | - | VPS8 | chr3 | 184708737 | - |
| intron-intron | ENST00000555202 | ENST00000446204 | TCL1A | chr14 | 96176304 | - | VPS8 | chr3 | 184708737 | - |
| intron-intron | ENST00000555202 | ENST00000424463 | TCL1A | chr14 | 96176304 | - | VPS8 | chr3 | 184708737 | - |
| intron-intron | ENST00000555202 | ENST00000463687 | TCL1A | chr14 | 96176304 | - | VPS8 | chr3 | 184708737 | - |
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FusionProtFeatures for TCL1A_VPS8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TCL1A | VPS8 |
| Enhances the phosphorylation and activation of AKT1,AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhancescell proliferation, stabilizes mitochondrial membrane potentialand promotes cell survival. {ECO:0000269|PubMed:10716693,ECO:0000269|PubMed:10983986, ECO:0000269|PubMed:11707444,ECO:0000269|PubMed:11839817}. | Plays a role in vesicle-mediated protein trafficking ofthe endocytic membrane transport pathway. Believed to act as acomponent of the putative CORVET endosomal tethering complexeswhich is proposed to be involved in the Rab5-to-Rab7 endosomeconversion probably implicating MON1A/B, and via binding SNAREsand SNARE complexes to mediate tethering and docking events duringSNARE-mediated membrane fusion. The CORVET complex is proposed tofunction as a Rab5 effector to mediate early endosome fusionprobably in specific endosome subpopulations (PubMed:25266290).Functions predominantly in APPL1-containing endosomes(PubMed:25266290). {ECO:0000269|PubMed:25266290,ECO:0000305|PubMed:25266290}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TCL1A_VPS8 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TCL1A_VPS8 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TCL1A_VPS8 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TCL1A_VPS8 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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