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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 37582

FusionGeneSummary for TCF3_PBX1

check button Fusion gene summary
Fusion gene informationFusion gene name: TCF3_PBX1
Fusion gene ID: 37582
HgeneTgene
Gene symbol

TCF3

PBX1

Gene ID

83439

5087

Gene nametranscription factor 7 like 1PBX homeobox 1
SynonymsTCF-3|TCF3CAKUHED
Cytomap

2p11.2

1q23.3

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor 7-like 1HMG box transcription factor 3transcription factor 7-like 1 (T-cell specific, HMG-box)pre-B-cell leukemia transcription factor 1homeobox protein PBX1homeobox protein PRLpre-B-cell leukemia homeobox 1
Modification date2018052320180519
UniProtAcc

P15923

P40424

Ensembl transtripts involved in fusion geneENST00000344749, ENST00000262965, 
ENST00000453954, ENST00000395423, 
ENST00000588136, 
ENST00000420696, 
ENST00000401534, ENST00000559240, 
ENST00000367897, ENST00000540236, 
ENST00000560641, ENST00000474046, 
ENST00000485769, ENST00000540246, 
Fusion gene scores* DoF score12 X 12 X 5=7207 X 8 X 5=280
# samples 1811
** MAII scorelog2(18/720*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/280*10)=-1.34792330342031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TCF3 [Title/Abstract] AND PBX1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AY311345TCF3chr19

1619110

-PBX1chr1

164761730

+
ChiTaRS3.1M31522TCF3chr19

1619110

-PBX1chr1

164761730

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000344749ENST00000420696TCF3chr19

1619110

-PBX1chr1

164761730

+
Frame-shitENST00000344749ENST00000401534TCF3chr19

1619110

-PBX1chr1

164761730

+
Frame-shitENST00000344749ENST00000559240TCF3chr19

1619110

-PBX1chr1

164761730

+
Frame-shitENST00000344749ENST00000367897TCF3chr19

1619110

-PBX1chr1

164761730

+
Frame-shitENST00000344749ENST00000540236TCF3chr19

1619110

-PBX1chr1

164761730

+
5CDS-5UTRENST00000344749ENST00000560641TCF3chr19

1619110

-PBX1chr1

164761730

+
5CDS-intronENST00000344749ENST00000474046TCF3chr19

1619110

-PBX1chr1

164761730

+
5CDS-intronENST00000344749ENST00000485769TCF3chr19

1619110

-PBX1chr1

164761730

+
5CDS-intronENST00000344749ENST00000540246TCF3chr19

1619110

-PBX1chr1

164761730

+
Frame-shitENST00000262965ENST00000420696TCF3chr19

1619110

-PBX1chr1

164761730

+
Frame-shitENST00000262965ENST00000401534TCF3chr19

1619110

-PBX1chr1

164761730

+
Frame-shitENST00000262965ENST00000559240TCF3chr19

1619110

-PBX1chr1

164761730

+
Frame-shitENST00000262965ENST00000367897TCF3chr19

1619110

-PBX1chr1

164761730

+
Frame-shitENST00000262965ENST00000540236TCF3chr19

1619110

-PBX1chr1

164761730

+
5CDS-5UTRENST00000262965ENST00000560641TCF3chr19

1619110

-PBX1chr1

164761730

+
5CDS-intronENST00000262965ENST00000474046TCF3chr19

1619110

-PBX1chr1

164761730

+
5CDS-intronENST00000262965ENST00000485769TCF3chr19

1619110

-PBX1chr1

164761730

+
5CDS-intronENST00000262965ENST00000540246TCF3chr19

1619110

-PBX1chr1

164761730

+
Frame-shitENST00000453954ENST00000420696TCF3chr19

1619110

-PBX1chr1

164761730

+
Frame-shitENST00000453954ENST00000401534TCF3chr19

1619110

-PBX1chr1

164761730

+
Frame-shitENST00000453954ENST00000559240TCF3chr19

1619110

-PBX1chr1

164761730

+
Frame-shitENST00000453954ENST00000367897TCF3chr19

1619110

-PBX1chr1

164761730

+
Frame-shitENST00000453954ENST00000540236TCF3chr19

1619110

-PBX1chr1

164761730

+
5CDS-5UTRENST00000453954ENST00000560641TCF3chr19

1619110

-PBX1chr1

164761730

+
5CDS-intronENST00000453954ENST00000474046TCF3chr19

1619110

-PBX1chr1

164761730

+
5CDS-intronENST00000453954ENST00000485769TCF3chr19

1619110

-PBX1chr1

164761730

+
5CDS-intronENST00000453954ENST00000540246TCF3chr19

1619110

-PBX1chr1

164761730

+
In-frameENST00000395423ENST00000420696TCF3chr19

1619110

-PBX1chr1

164761730

+
In-frameENST00000395423ENST00000401534TCF3chr19

1619110

-PBX1chr1

164761730

+
In-frameENST00000395423ENST00000559240TCF3chr19

1619110

-PBX1chr1

164761730

+
In-frameENST00000395423ENST00000367897TCF3chr19

1619110

-PBX1chr1

164761730

+
In-frameENST00000395423ENST00000540236TCF3chr19

1619110

-PBX1chr1

164761730

+
5CDS-5UTRENST00000395423ENST00000560641TCF3chr19

1619110

-PBX1chr1

164761730

+
5CDS-intronENST00000395423ENST00000474046TCF3chr19

1619110

-PBX1chr1

164761730

+
5CDS-intronENST00000395423ENST00000485769TCF3chr19

1619110

-PBX1chr1

164761730

+
5CDS-intronENST00000395423ENST00000540246TCF3chr19

1619110

-PBX1chr1

164761730

+
Frame-shitENST00000588136ENST00000420696TCF3chr19

1619110

-PBX1chr1

164761730

+
Frame-shitENST00000588136ENST00000401534TCF3chr19

1619110

-PBX1chr1

164761730

+
Frame-shitENST00000588136ENST00000559240TCF3chr19

1619110

-PBX1chr1

164761730

+
Frame-shitENST00000588136ENST00000367897TCF3chr19

1619110

-PBX1chr1

164761730

+
Frame-shitENST00000588136ENST00000540236TCF3chr19

1619110

-PBX1chr1

164761730

+
5CDS-5UTRENST00000588136ENST00000560641TCF3chr19

1619110

-PBX1chr1

164761730

+
5CDS-intronENST00000588136ENST00000474046TCF3chr19

1619110

-PBX1chr1

164761730

+
5CDS-intronENST00000588136ENST00000485769TCF3chr19

1619110

-PBX1chr1

164761730

+
5CDS-intronENST00000588136ENST00000540246TCF3chr19

1619110

-PBX1chr1

164761730

+

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FusionProtFeatures for TCF3_PBX1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TCF3

P15923

PBX1

P40424

Transcriptional regulator. Involved in the initiation ofneuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major rolesin determining tissue-specific cell fate during embryogenesis,like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappaimmunoglobulin gene enhancer. Binds to IEB1 and IEB2, which areshort DNA sequences in the insulin gene transcription controlregion. {ECO:0000250|UniProtKB:P15806}. Binds the sequence 5'-ATCAATCAA-3'. Acts as atranscriptional activator of PF4 in complex with MEIS1. Convertedinto a potent transcriptional activator by the (1;19)translocation. May have a role in steroidogenesis and,subsequently, sexual development and differentiation. IsoformPBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinarcells is involved in the transcriptional activation of the ELA1enhancer; the complex binds to the enhancer B element andcooperates with the transcription factor 1 complex (PTF1) bound tothe enhancer A element. Probably in complex with MEIS2, isinvolved in transcriptional regulation by KLF4. Acts as atranscriptional activator of NKX2-5 and a transcriptionalrepressor of CDKN2B. Together with NKX2-5, it is required forspleen development through a mechanism that involves CDKN2Brepression (By similarity). {ECO:0000250,ECO:0000269|PubMed:12609849, ECO:0000269|PubMed:21746878}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TCF3_PBX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).
>In-frame_TCF3_ENST00000395423_chr19_1619110_-_PBX1_ENST00000420696_chr1_164761730_+_7508nt
CTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAGAGGATGGCGCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGA
CTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGCCGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGCAAGAG
CGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTCCTGTCAGGCGAGCTGGCCCT
CAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACTCCGGCAGCTCCCGGCGGAGAGCGGC
AGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGGTGTACCCACCCAGCTCAGGTGAGGA
CTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCTTCTACGTGGCAGATGGCAGCCTGCA
CCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCTCATCCCCGCTGCCCCTCCCGCCCGG
TAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTATGGGCTACCAGCTGCATGGAGCAGA
GGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCGTCTCCAGCCACACGCCGCCTGTCAG
CGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCACTGGCCTCGATCTACTCCCC
GGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGAACGTCACAGTGGCCTCGAGC
AGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAGAAGACCACCTGGACGAGGCCATCCA
CGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGGCGCTGGCCTCAGGTTTCACCGGCCC
CATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAGGCAGCACCAGCCTCATGCACAACCA
CGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTGTTTTGAGTATCCGAGGAGCCCAGGA
GGAGGAACCCACAGACCCCCAGCTGATGCGGCTGGACAACATGCTGTTAGCGGAAGGCGTGGCGGGGCCTGAGAAGGGCGGAGGGTCGGC
GGCAGCGGCGGCAGCGGCGGCGGCTTCTGGAGGGGCAGGTTCAGACAACTCAGTGGAGCATTCAGATTACAGAGCCAAACTCTCACAGAT
CAGACAAATCTACCATACGGAGCTGGAGAAATACGAGCAGGCCTGCAACGAGTTCACCACCCACGTGATGAATCTCCTGCGAGAGCAAAG
CCGGACCAGGCCCATCTCCCCAAAGGAGATTGAGCGGATGGTCAGCATCATCCACCGCAAGTTCAGCTCCATCCAGATGCAGCTCAAGCA
GAGCACGTGCGAGGCGGTGATGATCCTGCGTTCCCGATTTCTGGATGCGCGGCGGAAGAGACGGAATTTCAACAAGCAAGCGACAGAAAT
CCTGAATGAATATTTCTATTCCCATCTCAGCAACCCTTACCCCAGTGAGGAAGCCAAAGAGGAGTTAGCCAAGAAGTGTGGCATCACAGT
CTCCCAGGTATCAAACTGGTTTGGAAATAAGCGAATCCGGTACAAGAAGAACATAGGTAAATTTCAAGAGGAAGCCAATATTTATGCTGC
CAAAACAGCTGTCACTGCTACCAATGTGTCAGCCCATGGAAGCCAAGCTAACTCGCCCTCAACTCCCAACTCGGCTGGTTCTTCCAGTTC
TTTTAACATGTCAAACTCTGGAGATTTGTTCATGAGCGTGCAGTCACTCAATGGGGATTCTTACCAAGGGGCCCAGGTTGGAGCCAACGT
GCAATCACAGGTGGATACCCTTCGCCATGTTATCAGCCAGACAGGAGGATACAGTGATGGACTCGCAGCCAGTCAGATGTACAGTCCGCA
GGGCATCAGTGCTAATGGAGGTTGGCAGGATGCTACTACCCCTTCATCAGTGACCTCCCCTACAGAAGGCCCTGGCAGTGTTCACTCTGA
TACCTCCAACTGATCTCCCAGCAATCGCATCCCGGCTGACCCTGTGCCCCAGTTGGGGCAGGGGCAGGAGGGAGGGTTTCTCTCCCAACG
CTGAAGCGGTCAGACTGGAGGTCGAAGCAATCAGCAAACACAATAAGAGTCTCCTTCTCTTCTCTTCTTTGGGATGCTATTTCAGCCAAT
CTGGACACTTCTTTATACTCTCTTCCCTTTTTTTTCTGGGTAGAAGCCACCCTTCCCTGCCTCCAGCTGTCAGCCTGGTTTTCGTCATCT
TCCCTGCCCCTGTGCCTCTGTCCTAGACTCCCGGGGTCCCCGCCCTCTCTCATATCACTGAAGGATATTTTCAACAATTAGAGGAATTTA
AAGAGGAAAAAAATTACAAAGAAAATAATAAAAGTGTTTGTACGTTTTCATGCTGGTGGTTTGAGGAGCCAAATTTACCTCACTCGAATC
CCTCACTCCCTATGTTAACAGGCAATCCTTCTCTGTTTCTCTTATTACTCTCACTACCTCTTAGCAGGAATACTCCACATTGCCCTATTC
ATTCCAGGCCTCCCTGCTTCCTCTTGCTCTTCCTCCCTGGGGACAGTACTGATTGGAACACTTTCCTCCTCTTCCTTCCTAGCCCCAGCT
ATTCACTGGGGACTGTCATAGCTGGGATTCTAAAGGTGCCACATTTTTCAGTTTCATCTCCACTAGGTTGGTTCCCGGGCAGGAAGTCAG
GCAGCAGGGAAGGACACGGGAACAGCAGGTGGAGAATTCCTACAGTCTTTCTTACCCTGCTAGCAATAGCTCTCAGTTTCAGAGGCACAG
TCTTTGGAGACCATTCAGCACTGAGAAAGCAATATTTAGAACCTATTGCAAAACTGGGCCTGAGTTAGGCATGGTGATGAATGCATCAGC
AAGGAATAGAAAGTTCTTATCGTGAAACCCTTCAACCTCAACTATGCCTTCATAGACACACACGTTCATGCACATGTAGGCACATGTACC
ATCTCACATCTTCACTTTCCCGAGATGCCATATACAATTACCTACATTAATAACTGTAGCACTATGCCTTTTGAGCCCGAGAGAGGGAAT
TAGTGACTCTAAGTGAAGGTCACTGACACAGAGAAGCAGTATGTGTCTGGGGCTTCCAGGACCTGCAGGCCCACTAGCGTGCACTTACCA
GAATGGCATACACAGGACCTGATCATGAGGAAGACCAGGTTTCCAGTGTAAACTACTCTTGTTCCCACCACCTCTGGAGCACTCAGGGAG
CCCCATACAGTACTTACAATGTCTTTAATGGACTTGATTCTGTTTAATTTTTTGTTTTATATTAGGCACACTGTATTAATTTTCCAAAAT
GTTATACCACACTATGTTCTTGGTCCTGACCTATTGCTCTGGAGGAAAGAGTTGTATAAGAACGTGGCTCATGTGAACTTTTGCTAGCTT
CATTTGAGGACCTGAGAATCATGGGGAAAGGGAAGGTAATGTTTTCATTGAAATCATCACAGTGATTTTTATTCCCTGGGAACACAGCGT
GTACTAAAAATACATGAGAAAATAGCATGTATATGAAAGCTATTCTCAAAAGTCACCTGAGCTCACCATCTTCATAGCCAACCCTACCAG
TTATAAAGATGGCAGCTCTATCACTTGATTAAGTGGGAGGTGGTCAAATATTTTGGTGCCTCATTTTCTTCATCTGTGAGATGGGAACTG
TTATGCCTGGCTTACTAAGAGTCTTGTGAGAGACTGAGAAGTTGATTTTGTTCATATCCAATCTGTAAATGCGAAGTCAGGGGAAGTAAT
GTCCCTGAAATAAACGGGTTCATGCCATCTAGGGACAATAAATGGTTTTCTTGTTGTAACTTCTGGTTAATATCAGTACCTTGATGTCAT
CACCGTGATGACAAAGAGAAGAGTTATTGTTGATCTTCTTGGTTTTGGTCTGTCTCTTTTCTTAGGATAAAGAAAAACTTCCAAACTAGA
AAAACAGGCCCTGGTTCCCTTAGTTTGCACTTGAACCCAATATGTTGCCTTGTACATACTTGGTCCCTGTCACATTGACTGCTTGGGAGG
CTTCCAGGGAGAAGTATGAGACCCTGAGGGGTGAGAATGGGCAGCTAGCAAGAACATGGAAATTCTGCTTGGCACTACAGTCATAAATAG
AAAACACTGTGTGTGCTCAGGGGAGCAGGGGATGCCACTGAAGAAACTCAAGGGAATGTGTATTTGAAGGAAATGCAAAAACTAAGTATT
TAGCAAAATGAAATTATGCCTTGATGACTAAAAGGCACTAGAAAGGTTGTGTCTACTAACTTCAGCCCTAATCAGAACAGATGCCTAGAA
GGAGCATTTTTGTGACAACTTCATAGTGATTAGAATCAGTGGAGAACTCCATCTTAGTGGCAGGAATATAATGAAACTACCCACGCAAGA
ACATGGTTGAATCACATTTGCTTGACTTAGGGCAAAGTACGAAAGAGAGACAAAAGGGTTCTCTTGGAAACAAGAAGAGTGACTCCAGAT
GTGGCCTGAATAATTGCCATGTTAAGTTAATGCAAAAGATCAGAACAGGGCTACATTTGCACAGGCAGTTTCTCTCCGGGCCGTAGTTTT
CACTGATGATCACCTTTCACAGCATTTTCCCCAACCAGCATTTCACTTAGTCTTCTCTATACCCAGCACCTCCCCCGGCACCCCCGGCAA
GCCCACTATCACTTCCGACTTCCAACGTGGCATCCGTGAGATCTGTCCACATTAGGCGAAGCAGGAGAACACTGAGAGCAGCAGGATGGG
TTTGGAAAGAGCATGCCTCTGGAAACACAGCTTCCTGGGAATTCACATGAGGCCAGTCCTACAGAGAGCAAGATGCACCCCAGGATTTCT
TCATTTTCTAATAGATGTGGGAGTGCTCCATTTTCCCCGACAGCGAATTTCCCCTGAGAAACGATACTAGACCCTGGGTTTGCCCACCTT
GTAACTCTTCCTTATCTCCTCCTTTTCATCCCTAATCCATCCTCCCTCTGGCATGGAATTGACGCCCGTGCAGTACATTTGCCAAGTGGC
ACCTTCTTTCAATTTATGTTTTATTTTGCTATGGTGGTGATTCTTTATTTGCTGGTTGTCTTTTCTCACACATCTTTCTCTCTGTCTCTC
TCTTTCCTGCTCTTTGTTTTTCTGCCCAGAAAAACCTGACTTCGATACCAAAAAAGATGAAACTACAGAAACTCAAATTTAAAAAAAACT
TTAAAAGAAACAAAAAAATACTCAACGATTCTTTCAGCTTTATTAACATTTTCCATTGTTTCTTGCGACTTGTGTCTCGTTCTTTGTAGT
ATTGATGATGAACATTTGATAATGAATGTTCTTGTATATTCAGATAAAGAAAAAAAAAACCAAAAAAGCGGTCTGAATTTAATAGTGTTT
ATAATAAAAATTTTAAAAATGACCCTCATAGCACGCAAAACAGGATGGGGAATTTCCCCTCTTCTTTCTGTGACAATGCGCATCATTCCT
GCATTAGTTTTTAACACCAGACTACCTACATTCATCATTTCCCTCATTTTTCTTTTATTTTCTTGCATTTGTGAATTAGTTCAAGAATGC
TAGAAAAGTGTCGAGTTGTGCACATCCATTTCTTGTTTCACAATGTTTAAAAGTGACAGTAATTCATTTTGTAAACTAAAAAAAAAAAAA
AAAAGGTTGGAATAGTGAGCATAATAGGTACAACCTAACACATTATTATGTTTATTAACTTTGAGACCCAGAAATAAATTCTTTTCTTTT
CTTGATTCTTGCTCTTAAAAATACAAAAAAAAAAATGTTTTGTTTTGTGTTATTTTTGGTTTGTTTATTGGGGGGCTTTTTTTAATTGTC
AGGATTATGATCTTGCTGTTTTTCTTCAATATGTATACAAGGTGATGTGAAAAGATGACTTGGGCAGAGGAGTAAGAACAAGTAGGCTTG
TTCTTCTACTTTGCTTCAGAATTCAGTTAATGCCAAAAGCGAAGATCAAGCCCATGTTGATGTCTCGTTGCTCACCTGCATTTCCAGAGA
GTGTGACACTCATGCAGTCCCTGAGAAAAATAAAATCAGGGACATACTTCTCCTTTTAGCCTTTTAAAAATTCAAAAACGTTTAGTCCAA
GGGAACTTTTTATGCTATCAGGAAAGGTTTTTGCTGTTTTTGATTCTGATTATCACAGCCAAGTACTTTGTTTTATTTCTCCCTAATTAA
TAACTACATTCCATGAGGCCTCTTCCAACCAAAGAGGCCTTTTCTTCCAGGAGAGTCCCGCAGGAGATGCTGGTATGATGGGCACCATTG
GTTAAGTAAACTACATGCAGGAAGAAGTCCTTGGGGCCAGTCTGCCAGCTGAGTCCTGGTTTTGGATGAAGAGTTAATGAGATATTGGGC
CAGGCTCAATGCTGTAGTTTTAATGCTAAGAGGTTACGTTTACTTCACAGAGTACACCTCTTAGTAACCTCTGACTTAGGCAGCTGCTTA
AAGCAAATTGCAAAACTGGCTTGATTTGGAATGTTTTTATTAGAGGAAAAAAGAAAGCCATATTATCTGGAAAAAAATTCATTTTAAATA
CCATCATTCAACAAATTATGTTCAGAAAGTGGTCAGAACTTAAGCAAGAAAAGTAAAGAAAGAATGCAGAATTGTGGAGCAATGCTTTAG
GAAATATTTCTACCTGAACACTTGTACTCTTGAAGTCACAACAAAATAATGATGAGCTTTTCACATCACCTTTATGGTTTCAATCCCTAG
CTCAAAGCTTCCTGGAATCTTTTATTTTTTGTAAACTTTTTTTTCTTTTGTTAAAATAAATAAAACATTCAATGTTTTTCTCCTTTTCTC
TCTTATTACTTCTTTCCTTTGGCATTTTCAATTTGAAATGCTTTCCTTTGGTTGTTGGTTTTATTCTCCCCCTACCCCTCCCCTTTTCTT
ATTATTCAGAATATAAACCTGCAAAGCTCTGCTCTGTTTTGGTTTTGAAAGTTTAAGCTTTTCTGCTTCTGTGAGAGCACAGGCTTCTGT
CCCTTTTGATTCCAACTGAACTTTTGTGTTCTCTAATGATACTAACACGGTGTAGGTTTTACAGTCTCCTAATTTGTACTGGTAATGCAT

>In-frame_TCF3_ENST00000395423_chr19_1619110_-_PBX1_ENST00000401534_chr1_164761730_+_2104nt
CTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAGAGGATGGCGCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGA
CTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGCCGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGCAAGAG
CGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTCCTGTCAGGCGAGCTGGCCCT
CAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACTCCGGCAGCTCCCGGCGGAGAGCGGC
AGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGGTGTACCCACCCAGCTCAGGTGAGGA
CTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCTTCTACGTGGCAGATGGCAGCCTGCA
CCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCTCATCCCCGCTGCCCCTCCCGCCCGG
TAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTATGGGCTACCAGCTGCATGGAGCAGA
GGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCGTCTCCAGCCACACGCCGCCTGTCAG
CGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCACTGGCCTCGATCTACTCCCC
GGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGAACGTCACAGTGGCCTCGAGC
AGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAGAAGACCACCTGGACGAGGCCATCCA
CGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGGCGCTGGCCTCAGGTTTCACCGGCCC
CATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAGGCAGCACCAGCCTCATGCACAACCA
CGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTGTTTTGAGTATCCGAGGAGCCCAGGA
GGAGGAACCCACAGACCCCCAGCTGATGCGGCTGGACAACATGCTGTTAGCGGAAGGCGTGGCGGGGCCTGAGAAGGGCGGAGGGTCGGC
GGCAGCGGCGGCAGCGGCGGCGGCTTCTGGAGGGGCAGGTTCAGACAACTCAGTGGAGCATTCAGATTACAGAGCCAAACTCTCACAGAT
CAGACAAATCTACCATACGGAGCTGGAGAAATACGAGCAGGCCTGCAACGAGTTCACCACCCACGTGATGAATCTCCTGCGAGAGCAAAG
CCGGACCAGGCCCATCTCCCCAAAGGAGATTGAGCGGATGGTCAGCATCATCCACCGCAAGTTCAGCTCCATCCAGATGCAGCTCAAGCA
GAGCACGTGCGAGGCGGTGATGATCCTGCGTTCCCGATTTCTGGATGCGCGGCGGAAGAGACGGAATTTCAACAAGCAAGCGACAGAAAT
CCTGAATGAATATTTCTATTCCCATCTCAGCAACCCTTACCCCAGTGAGGAAGCCAAAGAGGAGTTAGCCAAGAAGTGTGGCATCACAGT
CTCCCAGGTATCAAACTGGTTTGGAAATAAGCGAATCCGGTACAAGAAGAACATAGGTAAATTTCAAGAGGAAGCCAATATTTATGCTGC
CAAAACAGCTGTCACTGCTACCAATGTGTCAGCCCATGGAAGCCAAGCTAACTCGCCCTCAACTCCCAACTCGGCTGGTGGATACCCTTC

>In-frame_TCF3_ENST00000395423_chr19_1619110_-_PBX1_ENST00000559240_chr1_164761730_+_2080nt
CTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAGAGGATGGCGCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGA
CTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGCCGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGCAAGAG
CGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTCCTGTCAGGCGAGCTGGCCCT
CAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACTCCGGCAGCTCCCGGCGGAGAGCGGC
AGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGGTGTACCCACCCAGCTCAGGTGAGGA
CTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCTTCTACGTGGCAGATGGCAGCCTGCA
CCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCTCATCCCCGCTGCCCCTCCCGCCCGG
TAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTATGGGCTACCAGCTGCATGGAGCAGA
GGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCGTCTCCAGCCACACGCCGCCTGTCAG
CGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCACTGGCCTCGATCTACTCCCC
GGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGAACGTCACAGTGGCCTCGAGC
AGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAGAAGACCACCTGGACGAGGCCATCCA
CGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGGCGCTGGCCTCAGGTTTCACCGGCCC
CATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAGGCAGCACCAGCCTCATGCACAACCA
CGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTGTTTTGAGTATCCGAGGAGCCCAGGA
GGAGGAACCCACAGACCCCCAGCTGATGCGGCTGGACAACATGCTGTTAGCGGAAGGCGTGGCGGGGCCTGAGAAGGGCGGAGGGTCGGC
GGCAGCGGCGGCAGCGGCGGCGGCTTCTGGAGGGGCAGGTTCAGACAACTCAGTGGAGCATTCAGATTACAGAGCCAAACTCTCACAGAT
CAGACAAATCTACCATACGGAGCTGGAGAAATACGAGCAGGCCTGCAACGAGTTCACCACCCACGTGATGAATCTCCTGCGAGAGCAAAG
CCGGACCAGGCCCATCTCCCCAAAGGAGATTGAGCGGATGGTCAGCATCATCCACCGCAAGTTCAGCTCCATCCAGATGCAGCTCAAGCA
GAGCACGTGCGAGGCGGTGATGATCCTGCGTTCCCGATTTCTGGATGCGCGGCGGAAGAGACGGAATTTCAACAAGCAAGCGACAGAAAT
CCTGAATGAATATTTCTATTCCCATCTCAGCAACCCTTACCCCAGTGAGGAAGCCAAAGAGGAGTTAGCCAAGAAGTGTGGCATCACAGT
CTCCCAGGTGGATACCCTTCGCCATGTTATCAGCCAGACAGGAGGATACAGTGATGGACTCGCAGCCAGTCAGATGTACAGTCCGCAGGG
CATCAGTGCTAATGGAGGTTGGCAGGATGCTACTACCCCTTCATCAGTGACCTCCCCTACAGAAGGCCCTGGCAGTGTTCACTCTGATAC

>In-frame_TCF3_ENST00000395423_chr19_1619110_-_PBX1_ENST00000367897_chr1_164761730_+_2519nt
CTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAGAGGATGGCGCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGA
CTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGCCGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGCAAGAG
CGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTCCTGTCAGGCGAGCTGGCCCT
CAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACTCCGGCAGCTCCCGGCGGAGAGCGGC
AGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGGTGTACCCACCCAGCTCAGGTGAGGA
CTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCTTCTACGTGGCAGATGGCAGCCTGCA
CCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCTCATCCCCGCTGCCCCTCCCGCCCGG
TAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTATGGGCTACCAGCTGCATGGAGCAGA
GGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCGTCTCCAGCCACACGCCGCCTGTCAG
CGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCACTGGCCTCGATCTACTCCCC
GGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGAACGTCACAGTGGCCTCGAGC
AGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAGAAGACCACCTGGACGAGGCCATCCA
CGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGGCGCTGGCCTCAGGTTTCACCGGCCC
CATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAGGCAGCACCAGCCTCATGCACAACCA
CGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTGTTTTGAGTATCCGAGGAGCCCAGGA
GGAGGAACCCACAGACCCCCAGCTGATGCGGCTGGACAACATGCTGTTAGCGGAAGGCGTGGCGGGGCCTGAGAAGGGCGGAGGGTCGGC
GGCAGCGGCGGCAGCGGCGGCGGCTTCTGGAGGGGCAGGTTCAGACAACTCAGTGGAGCATTCAGATTACAGAGCCAAACTCTCACAGAT
CAGACAAATCTACCATACGGAGCTGGAGAAATACGAGCAGGCCTGCAACGAGTTCACCACCCACGTGATGAATCTCCTGCGAGAGCAAAG
CCGGACCAGGCCCATCTCCCCAAAGGAGATTGAGCGGATGGTCAGCATCATCCACCGCAAGTTCAGCTCCATCCAGATGCAGCTCAAGCA
GAGCACGTGCGAGGCGGTGATGATCCTGCGTTCCCGATTTCTGGATGCGCGGCGGAAGAGACGGAATTTCAACAAGCAAGCGACAGAAAT
CCTGAATGAATATTTCTATTCCCATCTCAGCAACCCTTACCCCAGTGAGGAAGCCAAAGAGGAGTTAGCCAAGAAGTGTGGCATCACAGT
CTCCCAGGTATCAAACTGGTTTGGAAATAAGCGAATCCGGTACAAGAAGAACATAGGTAAATTTCAAGAGGAAGCCAATATTTATGCTGC
CAAAACAGCTGTCACTGCTACCAATGTGTCAGCCCATGGAAGCCAAGCTAACTCGCCCTCAACTCCCAACTCGGCTGGTGGATACCCTTC
GCCATGTTATCAGCCAGACAGGAGGATACAGTGATGGACTCGCAGCCAGTCAGATGTACAGTCCGCAGGGCATCAGTGCTAATGGAGGTT
GGCAGGATGCTACTACCCCTTCATCAGTGACCTCCCCTACAGAAGGCCCTGGCAGTGTTCACTCTGATACCTCCAACTGATCTCCCAGCA
ATCGCATCCCGGCTGACCCTGTGCCCCAGTTGGGGCAGGGGCAGGAGGGAGGGTTTCTCTCCCAACGCTGAAGCGGTCAGACTGGAGGTC
GAAGCAATCAGCAAACACAATAAGAGTCTCCTTCTCTTCTCTTCTTTGGGATGCTATTTCAGCCAATCTGGACACTTCTTTATACTCTCT

>In-frame_TCF3_ENST00000395423_chr19_1619110_-_PBX1_ENST00000540236_chr1_164761730_+_2323nt
CTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAGAGGATGGCGCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGA
CTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGCCGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGCAAGAG
CGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTCCTGTCAGGCGAGCTGGCCCT
CAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACTCCGGCAGCTCCCGGCGGAGAGCGGC
AGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGGTGTACCCACCCAGCTCAGGTGAGGA
CTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCTTCTACGTGGCAGATGGCAGCCTGCA
CCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCTCATCCCCGCTGCCCCTCCCGCCCGG
TAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTATGGGCTACCAGCTGCATGGAGCAGA
GGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCGTCTCCAGCCACACGCCGCCTGTCAG
CGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCACTGGCCTCGATCTACTCCCC
GGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGAACGTCACAGTGGCCTCGAGC
AGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAGAAGACCACCTGGACGAGGCCATCCA
CGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGGCGCTGGCCTCAGGTTTCACCGGCCC
CATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAGGCAGCACCAGCCTCATGCACAACCA
CGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTGTTTTGAGTATCCGAGGAGCCCAGGA
GGAGGAACCCACAGACCCCCAGCTGATGCGGCTGGACAACATGCTGTTAGCGGAAGGCGTGGCGGGGCCTGAGAAGGGCGGAGGGTCGGC
GGCAGCGGCGGCAGCGGCGGCGGCTTCTGGAGGGGCAGGTTCAGACAACTCAGTGGAGCATTCAGATTACAGAGCCAAACTCTCACAGAT
CAGACAAATCTACCATACGGAGCTGGAGAAATACGAGCAGGCCTGCAACGAGTTCACCACCCACGTGATGAATCTCCTGCGAGAGCAAAG
CCGGACCAGGCCCATCTCCCCAAAGGAGATTGAGCGGATGGTCAGCATCATCCACCGCAAGTTCAGCTCCATCCAGATGCAGCTCAAGCA
GAGCACGTGCGAGGCGGTGATGATCCTGCGTTCCCGATTTCTGGATGCGCGGCGGAAGAGACGGAATTTCAACAAGCAAGCGACAGAAAT
CCTGAATGAATATTTCTATTCCCATCTCAGCAACCCTTACCCCAGTGAGGAAGCCAAAGAGGAGTTAGCCAAGAAGTGTGGCATCACAGT
CTCCCAGGTATCAAACTGGTTTGGAAATAAGCGAATCCGGTACAAGAAGAACATAGGTAAATTTCAAGAGGAAGCCAATATTTATGCTGC
CAAAACAGCTGTCACTGCTACCAATGTGTCAGCCCATGGAAGCCAAGCTAACTCGCCCTCAACTCCCAACTCGGCTGGTTCTTCCAGTTC
TTTTAACATGTCAAACTCTGGAGATTTGTTCATGAGCGTGCAGTCACTCAATGGGGATTCTTACCAAGGGGCCCAGGTTGGAGCCAACGT
GCAATCACAGGTGGATACCCTTCGCCATGTTATCAGCCAGACAGGAGGATACAGTGATGGACTCGCAGCCAGTCAGATGTACAGTCCGCA

>In-frame_TCF3_ENST00000395423_chr19_1619110_-_PBX1_ENST00000420696_chr1_164761730_+_7508nt
CTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAGAGGATGGCGCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGA
CTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGCCGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGCAAGAG
CGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTCCTGTCAGGCGAGCTGGCCCT
CAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACTCCGGCAGCTCCCGGCGGAGAGCGGC
AGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGGTGTACCCACCCAGCTCAGGTGAGGA
CTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCTTCTACGTGGCAGATGGCAGCCTGCA
CCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCTCATCCCCGCTGCCCCTCCCGCCCGG
TAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTATGGGCTACCAGCTGCATGGAGCAGA
GGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCGTCTCCAGCCACACGCCGCCTGTCAG
CGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCACTGGCCTCGATCTACTCCCC
GGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGAACGTCACAGTGGCCTCGAGC
AGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAGAAGACCACCTGGACGAGGCCATCCA
CGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGGCGCTGGCCTCAGGTTTCACCGGCCC
CATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAGGCAGCACCAGCCTCATGCACAACCA
CGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTGTTTTGAGTATCCGAGGAGCCCAGGA
GGAGGAACCCACAGACCCCCAGCTGATGCGGCTGGACAACATGCTGTTAGCGGAAGGCGTGGCGGGGCCTGAGAAGGGCGGAGGGTCGGC
GGCAGCGGCGGCAGCGGCGGCGGCTTCTGGAGGGGCAGGTTCAGACAACTCAGTGGAGCATTCAGATTACAGAGCCAAACTCTCACAGAT
CAGACAAATCTACCATACGGAGCTGGAGAAATACGAGCAGGCCTGCAACGAGTTCACCACCCACGTGATGAATCTCCTGCGAGAGCAAAG
CCGGACCAGGCCCATCTCCCCAAAGGAGATTGAGCGGATGGTCAGCATCATCCACCGCAAGTTCAGCTCCATCCAGATGCAGCTCAAGCA
GAGCACGTGCGAGGCGGTGATGATCCTGCGTTCCCGATTTCTGGATGCGCGGCGGAAGAGACGGAATTTCAACAAGCAAGCGACAGAAAT
CCTGAATGAATATTTCTATTCCCATCTCAGCAACCCTTACCCCAGTGAGGAAGCCAAAGAGGAGTTAGCCAAGAAGTGTGGCATCACAGT
CTCCCAGGTATCAAACTGGTTTGGAAATAAGCGAATCCGGTACAAGAAGAACATAGGTAAATTTCAAGAGGAAGCCAATATTTATGCTGC
CAAAACAGCTGTCACTGCTACCAATGTGTCAGCCCATGGAAGCCAAGCTAACTCGCCCTCAACTCCCAACTCGGCTGGTTCTTCCAGTTC
TTTTAACATGTCAAACTCTGGAGATTTGTTCATGAGCGTGCAGTCACTCAATGGGGATTCTTACCAAGGGGCCCAGGTTGGAGCCAACGT
GCAATCACAGGTGGATACCCTTCGCCATGTTATCAGCCAGACAGGAGGATACAGTGATGGACTCGCAGCCAGTCAGATGTACAGTCCGCA
GGGCATCAGTGCTAATGGAGGTTGGCAGGATGCTACTACCCCTTCATCAGTGACCTCCCCTACAGAAGGCCCTGGCAGTGTTCACTCTGA
TACCTCCAACTGATCTCCCAGCAATCGCATCCCGGCTGACCCTGTGCCCCAGTTGGGGCAGGGGCAGGAGGGAGGGTTTCTCTCCCAACG
CTGAAGCGGTCAGACTGGAGGTCGAAGCAATCAGCAAACACAATAAGAGTCTCCTTCTCTTCTCTTCTTTGGGATGCTATTTCAGCCAAT
CTGGACACTTCTTTATACTCTCTTCCCTTTTTTTTCTGGGTAGAAGCCACCCTTCCCTGCCTCCAGCTGTCAGCCTGGTTTTCGTCATCT
TCCCTGCCCCTGTGCCTCTGTCCTAGACTCCCGGGGTCCCCGCCCTCTCTCATATCACTGAAGGATATTTTCAACAATTAGAGGAATTTA
AAGAGGAAAAAAATTACAAAGAAAATAATAAAAGTGTTTGTACGTTTTCATGCTGGTGGTTTGAGGAGCCAAATTTACCTCACTCGAATC
CCTCACTCCCTATGTTAACAGGCAATCCTTCTCTGTTTCTCTTATTACTCTCACTACCTCTTAGCAGGAATACTCCACATTGCCCTATTC
ATTCCAGGCCTCCCTGCTTCCTCTTGCTCTTCCTCCCTGGGGACAGTACTGATTGGAACACTTTCCTCCTCTTCCTTCCTAGCCCCAGCT
ATTCACTGGGGACTGTCATAGCTGGGATTCTAAAGGTGCCACATTTTTCAGTTTCATCTCCACTAGGTTGGTTCCCGGGCAGGAAGTCAG
GCAGCAGGGAAGGACACGGGAACAGCAGGTGGAGAATTCCTACAGTCTTTCTTACCCTGCTAGCAATAGCTCTCAGTTTCAGAGGCACAG
TCTTTGGAGACCATTCAGCACTGAGAAAGCAATATTTAGAACCTATTGCAAAACTGGGCCTGAGTTAGGCATGGTGATGAATGCATCAGC
AAGGAATAGAAAGTTCTTATCGTGAAACCCTTCAACCTCAACTATGCCTTCATAGACACACACGTTCATGCACATGTAGGCACATGTACC
ATCTCACATCTTCACTTTCCCGAGATGCCATATACAATTACCTACATTAATAACTGTAGCACTATGCCTTTTGAGCCCGAGAGAGGGAAT
TAGTGACTCTAAGTGAAGGTCACTGACACAGAGAAGCAGTATGTGTCTGGGGCTTCCAGGACCTGCAGGCCCACTAGCGTGCACTTACCA
GAATGGCATACACAGGACCTGATCATGAGGAAGACCAGGTTTCCAGTGTAAACTACTCTTGTTCCCACCACCTCTGGAGCACTCAGGGAG
CCCCATACAGTACTTACAATGTCTTTAATGGACTTGATTCTGTTTAATTTTTTGTTTTATATTAGGCACACTGTATTAATTTTCCAAAAT
GTTATACCACACTATGTTCTTGGTCCTGACCTATTGCTCTGGAGGAAAGAGTTGTATAAGAACGTGGCTCATGTGAACTTTTGCTAGCTT
CATTTGAGGACCTGAGAATCATGGGGAAAGGGAAGGTAATGTTTTCATTGAAATCATCACAGTGATTTTTATTCCCTGGGAACACAGCGT
GTACTAAAAATACATGAGAAAATAGCATGTATATGAAAGCTATTCTCAAAAGTCACCTGAGCTCACCATCTTCATAGCCAACCCTACCAG
TTATAAAGATGGCAGCTCTATCACTTGATTAAGTGGGAGGTGGTCAAATATTTTGGTGCCTCATTTTCTTCATCTGTGAGATGGGAACTG
TTATGCCTGGCTTACTAAGAGTCTTGTGAGAGACTGAGAAGTTGATTTTGTTCATATCCAATCTGTAAATGCGAAGTCAGGGGAAGTAAT
GTCCCTGAAATAAACGGGTTCATGCCATCTAGGGACAATAAATGGTTTTCTTGTTGTAACTTCTGGTTAATATCAGTACCTTGATGTCAT
CACCGTGATGACAAAGAGAAGAGTTATTGTTGATCTTCTTGGTTTTGGTCTGTCTCTTTTCTTAGGATAAAGAAAAACTTCCAAACTAGA
AAAACAGGCCCTGGTTCCCTTAGTTTGCACTTGAACCCAATATGTTGCCTTGTACATACTTGGTCCCTGTCACATTGACTGCTTGGGAGG
CTTCCAGGGAGAAGTATGAGACCCTGAGGGGTGAGAATGGGCAGCTAGCAAGAACATGGAAATTCTGCTTGGCACTACAGTCATAAATAG
AAAACACTGTGTGTGCTCAGGGGAGCAGGGGATGCCACTGAAGAAACTCAAGGGAATGTGTATTTGAAGGAAATGCAAAAACTAAGTATT
TAGCAAAATGAAATTATGCCTTGATGACTAAAAGGCACTAGAAAGGTTGTGTCTACTAACTTCAGCCCTAATCAGAACAGATGCCTAGAA
GGAGCATTTTTGTGACAACTTCATAGTGATTAGAATCAGTGGAGAACTCCATCTTAGTGGCAGGAATATAATGAAACTACCCACGCAAGA
ACATGGTTGAATCACATTTGCTTGACTTAGGGCAAAGTACGAAAGAGAGACAAAAGGGTTCTCTTGGAAACAAGAAGAGTGACTCCAGAT
GTGGCCTGAATAATTGCCATGTTAAGTTAATGCAAAAGATCAGAACAGGGCTACATTTGCACAGGCAGTTTCTCTCCGGGCCGTAGTTTT
CACTGATGATCACCTTTCACAGCATTTTCCCCAACCAGCATTTCACTTAGTCTTCTCTATACCCAGCACCTCCCCCGGCACCCCCGGCAA
GCCCACTATCACTTCCGACTTCCAACGTGGCATCCGTGAGATCTGTCCACATTAGGCGAAGCAGGAGAACACTGAGAGCAGCAGGATGGG
TTTGGAAAGAGCATGCCTCTGGAAACACAGCTTCCTGGGAATTCACATGAGGCCAGTCCTACAGAGAGCAAGATGCACCCCAGGATTTCT
TCATTTTCTAATAGATGTGGGAGTGCTCCATTTTCCCCGACAGCGAATTTCCCCTGAGAAACGATACTAGACCCTGGGTTTGCCCACCTT
GTAACTCTTCCTTATCTCCTCCTTTTCATCCCTAATCCATCCTCCCTCTGGCATGGAATTGACGCCCGTGCAGTACATTTGCCAAGTGGC
ACCTTCTTTCAATTTATGTTTTATTTTGCTATGGTGGTGATTCTTTATTTGCTGGTTGTCTTTTCTCACACATCTTTCTCTCTGTCTCTC
TCTTTCCTGCTCTTTGTTTTTCTGCCCAGAAAAACCTGACTTCGATACCAAAAAAGATGAAACTACAGAAACTCAAATTTAAAAAAAACT
TTAAAAGAAACAAAAAAATACTCAACGATTCTTTCAGCTTTATTAACATTTTCCATTGTTTCTTGCGACTTGTGTCTCGTTCTTTGTAGT
ATTGATGATGAACATTTGATAATGAATGTTCTTGTATATTCAGATAAAGAAAAAAAAAACCAAAAAAGCGGTCTGAATTTAATAGTGTTT
ATAATAAAAATTTTAAAAATGACCCTCATAGCACGCAAAACAGGATGGGGAATTTCCCCTCTTCTTTCTGTGACAATGCGCATCATTCCT
GCATTAGTTTTTAACACCAGACTACCTACATTCATCATTTCCCTCATTTTTCTTTTATTTTCTTGCATTTGTGAATTAGTTCAAGAATGC
TAGAAAAGTGTCGAGTTGTGCACATCCATTTCTTGTTTCACAATGTTTAAAAGTGACAGTAATTCATTTTGTAAACTAAAAAAAAAAAAA
AAAAGGTTGGAATAGTGAGCATAATAGGTACAACCTAACACATTATTATGTTTATTAACTTTGAGACCCAGAAATAAATTCTTTTCTTTT
CTTGATTCTTGCTCTTAAAAATACAAAAAAAAAAATGTTTTGTTTTGTGTTATTTTTGGTTTGTTTATTGGGGGGCTTTTTTTAATTGTC
AGGATTATGATCTTGCTGTTTTTCTTCAATATGTATACAAGGTGATGTGAAAAGATGACTTGGGCAGAGGAGTAAGAACAAGTAGGCTTG
TTCTTCTACTTTGCTTCAGAATTCAGTTAATGCCAAAAGCGAAGATCAAGCCCATGTTGATGTCTCGTTGCTCACCTGCATTTCCAGAGA
GTGTGACACTCATGCAGTCCCTGAGAAAAATAAAATCAGGGACATACTTCTCCTTTTAGCCTTTTAAAAATTCAAAAACGTTTAGTCCAA
GGGAACTTTTTATGCTATCAGGAAAGGTTTTTGCTGTTTTTGATTCTGATTATCACAGCCAAGTACTTTGTTTTATTTCTCCCTAATTAA
TAACTACATTCCATGAGGCCTCTTCCAACCAAAGAGGCCTTTTCTTCCAGGAGAGTCCCGCAGGAGATGCTGGTATGATGGGCACCATTG
GTTAAGTAAACTACATGCAGGAAGAAGTCCTTGGGGCCAGTCTGCCAGCTGAGTCCTGGTTTTGGATGAAGAGTTAATGAGATATTGGGC
CAGGCTCAATGCTGTAGTTTTAATGCTAAGAGGTTACGTTTACTTCACAGAGTACACCTCTTAGTAACCTCTGACTTAGGCAGCTGCTTA
AAGCAAATTGCAAAACTGGCTTGATTTGGAATGTTTTTATTAGAGGAAAAAAGAAAGCCATATTATCTGGAAAAAAATTCATTTTAAATA
CCATCATTCAACAAATTATGTTCAGAAAGTGGTCAGAACTTAAGCAAGAAAAGTAAAGAAAGAATGCAGAATTGTGGAGCAATGCTTTAG
GAAATATTTCTACCTGAACACTTGTACTCTTGAAGTCACAACAAAATAATGATGAGCTTTTCACATCACCTTTATGGTTTCAATCCCTAG
CTCAAAGCTTCCTGGAATCTTTTATTTTTTGTAAACTTTTTTTTCTTTTGTTAAAATAAATAAAACATTCAATGTTTTTCTCCTTTTCTC
TCTTATTACTTCTTTCCTTTGGCATTTTCAATTTGAAATGCTTTCCTTTGGTTGTTGGTTTTATTCTCCCCCTACCCCTCCCCTTTTCTT
ATTATTCAGAATATAAACCTGCAAAGCTCTGCTCTGTTTTGGTTTTGAAAGTTTAAGCTTTTCTGCTTCTGTGAGAGCACAGGCTTCTGT
CCCTTTTGATTCCAACTGAACTTTTGTGTTCTCTAATGATACTAACACGGTGTAGGTTTTACAGTCTCCTAATTTGTACTGGTAATGCAT

>In-frame_TCF3_ENST00000395423_chr19_1619110_-_PBX1_ENST00000401534_chr1_164761730_+_2104nt
CTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAGAGGATGGCGCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGA
CTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGCCGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGCAAGAG
CGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTCCTGTCAGGCGAGCTGGCCCT
CAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACTCCGGCAGCTCCCGGCGGAGAGCGGC
AGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGGTGTACCCACCCAGCTCAGGTGAGGA
CTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCTTCTACGTGGCAGATGGCAGCCTGCA
CCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCTCATCCCCGCTGCCCCTCCCGCCCGG
TAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTATGGGCTACCAGCTGCATGGAGCAGA
GGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCGTCTCCAGCCACACGCCGCCTGTCAG
CGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCACTGGCCTCGATCTACTCCCC
GGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGAACGTCACAGTGGCCTCGAGC
AGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAGAAGACCACCTGGACGAGGCCATCCA
CGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGGCGCTGGCCTCAGGTTTCACCGGCCC
CATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAGGCAGCACCAGCCTCATGCACAACCA
CGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTGTTTTGAGTATCCGAGGAGCCCAGGA
GGAGGAACCCACAGACCCCCAGCTGATGCGGCTGGACAACATGCTGTTAGCGGAAGGCGTGGCGGGGCCTGAGAAGGGCGGAGGGTCGGC
GGCAGCGGCGGCAGCGGCGGCGGCTTCTGGAGGGGCAGGTTCAGACAACTCAGTGGAGCATTCAGATTACAGAGCCAAACTCTCACAGAT
CAGACAAATCTACCATACGGAGCTGGAGAAATACGAGCAGGCCTGCAACGAGTTCACCACCCACGTGATGAATCTCCTGCGAGAGCAAAG
CCGGACCAGGCCCATCTCCCCAAAGGAGATTGAGCGGATGGTCAGCATCATCCACCGCAAGTTCAGCTCCATCCAGATGCAGCTCAAGCA
GAGCACGTGCGAGGCGGTGATGATCCTGCGTTCCCGATTTCTGGATGCGCGGCGGAAGAGACGGAATTTCAACAAGCAAGCGACAGAAAT
CCTGAATGAATATTTCTATTCCCATCTCAGCAACCCTTACCCCAGTGAGGAAGCCAAAGAGGAGTTAGCCAAGAAGTGTGGCATCACAGT
CTCCCAGGTATCAAACTGGTTTGGAAATAAGCGAATCCGGTACAAGAAGAACATAGGTAAATTTCAAGAGGAAGCCAATATTTATGCTGC
CAAAACAGCTGTCACTGCTACCAATGTGTCAGCCCATGGAAGCCAAGCTAACTCGCCCTCAACTCCCAACTCGGCTGGTGGATACCCTTC

>In-frame_TCF3_ENST00000395423_chr19_1619110_-_PBX1_ENST00000559240_chr1_164761730_+_2080nt
CTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAGAGGATGGCGCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGA
CTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGCCGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGCAAGAG
CGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTCCTGTCAGGCGAGCTGGCCCT
CAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACTCCGGCAGCTCCCGGCGGAGAGCGGC
AGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGGTGTACCCACCCAGCTCAGGTGAGGA
CTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCTTCTACGTGGCAGATGGCAGCCTGCA
CCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCTCATCCCCGCTGCCCCTCCCGCCCGG
TAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTATGGGCTACCAGCTGCATGGAGCAGA
GGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCGTCTCCAGCCACACGCCGCCTGTCAG
CGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCACTGGCCTCGATCTACTCCCC
GGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGAACGTCACAGTGGCCTCGAGC
AGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAGAAGACCACCTGGACGAGGCCATCCA
CGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGGCGCTGGCCTCAGGTTTCACCGGCCC
CATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAGGCAGCACCAGCCTCATGCACAACCA
CGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTGTTTTGAGTATCCGAGGAGCCCAGGA
GGAGGAACCCACAGACCCCCAGCTGATGCGGCTGGACAACATGCTGTTAGCGGAAGGCGTGGCGGGGCCTGAGAAGGGCGGAGGGTCGGC
GGCAGCGGCGGCAGCGGCGGCGGCTTCTGGAGGGGCAGGTTCAGACAACTCAGTGGAGCATTCAGATTACAGAGCCAAACTCTCACAGAT
CAGACAAATCTACCATACGGAGCTGGAGAAATACGAGCAGGCCTGCAACGAGTTCACCACCCACGTGATGAATCTCCTGCGAGAGCAAAG
CCGGACCAGGCCCATCTCCCCAAAGGAGATTGAGCGGATGGTCAGCATCATCCACCGCAAGTTCAGCTCCATCCAGATGCAGCTCAAGCA
GAGCACGTGCGAGGCGGTGATGATCCTGCGTTCCCGATTTCTGGATGCGCGGCGGAAGAGACGGAATTTCAACAAGCAAGCGACAGAAAT
CCTGAATGAATATTTCTATTCCCATCTCAGCAACCCTTACCCCAGTGAGGAAGCCAAAGAGGAGTTAGCCAAGAAGTGTGGCATCACAGT
CTCCCAGGTGGATACCCTTCGCCATGTTATCAGCCAGACAGGAGGATACAGTGATGGACTCGCAGCCAGTCAGATGTACAGTCCGCAGGG
CATCAGTGCTAATGGAGGTTGGCAGGATGCTACTACCCCTTCATCAGTGACCTCCCCTACAGAAGGCCCTGGCAGTGTTCACTCTGATAC

>In-frame_TCF3_ENST00000395423_chr19_1619110_-_PBX1_ENST00000367897_chr1_164761730_+_2519nt
CTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAGAGGATGGCGCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGA
CTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGCCGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGCAAGAG
CGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTCCTGTCAGGCGAGCTGGCCCT
CAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACTCCGGCAGCTCCCGGCGGAGAGCGGC
AGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGGTGTACCCACCCAGCTCAGGTGAGGA
CTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCTTCTACGTGGCAGATGGCAGCCTGCA
CCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCTCATCCCCGCTGCCCCTCCCGCCCGG
TAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTATGGGCTACCAGCTGCATGGAGCAGA
GGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCGTCTCCAGCCACACGCCGCCTGTCAG
CGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCACTGGCCTCGATCTACTCCCC
GGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGAACGTCACAGTGGCCTCGAGC
AGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAGAAGACCACCTGGACGAGGCCATCCA
CGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGGCGCTGGCCTCAGGTTTCACCGGCCC
CATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAGGCAGCACCAGCCTCATGCACAACCA
CGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTGTTTTGAGTATCCGAGGAGCCCAGGA
GGAGGAACCCACAGACCCCCAGCTGATGCGGCTGGACAACATGCTGTTAGCGGAAGGCGTGGCGGGGCCTGAGAAGGGCGGAGGGTCGGC
GGCAGCGGCGGCAGCGGCGGCGGCTTCTGGAGGGGCAGGTTCAGACAACTCAGTGGAGCATTCAGATTACAGAGCCAAACTCTCACAGAT
CAGACAAATCTACCATACGGAGCTGGAGAAATACGAGCAGGCCTGCAACGAGTTCACCACCCACGTGATGAATCTCCTGCGAGAGCAAAG
CCGGACCAGGCCCATCTCCCCAAAGGAGATTGAGCGGATGGTCAGCATCATCCACCGCAAGTTCAGCTCCATCCAGATGCAGCTCAAGCA
GAGCACGTGCGAGGCGGTGATGATCCTGCGTTCCCGATTTCTGGATGCGCGGCGGAAGAGACGGAATTTCAACAAGCAAGCGACAGAAAT
CCTGAATGAATATTTCTATTCCCATCTCAGCAACCCTTACCCCAGTGAGGAAGCCAAAGAGGAGTTAGCCAAGAAGTGTGGCATCACAGT
CTCCCAGGTATCAAACTGGTTTGGAAATAAGCGAATCCGGTACAAGAAGAACATAGGTAAATTTCAAGAGGAAGCCAATATTTATGCTGC
CAAAACAGCTGTCACTGCTACCAATGTGTCAGCCCATGGAAGCCAAGCTAACTCGCCCTCAACTCCCAACTCGGCTGGTGGATACCCTTC
GCCATGTTATCAGCCAGACAGGAGGATACAGTGATGGACTCGCAGCCAGTCAGATGTACAGTCCGCAGGGCATCAGTGCTAATGGAGGTT
GGCAGGATGCTACTACCCCTTCATCAGTGACCTCCCCTACAGAAGGCCCTGGCAGTGTTCACTCTGATACCTCCAACTGATCTCCCAGCA
ATCGCATCCCGGCTGACCCTGTGCCCCAGTTGGGGCAGGGGCAGGAGGGAGGGTTTCTCTCCCAACGCTGAAGCGGTCAGACTGGAGGTC
GAAGCAATCAGCAAACACAATAAGAGTCTCCTTCTCTTCTCTTCTTTGGGATGCTATTTCAGCCAATCTGGACACTTCTTTATACTCTCT

>In-frame_TCF3_ENST00000395423_chr19_1619110_-_PBX1_ENST00000540236_chr1_164761730_+_2323nt
CTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAGAGGATGGCGCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGA
CTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGCCGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGCAAGAG
CGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTCCTGTCAGGCGAGCTGGCCCT
CAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACTCCGGCAGCTCCCGGCGGAGAGCGGC
AGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGGTGTACCCACCCAGCTCAGGTGAGGA
CTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCTTCTACGTGGCAGATGGCAGCCTGCA
CCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCTCATCCCCGCTGCCCCTCCCGCCCGG
TAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTATGGGCTACCAGCTGCATGGAGCAGA
GGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCGTCTCCAGCCACACGCCGCCTGTCAG
CGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCACTGGCCTCGATCTACTCCCC
GGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGAACGTCACAGTGGCCTCGAGC
AGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAGAAGACCACCTGGACGAGGCCATCCA
CGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGGCGCTGGCCTCAGGTTTCACCGGCCC
CATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAGGCAGCACCAGCCTCATGCACAACCA
CGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTGTTTTGAGTATCCGAGGAGCCCAGGA
GGAGGAACCCACAGACCCCCAGCTGATGCGGCTGGACAACATGCTGTTAGCGGAAGGCGTGGCGGGGCCTGAGAAGGGCGGAGGGTCGGC
GGCAGCGGCGGCAGCGGCGGCGGCTTCTGGAGGGGCAGGTTCAGACAACTCAGTGGAGCATTCAGATTACAGAGCCAAACTCTCACAGAT
CAGACAAATCTACCATACGGAGCTGGAGAAATACGAGCAGGCCTGCAACGAGTTCACCACCCACGTGATGAATCTCCTGCGAGAGCAAAG
CCGGACCAGGCCCATCTCCCCAAAGGAGATTGAGCGGATGGTCAGCATCATCCACCGCAAGTTCAGCTCCATCCAGATGCAGCTCAAGCA
GAGCACGTGCGAGGCGGTGATGATCCTGCGTTCCCGATTTCTGGATGCGCGGCGGAAGAGACGGAATTTCAACAAGCAAGCGACAGAAAT
CCTGAATGAATATTTCTATTCCCATCTCAGCAACCCTTACCCCAGTGAGGAAGCCAAAGAGGAGTTAGCCAAGAAGTGTGGCATCACAGT
CTCCCAGGTATCAAACTGGTTTGGAAATAAGCGAATCCGGTACAAGAAGAACATAGGTAAATTTCAAGAGGAAGCCAATATTTATGCTGC
CAAAACAGCTGTCACTGCTACCAATGTGTCAGCCCATGGAAGCCAAGCTAACTCGCCCTCAACTCCCAACTCGGCTGGTTCTTCCAGTTC
TTTTAACATGTCAAACTCTGGAGATTTGTTCATGAGCGTGCAGTCACTCAATGGGGATTCTTACCAAGGGGCCCAGGTTGGAGCCAACGT
GCAATCACAGGTGGATACCCTTCGCCATGTTATCAGCCAGACAGGAGGATACAGTGATGGACTCGCAGCCAGTCAGATGTACAGTCCGCA


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FusionGenePPI for TCF3_PBX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TCF3HAND2, ID3, SKP2, NHLH1, TCF3, EP300, CREBBP, KAT2B, CALM1, LMX1A, TAL1, LDB1, CBFA2T3, ELK3, MYOD1, ID1, ID2, MYF5, MYF6, MYOG, UBE2I, LYL1, MAPKAPK3, TWIST1, DAXX, MEN1, TCF4, RUNX1T1, RUNX1, VDR, HDAC2, DNMT1, TRIM33, INO80E, YY1, RB1, ASB2, SOX2, ELAVL1, ID4, KDM1A, PRMT5, MRPL37, RPL23A, UQCRC2, MRPL49, DDX17, SAFB, EIF5A, MYO1B, GSE1, SLC25A10, BHLHA15, PIP, ALDH18A1, SF3A3, DNAJC10, RPL36A, IMMT, RPS13, DDX20, TET2, PRPF8, RCOR1, TCF24, RPL14, PON2, SSBP1, RPL31, MRPL44, C14orf166, SPIN1, CCT2, MYL6B, CHCHD3, ATP2A3, LANCL2, SLC9A3R1, TIMM50, ERLIN2, MRPL39, ATOH8, SERPINH1, SETSIP, SON, FBL, SLC25A4, EEF1A2, LGALS7, C1QBP, CPD, MRPL23, NHLH2, RPL13, COX7A2, CSTA, PCBP1, NDUFB4, TFF3, FLG2, HNRNPR, ERAL1, RPN2, RBM39, RPL24, LBR, CASP14, STK38, CANX, TCF12, FOXH1, TLE1, KAT2A, TRRAP, SUPT3H, TADA2A, USF1, SCX, TCF21, RPL37, MAPKAPK2, RNF14, FAM115A, PTF1A, HAND1, NEUROD1, MESP2, BHLHE40, PARP1, PSMD4, NEDD9, XPO1, BCOR, KIF18A, ATOH1, FERD3L, NEUROG3, FKBP9, COLGALT2PBX1MYH10, HOXB7, MEIS1, HOXA9, HOXD4, HOXD9, PKNOX1, HOXB1, HOXB8, NR3C1, MYOD1, MEIS2, HOXA10, SMARCA4, HDAC1, HDAC3, SIN3B, POU2F1, CREBBP, PDX1, ELAVL1, NEDD4L, HOXC8, KAT2A, MDM2, UCHL3, SMARCD3, LMX1B, MAGEA1, MAB21L1, MAB21L2, RBPJ, FOXA1, FOXC1, FOXE1, FOXQ1, TRAF1, FAM222A, VWA5A, C5orf24, CCDC120, C16orf71, ESR1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TCF3_PBX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TCF3_PBX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTCF3C0006413Burkitt Lymphoma2CTD_human
HgeneTCF3C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
HgeneTCF3C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgenePBX1C0006413Burkitt Lymphoma2CTD_human
TgenePBX1C0236969Substance-Related Disorders1CTD_human