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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37610

FusionGeneSummary for TCF7_MTPAP

check button Fusion gene summary
Fusion gene informationFusion gene name: TCF7_MTPAP
Fusion gene ID: 37610
HgeneTgene
Gene symbol

TCF7

MTPAP

Gene ID

6932

55149

Gene nametranscription factor 7mitochondrial poly(A) polymerase
SynonymsTCF-1PAPD1|SPAX4|TENT6
Cytomap

5q31.1

10p11.23

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor 7T-cell-factor-7T-cell-specific transcription factor 1transcription factor 7 (T-cell specific, HMG-box)poly(A) RNA polymerase, mitochondrialPAP-associated domain-containing protein 1TUTase 1polynucleotide adenylyltransferaseterminal uridylyltransferase 1
Modification date2018052320180522
UniProtAcc

P36402

Q9NVV4

Ensembl transtripts involved in fusion geneENST00000378564, ENST00000321584, 
ENST00000321603, ENST00000342854, 
ENST00000395029, ENST00000432532, 
ENST00000378560, ENST00000520958, 
ENST00000518915, ENST00000395023, 
ENST00000517478, 		ENST00000263063, 
ENST00000358107, ENST00000488290, 
Fusion gene scores* DoF score4 X 4 X 1=162 X 2 X 2=8
# samples 42
** MAII scorelog2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context

PubMed: TCF7 [Title/Abstract] AND MTPAP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTCF7

GO:0071353

cellular response to interleukin-4

18579517

TgeneMTPAP

GO:0006378

mRNA polyadenylation

21292163


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CN411934TCF7chr5

133482975

+MTPAPchr10

30599325

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000378564ENST00000263063TCF7chr5

133482975

+MTPAPchr10

30599325

-
intron-3UTRENST00000378564ENST00000358107TCF7chr5

133482975

+MTPAPchr10

30599325

-
intron-intronENST00000378564ENST00000488290TCF7chr5

133482975

+MTPAPchr10

30599325

-
intron-3UTRENST00000321584ENST00000263063TCF7chr5

133482975

+MTPAPchr10

30599325

-
intron-3UTRENST00000321584ENST00000358107TCF7chr5

133482975

+MTPAPchr10

30599325

-
intron-intronENST00000321584ENST00000488290TCF7chr5

133482975

+MTPAPchr10

30599325

-
intron-3UTRENST00000321603ENST00000263063TCF7chr5

133482975

+MTPAPchr10

30599325

-
intron-3UTRENST00000321603ENST00000358107TCF7chr5

133482975

+MTPAPchr10

30599325

-
intron-intronENST00000321603ENST00000488290TCF7chr5

133482975

+MTPAPchr10

30599325

-
3UTR-3UTRENST00000342854ENST00000263063TCF7chr5

133482975

+MTPAPchr10

30599325

-
3UTR-3UTRENST00000342854ENST00000358107TCF7chr5

133482975

+MTPAPchr10

30599325

-
3UTR-intronENST00000342854ENST00000488290TCF7chr5

133482975

+MTPAPchr10

30599325

-
3UTR-3UTRENST00000395029ENST00000263063TCF7chr5

133482975

+MTPAPchr10

30599325

-
3UTR-3UTRENST00000395029ENST00000358107TCF7chr5

133482975

+MTPAPchr10

30599325

-
3UTR-intronENST00000395029ENST00000488290TCF7chr5

133482975

+MTPAPchr10

30599325

-
intron-3UTRENST00000432532ENST00000263063TCF7chr5

133482975

+MTPAPchr10

30599325

-
intron-3UTRENST00000432532ENST00000358107TCF7chr5

133482975

+MTPAPchr10

30599325

-
intron-intronENST00000432532ENST00000488290TCF7chr5

133482975

+MTPAPchr10

30599325

-
3UTR-3UTRENST00000378560ENST00000263063TCF7chr5

133482975

+MTPAPchr10

30599325

-
3UTR-3UTRENST00000378560ENST00000358107TCF7chr5

133482975

+MTPAPchr10

30599325

-
3UTR-intronENST00000378560ENST00000488290TCF7chr5

133482975

+MTPAPchr10

30599325

-
intron-3UTRENST00000520958ENST00000263063TCF7chr5

133482975

+MTPAPchr10

30599325

-
intron-3UTRENST00000520958ENST00000358107TCF7chr5

133482975

+MTPAPchr10

30599325

-
intron-intronENST00000520958ENST00000488290TCF7chr5

133482975

+MTPAPchr10

30599325

-
intron-3UTRENST00000518915ENST00000263063TCF7chr5

133482975

+MTPAPchr10

30599325

-
intron-3UTRENST00000518915ENST00000358107TCF7chr5

133482975

+MTPAPchr10

30599325

-
intron-intronENST00000518915ENST00000488290TCF7chr5

133482975

+MTPAPchr10

30599325

-
3UTR-3UTRENST00000395023ENST00000263063TCF7chr5

133482975

+MTPAPchr10

30599325

-
3UTR-3UTRENST00000395023ENST00000358107TCF7chr5

133482975

+MTPAPchr10

30599325

-
3UTR-intronENST00000395023ENST00000488290TCF7chr5

133482975

+MTPAPchr10

30599325

-
intron-3UTRENST00000517478ENST00000263063TCF7chr5

133482975

+MTPAPchr10

30599325

-
intron-3UTRENST00000517478ENST00000358107TCF7chr5

133482975

+MTPAPchr10

30599325

-
intron-intronENST00000517478ENST00000488290TCF7chr5

133482975

+MTPAPchr10

30599325

-

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FusionProtFeatures for TCF7_MTPAP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TCF7

P36402

MTPAP

Q9NVV4

Transcriptional activator involved in T-cell lymphocytedifferentiation. Necessary for the survival of CD4(+) CD8(+)immature thymocytes. Isoforms lacking the N-terminal CTNNB1binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in thepromoter of the CD3E gene. May also act as feedbacktranscriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1,TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 andCTNNB1. Polymerase that creates the 3' poly(A) tail ofmitochondrial transcripts. Can use all four nucleotides, but hashigher activity with ATP and UTP (in vitro). Plays a role inreplication-dependent histone mRNA degradation. May be involved inthe terminal uridylation of mature histone mRNAs before theirdegradation is initiated. Might be responsible for the creation ofsome UAA stop codons which are not encoded in mtDNA.{ECO:0000269|PubMed:15547249, ECO:0000269|PubMed:15769737,ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:20970105,ECO:0000269|PubMed:21292163}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TCF7_MTPAP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TCF7_MTPAP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TCF7_MTPAP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TCF7_MTPAP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTCF7C0010346Crohn Disease1CTD_human
HgeneTCF7C0024141Lupus Erythematosus, Systemic1CTD_human
TgeneMTPAPC0025202melanoma1CTD_human
TgeneMTPAPC3150925SPASTIC ATAXIA 4, AUTOSOMAL RECESSIVE1CTD_human;ORPHANET;UNIPROT