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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37577

FusionGeneSummary for TCF3_APC2

check button Fusion gene summary
Fusion gene informationFusion gene name: TCF3_APC2
Fusion gene ID: 37577
HgeneTgene
Gene symbol

TCF3

APC2

Gene ID

83439

79085

Gene nametranscription factor 7 like 1solute carrier family 25 member 23
SynonymsTCF-3|TCF3APC2|MCSC2|SCaMC-3
Cytomap

2p11.2

19p13.3

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor 7-like 1HMG box transcription factor 3transcription factor 7-like 1 (T-cell specific, HMG-box)calcium-binding mitochondrial carrier protein SCaMC-3mitochondrial ATP-Mg/Pi carrier protein 2mitochondrial Ca(2+)-dependent solute carrier protein 2mitochondrial Ca2+-dependent solute carrier protein 2short calcium-binding mitochondrial carrier 3sma
Modification date2018052320180523
UniProtAcc

P15923

O95996

Ensembl transtripts involved in fusion geneENST00000344749, ENST00000262965, 
ENST00000453954, ENST00000395423, 
ENST00000588136, 
ENST00000238483, 
ENST00000233607, ENST00000535453, 
Fusion gene scores* DoF score12 X 12 X 5=7202 X 2 X 2=8
# samples 182
** MAII scorelog2(18/720*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: TCF3 [Title/Abstract] AND APC2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-HC-7744-01ATCF3chr19

1619110

-APC2chr19

1452983

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000344749ENST00000238483TCF3chr19

1619110

-APC2chr19

1452983

+
5CDS-5UTRENST00000344749ENST00000233607TCF3chr19

1619110

-APC2chr19

1452983

+
5CDS-5UTRENST00000344749ENST00000535453TCF3chr19

1619110

-APC2chr19

1452983

+
5CDS-5UTRENST00000262965ENST00000238483TCF3chr19

1619110

-APC2chr19

1452983

+
5CDS-5UTRENST00000262965ENST00000233607TCF3chr19

1619110

-APC2chr19

1452983

+
5CDS-5UTRENST00000262965ENST00000535453TCF3chr19

1619110

-APC2chr19

1452983

+
5CDS-5UTRENST00000453954ENST00000238483TCF3chr19

1619110

-APC2chr19

1452983

+
5CDS-5UTRENST00000453954ENST00000233607TCF3chr19

1619110

-APC2chr19

1452983

+
5CDS-5UTRENST00000453954ENST00000535453TCF3chr19

1619110

-APC2chr19

1452983

+
5CDS-5UTRENST00000395423ENST00000238483TCF3chr19

1619110

-APC2chr19

1452983

+
5CDS-5UTRENST00000395423ENST00000233607TCF3chr19

1619110

-APC2chr19

1452983

+
5CDS-5UTRENST00000395423ENST00000535453TCF3chr19

1619110

-APC2chr19

1452983

+
5CDS-5UTRENST00000588136ENST00000238483TCF3chr19

1619110

-APC2chr19

1452983

+
5CDS-5UTRENST00000588136ENST00000233607TCF3chr19

1619110

-APC2chr19

1452983

+
5CDS-5UTRENST00000588136ENST00000535453TCF3chr19

1619110

-APC2chr19

1452983

+

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FusionProtFeatures for TCF3_APC2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TCF3

P15923

APC2

O95996

Transcriptional regulator. Involved in the initiation ofneuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major rolesin determining tissue-specific cell fate during embryogenesis,like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappaimmunoglobulin gene enhancer. Binds to IEB1 and IEB2, which areshort DNA sequences in the insulin gene transcription controlregion. {ECO:0000250|UniProtKB:P15806}. Stabilizes microtubules and may regulate actin fiberdynamics through the activation of Rho family GTPases(PubMed:25753423). May also function in Wnt signaling by promotingthe rapid degradation of CTNNB1 (PubMed:10021369, PubMed:11691822,PubMed:9823329). {ECO:0000269|PubMed:10021369,ECO:0000269|PubMed:11691822, ECO:0000269|PubMed:25753423,ECO:0000269|PubMed:9823329}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TCF3_APC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TCF3_APC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TCF3HAND2, ID3, SKP2, NHLH1, TCF3, EP300, CREBBP, KAT2B, CALM1, LMX1A, TAL1, LDB1, CBFA2T3, ELK3, MYOD1, ID1, ID2, MYF5, MYF6, MYOG, UBE2I, LYL1, MAPKAPK3, TWIST1, DAXX, MEN1, TCF4, RUNX1T1, RUNX1, VDR, HDAC2, DNMT1, TRIM33, INO80E, YY1, RB1, ASB2, SOX2, ELAVL1, ID4, KDM1A, PRMT5, MRPL37, RPL23A, UQCRC2, MRPL49, DDX17, SAFB, EIF5A, MYO1B, GSE1, SLC25A10, BHLHA15, PIP, ALDH18A1, SF3A3, DNAJC10, RPL36A, IMMT, RPS13, DDX20, TET2, PRPF8, RCOR1, TCF24, RPL14, PON2, SSBP1, RPL31, MRPL44, C14orf166, SPIN1, CCT2, MYL6B, CHCHD3, ATP2A3, LANCL2, SLC9A3R1, TIMM50, ERLIN2, MRPL39, ATOH8, SERPINH1, SETSIP, SON, FBL, SLC25A4, EEF1A2, LGALS7, C1QBP, CPD, MRPL23, NHLH2, RPL13, COX7A2, CSTA, PCBP1, NDUFB4, TFF3, FLG2, HNRNPR, ERAL1, RPN2, RBM39, RPL24, LBR, CASP14, STK38, CANX, TCF12, FOXH1, TLE1, KAT2A, TRRAP, SUPT3H, TADA2A, USF1, SCX, TCF21, RPL37, MAPKAPK2, RNF14, FAM115A, PTF1A, HAND1, NEUROD1, MESP2, BHLHE40, PARP1, PSMD4, NEDD9, XPO1, BCOR, KIF18A, ATOH1, FERD3L, NEUROG3, FKBP9, COLGALT2APC2ACTA1, AXIN2, CTNNB1, NFX1, TP53BP2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TCF3_APC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TCF3_APC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTCF3C0006413Burkitt Lymphoma2CTD_human
HgeneTCF3C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
HgeneTCF3C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneAPC2C0009404Colorectal Neoplasms3CTD_human
TgeneAPC2C0021390Inflammatory Bowel Diseases1CTD_human
TgeneAPC2C1458155Mammary Neoplasms1CTD_human