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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 37540

FusionGeneSummary for TCF12_C14orf1

check button Fusion gene summary
Fusion gene informationFusion gene name: TCF12_C14orf1
Fusion gene ID: 37540
HgeneTgene
Gene symbol

TCF12

C14orf1

Gene ID

6938

Gene nametranscription factor 12
SynonymsCRS3|HEB|HTF4|HsT17266|TCF-12|bHLHb20|p64
Cytomap

15q21.3

Type of geneprotein-coding
Descriptiontranscription factor 12DNA-binding protein HTF4E-box-binding proteinclass B basic helix-loop-helix protein 20helix-loop-helix transcription factor 4transcription factor HTF-4
Modification date20180523
UniProtAcc

Q99081

Ensembl transtripts involved in fusion geneENST00000438423, ENST00000267811, 
ENST00000452095, ENST00000333725, 
ENST00000557843, ENST00000560764, 
ENST00000543579, ENST00000537840, 
ENST00000343827, ENST00000559710, 
ENST00000559703, 
ENST00000256319, 
Fusion gene scores* DoF score22 X 12 X 9=23762 X 2 X 2=8
# samples 222
** MAII scorelog2(22/2376*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: TCF12 [Title/Abstract] AND C14orf1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTCF12

GO:0045944

positive regulation of transcription by RNA polymerase II

11802795


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-J4-AATZ-01ATCF12chr15

57356021

+C14orf1chr14

76118232

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000438423ENST00000256319TCF12chr15

57356021

+C14orf1chr14

76118232

-
Frame-shiftENST00000267811ENST00000256319TCF12chr15

57356021

+C14orf1chr14

76118232

-
intron-3CDSENST00000452095ENST00000256319TCF12chr15

57356021

+C14orf1chr14

76118232

-
Frame-shiftENST00000333725ENST00000256319TCF12chr15

57356021

+C14orf1chr14

76118232

-
Frame-shiftENST00000557843ENST00000256319TCF12chr15

57356021

+C14orf1chr14

76118232

-
intron-3CDSENST00000560764ENST00000256319TCF12chr15

57356021

+C14orf1chr14

76118232

-
intron-3CDSENST00000543579ENST00000256319TCF12chr15

57356021

+C14orf1chr14

76118232

-
intron-3CDSENST00000537840ENST00000256319TCF12chr15

57356021

+C14orf1chr14

76118232

-
intron-3CDSENST00000343827ENST00000256319TCF12chr15

57356021

+C14orf1chr14

76118232

-
intron-3CDSENST00000559710ENST00000256319TCF12chr15

57356021

+C14orf1chr14

76118232

-
intron-3CDSENST00000559703ENST00000256319TCF12chr15

57356021

+C14orf1chr14

76118232

-

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FusionProtFeatures for TCF12_C14orf1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TCF12

Q99081

C14orf1

Transcriptional regulator. Involved in the initiation ofneuronal differentiation. Activates transcription by binding tothe E box (5'-CANNTG-3'). Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TCF12_C14orf1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TCF12_C14orf1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TCF12ID2, ASCL4, TCF23, OLIG3, PRSS23, TAL1, ID1, ID3, TAL2, RUNX1T1, CREBBP, EP300, TAF4, TBP, RUNX1, TRIM33, ELAVL1, SMAD2, SMAD3, TCF3, FOXH1, NOTCH1, MYC, SOX2, TCF21, BMF, DGCR6, CDKN2C, MLLT6, PSMA1, QARS, RNASEL, SRI, STAT5A, TSNAX, STK16, MAPKBP1, ARMC8, EDRF1, CRCP, OSGIN1, NEUROG3, VPS28, SPG21, C1orf109, NAGK, HOPX, C16orf45, TWIST2, MORN4, HEXIM2, C6orf165, LYSMD1, TRIM72, SHMT2, MOV10, NXF1, MYOG, CCDC101, NEUROD1, MESP2, NTRK1, TCF12, FRMD6, MYF6, XPO1, ZWINT, STRN3, TCF4, NFATC2, ATOH1, FERD3L, TRIM25C14orf1BAIAP2, HYLS1, MPHOSPH6, MRPL38, PQBP1, S100A8, SULT1E1, FAS, CELF3, ZFP64, KLHL20, BTBD2, CCL18, CRADD, CREB1, HMGB1, NDUFA4L2, PCDHA4, PFN1, PHYHIP, PPP1R8, RAB27A, SNRPB, TFG, CDC42, CDK5RAP2, COX17, NAT9, DYNLL1, FXR1, HNRNPUL1, CCDC106, MRPS12, PAFAH1B3, POLE2, POLR2C, PEX2, SEPHS1, SERPINB9, SNRPG, TK1, ZNF24, ALDH2, CSTF2, HNRNPH3, LSM2, NSF, POLR3F, SAT1, HSPE1, MAPK8IP2, GSK3B, BID, ANXA1, RPS6KA6, TTR, NR1H2, ANXA7, TSC22D1, GADD45A, CLN8, ENO1, MOV10, CREB3, MTNR1B, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TCF12_C14orf1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TCF12_C14orf1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTCF12C3715051CRANIOSYNOSTOSIS 32UNIPROT
HgeneTCF12C0010278Craniosynostosis1CTD_human;HPO