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Fusion gene ID: 37568 |
FusionGeneSummary for TCF20_RRAS |
Fusion gene summary |
Fusion gene information | Fusion gene name: TCF20_RRAS | Fusion gene ID: 37568 | Hgene | Tgene | Gene symbol | TCF20 | RRAS | Gene ID | 6942 | 6237 |
Gene name | transcription factor 20 | RAS related | |
Synonyms | AR1|SPBP|TCF-20 | R-Ras | |
Cytomap | 22q13.2|22q13.3 | 19q13.33 | |
Type of gene | protein-coding | protein-coding | |
Description | transcription factor 20SPRE-binding proteinnuclear factor SPBPstromelysin-1 PDGF-responsive element-binding proteinstromelysin-1 platelet-derived growth factor-responsive element binding protein | ras-related protein R-Rasoncogene RRASp23ras family small GTP binding protein R-Rasrelated RAS viral (r-ras) oncogene homolog | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9UGU0 | P10301 | |
Ensembl transtripts involved in fusion gene | ENST00000359486, ENST00000335626, ENST00000404876, | ENST00000246792, | |
Fusion gene scores | * DoF score | 9 X 4 X 7=252 | 1 X 1 X 1=1 |
# samples | 12 | 1 | |
** MAII score | log2(12/252*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: TCF20 [Title/Abstract] AND RRAS [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | UCEC | TCGA-B5-A5OD-01A | TCF20 | chr22 | 42739485 | - | RRAS | chr19 | 50140183 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000359486 | ENST00000246792 | TCF20 | chr22 | 42739485 | - | RRAS | chr19 | 50140183 | - |
intron-3CDS | ENST00000335626 | ENST00000246792 | TCF20 | chr22 | 42739485 | - | RRAS | chr19 | 50140183 | - |
intron-3CDS | ENST00000404876 | ENST00000246792 | TCF20 | chr22 | 42739485 | - | RRAS | chr19 | 50140183 | - |
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FusionProtFeatures for TCF20_RRAS |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
TCF20 | RRAS |
Transcriptional activator that binds to the regulatoryregion of MMP3 and thereby controls stromelysin expression. Itstimulates the activity of various transcriptional activators suchas JUN, SP1, PAX6 and ETS1, suggesting a function as acoactivator. | Regulates the organization of the actin cytoskeleton(PubMed:16537651, PubMed:18270267). With OSPBL3, modulatesintegrin beta-1 (ITGB1) activity (PubMed:18270267).{ECO:0000269|PubMed:16537651, ECO:0000269|PubMed:18270267}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TCF20_RRAS |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TCF20_RRAS |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TCF20 | JUN, RNF4, MAPK14, SMAD1, SIRT7, HIST2H2AC, HIST2H2BE, AR, NFE2L2, OBSL1, HIST1H2BA, EWSR1, ADARB1, CLTB, COPB1, BRF1, RBBP7, TRIM27, HDAC1, USP7, CDK2AP1, NIPSNAP1, HMG20A, NOP9, MTA2, PHF14, RAI1, SIN3A, GATAD2A, SLC39A10, GATAD2B, MTA3, ACTL8, NANOG, POU5F1, FKBP9, NR3C1, TRIM25 | RRAS | ARAF, BCL2, NCK1, RASSF5, RALGDS, RAF1, ZHX2, EEF1A1, MRPL36, ATP6V1B1, ACY3, SLC25A41, ITLN1, TMEM185A, JSRP1, CCNL2, LIMK1, HMGXB4, DUSP9, RIN1, IL36RN, NCSTN, SDC1, PRDM1, SSC5D, BZW2, CRH |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TCF20_RRAS |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TCF20_RRAS |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TCF20 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | RRAS | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | RRAS | C0349639 | Juvenile Myelomonocytic Leukemia | 1 | CTD_human |