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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 37578

FusionGeneSummary for TCF3_C19orf25

check button Fusion gene summary
Fusion gene informationFusion gene name: TCF3_C19orf25
Fusion gene ID: 37578
HgeneTgene
Gene symbol

TCF3

C19orf25

Gene ID

83439

148223

Gene nametranscription factor 7 like 1chromosome 19 open reading frame 25
SynonymsTCF-3|TCF3-
Cytomap

2p11.2

19p13.3

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor 7-like 1HMG box transcription factor 3transcription factor 7-like 1 (T-cell specific, HMG-box)UPF0449 protein C19orf25
Modification date2018052320180519
UniProtAcc

P15923

Q9UFG5

Ensembl transtripts involved in fusion geneENST00000344749, ENST00000262965, 
ENST00000453954, ENST00000395423, 
ENST00000588136, 
ENST00000588427, 
ENST00000436106, ENST00000588871, 
ENST00000427685, ENST00000588849, 
ENST00000586564, ENST00000592872, 
ENST00000585675, ENST00000591027, 
Fusion gene scores* DoF score12 X 12 X 5=7202 X 2 X 2=8
# samples 182
** MAII scorelog2(18/720*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: TCF3 [Title/Abstract] AND C19orf25 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-BR-8080-01ATCF3chr19

1619110

-C19orf25chr19

1461823

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000344749ENST00000588427TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000344749ENST00000436106TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000344749ENST00000588871TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000344749ENST00000427685TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000344749ENST00000588849TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000344749ENST00000586564TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000344749ENST00000592872TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000344749ENST00000585675TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000344749ENST00000591027TCF3chr19

1619110

-C19orf25chr19

1461823

-
Frame-shitENST00000262965ENST00000588427TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000262965ENST00000436106TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000262965ENST00000588871TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000262965ENST00000427685TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000262965ENST00000588849TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000262965ENST00000586564TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000262965ENST00000592872TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000262965ENST00000585675TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000262965ENST00000591027TCF3chr19

1619110

-C19orf25chr19

1461823

-
In-frameENST00000453954ENST00000588427TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000453954ENST00000436106TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000453954ENST00000588871TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000453954ENST00000427685TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000453954ENST00000588849TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000453954ENST00000586564TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000453954ENST00000592872TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000453954ENST00000585675TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000453954ENST00000591027TCF3chr19

1619110

-C19orf25chr19

1461823

-
Frame-shitENST00000395423ENST00000588427TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000395423ENST00000436106TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000395423ENST00000588871TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000395423ENST00000427685TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000395423ENST00000588849TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000395423ENST00000586564TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000395423ENST00000592872TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000395423ENST00000585675TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000395423ENST00000591027TCF3chr19

1619110

-C19orf25chr19

1461823

-
In-frameENST00000588136ENST00000588427TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000588136ENST00000436106TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000588136ENST00000588871TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000588136ENST00000427685TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000588136ENST00000588849TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000588136ENST00000586564TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000588136ENST00000592872TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000588136ENST00000585675TCF3chr19

1619110

-C19orf25chr19

1461823

-
5CDS-intronENST00000588136ENST00000591027TCF3chr19

1619110

-C19orf25chr19

1461823

-

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FusionProtFeatures for TCF3_C19orf25


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TCF3

P15923

C19orf25

Q9UFG5

Transcriptional regulator. Involved in the initiation ofneuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major rolesin determining tissue-specific cell fate during embryogenesis,like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappaimmunoglobulin gene enhancer. Binds to IEB1 and IEB2, which areshort DNA sequences in the insulin gene transcription controlregion. {ECO:0000250|UniProtKB:P15806}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TCF3_C19orf25


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TCF3_ENST00000453954_chr19_1619110_-_C19orf25_ENST00000588427_chr19_1461823_-_428aa
MCRRGPWHGQCTHSARQSGERGATASFGRDAGVGGLTQAGFLSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVR
KVPPGLPSSVYPPSSGEDYGRDATAYPSAKTPSSTTPAPFYVADGSLHPSAELWSPPGQAGFGPMLGGGSSPLPLPPGSGPVGSSGSSST
FGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHSSNNFSSSPS
TPVGSPQGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLPGHGALASGFTGPMSLGGRHAGLVG

>In-frame_TCF3_ENST00000588136_chr19_1619110_-_C19orf25_ENST00000588427_chr19_1461823_-_512aa
MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSGLEDRPSSGSWGSGDQSSSSFDPSRTFSEGTHFTESHSSLSS
STFLGPGLGGKSGERGATASFGRDAGVGGLTQAGFLSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGL
PSSVYPPSSGEDYGRDATAYPSAKTPSSTTPAPFYVADGSLHPSAELWSPPGQAGFGPMLGGGSSPLPLPPGSGPVGSSGSSSTFGGLHQ
HERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSP
QGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLPGHGALASGFTGPMSLGGRHAGLVGGSHPED


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TCF3_ENST00000453954_chr19_1619110_-_C19orf25_ENST00000588427_chr19_1461823_-_1284nt
ATGTGCAGACGTGGGCCTTGGCATGGTCAGTGCACGCACAGCGCCAGGCAAAGCGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGAC
GCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTCCTGTCAGGCGAGCTGGCCCTCAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAG
GGGACCTCCCAGTACTACCCCTCCTACTCCGGCAGCTCCCGGCGGAGAGCGGCAGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGG
AAGGTCCCGCCGGGTCTTCCATCCTCGGTGTACCCACCCAGCTCAGGTGAGGACTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAG
ACCCCCAGCAGCACCTATCCCGCCCCCTTCTACGTGGCAGATGGCAGCCTGCACCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCG
GGCTTCGGGCCCATGCTGGGTGGGGGCTCATCCCCGCTGCCCCTCCCGCCCGGTAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACG
TTTGGTGGCCTGCACCAGCACGAGCGTATGGGCTACCAGCTGCATGGAGCAGAGGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCC
TCAGCCCCCGGAGCCACGTACGGCGGCGTCTCCAGCCACACGCCGCCTGTCAGCGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACA
GCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCACTGGCCTCGATCTACTCCCCGGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCT
ACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGAACGTCACAGTGGCCTCGAGCAGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGG
GGTCTCCACGGCCTGCAGAGTAAGATAGAAGACCACCTGGACGAGGCCATCCACGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGAC
ATGCACACGCTGCTGCCTGGCCACGGGGCGCTGGCCTCAGGTTTCACCGGCCCCATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGA
GGCAGCCACCCCGAGGACGGCCTCGCAGGCAGCACCAGCCTCATGCACAACCACGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGAC
CTGTCTCGGCCTCCCGACTCCTACAGTGGCTGGAGTGCAGTGGCGAGATCTCGACTCACTGCAGGCTCCGACTCCCCAGTTCAAGCGATT

>In-frame_TCF3_ENST00000588136_chr19_1619110_-_C19orf25_ENST00000588427_chr19_1461823_-_1536nt
ATGAACCAGCCGCAGAGGATGGCGCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGACTTCAGCATGATGTTCCCGCTGCCTGTC
ACCAACGGGAAGGGCCGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGTCTTGAGGACCGGCCCAGCTCAGGCTCCTGGGGC
AGCGGCGACCAGAGCAGCTCCTCCTTTGACCCCAGCCGGACCTTCAGCGAGGGCACCCACTTCACTGAGTCGCACAGCAGCCTCTCTTCA
TCCACATTCCTGGGACCGGGACTCGGAGGCAAGAGCGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTG
ACTCAGGCTGGCTTCCTGTCAGGCGAGCTGGCCCTCAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTAC
CCCTCCTACTCCGGCAGCTCCCGGCGGAGAGCGGCAGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTT
CCATCCTCGGTGTACCCACCCAGCTCAGGTGAGGACTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTAT
CCCGCCCCCTTCTACGTGGCAGATGGCAGCCTGCACCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTG
GGTGGGGGCTCATCCCCGCTGCCCCTCCCGCCCGGTAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAG
CACGAGCGTATGGGCTACCAGCTGCATGGAGCAGAGGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACG
TACGGCGGCGTCTCCAGCCACACGCCGCCTGTCAGCGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGAT
GCCCTCGGCAAAGCACTGGCCTCGATCTACTCCCCGGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCC
CAGGGCCTGGCAGGAACGTCACAGTGGCCTCGAGCAGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGCAG
AGTAAGATAGAAGACCACCTGGACGAGGCCATCCACGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCT
GGCCACGGGGCGCTGGCCTCAGGTTTCACCGGCCCCATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGAC
GGCCTCGCAGGCAGCACCAGCCTCATGCACAACCACGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGAC
TCCTACAGTGGCTGGAGTGCAGTGGCGAGATCTCGACTCACTGCAGGCTCCGACTCCCCAGTTCAAGCGATTCTCCTGCCTCAGCCTCCG


* Fusion transcript sequences (Full-length transcript).
>In-frame_TCF3_ENST00000453954_chr19_1619110_-_C19orf25_ENST00000588427_chr19_1461823_-_1924nt
GGAGGTGAGTGCCTGGCCTGGTGCGGTCCCTCTGCTGTGCACAGATGTGCAGACGTGGGCCTTGGCATGGTCAGTGCACGCACAGCGCCA
GGCAAAGCGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTCCTGTCAGGCGAGC
TGGCCCTCAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACTCCGGCAGCTCCCGGCGGA
GAGCGGCAGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGGTGTACCCACCCAGCTCAG
GTGAGGACTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCTTCTACGTGGCAGATGGCA
GCCTGCACCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCTCATCCCCGCTGCCCCTCC
CGCCCGGTAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTATGGGCTACCAGCTGCATG
GAGCAGAGGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCGTCTCCAGCCACACGCCGC
CTGTCAGCGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCACTGGCCTCGATCT
ACTCCCCGGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGAACGTCACAGTGGC
CTCGAGCAGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAGAAGACCACCTGGACGAGG
CCATCCACGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGGCGCTGGCCTCAGGTTTCA
CCGGCCCCATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAGGCAGCACCAGCCTCATGC
ACAACCACGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTGGCTGGAGTGCAGTGGCGA
GATCTCGACTCACTGCAGGCTCCGACTCCCCAGTTCAAGCGATTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGACTACAGACACCCGCCA
CCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCG
CCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCAAGAGCCACCGCGCCCGGCCCAGTGAGGTTGTTTTTTTGAGACGCAGTCTTGCT
CTGTGGCCCAGGCTGGAATGCAGTGGCGCAACCTCCGCCTCCTAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGACTAA
CAGGCGCCCGCTGCCACGCCTGGCTGTTTTTTTTAGTAGAGATGGGGTCTGACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAA
GTGAGCCACGGCGCCCAGCCCACATTTGCTTTCAAAGAGCAGTGACATGAGGAGTGAGCCCCAGCCGGTCTGAGGCTGGACCACCCGCTA
AGCAGTGAGCTGTTCAACTTGATTTCCTCCCAAGTCGGAGAGCTCGCCCGCTGCCGCCAGCAGTCTCCTTCCAGTGACTGAAGAAGCATC

>In-frame_TCF3_ENST00000588136_chr19_1619110_-_C19orf25_ENST00000588427_chr19_1461823_-_2629nt
GGGGAATCACCAAATTTCCCTCGGGGCGGGGTAGGATCGGGCTGTTCCTCCCTTTCCCGGGGGTAGGGGGCCTCAGAGGAAGCCCGGGGT
TGGTTGGAAATGAGAGAGTTGGAGAAAGGAGAGGTTCTGGCTGCCCTGCGTGCAGTTTAAACTTGGCAACTTGATGCCCTGGTGTTCCCT
GGGGGAGTTAGGGAGTTTATATTTGCACACCCTCCCCCCATTTTTCAGACTCCCTGTGGTCTCTGGGGAGGACTCTGCAGGGACCTAGAC
TCTGGAATTCCAGCTTCCCTGCGCCTGCTCCCAGGGCTCCCCGTGCCCCCAGGGCTCTGCTGGAACTCAGACCCCAGGGCGGTTGAGGGT
TTTTTAGGTGGCTTTTAGCACTCTGTGCTTTGACCACTCACAACTCTTCTCCCCTCCCTGTTTCTCCCTGTCCATCTGTCCCCACATCCA
CCAAGCAGGGTTTCCAGGCCTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAGAGGATGGCGCCTGTGGGCACAGACAAGG
AGCTCAGTGACCTCCTGGACTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGCCGGCCCGCCTCCCTGGCCGGGGCGCAGT
TCGGAGGTTCAGGTCTTGAGGACCGGCCCAGCTCAGGCTCCTGGGGCAGCGGCGACCAGAGCAGCTCCTCCTTTGACCCCAGCCGGACCT
TCAGCGAGGGCACCCACTTCACTGAGTCGCACAGCAGCCTCTCTTCATCCACATTCCTGGGACCGGGACTCGGAGGCAAGAGCGGTGAGC
GGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTCCTGTCAGGCGAGCTGGCCCTCAACAGCC
CCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACTCCGGCAGCTCCCGGCGGAGAGCGGCAGACGGCA
GCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGGTGTACCCACCCAGCTCAGGTGAGGACTACGGCA
GGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCTTCTACGTGGCAGATGGCAGCCTGCACCCCTCAG
CCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCTCATCCCCGCTGCCCCTCCCGCCCGGTAGCGGCC
CGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTATGGGCTACCAGCTGCATGGAGCAGAGGTGAACG
GTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCGTCTCCAGCCACACGCCGCCTGTCAGCGGGGCCG
ACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCACTGGCCTCGATCTACTCCCCGGATCACT
CAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGAACGTCACAGTGGCCTCGAGCAGGAGCCC
CCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAGAAGACCACCTGGACGAGGCCATCCACGTGCTCC
GCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGGCGCTGGCCTCAGGTTTCACCGGCCCCATGTCAC
TGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAGGCAGCACCAGCCTCATGCACAACCACGCGGCCC
TCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTGGCTGGAGTGCAGTGGCGAGATCTCGACTCACTG
CAGGCTCCGACTCCCCAGTTCAAGCGATTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGACTACAGACACCCGCCACCACGCCCGGCTAAT
TTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCGCCCGCCTCGGCCTCC
CAAAGTGCTGGGATTACAGGCAAGAGCCACCGCGCCCGGCCCAGTGAGGTTGTTTTTTTGAGACGCAGTCTTGCTCTGTGGCCCAGGCTG
GAATGCAGTGGCGCAACCTCCGCCTCCTAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGACTAACAGGCGCCCGCTGCC
ACGCCTGGCTGTTTTTTTTAGTAGAGATGGGGTCTGACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGAGCCACGGCGCC
CAGCCCACATTTGCTTTCAAAGAGCAGTGACATGAGGAGTGAGCCCCAGCCGGTCTGAGGCTGGACCACCCGCTAAGCAGTGAGCTGTTC
AACTTGATTTCCTCCCAAGTCGGAGAGCTCGCCCGCTGCCGCCAGCAGTCTCCTTCCAGTGACTGAAGAAGCATCCCTGCCGCCCACCGG


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FusionGenePPI for TCF3_C19orf25


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TCF3HAND2, ID3, SKP2, NHLH1, TCF3, EP300, CREBBP, KAT2B, CALM1, LMX1A, TAL1, LDB1, CBFA2T3, ELK3, MYOD1, ID1, ID2, MYF5, MYF6, MYOG, UBE2I, LYL1, MAPKAPK3, TWIST1, DAXX, MEN1, TCF4, RUNX1T1, RUNX1, VDR, HDAC2, DNMT1, TRIM33, INO80E, YY1, RB1, ASB2, SOX2, ELAVL1, ID4, KDM1A, PRMT5, MRPL37, RPL23A, UQCRC2, MRPL49, DDX17, SAFB, EIF5A, MYO1B, GSE1, SLC25A10, BHLHA15, PIP, ALDH18A1, SF3A3, DNAJC10, RPL36A, IMMT, RPS13, DDX20, TET2, PRPF8, RCOR1, TCF24, RPL14, PON2, SSBP1, RPL31, MRPL44, C14orf166, SPIN1, CCT2, MYL6B, CHCHD3, ATP2A3, LANCL2, SLC9A3R1, TIMM50, ERLIN2, MRPL39, ATOH8, SERPINH1, SETSIP, SON, FBL, SLC25A4, EEF1A2, LGALS7, C1QBP, CPD, MRPL23, NHLH2, RPL13, COX7A2, CSTA, PCBP1, NDUFB4, TFF3, FLG2, HNRNPR, ERAL1, RPN2, RBM39, RPL24, LBR, CASP14, STK38, CANX, TCF12, FOXH1, TLE1, KAT2A, TRRAP, SUPT3H, TADA2A, USF1, SCX, TCF21, RPL37, MAPKAPK2, RNF14, FAM115A, PTF1A, HAND1, NEUROD1, MESP2, BHLHE40, PARP1, PSMD4, NEDD9, XPO1, BCOR, KIF18A, ATOH1, FERD3L, NEUROG3, FKBP9, COLGALT2C19orf25C19orf57, CCDC85B, CEP170P1, MYEOV2, DUT, HNRNPH2, ZW10, EPS8, SAT1, BAIAP2, VTI1B, USE1, BSG, P2RY12, P2RY8, SLC30A4, SCARA3, SCLT1, SSX2IP, PTPRJ, RINT1, SCFD2, SEC22B, APLNR, TMEM206, SLC15A1, HTR2C, F2RL1, PTPRN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TCF3_C19orf25


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TCF3_C19orf25


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTCF3C0006413Burkitt Lymphoma2CTD_human
HgeneTCF3C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
HgeneTCF3C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human