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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37568

FusionGeneSummary for TCF20_RRAS

check button Fusion gene summary
Fusion gene informationFusion gene name: TCF20_RRAS
Fusion gene ID: 37568
HgeneTgene
Gene symbol

TCF20

RRAS

Gene ID

6942

6237

Gene nametranscription factor 20RAS related
SynonymsAR1|SPBP|TCF-20R-Ras
Cytomap

22q13.2|22q13.3

19q13.33

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor 20SPRE-binding proteinnuclear factor SPBPstromelysin-1 PDGF-responsive element-binding proteinstromelysin-1 platelet-derived growth factor-responsive element binding proteinras-related protein R-Rasoncogene RRASp23ras family small GTP binding protein R-Rasrelated RAS viral (r-ras) oncogene homolog
Modification date2018052320180519
UniProtAcc

Q9UGU0

P10301

Ensembl transtripts involved in fusion geneENST00000359486, ENST00000335626, 
ENST00000404876, 
ENST00000246792, 
Fusion gene scores* DoF score9 X 4 X 7=2521 X 1 X 1=1
# samples 121
** MAII scorelog2(12/252*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: TCF20 [Title/Abstract] AND RRAS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCECTCGA-B5-A5OD-01ATCF20chr22

42739485

-RRASchr19

50140183

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000359486ENST00000246792TCF20chr22

42739485

-RRASchr19

50140183

-
intron-3CDSENST00000335626ENST00000246792TCF20chr22

42739485

-RRASchr19

50140183

-
intron-3CDSENST00000404876ENST00000246792TCF20chr22

42739485

-RRASchr19

50140183

-

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FusionProtFeatures for TCF20_RRAS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TCF20

Q9UGU0

RRAS

P10301

Transcriptional activator that binds to the regulatoryregion of MMP3 and thereby controls stromelysin expression. Itstimulates the activity of various transcriptional activators suchas JUN, SP1, PAX6 and ETS1, suggesting a function as acoactivator. Regulates the organization of the actin cytoskeleton(PubMed:16537651, PubMed:18270267). With OSPBL3, modulatesintegrin beta-1 (ITGB1) activity (PubMed:18270267).{ECO:0000269|PubMed:16537651, ECO:0000269|PubMed:18270267}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TCF20_RRAS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TCF20_RRAS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TCF20JUN, RNF4, MAPK14, SMAD1, SIRT7, HIST2H2AC, HIST2H2BE, AR, NFE2L2, OBSL1, HIST1H2BA, EWSR1, ADARB1, CLTB, COPB1, BRF1, RBBP7, TRIM27, HDAC1, USP7, CDK2AP1, NIPSNAP1, HMG20A, NOP9, MTA2, PHF14, RAI1, SIN3A, GATAD2A, SLC39A10, GATAD2B, MTA3, ACTL8, NANOG, POU5F1, FKBP9, NR3C1, TRIM25RRASARAF, BCL2, NCK1, RASSF5, RALGDS, RAF1, ZHX2, EEF1A1, MRPL36, ATP6V1B1, ACY3, SLC25A41, ITLN1, TMEM185A, JSRP1, CCNL2, LIMK1, HMGXB4, DUSP9, RIN1, IL36RN, NCSTN, SDC1, PRDM1, SSC5D, BZW2, CRH


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TCF20_RRAS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TCF20_RRAS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTCF20C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneRRASC0033578Prostatic Neoplasms1CTD_human
TgeneRRASC0349639Juvenile Myelomonocytic Leukemia1CTD_human