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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37613

FusionGeneSummary for TCFL5_SNRPB

check button Fusion gene summary
Fusion gene informationFusion gene name: TCFL5_SNRPB
Fusion gene ID: 37613
HgeneTgene
Gene symbol

TCFL5

SNRPB

Gene ID

10732

6628

Gene nametranscription factor like 5small nuclear ribonucleoprotein polypeptides B and B1
SynonymsCHA|E2BP-1|Figlb|SOSF1|bHLHe82CCMS|COD|SNRPB1|Sm-B/B'|SmB/B'|SmB/SmB'|snRNP-B
Cytomap

20q13.33

20p13

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor-like 5 proteinHPV-16 E2-binding protein 1cha transcription factorspermatogenesis- and oogenesis-specific bHLH-containing protein 1transcription factor-like 5 (basic helix-loop-helix)small nuclear ribonucleoprotein-associated proteins B and B'B polypeptide of Sm proteinSm protein B/B'sm-B/Sm-B'small nuclear ribonucleoprotein polypeptide Bsmall nuclear ribonucleoprotein polypeptides B and B'
Modification date2018052320180523
UniProtAcc

Q9UL49

P14678

Ensembl transtripts involved in fusion geneENST00000335351, ENST00000217162, 
ENST00000438552, ENST00000381342, 
ENST00000339610, 
Fusion gene scores* DoF score2 X 2 X 1=45 X 4 X 3=60
# samples 48
** MAII scorelog2(4/4*10)=3.32192809488736log2(8/60*10)=0.415037499278844
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TCFL5 [Title/Abstract] AND SNRPB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTCFL5

GO:0000122

negative regulation of transcription by RNA polymerase II

12923186

HgeneTCFL5

GO:0006355

regulation of transcription, DNA-templated

9763657

TgeneSNRPB

GO:0000387

spliceosomal snRNP assembly

18984161

TgeneSNRPB

GO:0000398

mRNA splicing, via spliceosome

28781166

TgeneSNRPB

GO:0006479

protein methylation

18495660


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE252218TCFL5chr20

61476986

+SNRPBchr20

2451402

-
ChiTaRS3.1BG472482TCFL5chr20

61476986

+SNRPBchr20

2451402

-
ChiTaRS3.1BG472537TCFL5chr20

61476986

+SNRPBchr20

2451402

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000335351ENST00000438552TCFL5chr20

61476986

+SNRPBchr20

2451402

-
intron-5UTRENST00000335351ENST00000381342TCFL5chr20

61476986

+SNRPBchr20

2451402

-
intron-5UTRENST00000335351ENST00000339610TCFL5chr20

61476986

+SNRPBchr20

2451402

-
intron-5UTRENST00000217162ENST00000438552TCFL5chr20

61476986

+SNRPBchr20

2451402

-
intron-5UTRENST00000217162ENST00000381342TCFL5chr20

61476986

+SNRPBchr20

2451402

-
intron-5UTRENST00000217162ENST00000339610TCFL5chr20

61476986

+SNRPBchr20

2451402

-

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FusionProtFeatures for TCFL5_SNRPB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TCFL5

Q9UL49

SNRPB

P14678

Putative transcription factor. Isoform 3 may play a rolein early spermatogenesis. {ECO:0000269|PubMed:9763657}. Core component of the spliceosomal U1, U2, U4 and U5small nuclear ribonucleoproteins (snRNPs), the building blocks ofthe spliceosome. Thereby, plays an important role in the splicingof cellular pre-mRNAs. Most spliceosomal snRNPs contain a commonset of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF andSNRPG that assemble in a heptameric protein ring on the Sm site ofthe small nuclear RNA to form the core snRNP. As part of the U7snRNP it is involved in histone 3'-end processing.{ECO:0000269|PubMed:18984161}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TCFL5_SNRPB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TCFL5_SNRPB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TCFL5_SNRPB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TCFL5_SNRPB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSNRPBC0265342Cerebrocostomandibular Syndrome2ORPHANET;UNIPROT
TgeneSNRPBC0038356Stomach Neoplasms1CTD_human