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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37585

FusionGeneSummary for TCF3_SYTL5

check button Fusion gene summary
Fusion gene informationFusion gene name: TCF3_SYTL5
Fusion gene ID: 37585
HgeneTgene
Gene symbol

TCF3

SYTL5

Gene ID

83439

94122

Gene nametranscription factor 7 like 1synaptotagmin like 5
SynonymsTCF-3|TCF3slp5
Cytomap

2p11.2

Xp11.4

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor 7-like 1HMG box transcription factor 3transcription factor 7-like 1 (T-cell specific, HMG-box)synaptotagmin-like protein 5exophilin 9
Modification date2018052320180523
UniProtAcc

P15923

Q8TDW5

Ensembl transtripts involved in fusion geneENST00000344749, ENST00000262965, 
ENST00000453954, ENST00000395423, 
ENST00000588136, 
ENST00000297875, 
ENST00000357972, ENST00000456733, 
Fusion gene scores* DoF score12 X 12 X 5=7202 X 2 X 2=8
# samples 182
** MAII scorelog2(18/720*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: TCF3 [Title/Abstract] AND SYTL5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A0U3-01ATCF3chr19

1615284

-SYTL5chrX

37985841

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000344749ENST00000297875TCF3chr19

1615284

-SYTL5chrX

37985841

+
intron-3CDSENST00000344749ENST00000357972TCF3chr19

1615284

-SYTL5chrX

37985841

+
intron-3CDSENST00000344749ENST00000456733TCF3chr19

1615284

-SYTL5chrX

37985841

+
In-frameENST00000262965ENST00000297875TCF3chr19

1615284

-SYTL5chrX

37985841

+
In-frameENST00000262965ENST00000357972TCF3chr19

1615284

-SYTL5chrX

37985841

+
In-frameENST00000262965ENST00000456733TCF3chr19

1615284

-SYTL5chrX

37985841

+
intron-3CDSENST00000453954ENST00000297875TCF3chr19

1615284

-SYTL5chrX

37985841

+
intron-3CDSENST00000453954ENST00000357972TCF3chr19

1615284

-SYTL5chrX

37985841

+
intron-3CDSENST00000453954ENST00000456733TCF3chr19

1615284

-SYTL5chrX

37985841

+
Frame-shitENST00000395423ENST00000297875TCF3chr19

1615284

-SYTL5chrX

37985841

+
Frame-shitENST00000395423ENST00000357972TCF3chr19

1615284

-SYTL5chrX

37985841

+
Frame-shitENST00000395423ENST00000456733TCF3chr19

1615284

-SYTL5chrX

37985841

+
intron-3CDSENST00000588136ENST00000297875TCF3chr19

1615284

-SYTL5chrX

37985841

+
intron-3CDSENST00000588136ENST00000357972TCF3chr19

1615284

-SYTL5chrX

37985841

+
intron-3CDSENST00000588136ENST00000456733TCF3chr19

1615284

-SYTL5chrX

37985841

+

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FusionProtFeatures for TCF3_SYTL5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TCF3

P15923

SYTL5

Q8TDW5

Transcriptional regulator. Involved in the initiation ofneuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major rolesin determining tissue-specific cell fate during embryogenesis,like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappaimmunoglobulin gene enhancer. Binds to IEB1 and IEB2, which areshort DNA sequences in the insulin gene transcription controlregion. {ECO:0000250|UniProtKB:P15806}. May act as Rab effector protein and play a role invesicle trafficking. Binds phospholipids.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TCF3_SYTL5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TCF3_ENST00000262965_chr19_1615284_-_SYTL5_ENST00000297875_chrX_37985841_+_47aa

>In-frame_TCF3_ENST00000262965_chr19_1615284_-_SYTL5_ENST00000357972_chrX_37985841_+_47aa

>In-frame_TCF3_ENST00000262965_chr19_1615284_-_SYTL5_ENST00000456733_chrX_37985841_+_47aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TCF3_ENST00000262965_chr19_1615284_-_SYTL5_ENST00000297875_chrX_37985841_+_143nt
GTGTGAGCCATGGGAAGAACGTGGATTGGATGGACTCTCAGGGGGAAGAGCAGCGCCTTTGGCAGAAGATGGCCAACAACCCTGGAACTC

>In-frame_TCF3_ENST00000262965_chr19_1615284_-_SYTL5_ENST00000357972_chrX_37985841_+_143nt
GTGTGAGCCATGGGAAGAACGTGGATTGGATGGACTCTCAGGGGGAAGAGCAGCGCCTTTGGCAGAAGATGGCCAACAACCCTGGAACTC

>In-frame_TCF3_ENST00000262965_chr19_1615284_-_SYTL5_ENST00000456733_chrX_37985841_+_143nt
GTGTGAGCCATGGGAAGAACGTGGATTGGATGGACTCTCAGGGGGAAGAGCAGCGCCTTTGGCAGAAGATGGCCAACAACCCTGGAACTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_TCF3_ENST00000262965_chr19_1615284_-_SYTL5_ENST00000297875_chrX_37985841_+_4396nt
TCCCGCCGCAGGAAGATGAGGCAGCGGCGGCGGCTGCGGGCGTAGCGGGCCGGAGCCGACGCGGCGGCGGGCACCGCGGGCACCGCGCAC
GCCGCTGCCCCAGGGGCGCCCCGGCCGGCCGCGCGCACGGGCCCCGCGGGACGGGCCACGCGGGGGTGGGAGGGGCCCGGGCCACGCGCG
CCGCCGCCGCCGCCCACGCGCGACCCTCGGGGGCCCGGCCGCGACGCACCTTTGTCCGGGGGGGGGCCCCCCCGCTTCATGCCGCCGCCC
CCCCCCACGCGCCGCGTGCCCGGCCGCGCCCAGCAGGGTTTCCAGGCCTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAG
AGGATGGCGCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGACTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGC
CGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGTCTTGAGGACCGGCCCAGCTCAGGCTCCTGGGGCAGCGGCGACCAGAGC
AGCTCCTCCTTTGACCCCAGCCGGACCTTCAGCGAGGGCACCCACTTCACTGAGTCGCACAGCAGCCTCTCTTCATCCACATTCCTGGGA
CCGGGACTCGGAGGCAAGAGCGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTC
CTGTCAGGCGAGCTGGCCCTCAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACTCCGGC
AGCTCCCGGCGGAGAGCGGCAGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGGTGTAC
CCACCCAGCTCAGGTGAGGACTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCTTCTAC
GTGGCAGATGGCAGCCTGCACCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCTCATCC
CCGCTGCCCCTCCCGCCCGGTAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTATGGGC
TACCAGCTGCATGGAGCAGAGGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCGTCTCC
AGCCACACGCCGCCTGTCAGCGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCA
CTGGCCTCGATCTACTCCCCGGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGA
ACGTCACAGTGGCCTCGAGCAGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAGAAGAC
CACCTGGACGAGGCCATCCACGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGGCGCTG
GCCTCAGGTTTCACCGGCCCCATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAGGCAGC
ACCAGCCTCATGCACAACCACGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTGGGCTA
GGGCGAGCAGGTGCCACGGCGGCCGCCAGCGAGATCAAGCGGGAGGAGAAGGAGGACGAGGAGAACACGTCAGCGGCTGACCACTCGGAG
GAGGAGAAGAAGGAGCTGAAGGCCCCCCGGGCCCGGACCAGCCCAGACGAGGACGAGGACGACCTTCTCCCCCCAGAGCAGAAGGCCGAG
CGGGAGAAGGAGCGCCGGGTGGCCAATAACGCCCGGGAGCGGCTGCGGGTCCGTGACATCAACGAGGCCTTTAAGGAGCTGGGGCGCATG
TGCCAACTGCACCTCAACAGCGAGAAGCCCCAGACCAAACTGCTCATCCTGCACCAGGCTGTCTCGGTCATCCTGAACTTGGAGCAGCAA
GTGCGAGGTGTGAGCCATGGGAAGAACGTGGATTGGATGGACTCTCAGGGGGAAGAGCAGCGCCTTTGGCAGAAGATGGCCAACAACCCT
GGAACTCCCTTTGAGGGTGTACTCATGCTTCGTTCCAGCATGGGAAAATGTAGGCTCTAAAGGGACCAGTTCTCCAAGAATGAGGCCACC
AGGACCTATCTGGCTGTCTTTTCCTACCATTAGCAAACTGAGACCTGGGATTCTGCTTCCCTGCCATTTCTCACCTGACAGTGTTGGGAC
ATGAGGGGAGAGATGTCAGTAGTATGAACATTTAGGGTCTTGCTGAGTGCCTAAAAAACATATATTTCCATCCAATCAAGGCCTTCTTGA
TTGGATGATAGAAAGTGTACTACTTGTCCTGTCAACAAGCAAATTGTGCAAAGGCTTATAGGGTTTATGCCATAAAAGAAATGGCACAAG
CCTCCATTTGCTAATTATAAGTTACTTTAGATTTCCTCAAATCCTTTGAAGAGAAAGAGGACCACTGAGAAGGTAGATCACTTGAAAAGT
CAGAAGAAAGGATACTGGCCAACTTTTACTCACCCTAGGAATCCACATGATCTCAAGAAGGCATGGTGGAGATGGTTGCTTGAGCAAGGG
GATTGTCCTGTTATTGCAGCAAACTTGTGGATTAACCAAGTAGTATTTCAAGATGGATTGACAGGGCTTTCTATGATTACTATAGAATTT
ATCATCTAAATCAGTTTACTTTTTAGAACAAAGAGAGCTAAATAACTACATCAGAACGATTGATGTTGATTAGAATTGACCTGGGAAAAT
TGGGATGTAGGGTCACCCTACTGATGACCTAAGAGAGCTCTGTTTTAAACATTTATTTTATAAAATGTTCTAAGCCATTAACTAAAAGGA
AATGAGATATAATGGTCAATTGATATACCTTTTCACATTGTGTTCACTGACGAGACTAGTTTAATGAAAAAGGAGGTACTCTACCTGCTA
TTTTACTTCTGTTCCTCTTCTGCCCTGTTATGGGAGAGAATCAAAGACTCCATCTGCTCTCTTCCCCCTTGTTTTCTCCTTCACTGAGTT
TTTCTTATCTCCTTTTGCAGTGGTTAACTATTGTCACAATAATGCTGAATGAAAAAACACACCAAATGTCAGTGGCTTAAAATGACCATC
CTTTTTCTCACAGTTATGAAGATTGGCTATGGCACCTCTGCTTCCTGCTATAGGCCTGAGGTTCTAGGGCTTCTTATGCCTCATCCTCTT
TAAGCCAAAGGGATAGCCAGAGCATCTTGATGGCAGAAGTGCAATAAGATGAGCCCCACTGCTCGGGTACATTTTCAGCCCCTGGTTGTG
TCATGTCTACTGATATCTCATTGGTCAAAGGAAGTCAGAGGGCCAAGATGAAGAGGCAGGGAAATATGCACTGCCCACAGTGAAGCCATG
ACAAGAGTGAGGATGCAGGAAGGCATGAAGAATTGGGGCCAACAGTTCAATCTACCATACCTTCTCTCACCTGGAATTCCAGATGCTTGA
GCTACGAAACTTAGATGCAAAGAAAGTTAAAGCTAGAAGGAACCTCAGGCCCAGTTGCTCATTTTGCAGATTCCAAATGTGAATTTCAGA
GAGCTGAGATAACTTGCCCAAGGCCATATAGAGGCTGTGACTAAATCTGGACTTAAATCCAGACTATCAATCTTAGGCCAGTGTTCTTTT
TTCAATATAGTCCTTGGCATAATGCTATGCTTATTAGGTAGATAAAAGGGCTTATGTCAAGAAATTTGGAGCAGAGTCTGATTACTTGAG
CATGAACATACCCGACCAAGGTATGTTCTGGAGTCATATTCTAGCCTCTGAGCTCATTTTTTCATGCGAGTTCATATAAAATCCTCGAAA
GTTTAGAAACTAGGTTTTAGTAGTAACGGAGCTAGAATCATCTTCGGGCTTATTCCTGCTAGTTGTTCCATATTTCTAGATTTCATCTTG
AATTTTGAAAACTGATTTAAGAATATATTTAGTATTATTATTAGTAAGGGAATACGCAATCCAGTTTCAATTTTATTCAGAAGTAGGTCA
CCTAATTCTAGAAAATGGTTATTAGTCTAGTGTCGCTTAGCAAGGTACTTAAAAGAAAATCTGCACATATCCTTGTGCTGCCCTTCTTAA

>In-frame_TCF3_ENST00000262965_chr19_1615284_-_SYTL5_ENST00000357972_chrX_37985841_+_4399nt
TCCCGCCGCAGGAAGATGAGGCAGCGGCGGCGGCTGCGGGCGTAGCGGGCCGGAGCCGACGCGGCGGCGGGCACCGCGGGCACCGCGCAC
GCCGCTGCCCCAGGGGCGCCCCGGCCGGCCGCGCGCACGGGCCCCGCGGGACGGGCCACGCGGGGGTGGGAGGGGCCCGGGCCACGCGCG
CCGCCGCCGCCGCCCACGCGCGACCCTCGGGGGCCCGGCCGCGACGCACCTTTGTCCGGGGGGGGGCCCCCCCGCTTCATGCCGCCGCCC
CCCCCCACGCGCCGCGTGCCCGGCCGCGCCCAGCAGGGTTTCCAGGCCTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAG
AGGATGGCGCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGACTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGC
CGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGTCTTGAGGACCGGCCCAGCTCAGGCTCCTGGGGCAGCGGCGACCAGAGC
AGCTCCTCCTTTGACCCCAGCCGGACCTTCAGCGAGGGCACCCACTTCACTGAGTCGCACAGCAGCCTCTCTTCATCCACATTCCTGGGA
CCGGGACTCGGAGGCAAGAGCGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTC
CTGTCAGGCGAGCTGGCCCTCAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACTCCGGC
AGCTCCCGGCGGAGAGCGGCAGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGGTGTAC
CCACCCAGCTCAGGTGAGGACTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCTTCTAC
GTGGCAGATGGCAGCCTGCACCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCTCATCC
CCGCTGCCCCTCCCGCCCGGTAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTATGGGC
TACCAGCTGCATGGAGCAGAGGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCGTCTCC
AGCCACACGCCGCCTGTCAGCGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCA
CTGGCCTCGATCTACTCCCCGGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGA
ACGTCACAGTGGCCTCGAGCAGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAGAAGAC
CACCTGGACGAGGCCATCCACGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGGCGCTG
GCCTCAGGTTTCACCGGCCCCATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAGGCAGC
ACCAGCCTCATGCACAACCACGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTGGGCTA
GGGCGAGCAGGTGCCACGGCGGCCGCCAGCGAGATCAAGCGGGAGGAGAAGGAGGACGAGGAGAACACGTCAGCGGCTGACCACTCGGAG
GAGGAGAAGAAGGAGCTGAAGGCCCCCCGGGCCCGGACCAGCCCAGACGAGGACGAGGACGACCTTCTCCCCCCAGAGCAGAAGGCCGAG
CGGGAGAAGGAGCGCCGGGTGGCCAATAACGCCCGGGAGCGGCTGCGGGTCCGTGACATCAACGAGGCCTTTAAGGAGCTGGGGCGCATG
TGCCAACTGCACCTCAACAGCGAGAAGCCCCAGACCAAACTGCTCATCCTGCACCAGGCTGTCTCGGTCATCCTGAACTTGGAGCAGCAA
GTGCGAGGTGTGAGCCATGGGAAGAACGTGGATTGGATGGACTCTCAGGGGGAAGAGCAGCGCCTTTGGCAGAAGATGGCCAACAACCCT
GGAACTCCCTTTGAGGGTGTACTCATGCTTCGTTCCAGCATGGGAAAATGTAGGCTCTAAAGGGACCAGTTCTCCAAGAATGAGGCCACC
AGGACCTATCTGGCTGTCTTTTCCTACCATTAGCAAACTGAGACCTGGGATTCTGCTTCCCTGCCATTTCTCACCTGACAGTGTTGGGAC
ATGAGGGGAGAGATGTCAGTAGTATGAACATTTAGGGTCTTGCTGAGTGCCTAAAAAACATATATTTCCATCCAATCAAGGCCTTCTTGA
TTGGATGATAGAAAGTGTACTACTTGTCCTGTCAACAAGCAAATTGTGCAAAGGCTTATAGGGTTTATGCCATAAAAGAAATGGCACAAG
CCTCCATTTGCTAATTATAAGTTACTTTAGATTTCCTCAAATCCTTTGAAGAGAAAGAGGACCACTGAGAAGGTAGATCACTTGAAAAGT
CAGAAGAAAGGATACTGGCCAACTTTTACTCACCCTAGGAATCCACATGATCTCAAGAAGGCATGGTGGAGATGGTTGCTTGAGCAAGGG
GATTGTCCTGTTATTGCAGCAAACTTGTGGATTAACCAAGTAGTATTTCAAGATGGATTGACAGGGCTTTCTATGATTACTATAGAATTT
ATCATCTAAATCAGTTTACTTTTTAGAACAAAGAGAGCTAAATAACTACATCAGAACGATTGATGTTGATTAGAATTGACCTGGGAAAAT
TGGGATGTAGGGTCACCCTACTGATGACCTAAGAGAGCTCTGTTTTAAACATTTATTTTATAAAATGTTCTAAGCCATTAACTAAAAGGA
AATGAGATATAATGGTCAATTGATATACCTTTTCACATTGTGTTCACTGACGAGACTAGTTTAATGAAAAAGGAGGTACTCTACCTGCTA
TTTTACTTCTGTTCCTCTTCTGCCCTGTTATGGGAGAGAATCAAAGACTCCATCTGCTCTCTTCCCCCTTGTTTTCTCCTTCACTGAGTT
TTTCTTATCTCCTTTTGCAGTGGTTAACTATTGTCACAATAATGCTGAATGAAAAAACACACCAAATGTCAGTGGCTTAAAATGACCATC
CTTTTTCTCACAGTTATGAAGATTGGCTATGGCACCTCTGCTTCCTGCTATAGGCCTGAGGTTCTAGGGCTTCTTATGCCTCATCCTCTT
TAAGCCAAAGGGATAGCCAGAGCATCTTGATGGCAGAAGTGCAATAAGATGAGCCCCACTGCTCGGGTACATTTTCAGCCCCTGGTTGTG
TCATGTCTACTGATATCTCATTGGTCAAAGGAAGTCAGAGGGCCAAGATGAAGAGGCAGGGAAATATGCACTGCCCACAGTGAAGCCATG
ACAAGAGTGAGGATGCAGGAAGGCATGAAGAATTGGGGCCAACAGTTCAATCTACCATACCTTCTCTCACCTGGAATTCCAGATGCTTGA
GCTACGAAACTTAGATGCAAAGAAAGTTAAAGCTAGAAGGAACCTCAGGCCCAGTTGCTCATTTTGCAGATTCCAAATGTGAATTTCAGA
GAGCTGAGATAACTTGCCCAAGGCCATATAGAGGCTGTGACTAAATCTGGACTTAAATCCAGACTATCAATCTTAGGCCAGTGTTCTTTT
TTCAATATAGTCCTTGGCATAATGCTATGCTTATTAGGTAGATAAAAGGGCTTATGTCAAGAAATTTGGAGCAGAGTCTGATTACTTGAG
CATGAACATACCCGACCAAGGTATGTTCTGGAGTCATATTCTAGCCTCTGAGCTCATTTTTTCATGCGAGTTCATATAAAATCCTCGAAA
GTTTAGAAACTAGGTTTTAGTAGTAACGGAGCTAGAATCATCTTCGGGCTTATTCCTGCTAGTTGTTCCATATTTCTAGATTTCATCTTG
AATTTTGAAAACTGATTTAAGAATATATTTAGTATTATTATTAGTAAGGGAATACGCAATCCAGTTTCAATTTTATTCAGAAGTAGGTCA
CCTAATTCTAGAAAATGGTTATTAGTCTAGTGTCGCTTAGCAAGGTACTTAAAAGAAAATCTGCACATATCCTTGTGCTGCCCTTCTTAA

>In-frame_TCF3_ENST00000262965_chr19_1615284_-_SYTL5_ENST00000456733_chrX_37985841_+_4399nt
TCCCGCCGCAGGAAGATGAGGCAGCGGCGGCGGCTGCGGGCGTAGCGGGCCGGAGCCGACGCGGCGGCGGGCACCGCGGGCACCGCGCAC
GCCGCTGCCCCAGGGGCGCCCCGGCCGGCCGCGCGCACGGGCCCCGCGGGACGGGCCACGCGGGGGTGGGAGGGGCCCGGGCCACGCGCG
CCGCCGCCGCCGCCCACGCGCGACCCTCGGGGGCCCGGCCGCGACGCACCTTTGTCCGGGGGGGGGCCCCCCCGCTTCATGCCGCCGCCC
CCCCCCACGCGCCGCGTGCCCGGCCGCGCCCAGCAGGGTTTCCAGGCCTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAG
AGGATGGCGCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGACTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGC
CGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGTCTTGAGGACCGGCCCAGCTCAGGCTCCTGGGGCAGCGGCGACCAGAGC
AGCTCCTCCTTTGACCCCAGCCGGACCTTCAGCGAGGGCACCCACTTCACTGAGTCGCACAGCAGCCTCTCTTCATCCACATTCCTGGGA
CCGGGACTCGGAGGCAAGAGCGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTC
CTGTCAGGCGAGCTGGCCCTCAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACTCCGGC
AGCTCCCGGCGGAGAGCGGCAGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGGTGTAC
CCACCCAGCTCAGGTGAGGACTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCTTCTAC
GTGGCAGATGGCAGCCTGCACCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCTCATCC
CCGCTGCCCCTCCCGCCCGGTAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTATGGGC
TACCAGCTGCATGGAGCAGAGGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCGTCTCC
AGCCACACGCCGCCTGTCAGCGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCA
CTGGCCTCGATCTACTCCCCGGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGA
ACGTCACAGTGGCCTCGAGCAGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAGAAGAC
CACCTGGACGAGGCCATCCACGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGGCGCTG
GCCTCAGGTTTCACCGGCCCCATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAGGCAGC
ACCAGCCTCATGCACAACCACGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTGGGCTA
GGGCGAGCAGGTGCCACGGCGGCCGCCAGCGAGATCAAGCGGGAGGAGAAGGAGGACGAGGAGAACACGTCAGCGGCTGACCACTCGGAG
GAGGAGAAGAAGGAGCTGAAGGCCCCCCGGGCCCGGACCAGCCCAGACGAGGACGAGGACGACCTTCTCCCCCCAGAGCAGAAGGCCGAG
CGGGAGAAGGAGCGCCGGGTGGCCAATAACGCCCGGGAGCGGCTGCGGGTCCGTGACATCAACGAGGCCTTTAAGGAGCTGGGGCGCATG
TGCCAACTGCACCTCAACAGCGAGAAGCCCCAGACCAAACTGCTCATCCTGCACCAGGCTGTCTCGGTCATCCTGAACTTGGAGCAGCAA
GTGCGAGGTGTGAGCCATGGGAAGAACGTGGATTGGATGGACTCTCAGGGGGAAGAGCAGCGCCTTTGGCAGAAGATGGCCAACAACCCT
GGAACTCCCTTTGAGGGTGTACTCATGCTTCGTTCCAGCATGGGAAAATGTAGGCTCTAAAGGGACCAGTTCTCCAAGAATGAGGCCACC
AGGACCTATCTGGCTGTCTTTTCCTACCATTAGCAAACTGAGACCTGGGATTCTGCTTCCCTGCCATTTCTCACCTGACAGTGTTGGGAC
ATGAGGGGAGAGATGTCAGTAGTATGAACATTTAGGGTCTTGCTGAGTGCCTAAAAAACATATATTTCCATCCAATCAAGGCCTTCTTGA
TTGGATGATAGAAAGTGTACTACTTGTCCTGTCAACAAGCAAATTGTGCAAAGGCTTATAGGGTTTATGCCATAAAAGAAATGGCACAAG
CCTCCATTTGCTAATTATAAGTTACTTTAGATTTCCTCAAATCCTTTGAAGAGAAAGAGGACCACTGAGAAGGTAGATCACTTGAAAAGT
CAGAAGAAAGGATACTGGCCAACTTTTACTCACCCTAGGAATCCACATGATCTCAAGAAGGCATGGTGGAGATGGTTGCTTGAGCAAGGG
GATTGTCCTGTTATTGCAGCAAACTTGTGGATTAACCAAGTAGTATTTCAAGATGGATTGACAGGGCTTTCTATGATTACTATAGAATTT
ATCATCTAAATCAGTTTACTTTTTAGAACAAAGAGAGCTAAATAACTACATCAGAACGATTGATGTTGATTAGAATTGACCTGGGAAAAT
TGGGATGTAGGGTCACCCTACTGATGACCTAAGAGAGCTCTGTTTTAAACATTTATTTTATAAAATGTTCTAAGCCATTAACTAAAAGGA
AATGAGATATAATGGTCAATTGATATACCTTTTCACATTGTGTTCACTGACGAGACTAGTTTAATGAAAAAGGAGGTACTCTACCTGCTA
TTTTACTTCTGTTCCTCTTCTGCCCTGTTATGGGAGAGAATCAAAGACTCCATCTGCTCTCTTCCCCCTTGTTTTCTCCTTCACTGAGTT
TTTCTTATCTCCTTTTGCAGTGGTTAACTATTGTCACAATAATGCTGAATGAAAAAACACACCAAATGTCAGTGGCTTAAAATGACCATC
CTTTTTCTCACAGTTATGAAGATTGGCTATGGCACCTCTGCTTCCTGCTATAGGCCTGAGGTTCTAGGGCTTCTTATGCCTCATCCTCTT
TAAGCCAAAGGGATAGCCAGAGCATCTTGATGGCAGAAGTGCAATAAGATGAGCCCCACTGCTCGGGTACATTTTCAGCCCCTGGTTGTG
TCATGTCTACTGATATCTCATTGGTCAAAGGAAGTCAGAGGGCCAAGATGAAGAGGCAGGGAAATATGCACTGCCCACAGTGAAGCCATG
ACAAGAGTGAGGATGCAGGAAGGCATGAAGAATTGGGGCCAACAGTTCAATCTACCATACCTTCTCTCACCTGGAATTCCAGATGCTTGA
GCTACGAAACTTAGATGCAAAGAAAGTTAAAGCTAGAAGGAACCTCAGGCCCAGTTGCTCATTTTGCAGATTCCAAATGTGAATTTCAGA
GAGCTGAGATAACTTGCCCAAGGCCATATAGAGGCTGTGACTAAATCTGGACTTAAATCCAGACTATCAATCTTAGGCCAGTGTTCTTTT
TTCAATATAGTCCTTGGCATAATGCTATGCTTATTAGGTAGATAAAAGGGCTTATGTCAAGAAATTTGGAGCAGAGTCTGATTACTTGAG
CATGAACATACCCGACCAAGGTATGTTCTGGAGTCATATTCTAGCCTCTGAGCTCATTTTTTCATGCGAGTTCATATAAAATCCTCGAAA
GTTTAGAAACTAGGTTTTAGTAGTAACGGAGCTAGAATCATCTTCGGGCTTATTCCTGCTAGTTGTTCCATATTTCTAGATTTCATCTTG
AATTTTGAAAACTGATTTAAGAATATATTTAGTATTATTATTAGTAAGGGAATACGCAATCCAGTTTCAATTTTATTCAGAAGTAGGTCA
CCTAATTCTAGAAAATGGTTATTAGTCTAGTGTCGCTTAGCAAGGTACTTAAAAGAAAATCTGCACATATCCTTGTGCTGCCCTTCTTAA


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FusionGenePPI for TCF3_SYTL5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TCF3HAND2, ID3, SKP2, NHLH1, TCF3, EP300, CREBBP, KAT2B, CALM1, LMX1A, TAL1, LDB1, CBFA2T3, ELK3, MYOD1, ID1, ID2, MYF5, MYF6, MYOG, UBE2I, LYL1, MAPKAPK3, TWIST1, DAXX, MEN1, TCF4, RUNX1T1, RUNX1, VDR, HDAC2, DNMT1, TRIM33, INO80E, YY1, RB1, ASB2, SOX2, ELAVL1, ID4, KDM1A, PRMT5, MRPL37, RPL23A, UQCRC2, MRPL49, DDX17, SAFB, EIF5A, MYO1B, GSE1, SLC25A10, BHLHA15, PIP, ALDH18A1, SF3A3, DNAJC10, RPL36A, IMMT, RPS13, DDX20, TET2, PRPF8, RCOR1, TCF24, RPL14, PON2, SSBP1, RPL31, MRPL44, C14orf166, SPIN1, CCT2, MYL6B, CHCHD3, ATP2A3, LANCL2, SLC9A3R1, TIMM50, ERLIN2, MRPL39, ATOH8, SERPINH1, SETSIP, SON, FBL, SLC25A4, EEF1A2, LGALS7, C1QBP, CPD, MRPL23, NHLH2, RPL13, COX7A2, CSTA, PCBP1, NDUFB4, TFF3, FLG2, HNRNPR, ERAL1, RPN2, RBM39, RPL24, LBR, CASP14, STK38, CANX, TCF12, FOXH1, TLE1, KAT2A, TRRAP, SUPT3H, TADA2A, USF1, SCX, TCF21, RPL37, MAPKAPK2, RNF14, FAM115A, PTF1A, HAND1, NEUROD1, MESP2, BHLHE40, PARP1, PSMD4, NEDD9, XPO1, BCOR, KIF18A, ATOH1, FERD3L, NEUROG3, FKBP9, COLGALT2SYTL5RAB27A, RAB3A, RAB6A, RAB27B, WAC, CEP70


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TCF3_SYTL5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TCF3_SYTL5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTCF3C0006413Burkitt Lymphoma2CTD_human
HgeneTCF3C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
HgeneTCF3C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human