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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37594

FusionGeneSummary for TCF7L1_KCMF1

check button Fusion gene summary
Fusion gene informationFusion gene name: TCF7L1_KCMF1
Fusion gene ID: 37594
HgeneTgene
Gene symbol

TCF7L1

KCMF1

Gene ID

83439

56888

Gene nametranscription factor 7 like 1potassium channel modulatory factor 1
SynonymsTCF-3|TCF3DEBT91|FIGC|PCMF|ZZZ1
Cytomap

2p11.2

2p11.2

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor 7-like 1HMG box transcription factor 3transcription factor 7-like 1 (T-cell specific, HMG-box)E3 ubiquitin-protein ligase KCMF1FGF-induced in gastric cancerFGF-induced ubiquitin-protein ligase in gastric cancersRING-type E3 ubiquitin transferase KCMF1ZZ-type zinc finger-containing protein 1differentially expressed in branching tubulogenesis 9
Modification date2018052320180519
UniProtAcc

Q9HCS4

Q9P0J7

Ensembl transtripts involved in fusion geneENST00000282111, ENST00000494519, 
ENST00000409785, 
Fusion gene scores* DoF score9 X 5 X 8=3605 X 5 X 3=75
# samples 97
** MAII scorelog2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/75*10)=-0.0995356735509144
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TCF7L1 [Title/Abstract] AND KCMF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-E6-A8L9-01ATCF7L1chr2

85361573

+KCMF1chr2

85255012

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000282111ENST00000409785TCF7L1chr2

85361573

+KCMF1chr2

85255012

+
3UTR-3CDSENST00000494519ENST00000409785TCF7L1chr2

85361573

+KCMF1chr2

85255012

+

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FusionProtFeatures for TCF7L1_KCMF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TCF7L1

Q9HCS4

KCMF1

Q9P0J7

Participates in the Wnt signaling pathway. Binds to DNAand acts as a repressor in the absence of CTNNB1, and as anactivator in its presence. Necessary for the terminaldifferentiation of epidermal cells, the formation of keratohyalingranules and the development of the barrier function of theepidermis (By similarity). Down-regulates NQO1, leading toincreased mitomycin c resistance. {ECO:0000250}. Has intrinsic E3 ubiquitin ligase activity and promotesubiquitination. {ECO:0000269|PubMed:15581609}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TCF7L1_KCMF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TCF7L1_KCMF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TCF7L1CTNNB1, DAZAP2, NANOG, POU5F1KCMF1GRK5, VCP, SOX2, BYSL, EIF3L, FLNC, HDLBP, HERC1, IKBKG, PNO1, PSMC1, PSMC5, PSMD11, PSMD12, PSMD13, PSMD3, PSMD7, PSMD8, RPS13, TJP2, TXNL1, UBR4, UCHL5, WDR26, WIBG, KCMF1, UBE2D2, UBC, FIGF, TFDP3, ABHD10, SARS2, IDH2, CEP85, NIPSNAP3A, MRS2, TESPA1, POGLUT1, EDA, CHIA, CD96, CST9, RASSF9, RASSF10, UBE2A, UBE2B, NIPSNAP1, SSBP1, ACOT9, NUP188, OGT, NUP93, NUP214, PRCP, QARS, HSPB1, KRAS, MED20, XPO1, POU5F1, A1BG, FSTL4, C15orf27, VWA5A, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TCF7L1_KCMF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TCF7L1_KCMF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTCF7L1C0040136Thyroid Neoplasm1CTD_human