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Fusion gene ID: 37564 |
FusionGeneSummary for TCF20_CYP2D6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TCF20_CYP2D6 | Fusion gene ID: 37564 | Hgene | Tgene | Gene symbol | TCF20 | CYP2D6 | Gene ID | 6942 | 1565 |
| Gene name | transcription factor 20 | cytochrome P450 family 2 subfamily D member 6 | |
| Synonyms | AR1|SPBP|TCF-20 | CPD6|CYP2D|CYP2D7AP|CYP2D7BP|CYP2D7P2|CYP2D8P2|CYP2DL1|CYPIID6|P450-DB1|P450C2D|P450DB1 | |
| Cytomap | 22q13.2|22q13.3 | 22q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription factor 20SPRE-binding proteinnuclear factor SPBPstromelysin-1 PDGF-responsive element-binding proteinstromelysin-1 platelet-derived growth factor-responsive element binding protein | cytochrome P450 2D6cholesterol 25-hydroxylasecytochrome P450, family 2, subfamily D, polypeptide 6cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2cytochrome P450, sub | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UGU0 | P10635 | |
| Ensembl transtripts involved in fusion gene | ENST00000359486, ENST00000335626, ENST00000404876, | ENST00000360608, ENST00000389970, ENST00000359033, | |
| Fusion gene scores | * DoF score | 9 X 4 X 7=252 | 1 X 1 X 1=1 |
| # samples | 12 | 1 | |
| ** MAII score | log2(12/252*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: TCF20 [Title/Abstract] AND CYP2D6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CYP2D6 | GO:0009804 | coumarin metabolic process | 19438707 |
| Tgene | CYP2D6 | GO:0009820 | alkaloid metabolic process | 19651758 |
| Tgene | CYP2D6 | GO:0009822 | alkaloid catabolic process | 15039299 |
| Tgene | CYP2D6 | GO:0016098 | monoterpenoid metabolic process | 16401082 |
| Tgene | CYP2D6 | GO:0017144 | drug metabolic process | 19219744 |
| Tgene | CYP2D6 | GO:0033076 | isoquinoline alkaloid metabolic process | 19448135 |
| Tgene | CYP2D6 | GO:0042737 | drug catabolic process | 15039299 |
| Tgene | CYP2D6 | GO:0046483 | heterocycle metabolic process | 15327587|19651758 |
| Tgene | CYP2D6 | GO:0051100 | negative regulation of binding | 19448135 |
| Tgene | CYP2D6 | GO:0055114 | oxidation-reduction process | 16401082|19219744 |
| Tgene | CYP2D6 | GO:0070989 | oxidative demethylation | 15039299|19438707 |
| Tgene | CYP2D6 | GO:0090350 | negative regulation of cellular organofluorine metabolic process | 19448135 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-VQ-AA69-01A | TCF20 | chr22 | 42739485 | - | CYP2D6 | chr22 | 42524946 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000359486 | ENST00000360608 | TCF20 | chr22 | 42739485 | - | CYP2D6 | chr22 | 42524946 | - |
| intron-3CDS | ENST00000359486 | ENST00000389970 | TCF20 | chr22 | 42739485 | - | CYP2D6 | chr22 | 42524946 | - |
| intron-3CDS | ENST00000359486 | ENST00000359033 | TCF20 | chr22 | 42739485 | - | CYP2D6 | chr22 | 42524946 | - |
| intron-3CDS | ENST00000335626 | ENST00000360608 | TCF20 | chr22 | 42739485 | - | CYP2D6 | chr22 | 42524946 | - |
| intron-3CDS | ENST00000335626 | ENST00000389970 | TCF20 | chr22 | 42739485 | - | CYP2D6 | chr22 | 42524946 | - |
| intron-3CDS | ENST00000335626 | ENST00000359033 | TCF20 | chr22 | 42739485 | - | CYP2D6 | chr22 | 42524946 | - |
| intron-3CDS | ENST00000404876 | ENST00000360608 | TCF20 | chr22 | 42739485 | - | CYP2D6 | chr22 | 42524946 | - |
| intron-3CDS | ENST00000404876 | ENST00000389970 | TCF20 | chr22 | 42739485 | - | CYP2D6 | chr22 | 42524946 | - |
| intron-3CDS | ENST00000404876 | ENST00000359033 | TCF20 | chr22 | 42739485 | - | CYP2D6 | chr22 | 42524946 | - |
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FusionProtFeatures for TCF20_CYP2D6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TCF20 | CYP2D6 |
| Transcriptional activator that binds to the regulatoryregion of MMP3 and thereby controls stromelysin expression. Itstimulates the activity of various transcriptional activators suchas JUN, SP1, PAX6 and ETS1, suggesting a function as acoactivator. | Responsible for the metabolism of many drugs andenvironmental chemicals that it oxidizes. It is involved in themetabolism of drugs such as antiarrhythmics, adrenoceptorantagonists, and tricyclic antidepressants.{ECO:0000269|PubMed:16352597}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TCF20_CYP2D6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TCF20_CYP2D6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TCF20 | JUN, RNF4, MAPK14, SMAD1, SIRT7, HIST2H2AC, HIST2H2BE, AR, NFE2L2, OBSL1, HIST1H2BA, EWSR1, ADARB1, CLTB, COPB1, BRF1, RBBP7, TRIM27, HDAC1, USP7, CDK2AP1, NIPSNAP1, HMG20A, NOP9, MTA2, PHF14, RAI1, SIN3A, GATAD2A, SLC39A10, GATAD2B, MTA3, ACTL8, NANOG, POU5F1, FKBP9, NR3C1, TRIM25 | CYP2D6 | POR, CYB5A, CYP2C9, CYP2D6 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TCF20_CYP2D6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | CYP2D6 | P10635 | DB01267 | Paliperidone | Cytochrome P450 2D6 | small molecule | approved |
| Tgene | CYP2D6 | P10635 | DB11994 | Diacerein | Cytochrome P450 2D6 | small molecule | approved|investigational |
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RelatedDiseases for TCF20_CYP2D6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TCF20 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | CYP2D6 | C0011570 | Mental Depression | 5 | PSYGENET |
| Tgene | CYP2D6 | C0011581 | Depressive disorder | 5 | PSYGENET |
| Tgene | CYP2D6 | C0036341 | Schizophrenia | 5 | PSYGENET |
| Tgene | CYP2D6 | C0041696 | Unipolar Depression | 5 | PSYGENET |
| Tgene | CYP2D6 | C1269683 | Major Depressive Disorder | 5 | PSYGENET |
| Tgene | CYP2D6 | C0030567 | Parkinson Disease | 2 | CTD_human |
| Tgene | CYP2D6 | C0033953 | Psychosexual Disorders | 2 | CTD_human |
| Tgene | CYP2D6 | C0002395 | Alzheimer's Disease | 1 | CTD_human |
| Tgene | CYP2D6 | C0004782 | Basal Ganglia Diseases | 1 | CTD_human |
| Tgene | CYP2D6 | C0009421 | Comatose | 1 | CTD_human |
| Tgene | CYP2D6 | C0013421 | Dystonia | 1 | CTD_human |
| Tgene | CYP2D6 | C0014549 | Tonic-Clonic Epilepsy | 1 | CTD_human |
| Tgene | CYP2D6 | C0026837 | Muscle Rigidity | 1 | CTD_human |
| Tgene | CYP2D6 | C0027707 | Nephritis, Interstitial | 1 | CTD_human |
| Tgene | CYP2D6 | C0028797 | Occupational Diseases | 1 | CTD_human |
| Tgene | CYP2D6 | C0033054 | Prenatal Exposure Delayed Effects | 1 | CTD_human |
| Tgene | CYP2D6 | C0040822 | Tremor | 1 | CTD_human |
| Tgene | CYP2D6 | C0041755 | Adverse reaction to drug | 1 | CTD_human |
| Tgene | CYP2D6 | C0043094 | Weight Gain | 1 | CTD_human |
| Tgene | CYP2D6 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
| Tgene | CYP2D6 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| Tgene | CYP2D6 | C0428977 | Bradycardia | 1 | CTD_human |
| Tgene | CYP2D6 | C0525045 | Mood Disorders | 1 | PSYGENET |
| Tgene | CYP2D6 | C0677050 | Manganese Poisoning | 1 | CTD_human |
| Tgene | CYP2D6 | C0809983 | Schizophrenia and related disorders | 1 | PSYGENET |
| Tgene | CYP2D6 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | CYP2D6 | C2609414 | Acute kidney injury | 1 | CTD_human |
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