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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37587

FusionGeneSummary for TCF3_ZNF384

check button Fusion gene summary
Fusion gene informationFusion gene name: TCF3_ZNF384
Fusion gene ID: 37587
HgeneTgene
Gene symbol

TCF3

ZNF384

Gene ID

83439

171017

Gene nametranscription factor 7 like 1zinc finger protein 384
SynonymsTCF-3|TCF3CAGH1|CAGH1A|CIZ|ERDA2|NMP4|NP|TNRC1
Cytomap

2p11.2

12p13.31

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor 7-like 1HMG box transcription factor 3transcription factor 7-like 1 (T-cell specific, HMG-box)zinc finger protein 384CAG repeat protein 1Cas-interacting zinc finger proteinexpanded repeat domain, CAG/CTG 2nuclear matrix transcription factor 4trinucleotide repeat-containing gene 1 protein
Modification date2018052320180519
UniProtAcc

P15923

Q8TF68

Ensembl transtripts involved in fusion geneENST00000344749, ENST00000262965, 
ENST00000453954, ENST00000395423, 
ENST00000588136, 
ENST00000396795, 
ENST00000319770, ENST00000396801, 
ENST00000361959, ENST00000355772, 
ENST00000396799, 
Fusion gene scores* DoF score12 X 12 X 5=7202 X 4 X 1=8
# samples 184
** MAII scorelog2(18/720*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/8*10)=2.32192809488736
Context

PubMed: TCF3 [Title/Abstract] AND ZNF384 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1EU155119TCF3chr19

1621834

-ZNF384chr12

6788692

-
ChiTaRS3.1EF613330TCF3chr19

1619110

-ZNF384chr12

6797393

-
ChiTaRS3.1EU159436TCF3chr19

1621562

-ZNF384chr12

6794153

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000344749ENST00000396795TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000344749ENST00000319770TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000344749ENST00000396801TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000344749ENST00000361959TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000344749ENST00000355772TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000344749ENST00000396799TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000262965ENST00000396795TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000262965ENST00000319770TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000262965ENST00000396801TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000262965ENST00000361959TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000262965ENST00000355772TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000262965ENST00000396799TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000453954ENST00000396795TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000453954ENST00000319770TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000453954ENST00000396801TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000453954ENST00000361959TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000453954ENST00000355772TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000453954ENST00000396799TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000395423ENST00000396795TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000395423ENST00000319770TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000395423ENST00000396801TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000395423ENST00000361959TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000395423ENST00000355772TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000395423ENST00000396799TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000588136ENST00000396795TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000588136ENST00000319770TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000588136ENST00000396801TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000588136ENST00000361959TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000588136ENST00000355772TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000588136ENST00000396799TCF3chr19

1621834

-ZNF384chr12

6788692

-
5CDS-5UTRENST00000344749ENST00000396795TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000344749ENST00000319770TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000344749ENST00000396801TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000344749ENST00000361959TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000344749ENST00000355772TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000344749ENST00000396799TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000262965ENST00000396795TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000262965ENST00000319770TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000262965ENST00000396801TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000262965ENST00000361959TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000262965ENST00000355772TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000262965ENST00000396799TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000453954ENST00000396795TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000453954ENST00000319770TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000453954ENST00000396801TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000453954ENST00000361959TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000453954ENST00000355772TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000453954ENST00000396799TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000395423ENST00000396795TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000395423ENST00000319770TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000395423ENST00000396801TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000395423ENST00000361959TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000395423ENST00000355772TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000395423ENST00000396799TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000588136ENST00000396795TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000588136ENST00000319770TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000588136ENST00000396801TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000588136ENST00000361959TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000588136ENST00000355772TCF3chr19

1619110

-ZNF384chr12

6797393

-
5CDS-5UTRENST00000588136ENST00000396799TCF3chr19

1619110

-ZNF384chr12

6797393

-
intron-intronENST00000344749ENST00000396795TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000344749ENST00000319770TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000344749ENST00000396801TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000344749ENST00000361959TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000344749ENST00000355772TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000344749ENST00000396799TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000262965ENST00000396795TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000262965ENST00000319770TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000262965ENST00000396801TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000262965ENST00000361959TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000262965ENST00000355772TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000262965ENST00000396799TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000453954ENST00000396795TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000453954ENST00000319770TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000453954ENST00000396801TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000453954ENST00000361959TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000453954ENST00000355772TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000453954ENST00000396799TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000395423ENST00000396795TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000395423ENST00000319770TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000395423ENST00000396801TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000395423ENST00000361959TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000395423ENST00000355772TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000395423ENST00000396799TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000588136ENST00000396795TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000588136ENST00000319770TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000588136ENST00000396801TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000588136ENST00000361959TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000588136ENST00000355772TCF3chr19

1621562

-ZNF384chr12

6794153

-
intron-intronENST00000588136ENST00000396799TCF3chr19

1621562

-ZNF384chr12

6794153

-

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FusionProtFeatures for TCF3_ZNF384


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TCF3

P15923

ZNF384

Q8TF68

Transcriptional regulator. Involved in the initiation ofneuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major rolesin determining tissue-specific cell fate during embryogenesis,like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappaimmunoglobulin gene enhancer. Binds to IEB1 and IEB2, which areshort DNA sequences in the insulin gene transcription controlregion. {ECO:0000250|UniProtKB:P15806}. Transcription factor that binds the consensus DNAsequence [GC]AAAAA. Seems to bind and regulate the promoters ofMMP1, MMP3, MMP7 and COL1A1 (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TCF3_ZNF384


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TCF3_ZNF384


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TCF3HAND2, ID3, SKP2, NHLH1, TCF3, EP300, CREBBP, KAT2B, CALM1, LMX1A, TAL1, LDB1, CBFA2T3, ELK3, MYOD1, ID1, ID2, MYF5, MYF6, MYOG, UBE2I, LYL1, MAPKAPK3, TWIST1, DAXX, MEN1, TCF4, RUNX1T1, RUNX1, VDR, HDAC2, DNMT1, TRIM33, INO80E, YY1, RB1, ASB2, SOX2, ELAVL1, ID4, KDM1A, PRMT5, MRPL37, RPL23A, UQCRC2, MRPL49, DDX17, SAFB, EIF5A, MYO1B, GSE1, SLC25A10, BHLHA15, PIP, ALDH18A1, SF3A3, DNAJC10, RPL36A, IMMT, RPS13, DDX20, TET2, PRPF8, RCOR1, TCF24, RPL14, PON2, SSBP1, RPL31, MRPL44, C14orf166, SPIN1, CCT2, MYL6B, CHCHD3, ATP2A3, LANCL2, SLC9A3R1, TIMM50, ERLIN2, MRPL39, ATOH8, SERPINH1, SETSIP, SON, FBL, SLC25A4, EEF1A2, LGALS7, C1QBP, CPD, MRPL23, NHLH2, RPL13, COX7A2, CSTA, PCBP1, NDUFB4, TFF3, FLG2, HNRNPR, ERAL1, RPN2, RBM39, RPL24, LBR, CASP14, STK38, CANX, TCF12, FOXH1, TLE1, KAT2A, TRRAP, SUPT3H, TADA2A, USF1, SCX, TCF21, RPL37, MAPKAPK2, RNF14, FAM115A, PTF1A, HAND1, NEUROD1, MESP2, BHLHE40, PARP1, PSMD4, NEDD9, XPO1, BCOR, KIF18A, ATOH1, FERD3L, NEUROG3, FKBP9, COLGALT2ZNF384CEBPE, HOXC9, OPTN, SOX2, TUBA3C, TRIP6, NFATC2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TCF3_ZNF384


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TCF3_ZNF384


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTCF3C0006413Burkitt Lymphoma2CTD_human
HgeneTCF3C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
HgeneTCF3C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human