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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37550

FusionGeneSummary for TCF12_NCOA3

check button Fusion gene summary
Fusion gene informationFusion gene name: TCF12_NCOA3
Fusion gene ID: 37550
HgeneTgene
Gene symbol

TCF12

NCOA3

Gene ID

6938

8202

Gene nametranscription factor 12nuclear receptor coactivator 3
SynonymsCRS3|HEB|HTF4|HsT17266|TCF-12|bHLHb20|p64ACTR|AIB-1|AIB1|CAGH16|CTG26|KAT13B|RAC3|SRC-3|SRC3|TNRC14|TNRC16|TRAM-1|bHLHe42|pCIP
Cytomap

15q21.3

20q13.12

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor 12DNA-binding protein HTF4E-box-binding proteinclass B basic helix-loop-helix protein 20helix-loop-helix transcription factor 4transcription factor HTF-4nuclear receptor coactivator 3CBP-interacting proteinamplified in breast cancer 1 proteinclass E basic helix-loop-helix protein 42receptor-associated coactivator 3steroid receptor coactivator protein 3thyroid hormone receptor activator molecule 1
Modification date2018052320180523
UniProtAcc

Q99081

Q9Y6Q9

Ensembl transtripts involved in fusion geneENST00000438423, ENST00000267811, 
ENST00000452095, ENST00000333725, 
ENST00000557843, ENST00000560764, 
ENST00000543579, ENST00000537840, 
ENST00000343827, ENST00000559710, 
ENST00000559703, 
ENST00000341724, 
ENST00000372004, ENST00000371998, 
ENST00000371997, ENST00000497292, 
Fusion gene scores* DoF score22 X 12 X 9=23769 X 6 X 4=216
# samples 229
** MAII scorelog2(22/2376*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TCF12 [Title/Abstract] AND NCOA3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTCF12

GO:0045944

positive regulation of transcription by RNA polymerase II

11802795

TgeneNCOA3

GO:0045944

positive regulation of transcription by RNA polymerase II

9267036

TgeneNCOA3

GO:0071392

cellular response to estradiol stimulus

15831516


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-C4-A0F7-01ATCF12chr15

57213296

+NCOA3chr20

46211927

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000438423ENST00000341724TCF12chr15

57213296

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000438423ENST00000372004TCF12chr15

57213296

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000438423ENST00000371998TCF12chr15

57213296

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000438423ENST00000371997TCF12chr15

57213296

+NCOA3chr20

46211927

+
5CDS-intronENST00000438423ENST00000497292TCF12chr15

57213296

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000267811ENST00000341724TCF12chr15

57213296

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000267811ENST00000372004TCF12chr15

57213296

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000267811ENST00000371998TCF12chr15

57213296

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000267811ENST00000371997TCF12chr15

57213296

+NCOA3chr20

46211927

+
5CDS-intronENST00000267811ENST00000497292TCF12chr15

57213296

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000452095ENST00000341724TCF12chr15

57213296

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000452095ENST00000372004TCF12chr15

57213296

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000452095ENST00000371998TCF12chr15

57213296

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000452095ENST00000371997TCF12chr15

57213296

+NCOA3chr20

46211927

+
5CDS-intronENST00000452095ENST00000497292TCF12chr15

57213296

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000333725ENST00000341724TCF12chr15

57213296

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000333725ENST00000372004TCF12chr15

57213296

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000333725ENST00000371998TCF12chr15

57213296

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000333725ENST00000371997TCF12chr15

57213296

+NCOA3chr20

46211927

+
5CDS-intronENST00000333725ENST00000497292TCF12chr15

57213296

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000557843ENST00000341724TCF12chr15

57213296

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000557843ENST00000372004TCF12chr15

57213296

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000557843ENST00000371998TCF12chr15

57213296

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000557843ENST00000371997TCF12chr15

57213296

+NCOA3chr20

46211927

+
5CDS-intronENST00000557843ENST00000497292TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-5UTRENST00000560764ENST00000341724TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-5UTRENST00000560764ENST00000372004TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-5UTRENST00000560764ENST00000371998TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-5UTRENST00000560764ENST00000371997TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-intronENST00000560764ENST00000497292TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-5UTRENST00000543579ENST00000341724TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-5UTRENST00000543579ENST00000372004TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-5UTRENST00000543579ENST00000371998TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-5UTRENST00000543579ENST00000371997TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-intronENST00000543579ENST00000497292TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-5UTRENST00000537840ENST00000341724TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-5UTRENST00000537840ENST00000372004TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-5UTRENST00000537840ENST00000371998TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-5UTRENST00000537840ENST00000371997TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-intronENST00000537840ENST00000497292TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-5UTRENST00000343827ENST00000341724TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-5UTRENST00000343827ENST00000372004TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-5UTRENST00000343827ENST00000371998TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-5UTRENST00000343827ENST00000371997TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-intronENST00000343827ENST00000497292TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-5UTRENST00000559710ENST00000341724TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-5UTRENST00000559710ENST00000372004TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-5UTRENST00000559710ENST00000371998TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-5UTRENST00000559710ENST00000371997TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-intronENST00000559710ENST00000497292TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-5UTRENST00000559703ENST00000341724TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-5UTRENST00000559703ENST00000372004TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-5UTRENST00000559703ENST00000371998TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-5UTRENST00000559703ENST00000371997TCF12chr15

57213296

+NCOA3chr20

46211927

+
intron-intronENST00000559703ENST00000497292TCF12chr15

57213296

+NCOA3chr20

46211927

+

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FusionProtFeatures for TCF12_NCOA3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TCF12

Q99081

NCOA3

Q9Y6Q9

Transcriptional regulator. Involved in the initiation ofneuronal differentiation. Activates transcription by binding tothe E box (5'-CANNTG-3').

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TCF12_NCOA3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TCF12_NCOA3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TCF12ID2, ASCL4, TCF23, OLIG3, PRSS23, TAL1, ID1, ID3, TAL2, RUNX1T1, CREBBP, EP300, TAF4, TBP, RUNX1, TRIM33, ELAVL1, SMAD2, SMAD3, TCF3, FOXH1, NOTCH1, MYC, SOX2, TCF21, BMF, DGCR6, CDKN2C, MLLT6, PSMA1, QARS, RNASEL, SRI, STAT5A, TSNAX, STK16, MAPKBP1, ARMC8, EDRF1, CRCP, OSGIN1, NEUROG3, VPS28, SPG21, C1orf109, NAGK, HOPX, C16orf45, TWIST2, MORN4, HEXIM2, C6orf165, LYSMD1, TRIM72, SHMT2, MOV10, NXF1, MYOG, CCDC101, NEUROD1, MESP2, NTRK1, TCF12, FRMD6, MYF6, XPO1, ZWINT, STRN3, TCF4, NFATC2, ATOH1, FERD3L, TRIM25NCOA3AR, BRCA1, EP300, ANKRD11, NPAS2, NR3C1, YWHAQ, PRMT1, NR4A1, NR2F1, RXRA, CCND1, ESRRA, ESRRB, NKX2-1, CREBBP, ESR1, ESR2, NR0B2, NR5A2, NCOA2, TRIM21, IKBKG, IKBKB, CHUK, VDR, PGR, HIST3H3, HIST4H4, CARM1, ABL1, FOS, NCOR1, ETS1, ETS2, PPARG, NCOA1, THRA, STAT6, SMAD2, SMAD3, ATAD2, KAT2B, RARA, NCOR2, SPOP, CDKN3, IQCK, BRE, DCTN6, CSNK1E, RARG, NR1H3, NR1H2, THRB, SPTA1, MYH9, ACTA1, ANXA2, TPR, MORC2, NFATC3, PSME3, EIF3E, CUL3, NFKB1, MAPK14, MAPK1, MAPK8, GSK3B, RFX1, TP53BP1, PSMC5, PRKCZ, TFF1, PSMA3, MYOCD, CEBPA, CEBPD, UBE3A, E2F1, PIN1, ELAVL1, TP53, KANK2, NR1I2, ALB, MMS19, PTEN, FBXW7, ARNT2, PSMB9, ETV1, PPARD, PPARA, NR1I3, MN1, MKL1, MKL2, HNF1A, RELA, EWSR1, XPO1, XRCC5, TMEM132A, PIAS1, RAB28, FOXA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TCF12_NCOA3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TCF12_NCOA3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTCF12C3715051CRANIOSYNOSTOSIS 32UNIPROT
HgeneTCF12C0010278Craniosynostosis1CTD_human;HPO
TgeneNCOA3C0023418leukemia2CTD_human
TgeneNCOA3C0033578Prostatic Neoplasms2CTD_human
TgeneNCOA3C0001418Adenocarcinoma1CTD_human
TgeneNCOA3C0004114Astrocytoma1CTD_human
TgeneNCOA3C0005967Bone neoplasms1CTD_human
TgeneNCOA3C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneNCOA3C0007137Squamous cell carcinoma1CTD_human
TgeneNCOA3C1458155Mammary Neoplasms1CTD_human