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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37549

FusionGeneSummary for TCF12_MGST2

check button Fusion gene summary
Fusion gene informationFusion gene name: TCF12_MGST2
Fusion gene ID: 37549
HgeneTgene
Gene symbol

TCF12

MGST2

Gene ID

6938

4258

Gene nametranscription factor 12microsomal glutathione S-transferase 2
SynonymsCRS3|HEB|HTF4|HsT17266|TCF-12|bHLHb20|p64GST2|MGST-II
Cytomap

15q21.3

4q31.1

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor 12DNA-binding protein HTF4E-box-binding proteinclass B basic helix-loop-helix protein 20helix-loop-helix transcription factor 4transcription factor HTF-4microsomal glutathione S-transferase 2microsomal GST-2microsomal GST-II
Modification date2018052320180523
UniProtAcc

Q99081

Q99735

Ensembl transtripts involved in fusion geneENST00000438423, ENST00000267811, 
ENST00000452095, ENST00000333725, 
ENST00000557843, ENST00000560764, 
ENST00000543579, ENST00000537840, 
ENST00000343827, ENST00000559710, 
ENST00000559703, 		ENST00000515137, 
ENST00000265498, ENST00000506797, 
Fusion gene scores* DoF score22 X 12 X 9=23767 X 4 X 6=168
# samples 228
** MAII scorelog2(22/2376*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TCF12 [Title/Abstract] AND MGST2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTCF12

GO:0045944

positive regulation of transcription by RNA polymerase II

11802795

TgeneMGST2

GO:0006629

lipid metabolic process

9278457

TgeneMGST2

GO:0006750

glutathione biosynthetic process

8703034

TgeneMGST2

GO:0019370

leukotriene biosynthetic process

8703034|9092565|23409838

TgeneMGST2

GO:0046466

membrane lipid catabolic process

23409838


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-GI-A2C9-01ATCF12chr15

57213296

+MGST2chr4

140599697

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000438423ENST00000515137TCF12chr15

57213296

+MGST2chr4

140599697

+
5CDS-intronENST00000438423ENST00000265498TCF12chr15

57213296

+MGST2chr4

140599697

+
5CDS-intronENST00000438423ENST00000506797TCF12chr15

57213296

+MGST2chr4

140599697

+
5CDS-intronENST00000267811ENST00000515137TCF12chr15

57213296

+MGST2chr4

140599697

+
5CDS-intronENST00000267811ENST00000265498TCF12chr15

57213296

+MGST2chr4

140599697

+
5CDS-intronENST00000267811ENST00000506797TCF12chr15

57213296

+MGST2chr4

140599697

+
5CDS-intronENST00000452095ENST00000515137TCF12chr15

57213296

+MGST2chr4

140599697

+
5CDS-intronENST00000452095ENST00000265498TCF12chr15

57213296

+MGST2chr4

140599697

+
5CDS-intronENST00000452095ENST00000506797TCF12chr15

57213296

+MGST2chr4

140599697

+
5CDS-intronENST00000333725ENST00000515137TCF12chr15

57213296

+MGST2chr4

140599697

+
5CDS-intronENST00000333725ENST00000265498TCF12chr15

57213296

+MGST2chr4

140599697

+
5CDS-intronENST00000333725ENST00000506797TCF12chr15

57213296

+MGST2chr4

140599697

+
5CDS-intronENST00000557843ENST00000515137TCF12chr15

57213296

+MGST2chr4

140599697

+
5CDS-intronENST00000557843ENST00000265498TCF12chr15

57213296

+MGST2chr4

140599697

+
5CDS-intronENST00000557843ENST00000506797TCF12chr15

57213296

+MGST2chr4

140599697

+
intron-intronENST00000560764ENST00000515137TCF12chr15

57213296

+MGST2chr4

140599697

+
intron-intronENST00000560764ENST00000265498TCF12chr15

57213296

+MGST2chr4

140599697

+
intron-intronENST00000560764ENST00000506797TCF12chr15

57213296

+MGST2chr4

140599697

+
intron-intronENST00000543579ENST00000515137TCF12chr15

57213296

+MGST2chr4

140599697

+
intron-intronENST00000543579ENST00000265498TCF12chr15

57213296

+MGST2chr4

140599697

+
intron-intronENST00000543579ENST00000506797TCF12chr15

57213296

+MGST2chr4

140599697

+
intron-intronENST00000537840ENST00000515137TCF12chr15

57213296

+MGST2chr4

140599697

+
intron-intronENST00000537840ENST00000265498TCF12chr15

57213296

+MGST2chr4

140599697

+
intron-intronENST00000537840ENST00000506797TCF12chr15

57213296

+MGST2chr4

140599697

+
intron-intronENST00000343827ENST00000515137TCF12chr15

57213296

+MGST2chr4

140599697

+
intron-intronENST00000343827ENST00000265498TCF12chr15

57213296

+MGST2chr4

140599697

+
intron-intronENST00000343827ENST00000506797TCF12chr15

57213296

+MGST2chr4

140599697

+
intron-intronENST00000559710ENST00000515137TCF12chr15

57213296

+MGST2chr4

140599697

+
intron-intronENST00000559710ENST00000265498TCF12chr15

57213296

+MGST2chr4

140599697

+
intron-intronENST00000559710ENST00000506797TCF12chr15

57213296

+MGST2chr4

140599697

+
intron-intronENST00000559703ENST00000515137TCF12chr15

57213296

+MGST2chr4

140599697

+
intron-intronENST00000559703ENST00000265498TCF12chr15

57213296

+MGST2chr4

140599697

+
intron-intronENST00000559703ENST00000506797TCF12chr15

57213296

+MGST2chr4

140599697

+

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FusionProtFeatures for TCF12_MGST2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TCF12

Q99081

MGST2

Q99735

Transcriptional regulator. Involved in the initiation ofneuronal differentiation. Activates transcription by binding tothe E box (5'-CANNTG-3'). Can catalyze the production of LTC4 from LTA4 andreduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TCF12_MGST2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TCF12_MGST2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TCF12ID2, ASCL4, TCF23, OLIG3, PRSS23, TAL1, ID1, ID3, TAL2, RUNX1T1, CREBBP, EP300, TAF4, TBP, RUNX1, TRIM33, ELAVL1, SMAD2, SMAD3, TCF3, FOXH1, NOTCH1, MYC, SOX2, TCF21, BMF, DGCR6, CDKN2C, MLLT6, PSMA1, QARS, RNASEL, SRI, STAT5A, TSNAX, STK16, MAPKBP1, ARMC8, EDRF1, CRCP, OSGIN1, NEUROG3, VPS28, SPG21, C1orf109, NAGK, HOPX, C16orf45, TWIST2, MORN4, HEXIM2, C6orf165, LYSMD1, TRIM72, SHMT2, MOV10, NXF1, MYOG, CCDC101, NEUROD1, MESP2, NTRK1, TCF12, FRMD6, MYF6, XPO1, ZWINT, STRN3, TCF4, NFATC2, ATOH1, FERD3L, TRIM25MGST2MGST2, RELL2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TCF12_MGST2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMGST2Q99735DB00143GlutathioneMicrosomal glutathione S-transferase 2small moleculeapproved|investigational|nutraceutical

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RelatedDiseases for TCF12_MGST2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTCF12C3715051CRANIOSYNOSTOSIS 32UNIPROT
HgeneTCF12C0010278Craniosynostosis1CTD_human;HPO