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Fusion gene ID: 37620 |
FusionGeneSummary for TCHP_UBASH3A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TCHP_UBASH3A | Fusion gene ID: 37620 | Hgene | Tgene | Gene symbol | TCHP | UBASH3A | Gene ID | 84260 | 53347 |
| Gene name | trichoplein keratin filament binding | ubiquitin associated and SH3 domain containing A | |
| Synonyms | TpMs | CLIP4|STS-2|TULA|TULA-1 | |
| Cytomap | 12q24.11 | 21q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | trichoplein keratin filament-binding proteinmitochondrial protein with oncostatic activitymitostatintumor suppressor protein | ubiquitin-associated and SH3 domain-containing protein AT-cell ubiquitin ligand 1T-cell ubiquitin ligand proteincbl-interacting protein 4suppressor of T-cell receptor signaling 2 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9BT92 | P57075 | |
| Ensembl transtripts involved in fusion gene | ENST00000405876, ENST00000312777, ENST00000550780, | ENST00000291535, ENST00000450356, ENST00000319294, ENST00000398367, | |
| Fusion gene scores | * DoF score | 6 X 5 X 4=120 | 4 X 4 X 3=48 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TCHP [Title/Abstract] AND UBASH3A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TCHP | GO:0006915 | apoptotic process | 18931701 |
| Hgene | TCHP | GO:0030308 | negative regulation of cell growth | 18931701 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI024691 | TCHP | chr12 | 110390958 | + | UBASH3A | chr21 | 43867264 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000405876 | ENST00000291535 | TCHP | chr12 | 110390958 | + | UBASH3A | chr21 | 43867264 | + |
| intron-intron | ENST00000405876 | ENST00000450356 | TCHP | chr12 | 110390958 | + | UBASH3A | chr21 | 43867264 | + |
| intron-intron | ENST00000405876 | ENST00000319294 | TCHP | chr12 | 110390958 | + | UBASH3A | chr21 | 43867264 | + |
| intron-3UTR | ENST00000405876 | ENST00000398367 | TCHP | chr12 | 110390958 | + | UBASH3A | chr21 | 43867264 | + |
| intron-3CDS | ENST00000312777 | ENST00000291535 | TCHP | chr12 | 110390958 | + | UBASH3A | chr21 | 43867264 | + |
| intron-intron | ENST00000312777 | ENST00000450356 | TCHP | chr12 | 110390958 | + | UBASH3A | chr21 | 43867264 | + |
| intron-intron | ENST00000312777 | ENST00000319294 | TCHP | chr12 | 110390958 | + | UBASH3A | chr21 | 43867264 | + |
| intron-3UTR | ENST00000312777 | ENST00000398367 | TCHP | chr12 | 110390958 | + | UBASH3A | chr21 | 43867264 | + |
| intron-3CDS | ENST00000550780 | ENST00000291535 | TCHP | chr12 | 110390958 | + | UBASH3A | chr21 | 43867264 | + |
| intron-intron | ENST00000550780 | ENST00000450356 | TCHP | chr12 | 110390958 | + | UBASH3A | chr21 | 43867264 | + |
| intron-intron | ENST00000550780 | ENST00000319294 | TCHP | chr12 | 110390958 | + | UBASH3A | chr21 | 43867264 | + |
| intron-3UTR | ENST00000550780 | ENST00000398367 | TCHP | chr12 | 110390958 | + | UBASH3A | chr21 | 43867264 | + |
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FusionProtFeatures for TCHP_UBASH3A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TCHP | UBASH3A |
| Tumor suppressor which has the ability to inhibit cellgrowth and be pro-apoptotic during cell stress. Inhibits cellgrowth in bladder and prostate cancer cells by a down-regulationof HSPB1 by inhibiting its phosphorylation. May act as a 'capping'or 'branching' protein for keratin filaments in the cellperiphery. May regulate K8/K18 filament and desmosome organizationmainly at the apical or peripheral regions of simple epithelialcells (PubMed:15731013, PubMed:18931701). Is a negative regulatorof ciliogenesis (PubMed:25270598). {ECO:0000269|PubMed:15731013,ECO:0000269|PubMed:18931701, ECO:0000269|PubMed:25270598}. | Interferes with CBL-mediated down-regulation anddegradation of receptor-type tyrosine kinases. Promotesaccumulation of activated target receptors, such as T-cellreceptors, EGFR and PDGFRB, on the cell surface. Exhibitsnegligigle protein tyrosine phosphatase activity at neutral pH.May act as a dominant-negative regulator of UBASH3B-dependentdephosphorylation. May inhibit dynamin-dependent endocyticpathways by functionally sequestering dynamin via its SH3 domain.{ECO:0000269|PubMed:15159412, ECO:0000269|PubMed:17382318,ECO:0000269|PubMed:18189269}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TCHP_UBASH3A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TCHP_UBASH3A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TCHP_UBASH3A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TCHP_UBASH3A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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