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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37603

FusionGeneSummary for TCF7L2_EIF3D

check button Fusion gene summary
Fusion gene informationFusion gene name: TCF7L2_EIF3D
Fusion gene ID: 37603
HgeneTgene
Gene symbol

TCF7L2

EIF3D

Gene ID

6934

8664

Gene nametranscription factor 7 like 2eukaryotic translation initiation factor 3 subunit D
SynonymsTCF-4|TCF4EIF3S7|eIF3-p66|eIF3-zeta
Cytomap

10q25.2-q25.3

22q12.3

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor 7-like 2HMG box transcription factor 4T-cell factor 4T-cell-specific transcription factor 4hTCF-4transcription factor 7-like 2 (T-cell specific, HMG-box)eukaryotic translation initiation factor 3 subunit DeIF3 p66eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDatranslation initiation factor eIF3 p66 subunit
Modification date2018052720180523
UniProtAcc

Q9NQB0

O15371

Ensembl transtripts involved in fusion geneENST00000534894, ENST00000536810, 
ENST00000545257, ENST00000355995, 
ENST00000543371, ENST00000355717, 
ENST00000538897, ENST00000349937, 
ENST00000369397, ENST00000352065, 
ENST00000369395, ENST00000542695, 
ENST00000369389, ENST00000369386, 
ENST00000466338, 
ENST00000216190, 
ENST00000478547, ENST00000541106, 
ENST00000405442, 
Fusion gene scores* DoF score9 X 7 X 10=6307 X 8 X 5=280
# samples 159
** MAII scorelog2(15/630*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TCF7L2 [Title/Abstract] AND EIF3D [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTCF7L2

GO:0000122

negative regulation of transcription by RNA polymerase II

12799378

HgeneTCF7L2

GO:0006357

regulation of transcription by RNA polymerase II

9727977

HgeneTCF7L2

GO:0032092

positive regulation of protein binding

12799378

HgeneTCF7L2

GO:0032350

regulation of hormone metabolic process

15525634

HgeneTCF7L2

GO:0042593

glucose homeostasis

15525634

HgeneTCF7L2

GO:0043433

negative regulation of DNA binding transcription factor activity

12799378

HgeneTCF7L2

GO:0045444

fat cell differentiation

10937998

HgeneTCF7L2

GO:0045892

negative regulation of transcription, DNA-templated

12799378|15525634

HgeneTCF7L2

GO:0045944

positive regulation of transcription by RNA polymerase II

9065401|19168596

HgeneTCF7L2

GO:0048625

myoblast fate commitment

10937998

TgeneEIF3D

GO:0002191

cap-dependent translational initiation

27462815

TgeneEIF3D

GO:0006413

translational initiation

17581632

TgeneEIF3D

GO:0075522

IRES-dependent viral translational initiation

9573242

TgeneEIF3D

GO:0075525

viral translational termination-reinitiation

21347434


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-61-1918-01ATCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000534894ENST00000216190TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-intronENST00000534894ENST00000478547TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000534894ENST00000541106TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000534894ENST00000405442TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000536810ENST00000216190TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-intronENST00000536810ENST00000478547TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000536810ENST00000541106TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000536810ENST00000405442TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000545257ENST00000216190TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-intronENST00000545257ENST00000478547TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000545257ENST00000541106TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000545257ENST00000405442TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000355995ENST00000216190TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-intronENST00000355995ENST00000478547TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000355995ENST00000541106TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000355995ENST00000405442TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000543371ENST00000216190TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-intronENST00000543371ENST00000478547TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000543371ENST00000541106TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000543371ENST00000405442TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000355717ENST00000216190TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-intronENST00000355717ENST00000478547TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000355717ENST00000541106TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000355717ENST00000405442TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000538897ENST00000216190TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-intronENST00000538897ENST00000478547TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000538897ENST00000541106TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000538897ENST00000405442TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000349937ENST00000216190TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-intronENST00000349937ENST00000478547TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000349937ENST00000541106TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000349937ENST00000405442TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000369397ENST00000216190TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-intronENST00000369397ENST00000478547TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000369397ENST00000541106TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000369397ENST00000405442TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000352065ENST00000216190TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-intronENST00000352065ENST00000478547TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000352065ENST00000541106TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000352065ENST00000405442TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000369395ENST00000216190TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-intronENST00000369395ENST00000478547TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000369395ENST00000541106TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5CDS-5UTRENST00000369395ENST00000405442TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5UTR-5UTRENST00000542695ENST00000216190TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5UTR-intronENST00000542695ENST00000478547TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5UTR-5UTRENST00000542695ENST00000541106TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
5UTR-5UTRENST00000542695ENST00000405442TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
intron-5UTRENST00000369389ENST00000216190TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
intron-intronENST00000369389ENST00000478547TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
intron-5UTRENST00000369389ENST00000541106TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
intron-5UTRENST00000369389ENST00000405442TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
intron-5UTRENST00000369386ENST00000216190TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
intron-intronENST00000369386ENST00000478547TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
intron-5UTRENST00000369386ENST00000541106TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
intron-5UTRENST00000369386ENST00000405442TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
intron-5UTRENST00000466338ENST00000216190TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
intron-intronENST00000466338ENST00000478547TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
intron-5UTRENST00000466338ENST00000541106TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-
intron-5UTRENST00000466338ENST00000405442TCF7L2chr10

114799885

+EIF3Dchr22

36922178

-

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FusionProtFeatures for TCF7L2_EIF3D


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TCF7L2

Q9NQB0

EIF3D

O15371

mRNA cap-binding component of the eukaryotic translationinitiation factor 3 (eIF-3) complex, a complex required forseveral steps in the initiation of protein synthesis of aspecialized repertoire of mRNAs (PubMed:27462815). The eIF-3complex associates with the 40S ribosome and facilitates therecruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5to form the 43S pre-initiation complex (43S PIC). The eIF-3complex stimulates mRNA recruitment to the 43S PIC and scanning ofthe mRNA for AUG recognition. The eIF-3 complex is also requiredfor disassembly and recycling of post-termination ribosomalcomplexes and subsequently prevents premature joining of the 40Sand 60S ribosomal subunits prior to initiation (PubMed:18599441,PubMed:25849773). The eIF-3 complex specifically targets andinitiates translation of a subset of mRNAs involved in cellproliferation, including cell cycling, differentiation andapoptosis, and uses different modes of RNA stem-loop binding toexert either translational activation or repression(PubMed:25849773). In the eIF-3 complex, EIF3D specificallyrecognizes and binds the 7-methylguanosine cap of a subset ofmRNAs (PubMed:27462815). {ECO:0000269|PubMed:18599441,ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. (Microbial infection) In case of FCV infection, plays arole in the ribosomal termination-reinitiation event leading tothe translation of VP2 (PubMed:18056426).{ECO:0000269|PubMed:18056426}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TCF7L2_EIF3D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TCF7L2_EIF3D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TCF7L2NLK, JUP, PSEN1, DAZAP2, CTNNB1, CTBP1, PARP1, XRCC6, XRCC5, ELAVL1, MAD2L2, ZBTB33, DAXX, FBLN1, UBE2I, PSMA3, PML, MEN1, USP4, HBP1, AR, FUS, CDC73, RNF138, HIC1, EP300, SMAD7, SETD8, LEF1, RNF43, TLE3, XIAP, IKZF5, PRMT6, UHRF2EIF3DEIF1B, EIF4A2, EIF3A, EIF3L, PHLDA1, EIF3G, EIF3H, EIF3F, USP3, HAX1, CD4, EIF3E, PSMD12, DNAJB11, RAD21, SIRT7, CAND1, EIF3C, EIF3K, EIF3B, EIF3I, EIF3M, NCL, DDX3X, FN1, VCAM1, EIF3J, HNRNPU, RPL23A, RPL35, RPS11, RPS12, RPS18, RPS20, RPS27, RPS28, RPS4X, RPS9, STAU1, REL, TRIM27, SAT1, HOMER3, BEND5, LZTS2, CCDC8, RNF2, ABCE1, FBXW11, EIF3CL, SRSF7, SRSF5, SUPT4H1, NTRK1, HERC2, XPO1, MATR3, GAN, MCM2, BCOR, NANOG, POU5F1, ZNF746, EIF4A1, RAF1, CYLD, DLD, DNM1L, HSD17B10, SOD1, TRIM25, G3BP1, UBE2A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TCF7L2_EIF3D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TCF7L2_EIF3D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTCF7L2C0036341Schizophrenia4PSYGENET
HgeneTCF7L2C0009404Colorectal Neoplasms2CTD_human
HgeneTCF7L2C0011860Diabetes Mellitus, Non-Insulin-Dependent2CTD_human
HgeneTCF7L2C0001418Adenocarcinoma1CTD_human
HgeneTCF7L2C0005586Bipolar Disorder1PSYGENET
HgeneTCF7L2C0009375Colonic Neoplasms1CTD_human
HgeneTCF7L2C0020507Hyperplasia1CTD_human
HgeneTCF7L2C0036337Schizoaffective Disorder1PSYGENET
HgeneTCF7L2C3495559Juvenile arthritis1CTD_human